Disease on EC 1.6.5.4 - monodehydroascorbate reductase (NADH)
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Adenocarcinoma
Association studies of the copy-number variable ß-defensin cluster on 8p23.1 in adenocarcinoma and chronic pancreatitis.
Adenocarcinoma
Paneth cell differentiation in colonic epithelial neoplasms: evidence for the role of the Apc/beta-catenin/Tcf pathway.
Adenocarcinoma
PPARgamma as a sensor of lipase activity and a target for the lipase inhibitor orlistat.
Adenocarcinoma
Salivary Proteome and Peptidome Profiling in Type 1 Diabetes Mellitus Using a Quantitative Approach.
Adenoma
Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients.
Adenoma
Paneth cell differentiation in colonic epithelial neoplasms: evidence for the role of the Apc/beta-catenin/Tcf pathway.
Adenomatous Polyposis Coli
Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli.
Aggressive Periodontitis
Human beta defensin-1 and -2 expression in the gingiva of patients with specific periodontal diseases.
Airway Obstruction
Increased Expression of Beta-Defensin 1 (DEFB1) in Chronic Obstructive Pulmonary Disease.
Alzheimer Disease
Relevance of defensin ?-2 and ? defensins (HNP1-3) in Alzheimer's disease.
Anemia
Neutrophil gelatinase-associated lipocalin and hepcidin: what do they have in common and is there a potential interaction?
Appendicitis
Acute appendicitis: transcript profiling of blood identifies promising biomarkers and potential underlying processes.
Aspergillosis
Inducible expression of beta defensins by human respiratory epithelial cells exposed to Aspergillus fumigatus organisms.
Asthma
Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells.
Asthma
The signature of long-standing balancing selection at the human defensin beta-1 promoter.
Atherosclerosis
Defensin stimulates the binding of lipoprotein (a) to human vascular endothelial and smooth muscle cells.
Autoimmune Diseases
An evolutionary history of defensins: a role for copy number variation in maximizing host innate and adaptive immune responses.
Bacterial Infections
Defensin from disk abalone Haliotis discus discus: molecular cloning, sequence characterization and immune response against bacterial infection.
Bacterial Infections
Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m6A-GPR161 signalling axis.
Bacterial Infections
Genetic engineering strategies for biotic and abiotic stress tolerance and quality enhancement in horticultural crops: a comprehensive review.
Bacterial Infections
Inducible immune factors of the vector mosquito Anopheles gambiae: biochemical purification of a defensin antibacterial peptide and molecular cloning of preprodefensin cDNA.
Bacterial Infections
Inhibition of defensin A and cecropin A responses to dengue virus 1 infection in Aedes aegypti.
Bacterial Infections
Keratinocyte expression of human beta defensin 2 following bacterial infection: role in cutaneous host defense.
Bacterial Infections
Knock-down of REL2, but not defensin A, augments Aedes aegypti susceptibility to Bacillus subtilis and Escherichia coli.
Bacterial Infections
Natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: Calliphora vicina medicinal maggots.
Bacterial Infections
Neopterin, Interleukin-6, Procalcitonin, C-Reactive Protein And PET-CT Staining As Markers In Infected Total Knee Prosthesis, A Retrospective Analysis.
Bacterial Infections
Overexpression of Porcine Beta-Defensin 2 Enhances Resistance to Actinobacillus pleuropneumoniae Infection in Pigs.
Bacterial Infections
Parasitic infection protects wasp larvae against a bacterial challenge.
Bacterial Infections
Penicillin-binding protein 1a promotes resistance of group B streptococcus to antimicrobial peptides.
Bacterial Infections
Regulation of antimicrobial peptide expression in human gingival keratinocytes by interleukin-1?
Bacterial Infections
The sandfly Lutzomyia longipalpis LL5 embryonic cell line has active Toll and Imd pathways and shows immune responses to bacteria, yeast and Leishmania.
Breast Neoplasms
Plant defensin PvD1 modulates the membrane composition of breast tumour-derived exosomes.
Breast Neoplasms
The defensin from avocado (Persea americana var. drymifolia) PaDef induces apoptosis in the human breast cancer cell line MCF-7.
Bronchitis, Chronic
Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects.
Candidiasis
In vitro activity of the antifungal plant defensin RsAFP2 against Candida isolates and its in vivo efficacy in prophylactic murine models of candidiasis.
Candidiasis
Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms.
Candidiasis
The signature of long-standing balancing selection at the human defensin beta-1 promoter.
Candidiasis, Oral
Dynamic changes of Th1/Th2/Th17 cytokines and human beta defensin 2 in HIV-infected patients with oral candidiasis during the first year of highly active anti-retroviral therapy.
Carcinogenesis
Defensins induce the recruitment of dendritic cells in cervical human papillomavirus-associated (pre)neoplastic lesions formed in vitro and transplanted in vivo.
Carcinogenesis
Prevalent Homozygous Deletions of Type I Interferon and Defensin Genes in Human Cancers Associate with Immunotherapy Resistance.
Carcinogenesis
The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila.
Carcinoma
Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients.
Carcinoma
Effect of defensin peptides on eukaryotic cells: primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines.
Carcinoma
Expression profile of drosomycin-like defensin in oral epithelium and oral carcinoma cell lines.
Carcinoma
Presence of defensin in epithelial Langerhans cells adjacent to oral carcinomas and precancerous lesions.
Carcinoma, Squamous Cell
Effect of defensin peptides on eukaryotic cells: primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines.
Cardiovascular Diseases
Cardiovascular disease and serum defensin levels in systemic lupus erythematosus.
Chagas Disease
Cellular Response to Trypanosoma cruzi infection induces Secretion of Defensin ?-1, Which Damages the Flagellum, Neutralizes Trypanosome Motility and Inhibits Infection.
Chagas Disease
Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction.
Chagas Disease
Isolation and characterization of a novel insect defensin from Rhodnius prolixus, a vector of Chagas disease.
Chediak-Higashi Syndrome
Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency.
Cholesteatoma
Association between human beta defensin expression and cholesteatoma formation.
Cholesteatoma
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma.
Cholesteatoma, Middle Ear
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatoma.
Chorioamnionitis
Amniotic fluid defensins: potential markers of subclinical intrauterine infection.
Chorioamnionitis
Neutrophil granule products: can they identify subclinical chorioamnionitis in patients with preterm premature rupture of membranes?
Chronic Periodontitis
DEFB4A Promoter Polymorphism Is Associated with Chronic Periodontitis: A Case-Control Study.
Chronic Periodontitis
Human beta defensin-1 and -2 expression in the gingiva of patients with specific periodontal diseases.
Chronic Periodontitis
[The impact of smoking on human beta defensin 2,3 in gingival crevicular fluid and gingival tissue of patients with chronic periodontitis].
Clostridium Infections
A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Is Effective in Treatment of Clostridioides difficile Infection in Mice.
Coinfection
Impact of Mixed Infections of Gut Parasites Lotmaria passim and Nosema ceranae on the Lifespan and Immune-related Biomarkers in Apis mellifera.
Coinfection
[Changes of functional activity of peripheral blood leukocytes during the immunotherapy of tick-borne infections in children].
Colitis
Chronic colitis induces expression of ?-defensins in murine intestinal epithelial cells.
Colitis
Human Defensin-5 Blocks Ethanol and Colitis-Induced Dysbiosis, Tight Junction Disruption and Inflammation in Mouse Intestine.
Colitis
Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease.
Colitis, Ulcerative
Construction of recombinant E. coli Nissle 1917 (EcN) strains for the expression and secretion of defensins.
Colitis, Ulcerative
Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli.
Colitis, Ulcerative
[Chronic inflammatory bowel diseases (IBD): novel pathophysiological concepts and their clinical relevance]
Colitis, Ulcerative
[The role of defensins in the pathogenesis of chronic-inflammatory bowel disease]
Colonic Diseases
A new look at Crohn's disease: breakdown of the mucosal antibacterial defense.
Colonic Diseases
Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease.
Colonic Diseases
Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease.
Colonic Neoplasms
Anticancer potential of human intestinal defensin 5 against 1, 2-dimethylhydrazine dihydrochloride induced colon cancer: A therapeutic approach.
Colonic Neoplasms
Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate.
Colonic Neoplasms
Human ?-defensin 5 suppressed colon cancer growth by targeting PI3K pathway.
Colonic Neoplasms
Identification of defensin alpha6 as a potential biomarker in colon adenocarcinoma.
Colonic Neoplasms
Paneth cell differentiation in colonic epithelial neoplasms: evidence for the role of the Apc/beta-catenin/Tcf pathway.
Colorectal Neoplasms
Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients.
Communicable Diseases
Antimycobacterial agent based on mRNA encoding human beta-defensin 2 enables primary macrophages to restrict growth of Mycobacterium tuberculosis.
Communicable Diseases
Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children.
Communicable Diseases
Diesel exhaust particles increase IL-1beta-induced human beta-defensin expression via NF-kappaB-mediated pathway in human lung epithelial cells.
Communicable Diseases
Is the Enzyme-linked Immunosorbent Assay More Accurate Than the Lateral Flow Alpha Defensin Test for Diagnosing Periprosthetic Joint Infection?
Communicable Diseases
Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity.
Communicable Diseases
[Transfection of human beta defensin 2 gene into the lung by aerosol inhalation: experiment with rats]
COVID-19
Evaluation of alpha defensin, IL-1 receptor antagonist, and IL-18 levels in COVID-19 patients with macrophage activation syndrome and acute respiratory distress syndrome.
COVID-19
High level of defensin alpha 5 in intestine may explain the low incidence of diarrhoea in COVID-19 patients.
Crohn Disease
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon.
Crohn Disease
Abnormal Pap smears in women with Crohn's disease: is there a role for defensin deficiency?
Crohn Disease
An evolutionary history of defensins: a role for copy number variation in maximizing host innate and adaptive immune responses.
Crohn Disease
Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease.
Crohn Disease
Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease.
Crohn Disease
Construction of recombinant E. coli Nissle 1917 (EcN) strains for the expression and secretion of defensins.
Crohn Disease
Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype.
Crohn Disease
Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease.
Crohn Disease
Defensin-barbed innate immunity: clinical associations in the pediatric population.
Crohn Disease
Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease.
Crohn Disease
Hepcidin and inflammatory bowel disease: dual role in host defence and iron homoeostasis.
Crohn Disease
Host-microbe interaction: mechanisms of defensin deficiency in Crohn's disease.
Crohn Disease
Impaired luminal processing of human defensin-5 in Crohn's disease: persistence in a complex with chymotrypsinogen and trypsin.
Crohn Disease
Influence of standard treatment on ileal and colonic antimicrobial defensin expression in active Crohn's disease.
Crohn Disease
NOD2 and defensins: translating innate to adaptive immunity in Crohn's disease.
Crohn Disease
NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation.
Crohn Disease
Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa.
Crohn Disease
Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease.
Crohn Disease
Two Cheers for Crohn's Disease and Periodontitis: Beta-Defensin-2 as an Actionable Target to Intervene on Two Clinically Distinct Diseases.
Crohn Disease
[Chronic inflammatory bowel diseases (IBD): novel pathophysiological concepts and their clinical relevance]
Crohn Disease
[The role of defensins in the pathogenesis of chronic-inflammatory bowel disease]
Cystic Fibrosis
Diesel exhaust particles increase IL-1beta-induced human beta-defensin expression via NF-kappaB-mediated pathway in human lung epithelial cells.
Cystic Fibrosis
Expression of human beta defensin (HBD-1 and HBD-2) mRNA in nasal epithelia of adult cystic fibrosis patients, healthy individuals, and individuals with acute cold.
Dehydration
Antioxidative protection in the inducible CAM plant Sedum album L. following the imposition of severe water stress and recovery.
Dehydration
Effect of short-term water deficit stress on antioxidative systems in cucumber seedling roots.
Dehydration
Effect of water stress on antioxidant systems and oxidative parameters in fruits of tomato (Solanum lycopersicon L, cv. Micro-tom).
Dehydration
Jasmonic acid regulates ascorbate and glutathione metabolism in Agropyron cristatum leaves under water stress
Dehydration
Redox Regulation of Monodehydroascorbate Reductase by Thioredoxin y in Plastids Revealed in the Context of Water Stress.
Dehydration
Response of the physiological parameters of mango fruit (transpiration, water relations and antioxidant system) to its light and temperature environment.
Dengue
Inhibition of defensin A and cecropin A responses to dengue virus 1 infection in Aedes aegypti.
Dental Caries
An association analysis for genetic factors for dental caries susceptibility in a cohort of Chinese children.
Dental Caries
Salivary protein polymorphisms and risk of dental caries: a systematic review.
Dermatitis, Atopic
IL-33 Modulates the Expression of Human Beta Defensin 2 in Human Primary Keratinocytes and may influence the susceptibility to bacterial superinfection in acute atopic dermatitis.
Dermatitis, Atopic
Intestinal defensin secretion in infancy is associated with the emergence of sensitization and atopic dermatitis.
Diabetic Neuropathies
Impact of Low-Frequency Pulsed Magnetic Fields on Defensin and CRP Concentrations in Patients with Painful Diabetic Polyneuropathy and in Healthy Subjects.
Dry Eye Syndromes
Effect of hyperosmolality on beta-defensin gene expression by human corneal epithelial cells.
Dry Eye Syndromes
Interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye.
Eczema
IL-33 Modulates the Expression of Human Beta Defensin 2 in Human Primary Keratinocytes and may influence the susceptibility to bacterial superinfection in acute atopic dermatitis.
Encephalitis, Japanese
Mosquito defensin facilitates Japanese encephalitis virus infection by downregulating the C6/36 cell-surface antiviral protein HSC70B.
Endometriosis
Peritoneal fluid biomarkers in patients with endometriosis: a cross-sectional study.
Enterovirus Infections
Induction and antiviral activity of human ?-defensin 3 in intestinal cells with picornavirus infection.
Escherichia coli Infections
Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m6A-GPR161 signalling axis.
Escherichia coli Infections
Structural and Functional Analysis of PGRP-LC Indicates Exclusive Dap-Type PGN Binding in Bumblebees.
Gastritis
Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status.
Gastritis
Defensin-mRNA Expression in the Upper Gastrointestinal Tract Is Modulated in Children With Celiac Disease and Helicobacter pylori-positive Gastritis.
Gastritis
Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis.
Gastritis
Potential role of human beta-defensin 1 in Helicobacter pylori-induced gastritis.
Gastroesophageal Reflux
Esophageal human ?-defensin expression in eosinophilic esophagitis.
Gingivitis
Human beta defensin-1 and -2 expression in the gingiva of patients with specific periodontal diseases.
Hepatitis
Administration of Poly[di(sodium carboxylatoethylphenoxy)phosphazene] (PCEP) and Avian Beta Defensin as Adjuvants in Inactivated Inclusion Body Hepatitis Virus and its Hexon Protein-Based Experimental Vaccine Formulations in Chickens.
Hepatitis B
The Improvement of Immune Effect of Recombinant Human Beta-Defensin 2 on Hepatitis B Vaccine in Mice.
Hepatitis C
Inhibitory Activity of a Scorpion Defensin BmKDfsin3 against Hepatitis C Virus.
Herpes Zoster
Differentially-Expressed Genes Associated with Faster Growth of the Pacific Abalone, Haliotis discus hannai.
HIV Infections
An evolutionary history of defensins: a role for copy number variation in maximizing host innate and adaptive immune responses.
HIV Infections
Are defensin beta 1 gene polymorphisms associated with HIV infection and virus replication?
HIV Infections
Chronic HIV infection is associated with upregulation of pro-inflammatory cytokine and chemokine and alpha defensin gene expression in colorectal mucosa.
HIV Infections
Copy number variation of defensin genes and HIV infection in Brazilian children.
Hyperglycemia
Glucose and insulin are needed for optimal defensin expression in human cell lines.
Hypersensitivity
Soluble CD14, ?-and ?-defensins in breast milk: Association with the emergence of allergy in a high-risk population.
Idiopathic Pulmonary Fibrosis
Diesel exhaust particles increase IL-1beta-induced human beta-defensin expression via NF-kappaB-mediated pathway in human lung epithelial cells.
Infections
?-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome.
Infections
A Case Report and Literature Review to Aid in the Management of Trunnion Failure in Hip Arthroplasty Patients: Can Trunnionosis and Prosthetic Joint Infection Co-Exist?
Infections
A comparative study of intraoperative frozen section and alpha defensin lateral flow test in the diagnosis of periprosthetic joint infection.
Infections
A Kampo (traditional Japanese herbal) medicine, Hochuekkito, pretreatment in mice prevented influenza virus replication accompanied with GM-CSF expression and increase in several defensin mRNA levels.
Infections
A Murine Model of Inflammatory Bladder Disease: Cathelicidin Peptide Induced Bladder Inflammation and Treatment With Sulfated Polysaccharides.
Infections
A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Is Effective in Treatment of Clostridioides difficile Infection in Mice.
Infections
A novel pepper membrane-located receptor-like protein gene CaMRP1 is required for disease susceptibility, methyl jasmonate insensitivity and salt tolerance.
Infections
A profile on the Synovasure Alpha Defensin Test for the detection of periprosthetic infections.
Infections
A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children.
Infections
Accuracy and Cost-Effectivenss of a Novel Method for Alpha Defensins Measurement in the Diagnosis of Periprosthetic Joint Infections.
Infections
Acute appendicitis: transcript profiling of blood identifies promising biomarkers and potential underlying processes.
Infections
Acute transcriptional response of the honeybee peptide-antibiotics gene repertoire and required post-translational conversion of the precursor structures.
Infections
Aedes aegypti Infection With Trypanosomatid Strigomonas culicis Alters Midgut Redox Metabolism and Reduces Mosquito Reproductive Fitness.
Infections
Alpha Defensin Lateral Flow Test for Diagnosis of Periprosthetic Joint Infection: Not a Screening but a Confirmatory Test.
Infections
Alpha defensin, leukocyte esterase, C-reactive protein, and leukocyte count in synovial fluid for pre-operative diagnosis of periprosthetic infection.
Infections
Alpha Defensin: A Diagnostic Accuracy Depending on the Infection Definition Used.
Infections
Amniotic fluid defensins: potential markers of subclinical intrauterine infection.
Infections
Antibacterial activity of a Tribolium castaneum defensin in an in vitro infection model of Streptococcus pneumoniae.
Infections
Antibacterial activity of human defensins on anaerobic intestinal bacterial species: a major role of HBD-3.
Infections
Antimicrobial peptide gene cecropin-2 and defensin respond to peptidoglycan infection in the female adult of oriental fruit fly, Bactrocera dorsalis (Hendel).
Infections
Antimicrobial Responses in the Male Reproductive Tract of Lipopolysaccharide Challenged Rats.
Infections
Arabidopsis thaliana plants differentially modulate auxin biosynthesis and transport during defense responses to the necrotrophic pathogen Alternaria brassicicola.
Infections
Bacterial feeding, Leishmania infection and distinct infection routes induce differential defensin expression in Lutzomyia longipalpis.
Infections
Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis.
Infections
Big defensins, a diverse family of antimicrobial peptides that follows different patterns of expression in hemocytes of the oyster Crassostrea gigas.
Infections
Blocking of Plasmodium transmission by cooperative action of Cecropin A and Defensin A in transgenic Aedes aegypti mosquitoes.
Infections
Brassinosteroids Antagonize Jasmonate-Activated Plant Defense Responses through BRI1-EMS-SUPPRESSOR1 (BES1).
Infections
Cellular Response to Trypanosoma cruzi infection induces Secretion of Defensin ?-1, Which Damages the Flagellum, Neutralizes Trypanosome Motility and Inhibits Infection.
Infections
Characterization of a defensin from the sand fly Phlebotomus duboscqi induced by challenge with bacteria or the protozoan parasite Leishmania major.
Infections
Characterization of an endogenous gene expressed in Aedes aegypti using an orally infectious recombinant Sindbis virus.
Infections
Clinical Evaluation of Alpha Defensin Test Following Staged Treatment of Prosthetic Joint Infections.
Infections
Clinical Evaluation of Synovial Alpha Defensin and Synovial C-Reactive Protein in the Diagnosis of Periprosthetic Joint Infection.
Infections
Comparison of the Effects of Human ?-defensin 3, Vancomycin, and Clindamycin on Staphylococcus aureus Biofilm Formation.
Infections
Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer.
Infections
Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota.
Infections
Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms.
Infections
Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells.
Infections
Defensin from disk abalone Haliotis discus discus: molecular cloning, sequence characterization and immune response against bacterial infection.
Infections
Defensin gene family in Medicago truncatula: structure, expression and induction by signal molecules.
Infections
Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status.
Infections
Diagnostic Accuracy of the Alpha Defensin Lateral Flow Device (Synovasure) for Periprosthetic Infections in Microbiologically Complex Situations: A Study of 42 Cases in a French Referral Centre.
Infections
Differential expression and in situ localization of a pepper defensin (CADEF1) gene in response to pathogen infection, abiotic elicitors and environmental stresses in Capsicum annuum.
Infections
Differential expression of ovine innate immune genes by preterm and neonatal lung epithelia infected with respiratory syncytial virus.
Infections
Differential regulation of beta-defensin gene expression during Cryptosporidium parvum infection.
Infections
Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions.
Infections
Drosophila melanogaster mounts a unique immune response to the Rhabdovirus sigma virus.
Infections
Effect of larval density and Sindbis virus infection on immune responses in Aedes aegypti.
Infections
Effect of Short-Term Desiccation, Recovery Time, and CAPA-PVK Neuropeptide on the Immune System of the Burying Beetle Nicrophorus vespilloides.
Infections
Endogenous production of antimicrobial peptides in innate immunity and human disease.
Infections
Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m6A-GPR161 signalling axis.
Infections
Evaluation of the Antimicrobial Activity of an Extract of Lactobacillus casei-Infected Hermetia illucens Larvae Produced Using an Automatic Injection System.
Infections
Evidence that the role of plant defensins in radish defense responses is independent of salicylic acid.
Infections
Exploring the Role of Relish on Antimicrobial Peptide Expressions (AMPs) Upon Nematode-Bacteria Complex Challenge in the Nipa Palm Hispid Beetle, Octodonta nipae Maulik (Coleoptera: Chrysomelidae).
Infections
Expression of defensin, cecropin, and transferrin in Aedes aegypti (Diptera: Culicidae) infected with Wuchereria bancrofti (Spirurida: Onchocercidae), and the abnormal development of nematodes in the mosquito.
Infections
Gene organization of a novel defensin of Ixodes ricinus: first annotation of an intron/exon structure in a hard tick defensin gene and first evidence of the occurrence of two isoforms of one member of the arthropod defensin family.
Infections
Genome Wide Identification and Functional Prediction of Long Non-Coding RNAs Responsive to Sclerotinia sclerotiorum Infection in Brassica napus.
Infections
Ha-DEF1, a sunflower defensin, induces cell death in Orobanche parasitic plants.
Infections
High throughput profiling of the cotton bollworm Helicoverpa armigera immunotranscriptome during the fungal and bacterial infections.
Infections
High-Fidelity Point-of-Care Diagnostic Test for Periprosthetic Joint Infection: Commentary on an article by Thorsten Gehrke, MD, et al.: "The Accuracy of the Alpha Defensin Lateral Flow Device for Diagnosis of Periprosthetic Joint Infection. Comparison with a Gold Standard".
Infections
Human ?-defensin-3 participates in intra-amniotic host defense in women with labor at term, spontaneous preterm labor and intact membranes, and preterm prelabor rupture of membranes.
Infections
Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission.
Infections
Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy.
Infections
Human beta-defensin 2 is up-regulated during re-epithelialization of the cornea.
Infections
Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract.
Infections
Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction.
Infections
Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23.
Infections
Identification of an inhibitor of tissue-type plasminogen activator-mediated fibrinolysis in human neutrophils. A role for defensin.
Infections
Immune factor Gambif1, a new rel family member from the human malaria vector, Anopheles gambiae.
Infections
Immune responses in the haemolymph and antimicrobial peptide expression in the abdomen of Apis mellifera challenged with Spiroplasma melliferum CH-1.
Infections
Immunological interactions of Chilo suppressalis Walker (Lepidoptera: Crambidae) with the native entomopathogenic fungi.
Infections
Improved diagnostic accuracy with the classification tree method for diagnosing low-grade periprosthetic joint infections by quantitative measurement of synovial fluid alpha-defensin and C-reactive protein.
Infections
Improved sulfur nutrition provides the basis for enhanced production of sulfur-containing defense compounds in Arabidopsis thaliana upon inoculation with Alternaria brassicicola.
Infections
Increased survivorship following bacterial infection by the mosquito Aedes aegypti as compared to Anopheles gambiae correlates with increased transcriptional induction of antimicrobial peptides.
Infections
Inducible immune factors of the vector mosquito Anopheles gambiae: biochemical purification of a defensin antibacterial peptide and molecular cloning of preprodefensin cDNA.
Infections
Infection: It's a Numbers Game: Commentary on an article by William Z. Stone, MD, et al.: "Clinical Evaluation of Synovial Alpha Defensin and Synovial C-Reactive Protein in the Diagnosis of Periprosthetic Joint Infection".
Infections
Inhibition of defensin A and cecropin A responses to dengue virus 1 infection in Aedes aegypti.
Infections
Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization.
Infections
Is infection the possible initiator of disc disease? An insight from proteomic analysis.
Infections
Is the Enzyme-linked Immunosorbent Assay More Accurate Than the Lateral Flow Alpha Defensin Test for Diagnosing Periprosthetic Joint Infection?
Infections
Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila.
Infections
Microbicidal effects of ?- and ?-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa.
Infections
Modulation of HIV peptide antigen specific cellular immune response by synthetic ?- and ?-defensin peptides.
Infections
Mosquito defensin facilitates Japanese encephalitis virus infection by downregulating the C6/36 cell-surface antiviral protein HSC70B.
Infections
Mosquito Defensins Enhance Japanese Encephalitis Virus Infection by Facilitating Virus Adsorption and Entry within the Mosquito.
Infections
Neopterin, Interleukin-6, Procalcitonin, C-Reactive Protein And PET-CT Staining As Markers In Infected Total Knee Prosthesis, A Retrospective Analysis.
Infections
Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation.
Infections
NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation.
Infections
Overexpression of PtDefensin enhances resistance to Septotis populiperda in transgenic poplar.
Infections
Parallel evolution of gene classes, but not genes: evidence from Hawai'ian honeycreeper populations exposed to avian malaria.
Infections
Pathogen blocking in Wolbachia-infected Aedes aegypti is not affected by Zika and dengue virus co-infection.
Infections
Plant defensins-Prospects for the biological functions and biotechnological properties.
Infections
Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis.
Infections
Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body.
Infections
Purification and antimicrobial properties of three defensins from rat neutrophils.
Infections
Reduced Gene Expression of Intestinal alpha -Defensins Predicts Diarrhea in a Cohort of African Adults.
Infections
Retrocyclin 2: a new therapy against avian influenza H5N1 virus in vivo and vitro.
Infections
Rickettsia peacockii, an endosymbiont of Dermacentor andersoni, does not elicit or inhibit humoral immune responses from immunocompetent D. andersoni or Ixodes scapularis cell lines.
Infections
Role of pathogen-induced volatiles in the Nicotiana tabacum-Golovinomyces cichoracearum interaction.
Infections
Safe, mild ultraviolet-B exposure: An essential human requirement for vitamin D and other vital bodily parameter adequacy: A review.
Infections
Screening and Validation of Reference Genes for RT-qPCR Under Different Honey Bee Viral Infections and dsRNA Treatment.
Infections
Silencing expression of the defensin, varisin, in male Dermacentor variabilis by RNA interference results in reduced Anaplasma marginale infections.
Infections
Structural and Functional Analysis of PGRP-LC Indicates Exclusive Dap-Type PGN Binding in Bumblebees.
Infections
Synovial fluid ? defensin has comparable accuracy to synovial fluid white blood cell count and polymorphonuclear percentage for periprosthetic joint infection diagnosis.
Infections
The Accuracy of the Alpha Defensin Lateral Flow Device for Diagnosis of Periprosthetic Joint Infection: Comparison with a Gold Standard.
Infections
The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
Infections
The effect of Botrytis cinerea infection on the antioxidant profile of mitochondria from tomato leaves.
Infections
The host defense peptide beta-defensin 1 confers protection against Bordetella pertussis in newborn piglets.
Infections
The human alpha defensin HD5 neutralizes JC polyomavirus infection by reducing endoplasmic reticulum traffic and stabilizing the viral capsid.
Infections
The Mediator subunit SFR6/MED16 controls defence gene expression mediated by salicylic acid and jasmonate responsive pathways.
Infections
The noa gene is functionally linked to the activation of the Toll/Imd signaling pathways in Bactrocera dorsalis (Hendel).
Infections
The Putative Role of Human Peritoneal Adipocytes in the Fight against Bacteria: Synthesis of the Antimicrobial Active Peptide DEFA1-3.
Infections
The Ras/ERK signaling pathway couples antimicrobial peptides to mediate resistance to dengue virus in Aedes mosquitoes.
Infections
The role of alpha defensin in prosthetic joint infection (PJI) diagnosis: a literature review.
Infections
Therapeutic effect of modified oligopeptides from the beetle Allomyrina dichotoma on methicillin-resistant Staphylococcus aureus (MRSA) infection in mice.
Infections
Theta-Defensins Inhibit High-Risk Human Papillomavirus Infection Through Charge-Driven Capsid Clustering.
Infections
Tribolium castaneum defensin 1 kills Moraxella catarrhalisin an in vitro infection model but does not harm commensal bacteria.
Infections
Trypanosoma cruzi Infection Modulates the Expression of Triatoma brasiliensis def1 in the Midgut.
Infections
Tsetse immune responses and trypanosome transmission: implications for the development of tsetse-based strategies to reduce trypanosomiasis.
Infections
Two-stage revision and systemic antifungal therapy of Candida glabrata primary prosthetic hip infection successfully treated: a case report.
Infections
Up-regulation of the ascorbate-dependent antioxidative system in barley leaves during powdery mildew infection.
Infections
Uropathogenic Escherichia coli (UPEC) induced antimicrobial gene expression in the male reproductive tract of rat: evaluation of the potential of Defensin 21 to limit infection.
Infections
Validation of the Alpha Defensin Lateral Flow Test for Periprosthetic Joint Infection.
Infections
[Effect of human beta defensin 2 on Staphylococcus aureus infection: in vivo study with transgenic mice]
Infertility
A Common Mutation in the Defensin DEFB126 Causes Impaired Sperm Function and Subfertility.
Infertility
Re: a common mutation in the defensin DEFB126 causes impaired sperm function and subfertility.
Inflammatory Bowel Diseases
A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion.
Inflammatory Bowel Diseases
Correction: Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease.
Inflammatory Bowel Diseases
Defensins and inflammation: the role of defensins in inflammatory bowel disease.
Inflammatory Bowel Diseases
Esophageal human ?-defensin expression in eosinophilic esophagitis.
Inflammatory Bowel Diseases
Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease.
Inflammatory Bowel Diseases
Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease.
Inflammatory Bowel Diseases
Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease.
Inflammatory Bowel Diseases
NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation.
Inflammatory Bowel Diseases
Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa.
Inflammatory Bowel Diseases
Precursor processing of human defensin-5 is essential to the multiple functions in vitro and in vivo.
Inflammatory Bowel Diseases
Single nucleotide polymorphisms in human Paneth cell defensin A5 may confer susceptibility to inflammatory bowel disease in a New Zealand Caucasian population.
Influenza in Birds
Retrocyclin 2: a new therapy against avian influenza H5N1 virus in vivo and vitro.
Influenza, Human
A Kampo (traditional Japanese herbal) medicine, Hochuekkito, pretreatment in mice prevented influenza virus replication accompanied with GM-CSF expression and increase in several defensin mRNA levels.
Intestinal Diseases
High-level expression, purification and characterisation of porcine ?-defensin 2 in Pichia pastoris and its potential as a cost-efficient growth promoter in porcine feed.
Keratitis
Immune Defense Single Nucleotide Polymorphisms and Recruitment Strategies Associated with Contact Lens Keratitis.
Kidney Calculi
Characterization of the Protein Components of Matrix Stones Sheds Light on S100-A8 and S100-A9 Relevance in the Inflammatory Pathogenesis of These Rare Renal Calculi.
Leishmaniasis
A synthetic peptide derived of the ?2-?3 loop of the plant defensin from Vigna unguiculata seeds induces Leishmania amazonensis apoptosis-like cell death.
Leishmaniasis
Bacterial feeding, Leishmania infection and distinct infection routes induce differential defensin expression in Lutzomyia longipalpis.
Leishmaniasis
The sandfly Lutzomyia longipalpis LL5 embryonic cell line has active Toll and Imd pathways and shows immune responses to bacteria, yeast and Leishmania.
Leukemia
Assessment of the cellular response to the induced expression of defensin sense and antisense cDNA in acute promyelocytic leukemia cell lines.
Leukemia
Distinct temporal patterns of defensin mRNA regulation during drug-induced differentiation of human myeloid leukemia cells.
Leukemia
Drug-activated multiple pathways of defensin mRNA regulation in HL-60 cells are defined by reversed roles of participating protein kinases.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
PaDef defensin from avocado (Persea americana var. drymifolia) is cytotoxic to K562 chronic myeloid leukemia cells through extrinsic apoptosis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Posttranslational processing of defensins in immature human myeloid cells.
Leukemia, Myeloid
Distinct temporal patterns of defensin mRNA regulation during drug-induced differentiation of human myeloid leukemia cells.
Leukemia, Promyelocytic, Acute
Assessment of the cellular response to the induced expression of defensin sense and antisense cDNA in acute promyelocytic leukemia cell lines.
Lichen Sclerosus et Atrophicus
Human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus.
Lung Diseases
Diesel exhaust particles increase IL-1beta-induced human beta-defensin expression via NF-kappaB-mediated pathway in human lung epithelial cells.
Lung Diseases
Implication of vitamin D-associated factors in patients with non-tuberculous mycobacterial lung disease.
Lung Neoplasms
Aptamers Selected to Postoperative Lung Adenocarcinoma Detect Circulating Tumor Cells in Human Blood.
Lung Neoplasms
Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study.
Lung Neoplasms
In Vitro and In Vivo Anticancer Activity of Human ?-Defensin-3 and Its Mouse Homolog.
Lung Neoplasms
LC-MS/MS-Based Quantitative Proteomics Analysis of Different Stages of Non-Small-Cell Lung Cancer.
Lupus Erythematosus, Systemic
Cardiovascular disease and serum defensin levels in systemic lupus erythematosus.
Lyme Disease
An arthropod defensin expressed by the hemocytes of the American dog tick, Dermacentor variabilis (Acari: Ixodidae).
Lyme Disease
Defensin from the ornate sheep tick Dermacentor marginatus and its effect on Lyme borreliosis spirochetes.
Lymphoma
Selenium Deficiency Aggravates Aflatoxin B1-Induced Immunotoxicity in Chick Spleen by Regulating 6 Selenoprotein Genes and Redox/Inflammation/Apoptotic Signaling.
Macrophage Activation Syndrome
Evaluation of alpha defensin, IL-1 receptor antagonist, and IL-18 levels in COVID-19 patients with macrophage activation syndrome and acute respiratory distress syndrome.
Malaria
Molecular and phylogenetic analysis of a novel salivary defensin cDNA from malaria vector Anopheles stephensi.
Malaria
Parallel evolution of gene classes, but not genes: evidence from Hawai'ian honeycreeper populations exposed to avian malaria.
Malaria
The defensin peptide of the malaria vector mosquito Anopheles gambiae: antimicrobial activities and expression in adult mosquitoes.
Malaria
The malaria vector mosquito Anopheles gambiae expresses a suite of larval-specific defensin genes.
Melanoma
Expression of Antimicrobial Peptides by Uveal and Cutaneous Melanoma Cells and Investigation of Their Role in Tumor Cell Migration and Vasculogenic Mimicry.
Melanoma
Pisum sativum Defensin 1 Eradicates Mouse Metastatic Lung Nodules from B16F10 Melanoma Cells.
Melanoma
Prevalent Homozygous Deletions of Type I Interferon and Defensin Genes in Human Cancers Associate with Immunotherapy Resistance.
Melanoma
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.
Meningitis
Levels of antimicrobial molecules defensin and lactoferrin are elevated in the cerebrospinal fluid of children with meningitis.
Meningitis
Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis.
Meningitis, Aseptic
Levels of antimicrobial molecules defensin and lactoferrin are elevated in the cerebrospinal fluid of children with meningitis.
Meningitis, Bacterial
Levels of antimicrobial molecules defensin and lactoferrin are elevated in the cerebrospinal fluid of children with meningitis.
Meningitis, Bacterial
Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis.
monodehydroascorbate reductase (nadh) deficiency
A marked decrease in defensin mRNA in the only case of congenital neutrophil-specific granule deficiency reported in Japan.
monodehydroascorbate reductase (nadh) deficiency
A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion.
monodehydroascorbate reductase (nadh) deficiency
Abnormal peroxidase-positive granules in "specific granule" deficiency.
monodehydroascorbate reductase (nadh) deficiency
Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease.
monodehydroascorbate reductase (nadh) deficiency
Crohn's disease: a defensin deficiency syndrome?
monodehydroascorbate reductase (nadh) deficiency
Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease.
monodehydroascorbate reductase (nadh) deficiency
Defensin-immunology in inflammatory bowel disease.
monodehydroascorbate reductase (nadh) deficiency
Defensins and inflammation: the role of defensins in inflammatory bowel disease.
monodehydroascorbate reductase (nadh) deficiency
Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion.
monodehydroascorbate reductase (nadh) deficiency
Host-microbe interaction: mechanisms of defensin deficiency in Crohn's disease.
monodehydroascorbate reductase (nadh) deficiency
Innate immune defenses in the intestinal tract.
monodehydroascorbate reductase (nadh) deficiency
NOD2 and defensins: translating innate to adaptive immunity in Crohn's disease.
monodehydroascorbate reductase (nadh) deficiency
Paneth cell defensins and the regulation of the microbiome: Détente at mucosal surfaces.
monodehydroascorbate reductase (nadh) deficiency
[The role of defensins in the pathogenesis of chronic-inflammatory bowel disease]
Mycoses
Anti-leishmanial activity of Brevinin 2R and its Lauric acid conjugate type against L. major: In vitro mechanism of actions and in vivo treatment potentials.
Mycoses
Enhanced resistance to Sclerotinia sclerotiorum in Brassica napus by co-expression of defensin and chimeric chitinase genes.
Mycoses
Evidence that the role of plant defensins in radish defense responses is independent of salicylic acid.
Mycoses
Extensive differences in antifungal immune response in two Drosophila species revealed by comparative transcriptome analysis.
Mycoses
Integrated transcriptomic and metabolomic analyses of a wax deficient citrus mutant exhibiting jasmonic acid-mediated defense against fungal pathogens.
Mycoses
Resistance to the Plant Defensin NaD1 Features Modifications to the Cell Wall and Osmo-Regulation Pathways of Yeast.
Mycoses
The limpet transcription factors of Triatoma infestans regulate the response to fungal infection and modulate the expression pattern of defensin genes.
Mycoses
Transgenic tobacco and peanut plants expressing a mustard defensin show resistance to fungal pathogens.
Nasal Polyps
Expression of antiviral molecular genes in nasal polyp-derived cultured epithelial cells.
Neonatal Sepsis
Pathological Role and Diagnostic Value of Endogenous Host Defense Peptides in Adult and Neonatal Sepsis: A Systematic Review.
Neoplasms
Aster glehni Extract Containing Caffeoylquinic Compounds Protects Human Keratinocytes through the TRPV4-PPAR?-AMPK Pathway.
Neoplasms
cDNA microarray analysis of differential gene expression in gastric cancer cells sensitive and resistant to 5-Fluorouracil and Cisplatin.
Neoplasms
Comparison of IL-1?, TNF-?, hBD-2, and hBD-3 Expression in the Dental Pulp of Smokers Versus Nonsmokers.
Neoplasms
Construction and characterization of a recombinant human beta defensin 2 fusion protein targeting the epidermal growth factor receptor: in vitro study.
Neoplasms
Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients.
Neoplasms
Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells.
Neoplasms
Differential innate immune responses of a living skin equivalent model colonized by Staphylococcus epidermidis or Staphylococcus aureus.
Neoplasms
Distinct temporal patterns of defensin mRNA regulation during drug-induced differentiation of human myeloid leukemia cells.
Neoplasms
Effects of antimicrobial peptides derived from the beetle Allomyrina dichotoma defensin on mouse peritoneal macrophages stimulated with lipopolysaccharide.
Neoplasms
Expression of Antimicrobial Peptides by Uveal and Cutaneous Melanoma Cells and Investigation of Their Role in Tumor Cell Migration and Vasculogenic Mimicry.
Neoplasms
Expression of defensin antimicrobial peptides in the peritoneal cavity of patients on peritoneal dialysis.
Neoplasms
Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Neoplasms
High-resolution mapping of the 8p23.1 beta-defensin cluster reveals strictly concordant copy number variation of all genes.
Neoplasms
Human ?-defensin 3 contains an oncolytic motif that binds PI(4,5)P2 to mediate tumour cell permeabilisation.
Neoplasms
Identification of defensin alpha6 as a potential biomarker in colon adenocarcinoma.
Neoplasms
Impact of Herpes Simplex Virus Type 2 and Human Immunodeficiency Virus Dual Infection on Female Genital Tract Mucosal Immunity and the Vaginal Microbiome.
Neoplasms
Local antimicrobial, protease and cytokine defense systems in psoriatic skin.
Neoplasms
Mass Spectrometry Imaging Reveals Neutrophil Defensins as Additional Biomarkers for Anti-PD-(L)1 Immunotherapy Response in NSCLC Patients.
Neoplasms
Modulation of the activity of certain genes involved in tumor cell metabolism in the presence of the cytotoxic peptides defensin and cathelicidin LL37.
Neoplasms
Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion.
Neoplasms
Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumour cell killing and an enhanced antifungal variant.
Neoplasms
Oncogenic relevant defensins: expression pattern and proliferation characteristics of human tumor cell lines.
Neoplasms
Presence of defensin in epithelial Langerhans cells adjacent to oral carcinomas and precancerous lesions.
Neoplasms
Prevalent Homozygous Deletions of Type I Interferon and Defensin Genes in Human Cancers Associate with Immunotherapy Resistance.
Neoplasms
Protease-activated receptor-2 mediates the expression of inflammatory cytokines, antimicrobial peptides, and matrix metalloproteinases in keratinocytes in response to Propionibacterium acnes.
Neoplasms
Protective effects of antimicrobial peptides derived from the beetle Allomyrina dichotoma defensin on endotoxic shock in mice.
Neoplasms
Regulatory effect of 17?-estradiol on the expression of ?-defensin-2 and proinflammatory cytokines in human oral epithelial cells.
Neoplasms
Stressors Due to Handling Impair Gut Immunity in Meagre (Argyrosomus regius): The Compensatory Role of Dietary L-Tryptophan.
Neoplasms
Structural and functional characterization of the membrane-permeabilizing activity of Nicotiana occidentalis defensin NoD173 and protein engineering to enhance oncolysis.
Neoplasms
Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial.
Neoplasms
The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila.
Neoplasms
The defensin from avocado (Persea americana var. drymifolia) PaDef induces apoptosis in the human breast cancer cell line MCF-7.
Neoplasms
The plant defensin NaD1 induces tumor cell death via a non-apoptotic, membranolytic process.
Neoplasms
The Tomato Defensin TPP3 Binds Phosphatidylinositol (4,5)-Bisphosphate via a Conserved Dimeric Cationic Grip Conformation To Mediate Cell Lysis.
Neoplasms
[Effects of human defensin HNP-1 on the production of tumor necrosis factor-alpha by human blood monocytes in vitro]
Neoplasms
[The antiangiogenic effect of DNA vaccine based on beta-defensin 2 fused with VE-cadherin]
Obstetric Labor, Premature
Amniotic fluid defensins: potential markers of subclinical intrauterine infection.
Obstetric Labor, Premature
Human ?-defensin-3 participates in intra-amniotic host defense in women with labor at term, spontaneous preterm labor and intact membranes, and preterm prelabor rupture of membranes.
Onchocerciasis
Human autoantibody to defensin: disease association with hyperreactive onchocerciasis (sowda).
Onychomycosis
Morphopathological aspects of healthy nails and nails affected by onychomycosis.
Onychomycosis
Triintsin, a human pathogenic fungus-derived defensin with broad-spectrum antimicrobial activity.
Opportunistic Infections
Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: high-throughput SNP assays and association with Candida carriage in type I diabetics and nondiabetic controls.
Otitis Media
Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children.
Pancreatitis, Chronic
Association studies of the copy-number variable ß-defensin cluster on 8p23.1 in adenocarcinoma and chronic pancreatitis.
Paralysis
Screening and Validation of Reference Genes for RT-qPCR Under Different Honey Bee Viral Infections and dsRNA Treatment.
Paramyxoviridae Infections
Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs.
Parasitic Diseases
Characterization of a defensin from the sand fly Phlebotomus duboscqi induced by challenge with bacteria or the protozoan parasite Leishmania major.
Peri-Implantitis
Levels and molecular forms of MMP-7 (matrilysin-1) and MMP-8 (collagenase-2) in diseased human peri-implant sulcular fluid.
Periapical Periodontitis
Association between genetic polymorphisms in the promoter region of the defensin beta 1 gene and persistent apical periodontitis.
Periodontal Diseases
Histone Methylation: Achilles Heel and Powerful Mediator of Periodontal Homeostasis.
Periodontal Diseases
Human beta defensin-1 and -2 expression in the gingiva of patients with specific periodontal diseases.
Periodontal Diseases
Reduced human beta defensin 3 in individuals with periodontal disease.
Periodontal Diseases
The Human Salivary Antimicrobial Peptide Profile according to the Oral Microbiota in Health, Periodontitis and Smoking.
Periodontitis
Two Cheers for Crohn's Disease and Periodontitis: Beta-Defensin-2 as an Actionable Target to Intervene on Two Clinically Distinct Diseases.
Peritonitis
Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation.
Persistent Infection
What is the Clinical Utility of Synovial Alpha Defensin Testing of Antibiotic Spacers Before Reimplantation?
Pituitary Neoplasms
Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines.
Plant Diseases
TaMDHAR4, a monodehydroascorbate reductase gene participates in the interactions between wheat and Puccinia striiformis f. sp. tritici.
Plant Diseases
The proteins of plant defensin family and their application beyond plant disease control.
Plant Diseases
[Biological characteristics of defensin and its disease-resistance genetic engineering].
Pneumonia
Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs.
Polyomavirus Infections
The human alpha defensin HD5 neutralizes JC polyomavirus infection by reducing endoplasmic reticulum traffic and stabilizing the viral capsid.
Pouchitis
Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli.
Pouchitis
Innate immune environment in ileal pouch mucosa: ?5 defensin up-regulation as predictor of chronic/relapsing pouchitis.
Prostatic Neoplasms
Genetic variants of the copy number polymorphic beta-defensin locus are associated with sporadic prostate cancer.
Prostatic Neoplasms
Whole blood defensin mRNA expression is a predictive biomarker of docetaxel response in castration-resistant prostate cancer.
Pruritus
Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors.
Pseudomonas Infections
Blocking of Plasmodium transmission by cooperative action of Cecropin A and Defensin A in transgenic Aedes aegypti mosquitoes.
Psoriasis
Alteration of tissue expression of human beta defensin-1 and human beta defensin-2 in psoriasis vulgaris following phototherapy.
Psoriasis
Antimicrobial peptide defensin: identification of novel isoforms and the characterization of their physiological roles and their significance in the pathogenesis of diseases.
Psoriasis
Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin.
Psoriasis
Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes.
Psoriasis
Defensin-barbed innate immunity: clinical associations in the pediatric population.
Psoriasis
Local antimicrobial, protease and cytokine defense systems in psoriatic skin.
Psoriasis
Resident T cells in resolved psoriasis steer tissue responses that stratify clinical outcome.
Pulmonary Disease, Chronic Obstructive
Antimicrobial peptide defensin: identification of novel isoforms and the characterization of their physiological roles and their significance in the pathogenesis of diseases.
Pulmonary Disease, Chronic Obstructive
Ciliary beating is depressed in nasal cilia from chronic obstructive pulmonary disease subjects.
Pulmonary Disease, Chronic Obstructive
Genetic linkage and association analysis of COPD-related traits on chromosome 8p.
Pulmonary Disease, Chronic Obstructive
Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells.
Pulmonary Disease, Chronic Obstructive
Increased Expression of Beta-Defensin 1 (DEFB1) in Chronic Obstructive Pulmonary Disease.
Pulmonary Eosinophilia
Elevated levels of antimicrobial peptides in bronchoalveolar lavage fluid in patients with chronic eosinophilic pneumonia.
Respiratory Distress Syndrome
Diesel exhaust particles increase IL-1beta-induced human beta-defensin expression via NF-kappaB-mediated pathway in human lung epithelial cells.
Respiratory Distress Syndrome
Evaluation of alpha defensin, IL-1 receptor antagonist, and IL-18 levels in COVID-19 patients with macrophage activation syndrome and acute respiratory distress syndrome.
Respiratory Distress Syndrome
[Defensin in plasma and in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome]
Respiratory Tract Infections
Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study.
Salivary Gland Calculi
Proteomic and scanning electron microscopic analysis of submandibular sialoliths.
Salmonella Infections
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin.
Salmonella Infections
Salmonella serovar specific upregulation of porcine defensins 1 and 2 in a jejunal epithelial cell line.
Sepsis
A Novel Peptide Antibiotic, Pro10-1D, Designed from Insect Defensin Shows Antibacterial and Anti-Inflammatory Activities in Sepsis Models.
Sepsis
Antimicrobial peptide defensin: identification of novel isoforms and the characterization of their physiological roles and their significance in the pathogenesis of diseases.
Sepsis
Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis.
Sepsis
Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein.
Sepsis
Pathological Role and Diagnostic Value of Endogenous Host Defense Peptides in Adult and Neonatal Sepsis: A Systematic Review.
Sepsis
Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis.
Sepsis
The signature of long-standing balancing selection at the human defensin beta-1 promoter.
Sexually Transmitted Diseases
Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions.
Sexually Transmitted Diseases
Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission.
Staphylococcal Infections
[Effect of human beta defensin 2 on Staphylococcus aureus infection: in vivo study with transgenic mice]
Sunburn
Photoprotection mechanism in the 'Fuji' apple peel at different levels of photooxidative sunburn.
Sunburn
Photoprotection mechanism in the Fuji apple peel at different levels of photooxidative sunburn
Superinfection
IL-33 Modulates the Expression of Human Beta Defensin 2 in Human Primary Keratinocytes and may influence the susceptibility to bacterial superinfection in acute atopic dermatitis.
Tick-Borne Diseases
[Changes of functional activity of peripheral blood leukocytes during the immunotherapy of tick-borne infections in children].
Tinea Capitis
Trichophyton tonsurans-induced kerion celsi with decreased defensin expression and paradoxically increased interleukin-17A production.
Tonsillitis
A newly discovered function of palatine tonsils in immune defence: the expression of defensins.
Tonsillitis
Chronic tonsillitis is not associated with beta defensin 1 gene polymorphisms in Turkish population.
Trichomonas Infections
Host immune consequences of asymptomatic Trichomonas vaginalis infection in pregnancy.
Tuberculosis
Expressions of Antimicrobial Peptides LL-37, Human Beta Defensin-2 and -3 in the Lesions of Cutaneous Tuberculosis and Tuberculids.
Tuberculosis
Hypoxia triggers the expression of human ? defensin 2 and antimicrobial activity against Mycobacterium tuberculosis in human macrophages.
Tuberculosis, Pulmonary
Expression of Beta defensin 2 in experimental pulmonary tuberculosis: tentative approach for vaccine development.
Tuberculosis, Pulmonary
[Association between human beta defensin-1 single nucleotide polymorphisms and susceptibility to pulmonary tuberculosis].
Urethritis
Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions.
Urinary Bladder Neoplasms
Development of a novel proteomic approach for the detection of transitional cell carcinoma of the bladder in urine.
Urinary Tract Infections
A Murine Model of Inflammatory Bladder Disease: Cathelicidin Peptide Induced Bladder Inflammation and Treatment With Sulfated Polysaccharides.
Uterine Cervical Neoplasms
Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer.
Uterine Cervicitis
[Study on vaginal production of human defensins and the correlated pathogenetic factors of vulvovaginal candidiasis]
Uterine Hemorrhage
Bacterial vaginosis, vaginal fluid neutrophil defensins, and preterm birth.
Uveitis
Immunohistochemical localization of T lymphocytes and macrophages and expression of interferon gamma and defensin in uveitis.
Vaginal Discharge
[Study on vaginal production of human defensins and the correlated pathogenetic factors of vulvovaginal candidiasis]
Vaginitis
Evaluation of the Antimicrobial Activity of an Extract of Lactobacillus casei-Infected Hermetia illucens Larvae Produced Using an Automatic Injection System.
Vaginosis, Bacterial
Atopobium vaginae triggers an innate immune response in an in vitro model of bacterial vaginosis.
Vaginosis, Bacterial
Bacterial Colonization and Beta Defensins in the Female Genital Tract in HIV Infection.
Vaginosis, Bacterial
Human defensins and cytokines in vaginal lavage fluid of women with bacterial vaginosis.
Vaginosis, Bacterial
Midpregnancy vaginal fluid defensins, bacterial vaginosis, and risk of preterm delivery.
Virus Diseases
Antisense expression of a omega-3 fatty acid desaturase gene in tobacco plants enhances susceptibility against pathogens.
Virus Diseases
Characterization of an endogenous gene expressed in Aedes aegypti using an orally infectious recombinant Sindbis virus.
Virus Diseases
DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy.
Virus Diseases
Mosquito defensin facilitates Japanese encephalitis virus infection by downregulating the C6/36 cell-surface antiviral protein HSC70B.
Virus Diseases
One-step RT-qPCR assay for ZIKV RNA detection in Aedes aegypti samples: a protocol to study infection and gene expression during ZIKV infection.
Virus Diseases
Screening and Validation of Reference Genes for RT-qPCR Under Different Honey Bee Viral Infections and dsRNA Treatment.
Virus Diseases
Structural Diversity and Highly Specific Host-Pathogen Transcriptional Regulation of Defensin Genes Is Revealed in Tomato.
Vitamin A Deficiency
Bacterial population and innate immunity-related genes in rat gastrointestinal tract are altered by vitamin A-deficient diet.
Vitiligo
DEFB1 gene polymorphisms modify vitiligo extent and response to NB-UVB phototherapy.
Whooping Cough
The host defense peptide beta-defensin 1 confers protection against Bordetella pertussis in newborn piglets.
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