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Disease on EC 1.8.3.2 - thiol oxidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
The structure of augmenter of liver regeneration crystallized in the presence of 50?mM CdCl(2) reveals a novel Cd(2)Cl(4)O(6) cluster that aids in crystal packing.
Acute Kidney Injury
Augmenter of liver regeneration attenuates inflammation of renal ischemia/reperfusion injury through the NF-kappa B pathway in rats.
Augmenter of Liver Regeneration Attenuates Tubular Cell Apoptosis in Acute Kidney Injury in Rats: The Possible Mechanisms.
Expression of augmenter of liver regeneration in rats with gentamicin-induced acute renal failure and its protective effect on kidney.
Acute-On-Chronic Liver Failure
Augmenter of Liver Regeneration may be a Candidate for Prognosis of HBV Related Acute-on-Chronic Liver Failure as a Regenerative Marker.
Adenocarcinoma
An Inhibitory Antibody Blocks the First Step in the Dithiol/Disulfide Relay Mechanism of the Enzyme QSOX1.
Analysis of the plasma peptidome from pancreas cancer patients connects a Peptide in plasma to overexpression of the parent protein in tumors.
High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients.
Quiescin sulfhydryl oxidase 1 (QSOX1) glycosite mutation perturbs secretion but not Golgi localization.
Quiescin sulfhydryl oxidase 1 promotes invasion of pancreatic tumor cells mediated by matrix metalloproteinases.
African Swine Fever
African Swine Fever Virus pB119L Protein Is a Flavin Adenine Dinucleotide-Linked Sulfhydryl Oxidase.
Dimer interface migration in a viral sulfhydryl oxidase.
Atherosclerosis
Quiescin sulfhydryl oxidase (QSOX) is expressed in the human atheroma core: possible role in apoptosis.
Breast Diseases
Effect of QSOX1 on cattle carcass traits as well as apoptosis and triglyceride production in bovine fetal fibroblasts and mammary epithelial cells.
Breast Neoplasms
Correction to: Expression of quiescin sulfhydryl oxidase 1 is associated with a highly invasive phenotype and correlates with a poor prognosis in luminal B breast cancer.
Elevated Transcription of the Gene QSOX1 Encoding Quiescin Q6 Sulfhydryl Oxidase 1 in Breast Cancer.
Expression of Quiescin Sulfhydryl Oxidase 1 is associated with a highly invasive phenotype and correlates with a poor prognosis in Luminal B breast cancer.
High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients.
Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models.
Involvement of sulfhydryl oxidase QSOX1 in the protection of cells against oxidative stress-induced apoptosis.
QSOX1 expression is associated with aggressive tumor features and reduced survival in breast carcinomas.
QSOX1 inhibits autophagic flux in breast cancer cells.
The Effect of Mammary Extracellular Matrix in Controlling Oral and Mammary Cancer Cells
The Emerging Role of QSOX1 in Cancer.
Carcinogenesis
High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients.
QSOX1 inhibits autophagic flux in breast cancer cells.
The Emerging Role of QSOX1 in Cancer.
Carcinoma
Expression of augmenter of liver regeneration (ALR) in human liver cirrhosis and carcinoma.
[Expression of augmenter of liver regeneration in hepatic tumor cells and its clinical significance]
Carcinoma, Ductal
High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients.
Carcinoma, Hepatocellular
Augmenter of liver regeneration gene expression in human colon cancer cell lines and clinical tissue samples.
Augmenter of liver regeneration links mitochondrial function to steatohepatitis and hepatocellular carcinoma.
Augmenter of liver regeneration potentiates doxorubicin anticancer efficacy by reducing the expression of ABCB1 and ABCG2 in hepatocellular carcinoma.
Effects of the augmenter of liver regeneration on the biological behavior of hepatocellular carcinoma.
Expression level of augmenter of liver regeneration in patients with hepatic failure and hepatocellular carcinoma.
Glycochenodeoxycholate-induced apoptosis is not reduced by augmenter of liver regeneration in the human hepatoma cell line HuH-7.
Hepatopoietin acts as an autocrine growth factor in hepatoma cells.
Hepatopoietin Cn suppresses apoptosis of human hepatocellular carcinoma cells by up-regulating myeloid cell leukemia-1.
High expression of 23 kDa protein of augmenter of liver regeneration (ALR) in human hepatocellular carcinoma.
Human augmenter of liver regeneration is important for hepatoma cell viability and resistance to radiation-induced oxidative stress.
Identification and characterization of receptor for mammalian hepatopoietin that is homologous to yeast ERV1.
Involvement of Hepatopoietin Cn in the development of human hepatocellular carcinoma.
Liver Regeneration Associated Protein (ALR) Exhibits Antimetastatic Potential in Hepatocellular Carcinoma.
Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice.
Macrophage migration inhibitory factor directly interacts with hepatopoietin and regulates the proliferation of hepatoma cell.
QSOX1 promotes mitochondrial apoptosis of hepatocellular carcinoma cells during anchorage-independent growth by inhibiting lipid synthesis.
Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation.
Rapid induction of PC3/BTG2 gene by hepatopoietin or partial hepatectomy and its mRNA expression in hepatocellular carcinoma.
Vitamin K epoxide reductase contributes to protein disulfide formation and redox homeostasis within the endoplasmic reticulum.
[In vitro stimulation of HTC hepatoma cell growth by recombinant human augmenter of liver regeneration (ALR)]
[Inhibitory effect of blocking expression of human augmenter of liver regeneration (hALR) on proliferation of hepatocellular carcinoma cell line HepG2]
Carcinoma, Non-Small-Cell Lung
QSOX2 Is an E2F1 Target Gene and a Novel Serum Biomarker for Monitoring Tumor Growth and Predicting Survival in Advanced NSCLC.
Cardiovascular Diseases
Recent trends in electrochemical biosensors of superoxide dismutases.
Unbiased plasma proteomics for novel diagnostic biomarkers in cardiovascular disease: identification of quiescin Q6 as a candidate biomarker of acutely decompensated heart failure.
Cataract
Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8.
Cholera
Cholera toxin-sensitive GTP-binding protein-coupled activation of augmenter of liver regeneration (ALR) receptor and its function in rat kupffer cells.
Colonic Neoplasms
Augmenter of liver regeneration gene expression in human colon cancer cell lines and clinical tissue samples.
Colorectal Neoplasms
Proteomic Analyses of Fibroblast- and Serum-Derived Exosomes Identify QSOX1 as a Marker for Non-invasive Detection of Colorectal Cancer.
Cryptorchidism
[Expression of augmenter of liver regeneration in cryptorchidism spermatogenic cells and its implication]
Fatty Liver
Alleviation of Ischemia-Reperfusion Injury in Liver Steatosis by Augmenter of Liver Regeneration Is Attributed to Antioxidation and Preservation of Mitochondria.
Augmenter of liver regeneration links mitochondrial function to steatohepatitis and hepatocellular carcinoma.
Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.
Hepatic Deficiency of Augmenter of Liver Regeneration Exacerbates Alcohol-Induced Liver Injury and Promotes Fibrosis in Mice.
Lipid deposition in liver cells: The influence of short form augmenter of liver regeneration.
Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice.
Glioblastoma
Quiescin Sulfhydryl Oxidase 1 Regulates the Proliferation, Migration and Invasion of Human Glioblastoma Cells via PI3K/Akt Pathway.
Glioma
Decreased expression of the augmenter of liver regeneration results in increased apoptosis and oxidative damage in human-derived glioma cells.
Quiescin Sulfhydryl Oxidase 1 Regulates the Proliferation, Migration and Invasion of Human Glioblastoma Cells via PI3K/Akt Pathway.
Heart Failure
Disulfide bond generation in mammalian blood serum: detection and purification of quiescin-sulfhydryl oxidase.
QSOX1, a novel actor of cardiac protection upon acute stress in mice.
Unbiased plasma proteomics for novel diagnostic biomarkers in cardiovascular disease: identification of quiescin Q6 as a candidate biomarker of acutely decompensated heart failure.
Hepatitis
Augmenter of liver regeneration (ALR) restrains concanavalin A-induced hepatitis in mice.
Protective effect of recombinant human augmenter of liver regeneration on CCl4-induced hepatitis in mice.
Serum proteomics with SELDI-TOF-MS in congenital human cytomegalovirus hepatitis.
[Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration hepatitis]
Herpes Zoster
Naturally occurring low molecular peptides identified in egg white show antioxidant activity.
Hyperglycemia
Defining the Regulated Secreted Proteome of Rodent Adipocytes upon the Induction of Insulin Resistance.
Hypersensitivity
Tellurite-mediated thiol oxidation in Escherichia coli.
Infections
Serum proteomics with SELDI-TOF-MS in congenital human cytomegalovirus hepatitis.
Insulin Resistance
Defining the Regulated Secreted Proteome of Rodent Adipocytes upon the Induction of Insulin Resistance.
Kidney Neoplasms
Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines.
Leukemia
Protective effect of augmenter of liver regeneration on vincristine-induced cell death in Jurkat T leukemia cells.
Liver Cirrhosis
Augmenter of liver regeneration gene expression in human colon cancer cell lines and clinical tissue samples.
Augmenter of Liver Regeneration Gene Therapy Using a Novel Minicircle DNA Vector Alleviates Liver Fibrosis in Rats.
Deficiency in augmenter of liver regeneration accelerates liver fibrosis by promoting migration of hepatic stellate cell.
Expression of augmenter of liver regeneration (ALR) in human liver cirrhosis and carcinoma.
TGF-? induces liver fibrosis via miRNA-181a-mediated down regulation of augmenter of liver regeneration in hepatic stellate cells.
[Effect of recombinant human augmenter of liver regeneration on gene expression of tissue inhibitor of metalloproteinase-1 in rat with experimental liver fibrosis]
Liver Diseases
Augmenter of liver regeneration (ALR) may promote liver regeneration by reducing natural killer (NK) cell activity in human liver diseases.
Correlation between augmenter of liver regeneration and IFN-? expression in graft after rat orthotopic liver transplantation.
Mammalian augmenter of liver regeneration protein is a sulfhydryl oxidase.
Liver Failure
Effect of naked eukaryotic expression plasmid encoding rat augmenter of liver regeneration on acute hepatic injury and hepatic failure in rats.
Expression level of augmenter of liver regeneration in patients with hepatic failure and hepatocellular carcinoma.
[Expression and role of augmenter of liver regeneration in patients with hepatic failure.]
Liver Failure, Acute
Augmenter of liver regeneration improves therapeutic effect of hepatocyte homotransplantation in acute liver failure rats.
Expression of augmenter of liver regeneration in rats with gentamicin-induced acute renal failure and its protective effect on kidney.
[Augmenter of liver regeneration: a novel cytokine]
[Intrasplenic transplantation of newborn rat hepatocytes with rALR for treating rats with acute hepatic failure]
Lung Neoplasms
QSOX2 Is an E2F1 Target Gene and a Novel Serum Biomarker for Monitoring Tumor Growth and Predicting Survival in Advanced NSCLC.
Quiescin Sulfhydryl Oxidase 1 (QSOX1) Secreted by Lung Cancer Cells Promotes Cancer Metastasis.
Malaria
Silencing an Anopheles gambiae catalase and sulfhydryl oxidase increases mosquito mortality after a blood meal.
Medulloblastoma
Immunohistochemical expression of sulfhydryl oxidase (QSOX1) in pediatric medulloblastomas.
Mitochondrial Myopathies
Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8.
Augmenter of liver regeneration, a protective factor against ROS-induced oxidative damage in muscle tissue of mitochondrial myopathy affected patients.
Multiple Myeloma
Blocking the short isoform of augmenter of liver regeneration inhibits proliferation of human multiple myeloma U266 cells via the MAPK/STAT3/cell cycle signaling pathway.
Silencing of augmenter of liver regeneration inhibited cell proliferation and triggered apoptosis in U266 human multiple myeloma cells.
Muscular Diseases
Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy .
Myocardial Infarction
Peripheral Blood RNA Levels of QSOX1 and PLBD1 Are New Independent Predictors of Left Ventricular Dysfunction After Acute Myocardial Infarction.
Nasopharyngeal Carcinoma
Reduced QSOX1 enhances radioresistance in nasopharyngeal carcinoma.
Neoplasm Metastasis
Augmenter of liver regeneration potentiates doxorubicin anticancer efficacy by reducing the expression of ABCB1 and ABCG2 in hepatocellular carcinoma.
Core fucosylated glycan-dependent inhibitory effect of QSOX1-S on invasion and metastasis of hepatocellular carcinoma.
Correction: Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models.
Expression of Quiescin Sulfhydryl Oxidase 1 is associated with a highly invasive phenotype and correlates with a poor prognosis in Luminal B breast cancer.
High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients.
Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models.
Molecular Inhibitor of QSOX1 Suppresses Tumor Growth In Vivo.
QSOX1 promotes mitochondrial apoptosis of hepatocellular carcinoma cells during anchorage-independent growth by inhibiting lipid synthesis.
Quiescin Sulfhydryl Oxidase 1 (QSOX1) Secreted by Lung Cancer Cells Promotes Cancer Metastasis.
Neoplasms
A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion.
An Inhibitory Antibody Blocks the First Step in the Dithiol/Disulfide Relay Mechanism of the Enzyme QSOX1.
Analysis of the plasma peptidome from pancreas cancer patients connects a Peptide in plasma to overexpression of the parent protein in tumors.
Augmenter of liver regeneration potentiates doxorubicin anticancer efficacy by reducing the expression of ABCB1 and ABCG2 in hepatocellular carcinoma.
Clinical Implications of Augmenter of Liver Regeneration in Cancer: A Systematic Review.
Comparative proteomic analysis of proteins involved in the tumorigenic process of seminal vesicle carcinoma in transgenic mice.
Core fucosylated glycan-dependent inhibitory effect of QSOX1-S on invasion and metastasis of hepatocellular carcinoma.
Correction: Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models.
Disulfide bond generation in mammalian blood serum: detection and purification of quiescin-sulfhydryl oxidase.
Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines.
Expression level of quiescin sulfhydryl oxidase 1 (QSOX1) in neuroblastomas.
Expression of Quiescin Sulfhydryl Oxidase 1 is associated with a highly invasive phenotype and correlates with a poor prognosis in Luminal B breast cancer.
High expression of QSOX1 is associated with tumor invasiveness and high grades groups in prostate cancer.
High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients.
Illuminating luminal B: QSOX1 as a subtype-specific biomarker.
Immunohistochemical expression of sulfhydryl oxidase (QSOX1) in pediatric medulloblastomas.
Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine cancer models.
Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis.
Molecular Inhibitor of QSOX1 Suppresses Tumor Growth In Vivo.
Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma.
Putative Biomarkers for Malignant Pleural Mesothelioma Suggested by Proteomic Analysis of Cell Secretome.
QSOX1 expression is associated with aggressive tumor features and reduced survival in breast carcinomas.
QSOX1 inhibits autophagic flux in breast cancer cells.
QSOX1 regulates trophoblastic apoptosis in preeclampsia through hydrogen peroxide production.
QSOX2 Is an E2F1 Target Gene and a Novel Serum Biomarker for Monitoring Tumor Growth and Predicting Survival in Advanced NSCLC.
Quiescin Sulfhydryl Oxidase 1 (QSOX1) Secreted by Lung Cancer Cells Promotes Cancer Metastasis.
Quiescin sulfhydryl oxidase 1 promotes invasion of pancreatic tumor cells mediated by matrix metalloproteinases.
Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation.
Quiescin Sulfhydryl Oxidase 1 Regulates the Proliferation, Migration and Invasion of Human Glioblastoma Cells via PI3K/Akt Pathway.
The dynamic disulphide relay of quiescin sulphydryl oxidase.
The Emerging Role of QSOX1 in Cancer.
The flavo-oxidase QSOX1 supports vascular smooth muscle cell migration and proliferation: evidence for a role in neointima growth.
[Expression of augmenter of liver regeneration in hepatic tumor cells and its clinical significance]
Neuroblastoma
Expression level of quiescin sulfhydryl oxidase 1 (QSOX1) in neuroblastomas.
Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulfhydryl oxidase/Quiescin6 family, regulates sensitization to interferon gamma-induced cell death in human neuroblastoma cells.
Protective effect of augmenter of liver regeneration on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells.
Non-alcoholic Fatty Liver Disease
Hepatic deficiency of augmenter of liver regeneration predisposes to nonalcoholic steatohepatitis and fibrosis.
Lack of Augmenter of Liver Regeneration Disrupts Cholesterol Homeostasis of Liver in Mice by Inhibiting the AMPK Pathway.
Lipid deposition in liver cells: The influence of short form augmenter of liver regeneration.
Pancreatic Neoplasms
Disulfide bond generation in mammalian blood serum: detection and purification of quiescin-sulfhydryl oxidase.
HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression.
Quiescin sulfhydryl oxidase 1 promotes invasion of pancreatic tumor cells mediated by matrix metalloproteinases.
Pancreatitis
Augmenter of liver regeneration (ALR) regulates acute pancreatitis via inhibiting HMGB1/TLR4/NF-?B signaling pathway.
Pre-Eclampsia
QSOX1 regulates trophoblastic apoptosis in preeclampsia through hydrogen peroxide production.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Decreased expression of the augmenter of liver regeneration results in growth inhibition and increased chemosensitivity of acute T lymphoblastic leukemia cells.
Prostatic Hyperplasia
Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis.
Prostatic Neoplasms
High expression of QSOX1 is associated with tumor invasiveness and high grades groups in prostate cancer.
High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients.
The Emerging Role of QSOX1 in Cancer.
The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1.
Protein Deficiency
Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.
Reperfusion Injury
Alleviation of Ischemia-Reperfusion Injury in Liver Steatosis by Augmenter of Liver Regeneration Is Attributed to Antioxidation and Preservation of Mitochondria.
Augmenter of liver regeneration ameliorates ischemia-reperfusion injury in steatotic liver via inhibition of the TLR4/NF-?B pathway.
Augmenter of liver regeneration promotes mitochondrial biogenesis in renal ischemia-reperfusion injury.
Augmenter of Liver Regeneration Protects Renal Tubular Epithelial Cells From Ischemia-Reperfusion Injury by Promoting PINK1/Parkin-Mediated Mitophagy.
Augmenter of Liver Regeneration Reduces Ischemia Reperfusion Injury by Less Chemokine Expression, Gr-1 Infiltration and Oxidative Stress.
Augmenter of liver regeneration regulates autophagy in renal ischemia-reperfusion injury via the AMPK/mTOR pathway.
Scurvy
Endoplasmic Reticulum Thiol Oxidase Deficiency Leads to Ascorbic Acid Depletion and Noncanonical Scurvy in Mice.
Starvation
QSOX1 inhibits autophagic flux in breast cancer cells.
thiol oxidase deficiency
Endoplasmic Reticulum Thiol Oxidase Deficiency Leads to Ascorbic Acid Depletion and Noncanonical Scurvy in Mice.
Ventricular Dysfunction, Left
Peripheral Blood RNA Levels of QSOX1 and PLBD1 Are New Independent Predictors of Left Ventricular Dysfunction After Acute Myocardial Infarction.