Any feedback?
Information on EC 1.7.2.5 - nitric oxide reductase (cytochrome c)
for references in articles please use BRENDA:EC1.7.2.5Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.7.2.5 nitric oxide reductase (cytochrome c)IUBMB Comments
The enzyme from Pseudomonas aeruginosa contains a dinuclear centre comprising a non-heme iron centre and heme b3, plus heme c, heme b and calcium; the acceptor is cytochrome c551
Specify your search results
Word Map
- 1.7.2.5
- nitrite
-
denitrification
- n2o
- heme
-
denitrify
- reductases
- paracoccus
- denitrificans
- oxidases
-
non-heme
-
cnors
-
heme-copper
- stutzeri
-
dissimilatory
-
diiron
-
high-spin
-
binuclear
-
low-spin
-
dinitrogen
-
dinitrosyl
-
flavodiiron
-
nitrifier
- nitrosomonas
- flavohemoglobins
-
diferrous
-
antiferromagnetically
-
ammonia-oxidizing
-
fnr-like
- environmental protection
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
+
2
+
=
2
+
2
+
2
Synonyms
nitric oxide reductase, no reductase, p450nor, flavorubredoxin, norcb, nitric-oxide reductase, norbc, no-reductase, ba3-oxidase, nitric oxide reductase cytochrome, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Anor
cNOR
cytochrome c dependent nitric oxide reductase
cytochrome c type NOR
cytochrome c-dependent nitric oxide reductase
cytochrome c-dependent NO reductase
EC 1.7.99.7
-
-
formerly
-
FprA
nitric oxide reductase
nitric oxide reductase cytochrome
nitric oxide-reductase
-
NorBC homologue, cytochrome cb-type enzyme with cytochrome c-oxidase activity
nitrogen oxide reductase
-
-
-
-
NO reductase
NOR
NorB
NorBC
NorC
NorCB
NorZ
P450nor
respiratory nitric oxide reductase
respiratory NO reductase
scavenging nitric oxide reductase
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
nitrous oxide + 2 ferricytochrome c + H2O = 2 nitric oxide + 2 ferrocytochrome c + 2 H+
-
-
-
-
nitrous oxide + 2 ferricytochrome c + H2O = 2 nitric oxide + 2 ferrocytochrome c + 2 H+
proton transfer by a trans-mechanism, not by cis-heme b3 mechanism,analysis, overview
nitrous oxide + 2 ferricytochrome c + H2O = 2 nitric oxide + 2 ferrocytochrome c + 2 H+
the reaction is nonelectrogenic, generation of a free energy profile for the entire catalytic cycle by hybrid density functional calculations. The energy profile shows that the reduction steps are endergonic and that the entire process is rate-limited by high proton uptake barriers during the reduction steps. Catalytic cycle and mechanism involving 2 different Fe atoms, modelling, detailed overview. Electrons and protons are taken from the same side of the membrane. The catalytic cycle can be divided into two parts. One part starts from the oxidized resting state with an oxo-bridge state 1, includes the two proton coupled reduction steps and results in the formation of a water molecule and the two-electron-reduced binuclear active site, states 3 and 4. The second part starts from the reduced state 4 and includes the main chemistry, that is, the reaction of two NO molecules with the reduced binuclear active site, formation and release of the nitrous oxide (N2O) molecule and ending up with the reformation of the oxidized state 1
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
reduction
-
-
-
-
redox reaction
-
-
-
-
redox reaction
-
the enzyme has nitric oxide reductase activity and oxidase activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
nitrous oxide:ferricytochrome-c oxidoreductase
The enzyme from Pseudomonas aeruginosa contains a dinuclear centre comprising a non-heme iron centre and heme b3, plus heme c, heme b and calcium; the acceptor is cytochrome c551
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
37256-43-2
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 nitric oxide + 2 reduced bovine heart cytochrome c + 2 H+
nitrous oxide + 2 oxidized bovine heart cytochrome c + H2O
-
-
-
-
?
nitric oxide + ferrocytochrome c552
nitrous oxide + ferricytochrome c552 + H2O
Marinobacter nauticus
-
-
-
-
?
nitric oxide + NAD(P)H + H+
nitrous oxide + NAD(P)+ + H2O
cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification
-
-
?
nitric oxide + NADH + H+
nitrous oxide + NAD+
cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification
-
-
?
nitric oxide + oxidized acceptor + H+
nitrous oxide + reduced acceptor + H2O
-
-
-
-
?
nitric oxide + reduced ascorbate
nitrous oxide + oxidized ascorbate + H2O
Marinobacter nauticus
-
-
-
-
?
nitric oxide + reduced N,N,N',N'-tetramethyl-p-phenylenediamine
nitrous oxide + oxidized N,N,N',N'-tetramethyl-p-phenylenediamine + H2O
nitric oxide + reduced phenazine methosulfate
nitrous oxide + oxidized phenazine methosulfate + H2O
nitric oxide + reduced pseudoazurin
nitrous oxide + pseudoazurin + H2O
-
-
-
-
?
nitrous oxide + 2 ferricytochrome c + H2O
2 nitric oxide + 2 ferrocytochrome c + 2 H+
-
-
-
?
NO + 5-hydroxy-1,4-naphthoquinol
N2O + H2O + 5-hydroxy-1,4-naphthoquinone
-
-
-
-
?
NO + 5-hydroxy-2-methyl-1,4-naphthoquinol
N2O + H2O + 5-hydroxy-2-methyl-1,4-naphthoquinone
-
-
-
-
?
NO + reduced cytochrome c551
N2O + H2O + oxidized cytochrome c551
-
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
Pyrodictium delaneyi Su06
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
D5GU62; D5GU63
-
-
-
?
2 nitric oxide + 2 ferrocytochrome c + 2 H+
nitrous oxide + 2 ferricytochrome c + H2O
D5GU62; D5GU63
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
as electron donors phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine, N,N,N',N'-tetramethyl-1,4-benzendiamine together with horse cytochrome c
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
Agrobacterium tumefaciens C58 / ATCC 33970
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate and phenazine methosulfate, NADH, NADH/menadione, NADH/duroquinone, NADH/2,3-dimethoxy-5-methyl-1,4-benzoquinone and N,N,N',N'-tetramethyl-1,4-benzendiamine/ascorbate as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
To degrade NO, FlRd has to be reduced by NADH via the FAD-binding protein flavorubredoxin reductase. NADH, but not NADPH, quickly reduces the FlRd-reductase. The reductase in turn quickly reduces the rubredoxin (Rd) center of FlRd
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
NAD(P)H and NAD(P)+ as electron donor/acceptor
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
NAD(P)H and NAD(P)+ as electron donor/acceptor
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
NAD(P)H and NAD(P)+ as electron donor/acceptor
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
as electron donors phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine, N,N,N',N'-tetramethyl-1,4-benzendiamine together with horse cytochrome c
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate/phenazine methosulfate as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
quinol-oxidising enzyme
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
395112, 395114, 395115, 395116, 395118, 395120, 395124, 395127, 395131, 395133, 395134, 395135, 395136, 395137, 395139, 395140, 395141, 671883, 671948, 671964, 672352, 674003
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
phenazine methosulfate and dithiothreitol as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
NADH, succinate or ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors in membrane vesicles
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
as electron donors phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine, N,N,N',N'-tetramethyl-1,4-benzendiamine together with horse cytochrome c
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ferrocytochrome c-550 as electron donor
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate/phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine/ascorbate, 2,3,5,6-tetramethyl-1,4-benzendiamine/ascorbate and NADH as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
investigation of proton and electron pathways, electron-transfer pathways are similar to those in oxygen-reducing heme-copper oxidases
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
NADH, succinate or isoascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate, phenazine methosulfate and horse heart cytochrome c as the electron donor/mediator system
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
N,N,N',N'-tetramethyl-1,4-benzendiamine/ascorbate as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
isoascorbate/2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors and horse heart cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
key step in the pathway of denitrification that uses N-oxyanions and N-oxides as respiratory electron acceptors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
key step in the pathway of denitrification that uses N-oxyanions and N-oxides as respiratory electron acceptors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
N,N,N',N'-tetramethyl-1,4-benzendiamine/ascorbate as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate, phenazine methosulfate and horse heart cytochrome c as the electron donor/mediator system
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
mechanism
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
cytochrome c as mediator
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O
-
-
-
-
?
2 nitric oxide + reduced acceptor
nitrous oxide + acceptor + H2O