Disease on EC 1.6.99.3 - NADH dehydrogenase

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DISEASE
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Acidosis
Respiratory chain defect of myocardial mitochondria in idiopathic dilated cardiomyopathy of Doberman pinscher dogs.
Acidosis, Lactic
Deficiency in ubiquinone cytochrome c reductase in a patient with mitochondrial myopathy and lactic acidosis.
Lactic Acidosis Complicating Metformin and Non-Nucleoside Reverse Transcriptase Inhibitor Combination Therapy: A Smoldering Threat in the Post-HAART Era.
Mitochondrial Encephalopathy and Optic Neuropathy Due to m.10158 MT-ND3 Complex I Mutation Presenting in an Adult Patient: Case Report and Review of the Literature.
Mitochondrial variations in the MT-ND4 and MT-TL1 genes are associated with male infertility.
Adenocarcinoma of Lung
Nonsense and missense mutation of mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma.
Alzheimer Disease
Brain regional analysis of NADH-cytochrome C reductase activity in Alzheimer's disease.
Mitochondrial variations in the MT-ND4 and MT-TL1 genes are associated with male infertility.
No association of mutations at nucleotide 5460 of mitochondrial NADH dehydrogenase with Alzheimer's disease.
The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease.
Anemia
Effects of oral contraceptive steroids (norethisterone/mestranol) on the activities of hepatic drug-metabolizing enzymes in iron-deficient anemic rats.
Anthrax
Immunoproteomically identified GBAA_0345, alkyl hydroperoxide reductase subunit C is a potential target for multivalent anthrax vaccine.
Antley-Bixler Syndrome Phenotype
Electron transfer by human wild-type and A287P mutant P450 oxidoreductase assessed by transient kinetics: Functional Basis of P450 Oxidoreductase Deficiency.
Apraxias
Congenital ocular motor apraxia associated with myopathy, external hydrocephalus and NADH dehydrogenase deficiency.
Atherosclerosis
[Association of mitochondrial genome mutations with lipofibrous plaques in human aortic intima].
Bartonella Infections
The population structure of Lutzomyia verrucarum (Diptera: Psycodidae), a Bartonella bacilliformis and Leishmania peruviana vector in Peru.
Bradycardia
Coenzyme q10 confers cardiovascular protection against acute mevinphos intoxication by ameliorating bioenergetic failure and hypoxia in the rostral ventrolateral medulla of the rat.
Brain Diseases
Mitochondrial targeting of human NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2) and its association with early-onset hypertrophic cardiomyopathy and encephalopathy.
Breast Neoplasms
Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism.
Immunochemical specificity of placental NADPH cytochrome c (P-450) reductase in neoplastic and non-neoplastic human tissue.
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.
The variation of mitochondrial NADH dehydrogenase subunit 4 (mtND4) and molecular dynamics simulation of SNPs among Iranian women with breast cancer.
Therapeutic effect of propolis and paclitaxel on hepatic phase I and II enzymes and marker enzymes in dimethylbenz(a)anthracene-induced breast cancer in female rats.
Ubiquinol cytochrome c reductase (UQCRFS1) gene amplification in primary breast cancer core biopsy samples.
Use of cytokeratin 8 immunohistochemistry for assessing cell death after radiofrequency ablation of breast cancers.
Carcinogenesis
A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis.
Carcinoma
Detection of mitochondrial genome depletion by a novel cDNA in renal cell carcinoma.
Differential expression of the mitochondrial gene cytochrome oxidase II in benign and malignant breast tissue.
Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: evidence for mismatch repair systems in mitochondrial genome.
Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma.
[Expression of MLRQ subunit gene of NADH oxidoreductase and its clinical significance in malignant tumors of digestive system]
Carcinoma, Adenoid Cystic
[Multiple trichoepitheliomas, cylindromas and milia. An entity]
Carcinoma, Ehrlich Tumor
Electron-transferring enzymes in the plasma membrane of the Ehrlich ascites tumor cell.
Purification and characterization of a plasma membrane ferricyanide-utilizing NADH dehydrogenase from Ehrlich tumour cells.
Carcinoma, Hepatocellular
A comparison of lipids from liver and hepatoma subcellular membranes.
Enhanced drug-metabolizing capacity within liver adjacent to human and rat liver tumors.
Evidence that 2,3,7,8-tetrachlorodibenzo-p-dioxin induces NADPH cytochrome c (P-450) reductase in rat hepatoma cells in culture.
Immunochemical specificity of placental NADPH cytochrome c (P-450) reductase in neoplastic and non-neoplastic human tissue.
Mitochondrial transcription factor A and its downstream targets are up-regulated in a rat hepatoma.
Nonspecific lipid transfer proteins as probes of membrane structure and function.
Respiratory chain-linked NADH dehydrogenase. Mechanisms of assembly.
Carcinoma, Renal Cell
Detection of mitochondrial genome depletion by a novel cDNA in renal cell carcinoma.
Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma.
Cardiomegaly
Maternal nutrient restriction alters gene expression in the ovine fetal heart.
Cardiomyopathies
Mitochondrial encoded NADH dehydrogenase 5 (MT-ND5) gene point mutation presents as late onset cardiomyopathy.
Myocardial energy metabolism of congestive and hypertrophic cardiomyopathy in man.
Oxidation of cytosolic NADH via complex I of heart mitochondria.
Cardiomyopathy, Dilated
A NADH dehydrogenase ubiquinone flavoprotein is decreased in patients with dilated cardiomyopathy.
Cardiomyopathy, Hypertrophic
Heteroplasmic mitochondrial DNA 3310 mutation in NADH dehydrogenase subunit 1 associated with type 2 diabetes, hypertrophic cardiomyopathy, and mental retardation in a single patient.
Mitochondrial targeting of human NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2) and its association with early-onset hypertrophic cardiomyopathy and encephalopathy.
Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy.
Cardiotoxicity
A critical risk-benefit assessment argues against the use of anthracyclines in induction regimens for newly diagnosed childhood acute lymphoblastic leukemia.
Identification of the site of adriamycin-activation in the heart cell.
The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines.
Cardiovascular Diseases
The reduction of NDUFC2 expression is associated with mitochondrial impairment in circulating mononuclear cells of patients with acute coronary syndrome.
Carotid Artery Diseases
Mutations of mitochondrial genome in carotid atherosclerosis.
Cerebral Palsy
Partial NADH dehydrogenase defect presenting as spastic cerebral palsy.
Cerebrovascular Disorders
Interaction between longevity-associated mitochondrial DNA 5178 C/A polymorphism and cigarette smoking on hematological parameters in Japanese men.
Cestode Infections
Contribution of NADH dehydrogenase subunit I and cytochrome C oxidase subunit I sequences toward identifying a case of human coenuriasis in France.
Chagas Disease
Differential transcription profiles in Trypanosoma cruzi associated with clinical forms of Chagas disease: Maxicircle NADH dehydrogenase subunit 7 gene truncation in asymptomatic patient isolates.
Variation in Mitochondrial NADH Dehydrogenase Subunit 5 and NADH Dehydrogenase Subunit 4 Genes in the Chagas Disease Vector Triatoma infestans (Hemiptera: Reduviidae).
Cholera
Increased aerobic glucose oxidation by cAMP in cultured regenerated skeletal myotubes.
Cholestasis
Effects of liver injury and cholestasis on microsomal enzyme activities and metabolism of halothane, enflurane and methoxyflurane in vivo in rats.
[Morpho-functional changes in the liver and the possibility of their correction in the offspring of rats with cholestasis].
Coinfection
Coexpression of cytochrome P4502A6 and human NADPH-P450 oxidoreductase in the baculovirus system.
Colitis, Ulcerative
Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis.
Colonic Neoplasms
NADH dehydrogenase complex I is overexpressed in incipient metastatic murine colon cancer cells.
Colorectal Neoplasms
A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis.
Crohn Disease
Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis.
Cystic Fibrosis
Mitrochondrial NADH dehydrogenase in cystic fibrosis.
NADH dehydrogenase in cystic fibrosis.
The Km of NADH dehydrogenase is decreased in mitochondria of cystic fibrosis cells.
Cysts
A first insight into the genotypes of Echinococcus granulosus from humans in Mongolia.
Genotyping of Echinococcus granulosus Isolates from Human in Khorasan Province, North-Eastern Iran.
Molecular characterization of Echinococcus granulosus in south-eastern Romania: evidence of G1-G3 and G6-G10 complexes in humans.
Multilocus sequence analysis of Echinococcus granulosus strains isolated from humans and animals in Iran.
Prevalence and Genotyping of Echinococcus Species from Livestock in Kajiado County, Kenya.
Dehydration
Enzyme histochemical demonstration of NADH dehydrogenase on resin-embedded tissue.
Identification of genes associated with stress tolerance in moth bean [Vigna aconitifolia (Jacq.) Marechal], a stress hardy crop.
Diabetes Mellitus, Type 1
Lymphocyte dysmetabolism: an immunocytochemical comparative approach in IDDM and control subjects.
mt-Nd2a modifies resistance against autoimmune Type 1 diabetes in NOD mice at the level of the pancreatic beta cell.
mt-Nd2a Suppresses Reactive Oxygen Species Production by Mitochondrial Complexes I and III.
Role of genetics in resistance to type 1 diabetes.
Diabetes Mellitus, Type 2
Heteroplasmic mitochondrial DNA 3310 mutation in NADH dehydrogenase subunit 1 associated with type 2 diabetes, hypertrophic cardiomyopathy, and mental retardation in a single patient.
Mitochondrial DNA 3394 mutation in the NADH dehydrogenase subunit 1 associated with non-insulin-dependent diabetes mellitus.
Dyslipidemias
NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study.
Dystonia
A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystonia.
Leber's hereditary optic neuropathy with dystonia in a Japanese family.
Movement disorders in mitochondrial diseases.
Use of transmitochondrial cybrids to assign a complex I defect to the mitochondrial DNA-encoded NADH dehydrogenase subunit 6 gene mutation at nucleotide pair 14459 that causes Leber hereditary optic neuropathy and dystonia.
Echinococcosis
Development of Three PCR Assays for the Differentiation between Echinococcus shiquicus, E. granulosus (G1 genotype), and E. multilocularis DNA in the Co-Endemic Region of Qinghai-Tibet plateau, China.
Genetic characterization of human-derived hydatid cysts of Echinococcus granulosus sensu lato in Heilongjiang Province and the first report of G7 genotype of E. canadensis in humans in China.
Molecular Genotyping of the Human Cystic Echinococcosis in Mazandaran Province, North of Iran.
Sequence analysis of cox1 and nad1 genes in Echinococcus granulosus G3 genotype in camels (Camelus dromedarius) from central Iran.
Surveillance for Echinococcus canadensis genotypes in Canadian ungulates.
The first report of human-derived G10 genotype of Echinococcus canadensis in China and possible sources and routes of transmission.
Encephalomyelitis
Inhibition of brain macrophage/microglial respiratory chain enzyme activity in experimental autoimmune encephalomyelitis of the Lewis rat.
Encephalomyelitis, Autoimmune, Experimental
Inhibition of brain macrophage/microglial respiratory chain enzyme activity in experimental autoimmune encephalomyelitis of the Lewis rat.
Endotoxemia
Dysfunction of the mitochondrial respiratory chain in the rostral ventrolateral medulla during experimental endotoxemia in the rat.
Esophageal Neoplasms
High incidence of coding gene mutations in mitochondrial DNA in esophageal cancer.
Fascioliasis
Induction of drug metabolizing enzymes in the liver of rats infested with Fasciola hepatica.
Fatty Liver
Highly expressed MT-ND3 positively associated with histological severity of hepatic steatosis.
Fibroadenoma
Differential expression of the mitochondrial gene cytochrome oxidase II in benign and malignant breast tissue.
Gastritis
Production of polyclonal antibody against alkyl hydroperoxide reductase of Helicobacter pylori and its antigenicity.
Genetic Diseases, Inborn
Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber's Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells.
Goiter
Ca(2+)/nicotinamide adenine dinucleotide phosphate-dependent H(2)O(2) generation is inhibited by iodide in human thyroids.
Goiter and hypothyroidism in two siblings due to impaired Ca(+2)/NAD(P)H-dependent H(2)O(2)-generating activity.
Granulomatous Disease, Chronic
Analytical subcellular fractionation of neutrophils from patients with chronic granulomatous disease. Demonstration of the enzyme defect in four cases.
Delineation of the catalytic components of the NADPH-dependent O2- generating oxidoreductase of human neutrophils.
Heart Neoplasms
[Expression of MLRQ subunit gene of NADH oxidoreductase and its clinical significance in malignant tumors of digestive system]
Hydrocephalus
Congenital ocular motor apraxia associated with myopathy, external hydrocephalus and NADH dehydrogenase deficiency.
Hyperlipidemias
Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study.
Hypertension
NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies the effects of alcohol consumption on risk for hypertension in middle-aged Japanese men.
NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of coffee consumption on the risk of hypertension in middle-aged Japanese men.
[Expression of nicotinamide edenine dinucleotide dehydrogenase gene in placenta of patients with pregnancy induced hypertension]
Hypertension, Pregnancy-Induced
[Expression of nicotinamide edenine dinucleotide dehydrogenase gene in placenta of patients with pregnancy induced hypertension]
Hyperthyroidism
Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity.
Enhancement of lindane-induced liver oxidative stress and hepatotoxicity by thyroid hormone is reduced by gadolinium chloride.
On the thyroid hormone-induced increase in respiratory capacity of isolated rat hepatocytes.
Hypokinesia
[The state of the monooxygenase enzymatic system of the rat liver in hypokinesia]
Hypotension
Coenzyme q10 confers cardiovascular protection against acute mevinphos intoxication by ameliorating bioenergetic failure and hypoxia in the rostral ventrolateral medulla of the rat.
Ileus
[State of the microsomal oxidative system of the rat liver in acute intestinal obstruction]
Infections
A study of the interaction between H. pylori mice passage strains and gastric epithelial cells.
Activities of membrane bound phosphatases, transaminases and mitochondrial enzymes in white spot syndrome virus infected tissues of Fenneropenaeus indicus.
Altered hepatic microsomal drug-metabolizing enzyme activity resulting from experimental infection of rats with Trypanosoma b. brucei.
Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis.
Hepatocarcinogenesis in hepatitis C: HCV shrewdly exacerbates oxidative stress by modulating both production and scavenging of reactive oxygen species.
Immunization with alkyl hydroperoxide reductase subunit C reduces Fusobacterium nucleatum load in the intestinal tract.
Influenza virus-induced alterations of cytochrome P-450 enzyme activities following exposure of mice to coal and diesel particulates.
Molecular discrimination of Opisthorchis-like eggs from residents in a rural community of central Thailand.
Mycoplasma pneumoniae infection induces reactive oxygen species and DNA damage in A549 human lung carcinoma cells.
Roles of alkyl hydroperoxide reductase subunit C (AhpC) in viable but nonculturable Vibrio parahaemolyticus.
Use of in vivo induced technology to identify antigens expressed by Photobacterium damselae subsp. piscicida during infection of Senegalese sole (Solea senegalensis).
Infertility, Male
A NADH dehydrogenase subunit gene is co-transcribed with the abnormal Petunia mitochondrial gene associated with cytoplasmic male sterility.
Mitochondrial gene organization and expression in petunia male fertile and sterile plants.
Mitochondrial nad2 gene is co-transcripted with CMS-associated orfB gene in cytoplasmic male-sterile stem mustard (Brassica juncea).
Transcription of the Petunia mitochondrial CMS-associated Pcf locus in male sterile and fertility-restored lines.
Influenza, Human
Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice.
Insulin Resistance
The Relationship between Mitochondrial Dysfunction and Insulin Resistance in HIV-infected Children Receiving Antiretroviral Therapy.
Intellectual Disability
Congenital enzymopenic methaemoglobinaemia. Clinical and biochemical study of a family with three homozygotes.
Heteroplasmic mitochondrial DNA 3310 mutation in NADH dehydrogenase subunit 1 associated with type 2 diabetes, hypertrophic cardiomyopathy, and mental retardation in a single patient.
Kidney Failure, Chronic
Light microscopic study of striated muscle in uremia.
Kidney Neoplasms
Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma.
Leigh Disease
Defect of NADH dehydrogenase in Leigh syndrome.
Leigh disease presenting in utero due to a novel missense mutation in the mitochondrial DNA-ND3.
Mitochondrial DNA 11777C>A mutation associated Leigh syndrome: case report with a review of the previously described pedigrees.
Movement disorders in mitochondrial diseases.
Novel Mitochondrial C15620A Variant may Modulate the Phenotype of Mitochondrial G11778A Mutation in a Chinese Family with Leigh Syndrome.
Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome.
Leishmaniasis, Cutaneous
The population structure of Lutzomyia verrucarum (Diptera: Psycodidae), a Bartonella bacilliformis and Leishmania peruviana vector in Peru.
Leukemia
NADH dehydrogenase deficiency in an apoptosis-resistant mutant isolated from a human HL-60 leukemia cell line.
Leukemia, Myeloid, Acute
Prognostic implications and molecular associations of NADH dehydrogenase subunit 4 (ND4) mutations in acute myeloid leukemia.
Liver Diseases
Antipyrine elimination and hepatic microsomal enzyme activity in patients with liver disease.
Highly expressed MT-ND3 positively associated with histological severity of hepatic steatosis.
Relationship between metabolic clearance rate of antipyrine and hepatic microsomal drug-oxidizing enzyme activities in humans without liver disease.
Lung Neoplasms
The Effect on Cognition of Mitochondrial Respiratory System Proteins in Peripheral Blood Mononuclear Cells in the Course of Lung Cancer.
Lymphoma
Comparative analysis of testis transcriptomes associated with male infertility in triploid cyprinid fish.
Lymphoma, B-Cell
Evidence of altered depression and dementia-related proteins in the brains of young rats after ovariectomy.
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Malaria
Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages.
Melanoma
Membrane lipids and enzymes of cultured high- and low-metastatic B16 melanoma variants.
Proteomic investigation of the sinulariolide-treated melanoma cells A375: effects on the cell apoptosis through mitochondrial-related pathway and activation of caspase cascade.
MELAS Syndrome
An mtDNA mutation, 14453G-->A, in the NADH dehydrogenase subunit 6 associated with severe MELAS syndrome.
Mitochondrial variations in the MT-ND4 and MT-TL1 genes are associated with male infertility.
The mitochondrial DNA G13513A MELAS mutation in the NADH dehydrogenase 5 gene is a frequent cause of Leigh-like syndrome with isolated complex I deficiency.
Melioidosis
T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis.
Methemoglobinemia
Hereditary methemoglobinemia associated with NADH diaphorase deficiency.
Mitochondrial Diseases
Can a single subunit yeast NADH dehydrogenase (Ndi1) remedy diseases caused by respiratory complex I defects?
Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation: a case report.
Mutations in ND subunits of complex I are an important genetic cause of childhood mitochondrial encephalopathies.
NADH dehydrogenases: from basic science to biomedicine.
Possibility of transkingdom gene therapy for complex I diseases.
The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
Titrating the effects of mitochondrial complex I impairment in the cell physiology.
Mitochondrial Encephalomyopathies
Changing phenotypic expression in a patient with a mitochondrial encephalopathy due to 13042G>A de novo mutation-a 5 year follow up.
Mitochondrial encephalomyopathy. Association with an NADH dehydrogenase deficiency.
Mitochondrial Encephalopathy and Optic Neuropathy Due to m.10158 MT-ND3 Complex I Mutation Presenting in an Adult Patient: Case Report and Review of the Literature.
Mitochondrial variations in the MT-ND4 and MT-TL1 genes are associated with male infertility.
Variations of activities in the segments of respiratory chain among tissues in a patient with mitochondrial encephalomyopathy.
Mitochondrial Myopathies
Benign mitochondrial myopathy with decreased succinate cytochrome C reductase activity.
Deficiency in ubiquinone cytochrome c reductase in a patient with mitochondrial myopathy and lactic acidosis.
Isolated and combined deficiencies of NADH dehydrogenase (complex I) in muscle tissue of children with mitochondrial myopathies.
Mitochondrial DNA deletions in inclusion body myositis.
Multiple deficiencies of mitochondrial DNA- and nuclear-encoded subunits of respiratory NADH dehydrogenase detected with peptide- and subunit-specific antibodies in mitochondrial myopathies.
Muscle Hypotonia
Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy.
Muscle Spasticity
Partial NADH dehydrogenase defect presenting as spastic cerebral palsy.
Muscular Diseases
Congenital ocular motor apraxia associated with myopathy, external hydrocephalus and NADH dehydrogenase deficiency.
Multiple deficiencies of mitochondrial DNA- and nuclear-encoded subunits of respiratory NADH dehydrogenase detected with peptide- and subunit-specific antibodies in mitochondrial myopathies.
NADH-2 cytochrome C reductase and cytochrome C oxidase in experimental muscle disorders.
Myocardial Ischemia
Inhibition of myocardial rotenone-insensitive NADH cytochrome c reductase by amphiphilic compounds.
Interaction between longevity-associated mitochondrial DNA 5178 C/A polymorphism and cigarette smoking on hematological parameters in Japanese men.
Myoglobinuria
Cytochrome c oxidase deficiency presenting as recurrent neonatal myoglobinuria.
nadh dehydrogenase deficiency
Coexisting hereditary methaemoglobinaemia and heterozygous beta-thalassaemia.
Congenital enzymopenic methaemoglobinaemia. Clinical and biochemical study of a family with three homozygotes.
Congenital methaemoglobinaemia due to NADH methaemoglobin reductase deficiency: successful treatment with oral riboflavin.
Congenital ocular motor apraxia associated with myopathy, external hydrocephalus and NADH dehydrogenase deficiency.
Fermentation and alternative respiration compensate for NADH dehydrogenase deficiency in a prokaryotic model of DJ-1-associated Parkinsonism.
Genetic counselling and prenatal diagnosis in disorders of the mitochondrial energy metabolism.
Hereditary methemoglobinemia associated with NADH diaphorase deficiency.
Liver-intestine transplant from a pediatric donor with unrecognized mitochondrial succinate cytochrome C reductase deficiency.
Mitochondrial encephalomyopathy. Association with an NADH dehydrogenase deficiency.
NADH dehydrogenase deficiency in an apoptosis-resistant mutant isolated from a human HL-60 leukemia cell line.
NADH dehydrogenase deficiency results in low respiration rate and improved aerobic growth of Zymomonas mobilis.
Nonsense and missense mutation of mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma.
Partial NADH dehydrogenase defect presenting as spastic cerebral palsy.
[Familial NADH diaphorase deficiency]
nadh:ubiquinone reductase (h+-translocating) deficiency
A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer.
Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism.
Functional expression of the single subunit NADH dehydrogenase in mitochondria in vivo: a potential therapy for complex I deficiencies.
Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy.
Replacement of the C6ORF66 Assembly Factor (NDUFAF4) Restores Complex I Activity in Patient Cells.
The mitochondrial DNA G13513A MELAS mutation in the NADH dehydrogenase 5 gene is a frequent cause of Leigh-like syndrome with isolated complex I deficiency.
Whole Exome Sequencing Identifies the Genetic Basis of Late-Onset Leigh Syndrome in a Patient with MRI but Little Biochemical Evidence of a Mitochondrial Disorder.
Neoplasm Metastasis
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.
Nonsense and missense mutation of mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma.
Neoplasms
?9-THC increases endogenous AHA1 expression in rat cerebellum and may modulate CB1 receptor function during chronic use.
Cell origin of human adenovirus type 12-induced subcutaneous tumor in Syrian hamsters.
Dehydrogenation of reduced pyridine nucleotides by Leydig cell tumors of the rat testis.
Detection of mitochondrial genome depletion by a novel cDNA in renal cell carcinoma.
Dissecting the expression landscape of mitochondrial genes in lung squamous cell carcinoma and lung adenocarcinoma.
Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism.
Electron-transferring enzymes in the plasma membrane of the Ehrlich ascites tumor cell.
Enhanced drug-metabolizing capacity within liver adjacent to human and rat liver tumors.
Feasibility study on radiofrequency ablation followed by partial mastectomy for stage I breast cancer patients.
Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.
Genomics of chromophobe renal cell carcinoma: implications from a rare tumor for pan-cancer studies.
Histopathological effect of radiofrequency ablation therapy for primary breast cancer, with special reference to changes in cancer cells and stromal structure and a comparison with enzyme histochemistry.
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Immunochemical specificity of placental NADPH cytochrome c (P-450) reductase in neoplastic and non-neoplastic human tissue.
Mitochondrial complex I is deficient in renal oncocytomas.
Mitochondrial DNA polymorphism in genes encoding ND1, COI and CYTB in canine malignant cancers.
NADH dehydrogenase complex I is overexpressed in incipient metastatic murine colon cancer cells.
Nonsense and missense mutation of mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma.
Novel tumor-ablation device for liver tumors utilizing heat energy generated under an alternating magnetic field.
Purification and characterization of a plasma membrane ferricyanide-utilizing NADH dehydrogenase from Ehrlich tumour cells.
Role of adipocyte mitochondria in inflammation, lipemia and insulin sensitivity in humans: effects of pioglitazone treatment.
S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2.
Spectrum of somatic mitochondrial mutations in five cancers.
The medial and lateral substantia nigra in Parkinson's disease: mRNA profiles associated with higher brain tissue vulnerability.
The pattern of natural selection in somatic cancer mutations of human mtDNA.
Therapeutic effect of tamoxifen and energy-modulating vitamins on carbohydrate-metabolizing enzymes in breast cancer.
Ubiquinol cytochrome c reductase (UQCRFS1) gene amplification in primary breast cancer core biopsy samples.
[Expression of MLRQ subunit gene of NADH oxidoreductase and its clinical significance in malignant tumors of digestive system]
[Identification of multidrug resistance related genes in leukemia by suppression subtractive hybridization]
[Multiple trichoepitheliomas, cylindromas and milia. An entity]
Nephrosis
Telmisartan improves kidney function through inhibition of the oxidative phosphorylation pathway in diabetic rats.
Nervous System Diseases
The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
Neuroblastoma
Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease.
Neurodegenerative Diseases
Titrating the effects of mitochondrial complex I impairment in the cell physiology.
Non-alcoholic Fatty Liver Disease
Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease.
Highly expressed MT-ND3 positively associated with histological severity of hepatic steatosis.
Onchocerciasis
Analysis of genetic variation in ribosomal DNA internal transcribed spacer and the NADH dehydrogenase subunit 4 mitochondrial genes of the onchocerciasis vector Simulium ochraceum.
Canine ocular onchocercosis in the United States is associated with Onchocerca lupi.
Optic Atrophy
Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice.
Optic Atrophy, Hereditary, Leber
A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystonia.
Allelic mutations of the fourth subunit of NADH dehydrogenase are not pathogenetically important in 11778-negative Leber hereditary optic neuropathy.
Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber's Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells.
Homoplasmic and exclusive ND4 gene mutation in Japanese pedigrees with Leber's disease.
Leber's hereditary optic neuropathy with dystonia in a Japanese family.
Mitochondrial DNA polymorphism in Finnish families with Leber's hereditary optic neuroretinopathy.
Next-generation sequencing of mitochondrial targeted AAV transfer of human ND4 in mice.
The ND1 gene of complex I is a mutational hot spot for Leber's hereditary optic neuropathy.
Use of transmitochondrial cybrids to assign a complex I defect to the mitochondrial DNA-encoded NADH dehydrogenase subunit 6 gene mutation at nucleotide pair 14459 that causes Leber hereditary optic neuropathy and dystonia.
Yeast NDI1 improves oxidative phosphorylation capacity and increases protection against oxidative stress and cell death in cells carrying a Leber's hereditary optic neuropathy mutation.
Optic Nerve Diseases
A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystonia.
Allelic mutations of the fourth subunit of NADH dehydrogenase are not pathogenetically important in 11778-negative Leber hereditary optic neuropathy.
Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber's Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells.
Homoplasmic and exclusive ND4 gene mutation in Japanese pedigrees with Leber's disease.
Leber's hereditary optic neuropathy with dystonia in a Japanese family.
Next-generation sequencing of mitochondrial targeted AAV transfer of human ND4 in mice.
The ND1 gene of complex I is a mutational hot spot for Leber's hereditary optic neuropathy.
Use of transmitochondrial cybrids to assign a complex I defect to the mitochondrial DNA-encoded NADH dehydrogenase subunit 6 gene mutation at nucleotide pair 14459 that causes Leber hereditary optic neuropathy and dystonia.
Yeast NDI1 improves oxidative phosphorylation capacity and increases protection against oxidative stress and cell death in cells carrying a Leber's hereditary optic neuropathy mutation.
Osteomyelitis
[The state of the microsomal oxidative system in the liver of rats with acute osteomyelitis of the mandible]
Ovarian Neoplasms
Novel insights into the phylogenetic relationships of the endangered marsupial genus Potorous.
Phylogenetic relationships of rock-wallabies, Petrogale (Marsupialia: Macropodidae) and their biogeographic history within Australia.
Pantothenate Kinase-Associated Neurodegeneration
Movement disorders in mitochondrial diseases.
Paratuberculosis
Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis.
Phagocytosis of M. paratuberculosis fails to activate expression of NADH dehydrogenase and nucleolin-related protein in bovine macrophages.
Parkinson Disease
Differential Effects of Yeast NADH Dehydrogenase (Ndi1) Expression on Mitochondrial Function and Inclusion Formation in a Cell Culture Model of Sporadic Parkinson's Disease.
Genetic variation of the mitochondrial complex I subunit NDUFV2 and Parkinson disease.
Mitochondrial variations in the MT-ND4 and MT-TL1 genes are associated with male infertility.
Parkinson's disease and mitochondrial DNA NADH dehydrogenase subunit 1 nucleotides 3337-3340: study in a population from the central region of Portugal (Coimbra).
Regional heterogeneity of mtDNA heteroplasmy in parkinsonian brain.
The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
Parkinsonian Disorders
Fermentation and alternative respiration compensate for NADH dehydrogenase deficiency in a prokaryotic model of DJ-1-associated Parkinsonism.
Peptic Ulcer
Production of polyclonal antibody against alkyl hydroperoxide reductase of Helicobacter pylori and its antigenicity.
Peripheral Arterial Disease
Decreased NADH dehydrogenase and ubiquinol-cytochrome c oxidoreductase in peripheral arterial disease.
Peripheral Nerve Injuries
Coupling of serotonergic input to NMDA receptor-phosphorylation following peripheral nerve injury via rapid, synaptic up-regulation of ND2.
Photosensitivity Disorders
Phthalocyanine-photosensitized inactivation of a pathogenic protozoan, Acanthamoeba palestinensis.
Respiratory Insufficiency
Characterization of oxygen-resistant Chinese hamster ovary cells. III. Relative resistance of succinate and alpha-ketoglutarate dehydrogenases to hyperoxic inactivation.
Sarcoma
Differential inhibition/inactivation of mitochondrial complex I implicates its alteration in malignant cells.
Schistosomiasis
Succinate cytochrome c reductase in schistosomiasis: in vitro inhibition by some schistosomicidal drugs.
Scrapie
The membrane location of scrapie infectivity.
Sjogren-Larsson Syndrome
Pre- and postnatal growth retardation, scaling skin, moderate mental retardation and quadrispasticity, hypospadias grade 2 and hydro-uretero nephrosis, postaxial polydactyly. A distinct MCA/MR syndrome?
Starvation
A proteome analysis of the tetracyanonickelate (II) responses in Klebsiella oxytoca.
Mutants defective in the energy-conserving NADH dehydrogenase of Salmonella typhimurium identified by a decrease in energy-dependent proteolysis after carbon starvation.
Relationship between respiratory enzymes and survival of Escherichia coli under starvation stress in lake water.
The response of Cupriavidus metallidurans CH34 to spaceflight in the international space station.
Status Epilepticus
Mitochondrial dysfunction and ultrastructural damage in the hippocampus during kainic acid-induced status epilepticus in the rat.
Stomach Neoplasms
Modulatory effect of naringenin on N-methyl-N'-nitro-N-nitrosoguanidine- and saturated sodium chloride-induced gastric carcinogenesis in male Wistar rats.
Serum Helicobacter pylori KatA and AhpC antibodies as novel biomarkers for gastric cancer.
Stroke
Disrupted mitochondrial genes and inflammation following stroke.
succinate dehydrogenase deficiency
A patient with mitochondrial myopathy associated with isolated succinate dehydrogenase deficiency.
Thymoma
Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma.
Tuberculosis
Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosis.
Compensatory functions of two alkyl hydroperoxide reductases in the oxidative defense system of Legionella pneumophila.
Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis.
Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages.
Kinetics of formation and reactivity of the persulfide in the one-cysteine peroxiredoxin from Mycobacterium tuberculosis.
Mode of Action of Clofazimine and Combination Therapy with Benzothiazinones against Mycobacterium tuberculosis.
Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid.
Novel mutations in ndh in isoniazid-resistant Mycobacterium tuberculosis isolates.
Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum.
Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis.
Oxidizing substrate specificity of Mycobacterium tuberculosis alkyl hydroperoxide reductase E: kinetics and mechanisms of oxidation and overoxidation.
Silencing of oxidative stress response in Mycobacterium tuberculosis: expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation.
Stereospecificity of the allosteric NADH dehydrogenase from Mycobacterium tuberculosis.
The active site architecture in peroxiredoxins: a case study on Mycobacterium tuberculosis AhpE.
The extraordinary catalytic ability of peroxiredoxins: a combined experimental and QM/MM study on the fast thiol oxidation step.
Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics.
[Mechanisms of drug-resistance in mycobacteria]
[Multidrug-resistant tuberculosis. 2. Mechanisms of drug-resistance in Mycobacterium tuberculosis--genetic mechanisms of drug-resistance]
Typhoid Fever
Protection of chickens against experimental fowl typhoid using a nuoG mutant of Salmonella serotype Gallinarum.
Urinary Bladder Neoplasms
Histochemistry of NADH diaphorase and gamma-glutamyltranspeptidase in rat bladder tumors.
Uterine Cervical Neoplasms
Identification and characterization of genes involved in the carcinogenesis of human squamous cell cervical carcinoma.
Varicose Veins
Muscle changes in patients with varicose veins.
Virus Diseases
Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice.