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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
4nqo reductase,
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4-nitroquinoline 1-oxide reductase
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EC 1.6.6.10
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formerly
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NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase
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4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+
4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+
4-(hydroxyamino)quinoline N-oxide may be the active intermediate essential in the carcinogenic process of 4-nitroquinoline N-oxide
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4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+
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4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase
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4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
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4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
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4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
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4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
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4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
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strong preference for NADH
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4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
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strong preference for NADH
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4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
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4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
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4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
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4-nitroquinoline N-oxide + NAD(P)H + H+
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
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NADH is preferred, 15% activity with NADPH
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additional information
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not inhibited by dicoumarol
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additional information
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not inhibited by dicoumarol
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additional information
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not inhibited by 0.015 mM dicoumarol
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Carcinogenesis
A relationship found between intra-oral sites of 4NQO reductase activity and chemical carcinogenesis.
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0.015
4-Nitroquinoline N-oxide
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0.032
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activity in cheek mucosa
0.07
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activity in corpus ventriculi and pyloric antrum
0.084
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activity in tongue mucosa
0.1
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activity in duodenum
0.12
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activity in esophagus
0.15
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activity in ileum and rectum
0.18
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activity in esophagus and caecum, cofactor NADH
0.25
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activity in forestomach and colon
0.3
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activity in cytosol from mucous membrane of esophagus
0.5
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activity in esophagus
0.4
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activity in pyloric antrum
0.4
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activity in glandular stomach and caecum
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most of the activity
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Suzuki, K.
Distribution of 4-nitroquinoline 1-oxide reductase in the mucosa of canine digestive tract
Gann
69
229-235
1978
Canis lupus familiaris
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Booth, D.R.
A relationship found between intra-oral sites of 4NQO reductase activity and chemical carcinogenesis
Cell Tissue Kinet.
23
331-340
1990
Rattus norvegicus
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Suzuki, K.
The distribution of 4-nitroquinoline 1-oxide reductase in the mucosa of animal digestive tracts
Nihon Univ. J. Med.
20
345-357
1978
Cavia porcellus, Oryctolagus cuniculus, Felis catus, Cricetinae, Rattus norvegicus
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Stanley, J.S.; York, J.L.; Benson, a.M.
Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice
Cancer Res.
52
58-63
1992
Mus musculus
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Benson, A.M.
Conversion of 4-nitroquinoline 1-oxide (4NQO) to 4-hydroxyaminoquinoline 1-oxide by a dicumarol-resistant hepatic 4NQO nitroreductase in rats and mice
Biochem. Pharmacol.
46
1217-1221
1993
Mus musculus, Rattus norvegicus
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1.7.1.9 nitroquinoline-N-oxide reductase
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