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Disease on EC 1.6.2.2 - cytochrome-b5 reductase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Habitual
Recessive congenital methemoglobinemia due to NADH-cytochrome b5 reductase deficiency associated with recurrent early pregnancy loss (REPL) in an Indian family.
Brain Diseases
Alteration of NADH-diaphorase and cytochrome b5 reductase activities of erythrocytes, platelets, and leucocytes in hereditary methaemoglobinaemia with and without mental retardation.
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Breast Neoplasms
DT-diaphorase and cytochrome B5 reductase in human lung and breast tumours.
Microsomal reductase activity in patients with thyroid neoplasms.
NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer.
Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women.
Carcinogenesis
Monooxygenase system in Guerin’s carcinoma of rats under conditions of ?-3 polyunsaturated fatty acids administration.
[Functional activity of NADH-dependent reductase system in the liver microsomal fraction and Guerin's carcinoma in rats exposed to preliminary irradiation].
Carcinoma
Monooxygenase system in Guerin’s carcinoma of rats under conditions of ?-3 polyunsaturated fatty acids administration.
[Functional activity of NADH-dependent reductase system in the liver microsomal fraction and Guerin's carcinoma in rats exposed to preliminary irradiation].
Cholestasis, Intrahepatic
Selective reduction of hepatic cytochrome P450 content in patients with intrahepatic cholestasis. A mechanism for impairment of microsomal drug oxidation.
Colonic Neoplasms
Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women.
Colorectal Neoplasms
Intratumoral Heterogeneity for Inactivating Frameshift Mutation of CYB5R2 Gene in Colorectal Cancers.
cytochrome-b5 reductase deficiency
A 5-hour-old male neonate with cyanosis.
A case of methemoglobinemia type II due to NADH-cytochrome b5 reductase deficiency: determination of the molecular basis.
A Thai boy with hereditary enzymopenic methemoglobinemia type II.
Alteration of NADH-diaphorase and cytochrome b5 reductase activities of erythrocytes, platelets, and leucocytes in hereditary methaemoglobinaemia with and without mental retardation.
Analysis of mutant NADH-cytochrome b5 reductase: apparent "type III" methemoglobinemia can be explained as type I with an unstable reductase.
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in cats.
Clinical, metabolic, and molecular genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in 30 dogs.
Congenital cyanosis due to methemoglobin reductase deficiency: first reported Tunisian case.
Congenital methemoglobin-reductase (cytochrome b5 reductase) deficiency associated with mental retardation in a Spanish girl.
Congenital methemoglobinemia due to methemoglobin reductase deficiency in two unrelated American black families.
Congenital Methemoglobinemia Identified by Pulse Oximetry Screening.
Congenital methemoglobinemia methemoglobin reductase deficiency.
Congenital Recessive Methemoglobinemia Revealed in Adulthood: Description of a New Mutation in Cytochrome b5 Reductase Gene.
Cytochrome B5 reductase deficiency and mental retardation.
Cytochrome b5 reductase deficiency, an uncommon cause of cyanosis.
Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency.
Deficient cytochrome b5 reductase activity in nontoxic goiter with iodide organification defect.
Enzymopenic hereditary methemoglobinemia: a clinical/biochemical classification.
Erratum for Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in cats.
Evaluation of the methemoglobinemia associated with sulofenur.
Hb Chile [beta28(B10)Leu-->Met]: an unstable hemoglobin associated with chronic methemoglobinemia and sulfonamide or methylene blue-induced hemolytic anemia.
Hereditary methemoglobinemia due to cytochrome b5 reductase deficiency in blood cells without associated neurologic and mental disorders.
Long-term Treatment with Methylene Blue in a Dog with Hereditary Methemoglobinemia Caused by Cytochrome b5 Reductase Deficiency.
Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice.
Membrane-Bound CYB5R3 Is a Common Effector of Nutritional and Oxidative Stress Response Through FOXO3a and Nrf2.
Methemoglobin reductase deficiency in a cat.
Methemoglobin reductase deficiency in a dog.
Methemoglobin reductase deficiency: novel mutation is associated with a disease phenotype of intermediate severity.
Methemoglobinemia as a complication of 20% benzocaine spray for endoscopy.
Methemoglobinemia: Living with Dormant Devil.
Molecular basis of two novel mutations found in type I methemoglobinemia.
Mutation update: Variants of the CYB5R3 gene in recessive congenital methemoglobinemia.
NADH cytochrome b5 reductase activity in lymphoid cell lines. Expression of the defect in epstein Barr virus transformed lymphoblastoid cell lines from patients with recessive congenital methemoglobinemia.
NCB5OR Deficiency in the Cerebellum and Midbrain Leads to Dehydration and Alterations in Thirst Response, Fasted Feeding Behavior, and Voluntary Exercise in Mice.
Ncb5or deficiency increases Fatty Acid catabolism and oxidative stress.
New variant of cytochrome b5 reductase deficiency (b5RKurashiki) in red cells, platelets, lymphocytes, and cultured fibroblasts with congenital methemoglobinemia, mental and neurological retardation, and skeletal anomalies.
Novel mutation (R192C) in CYB5R3 gene causing NADH-cytochrome b5 reductase deficiency in eight Indian patients associated with autosomal recessive congenital methemoglobinemia type-I.
Prenatal diagnosis of congenital enzymopenic methaemoglobinaemia with mental retardation due to generalized cytochrome b5 reductase deficiency: first report of two cases.
Quantitative variations of red-cell cytochrome b5 reductase (NADH-methemoglobin-reductase) in the Algerian population: evidence for defective alleles.
Recessive congenital methemoglobinemia due to NADH-cytochrome b5 reductase deficiency associated with recurrent early pregnancy loss (REPL) in an Indian family.
Recessive congenital methemoglobinemia type II: Hypoplastic basal ganglia in two siblings with a novel mutation of the cytochrome b5 reductase gene.
Recessive hereditary methemoglobinemia: two novel mutations in the NADH-cytochrome b5 reductase gene.
Red cell enzymes.
Smooth muscle cell CYB5R3 preserves cardiac and vascular function under chronic hypoxic stress.
Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice.
The Acute Treatment of Methemoglobinemia in Pregnancy.
The laboratory use of butylnitrite for the production of methemoglobin.
Transient Neonatal Cyanosis Associated With a New Hb F Variant: Hb F Viseu.
[A NEW CASE OF RECESSIVE CONGENITAL METHEMOGLOBINEMIA LINKED WITH A DIAPHORASE I DEFICIENCY.]
[Clinical and biological forms of cytochrome b5 reductase deficiency]
[Congenital methemoglobinemia due to NADH (DPNH) dependent methemoglobin reductase deficiency]
[Erythrocyte metabolism in congenital methemoglobin reductase deficiency]
[Establishment of a cellular model with human NADH-cytochrome b5 reductase deficiency via RNA interference]
[Gene analysis and genetic diagnosis of hereditary erythrocyte abnormalities. Cytochrome b5 reductase deficiency]
[Genetic injuries in 2 families with congenital methemoglobinemia caused by diaphorase I deficiency]
[Genetics and biochemistry of NADH-cytochrome b5 reductase deficiency]
[Hereditary methemoglobinemia caused by NADH methemoglobin reductase deficiency]
[On the mechanism of ascorbic acid induced methemoglobin reduction of human erythrocytes (author's transl)]
[Prenatal diagnosis of generalized cytochrome b5 reductase deficiency (congenital methemoglobinemia with mental retardation, type II) (author's transl)]
Dehydration
NCB5OR Deficiency in the Cerebellum and Midbrain Leads to Dehydration and Alterations in Thirst Response, Fasted Feeding Behavior, and Voluntary Exercise in Mice.
Diabetes Mellitus, Type 2
Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus.
Diabetes, Gestational
Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus.
Down Syndrome
Oxidative stress in Portuguese children with Down syndrome.
Drug Hypersensitivity
Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity.
Dyskinesias
Alteration of NADH-diaphorase and cytochrome b5 reductase activities of erythrocytes, platelets, and leucocytes in hereditary methaemoglobinaemia with and without mental retardation.
Dystonia
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Exanthema
Evaluation of sulfonamide detoxification pathways in haematologic malignancy patients prior to intermittent trimethoprim-sulfamethoxazole prophylaxis.
Genetic Diseases, Inborn
Amino acid sequence of NADH-cytochrome b5 reductase of human erythrocytes.
[Molecular analysis of the structure of the mutant NADH-cytochrome b5 reductase gene causing methemoglobinemia]
Glioblastoma
Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells.
Glucose Intolerance
Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with ?-cell failure.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Molecular Characterization of Glucose-6-Phosphate Dehydrogenase: Do Single Nucleotide Polymorphisms Affect Hematological Parameters in HIV-Positive Patients?
The laboratory use of butylnitrite for the production of methemoglobin.
Glucosephosphate Dehydrogenase Deficiency
Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue treatment.
Molecular Characterization of Glucose-6-Phosphate Dehydrogenase: Do Single Nucleotide Polymorphisms Affect Hematological Parameters in HIV-Positive Patients?
The laboratory use of butylnitrite for the production of methemoglobin.
Goiter
Deficient cytochrome b5 reductase activity in nontoxic goiter with iodide organification defect.
Microsomal reductase activity in patients with thyroid neoplasms.
Goiter, Nodular
Microsomal reductase activity in patients with thyroid neoplasms.
Granulomatous Disease, Chronic
Subcellular localization of the human neutrophil NADPH oxidase. b-Cytochrome and associated flavoprotein.
Hemoglobinopathies
Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency.
Herpes Zoster
Zonal distribution of cytochromes P-450 and related enzymes of bovine adrenal cortex--quantitative assay of concentrations and total contents.
Hyperglycemia
Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with ?-cell failure.
[Adaptation of rats following sodium-nitrite-induced methemoglobinemia]
Hypersensitivity
Cytochrome b5 and NADH cytochrome b5 reductase: genotype-phenotype correlations for hydroxylamine reduction.
Evaluation of Polymorphisms in the Sulfonamide Detoxification Genes CYB5A and CYB5R3 in Dogs with Sulfonamide Hypersensitivity.
Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity.
Hypertension
Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation.
Smooth muscle cell CYB5R3 preserves cardiac and vascular function under chronic hypoxic stress.
Hypertension, Pulmonary
Smooth muscle cell CYB5R3 preserves cardiac and vascular function under chronic hypoxic stress.
Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice.
Hyperthyroidism
Microsomal reductase activity in patients with thyroid neoplasms.
Infections
Changes in rodent-erythrocyte methemoglobin reductase system produced by two malaria parasites, viz. Plasmodium yoelii nigeriensis and Plasmodium berghei.
Effect of beta-arteether treatment on erythrocytic methemoglobin reductase system in Plasmodium yoelii nigeriensis infected mice.
Primaquine-induced severe methemoglobinemia developed during treatment of Plasmodium vivax malarial infection in an Indian family associated with a novel mutation (p.Agr57Trp) in the CYB5R3 gene.
Studies on erythrocytic methemoglobin reductase systems in Plasmodium yoelii nigeriensis infected mice.
Intellectual Disability
Adipose fatty acid composition in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation.
Alteration of NADH-diaphorase and cytochrome b5 reductase activities of erythrocytes, platelets, and leucocytes in hereditary methaemoglobinaemia with and without mental retardation.
Analysis of mutant NADH-cytochrome b5 reductase: apparent "type III" methemoglobinemia can be explained as type I with an unstable reductase.
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Cytochrome B5 reductase deficiency and mental retardation.
Decrease of palmitoyl-CoA elongation in platelets and leukocytes in the patient of hereditary methemoglobinemia associated with mental retardation.
Generalised deficiency of cytochrome b5 reductase in congenital methaemoglobinaemia with mental retardation.
Heterogeneity of the rat NADH-cytochrome-b5-reductase transcripts resulting from multiple alternative first exons.
Lipids of liver, kidney, spleen and muscle in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation.
Lipids of myelin, white matter and gray matter in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation.
Prenatal diagnosis of congenital enzymopenic methaemoglobinaemia with mental retardation due to generalized cytochrome b5 reductase deficiency: first report of two cases.
Severe mental retardation and recessive congenital methemoglobinemia in three Indian patients: compound heterozygous for NADH-cytochrome b5 reductase gene mutations.
Soluble and microsomal forms of NADH-cytochrome beta 5 reductase from human placenta. Similarity with NADH-methemoglobin reductase from human erythrocytes.
[An infant with hereditary methemoglobinemia]
[Prenatal diagnosis of generalized cytochrome b5 reductase deficiency (congenital methemoglobinemia with mental retardation, type II) (author's transl)]
Iron Deficiencies
Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice.
Kidney Failure, Chronic
[Effect of methylguanidine and guanidine succinic acid on methemoglobin reductase activity in human red cells]
Leishmaniasis
Changes in hepatic xenobiotic-metabolising enzymes in mouse liver following infection with Leishmania donovani.
Leukemia, Erythroblastic, Acute
Expression of NADH-cytochrome b5 reductase during dimethyl sulfoxide-induced differentiation of Friend erythroleukemia cells.
Lipid Metabolism Disorders
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Lymphatic Metastasis
Cytochrome b5 reductase 2 is a novel candidate tumor suppressor gene frequently inactivated by promoter hypermethylation in human nasopharyngeal carcinoma.
Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis.
Lymphoma
MicroRNA library screening identifies growth-suppressive microRNAs that regulate genes involved in cell cycle progression and apoptosis.
NADH cytochrome b5 reductase activity in lymphoid cell lines. Expression of the defect in epstein Barr virus transformed lymphoblastoid cell lines from patients with recessive congenital methemoglobinemia.
Lymphoma, B-Cell
MicroRNA library screening identifies growth-suppressive microRNAs that regulate genes involved in cell cycle progression and apoptosis.
Malaria
Changes in rodent-erythrocyte methemoglobin reductase system produced by two malaria parasites, viz. Plasmodium yoelii nigeriensis and Plasmodium berghei.
Metabolic Diseases
NADH cytochrome b5 reductase activity in lymphoid cell lines. Expression of the defect in epstein Barr virus transformed lymphoblastoid cell lines from patients with recessive congenital methemoglobinemia.
Methemoglobinemia
A case of methemoglobinemia type II due to NADH-cytochrome b5 reductase deficiency: determination of the molecular basis.
A compound heterozygote in the NADH-cytochrome b5 reductase gene from a Chinese patient with hereditary methemoglobinemia type I.
A linkage and physical map of chromosome 22, and some applications to gene mapping.
A microplate reader-based method to quantify NADH-cytochrome b5 reductase activity for diagnosis of recessive congenital methaemoglobinemia.
A novel G143D mutation in the NADH-cytochrome b5 reductase gene in an Indian patient with type I recessive hereditary methemoglobinemia.
A novel L218P mutation in NADH-cytochrome b5 reductase associated with type I recessive congenital methemoglobinemia.
A novel mutation found in the 3' domain of NADH-cytochrome B5 reductase in an African-American family with type I congenital methemoglobinemia.
A novel mutation in the NADH-cytochrome b5 reductase gene of a Chinese patient with recessive congenital methemoglobinemia.
A Novel Mutation in Type II Methemoglobinemia.
A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia.
A novel nine base deletion mutation in NADH-cytochrome b5 reductase gene in an Indian family with recessive congenital methemoglobinemia-type-II.
A novel point mutation in a 3' splice site of the NADH-cytochrome b5 reductase gene results in immunologically undetectable enzyme and impaired NADH-dependent ascorbate regeneration in cultured fibroblasts of a patient with type II hereditary methemoglobinemia.
A rare cause of mental motor retardation: recessive congenital methemoglobinemia type II.
A Thai boy with hereditary enzymopenic methemoglobinemia type II.
Acquired methemoglobinemia from multiple oxidants.
Adipose fatty acid composition in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation.
An in-frame deletion of codon 298 of the NADH-cytochrome b5 reductase gene results in hereditary methemoglobinemia type II (generalized type). A functional implication for the role of the COOH-terminal region of the enzyme.
Analysis of mutant NADH-cytochrome b5 reductase: apparent "type III" methemoglobinemia can be explained as type I with an unstable reductase.
Antibody-based spot test for NADH-cytochrome b5 reductase activity for the laboratory diagnosis of congenital methemoglobinemia.
Blue cures blue but be cautious.
Characterization of a novel nicotinamide adenine dinucleotide-cytochrome b5 reductase mutation associated with canine hereditary methemoglobinemia.
Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in cats.
Clinical, metabolic, and molecular genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in 30 dogs.
Concentration of NADH-cytochrome b5 reductase in erythrocytes of normal and methemoglobinemic individuals measured with a quantitative radioimmunoblotting assay.
Congenital erythrocyte enzyme deficiencies.
Congenital methemoglobinemia due to methemoglobin reductase deficiency in two unrelated American black families.
Congenital methemoglobinemia due to NADH-methemoglobin reductase deficiency in three Indian families.
Congenital Methemoglobinemia Identified by Pulse Oximetry Screening.
Congenital methemoglobinemia methemoglobin reductase deficiency.
Congenital methemoglobinemia misdiagnosed as polycythemia vera: Case report and review of literature.
Congenital methemoglobinemia: the result of age-dependent decay of methemoglobin reductase.
Congenital Recessive Methemoglobinemia Revealed in Adulthood: Description of a New Mutation in Cytochrome b5 Reductase Gene.
Cyanosis and congenital methemoglobinemia in a puppy.
Cytochrome b5 reductase: the roles of the recessive congenital methemoglobinemia mutants P144L, L148P, and R159*.
Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency.
Dapsone-induced methemoglobinemia: A dose-related occurrence?
Decrease of palmitoyl-CoA elongation in platelets and leukocytes in the patient of hereditary methemoglobinemia associated with mental retardation.
Delayed Diagnosis in Army Ranger Postdeployment Primaquine-Induced Methemoglobinemia.
Determination of concentration of cytosolic NADH-cytochrome b5 reductase in erythrocytes from normal Chinese adults, neonates and patients with hereditary methemoglobinemia by double-antibody sandwich ELISA.
Enzymatic instability of NADH-cytochrome b5 reductase as a cause of hereditary methemoglobinemia type I (red cell type).
Enzymopenic hereditary methemoglobinemia.
Erratum for Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in cats.
Establishment of monoclonal antibodies against human erythrocyte NADH-cytochrome b5 reductase.
Evaluation of the methemoglobinemia associated with sulofenur.
Exonic point mutations in NADH-cytochrome B5 reductase genes of homozygotes for hereditary methemoglobinemia, types I and III: putative mechanisms of tissue-dependent enzyme deficiency.
Expression of a novel P275L variant of NADH:cytochrome b5 reductase gives functional insight into the conserved motif important for pyridine nucleotide binding.
Familial Congenital Methemoglobinemia in Pomeranian Dogs Caused by a Missense Variant in the NADH-Cytochrome B5 Reductase Gene.
Familial idiopathic methemoglobinemia revisited: original cases reveal 2 novel mutations in NADH-cytochrome b5 reductase.
Four new mutations in the NADH-cytochrome b5 reductase gene from patients with recessive congenital methemoglobinemia type II.
Hb Chile [beta28(B10)Leu-->Met]: an unstable hemoglobin associated with chronic methemoglobinemia and sulfonamide or methylene blue-induced hemolytic anemia.
Hereditary methemoglobinemia due to cytochrome b5 reductase deficiency in blood cells without associated neurologic and mental disorders.
Heterogeneity of the rat NADH-cytochrome-b5-reductase transcripts resulting from multiple alternative first exons.
Heterologous expression of enzymopenic methemoglobinemia variants using a novel NADH:cytochrome c reductase fusion protein.
Human cytochrome b5 reductase: structure, function, and potential applications.
Lipids of liver, kidney, spleen and muscle in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation.
Lipids of myelin, white matter and gray matter in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation.
Long-term Treatment with Methylene Blue in a Dog with Hereditary Methemoglobinemia Caused by Cytochrome b5 Reductase Deficiency.
Methemoglobin reductase (cytochrome b5 reductase) deficiency in congenital methemoglobinemia.
Methemoglobin reductase activity and in vitro sensitivity towards oxidant induced methemoglobinemia in swiss mice and beagle dogs erythrocytes.
Methemoglobinemia and eccentrocytosis in equine erythrocyte flavin adenine dinucleotide deficiency.
Methemoglobinemia as a complication of 20% benzocaine spray for endoscopy.
Methemoglobinemia in a young man.
Methemoglobinemia in bronchoscopy: a case series and a review of the literature.
Methemoglobinemia in children with acute lymphoblastic leukemia (ALL) receiving dapsone for pneumocystis carinii pneumonia (PCP) prophylaxis: a correlation with cytochrome b5 reductase (Cb5R) enzyme levels.
Metoclopramide-induced methemoglobinemia in a patient with co-existing deficiency of glucose-6-phosphate dehydrogenase and NADH-cytochrome b5 reductase: failure of methylene blue treatment.
Metoclopramide-induced methemoglobinemia in an adult.
Molecular basis of recessive congenital methemoglobinemia, types I and II: Exon skipping and three novel missense mutations in the NADH-cytochrome b5 reductase (diaphorase 1) gene.
Molecular basis of two novel mutations found in type I methemoglobinemia.
Mutation update: Variants of the CYB5R3 gene in recessive congenital methemoglobinemia.
NADH cytochrome b5 reductase activity in lymphoid cell lines. Expression of the defect in epstein Barr virus transformed lymphoblastoid cell lines from patients with recessive congenital methemoglobinemia.
NADH-cytochrome b5 reductase in platelets and leukocytes with special reference to normal levels and to levels in carriers of hereditary methemoglobinemia with or without neurological symptoms.
New variant of cytochrome b5 reductase deficiency (b5RKurashiki) in red cells, platelets, lymphocytes, and cultured fibroblasts with congenital methemoglobinemia, mental and neurological retardation, and skeletal anomalies.
Novel mutation (R192C) in CYB5R3 gene causing NADH-cytochrome b5 reductase deficiency in eight Indian patients associated with autosomal recessive congenital methemoglobinemia type-I.
Pathogenesis, laboratory diagnosis, and clinical implications of erythrocyte enzyme deficiencies in dogs, cats, and horses.
Pharmacokinetics of sodium nitrite-induced methemoglobinemia in the rat.
Primaquine-induced severe methemoglobinemia developed during treatment of Plasmodium vivax malarial infection in an Indian family associated with a novel mutation (p.Agr57Trp) in the CYB5R3 gene.
Profiling the erythrocyte membrane proteome isolated from patients diagnosed with chronic obstructive pulmonary disease.
Quantitative variations of red-cell cytochrome b5 reductase (NADH-methemoglobin-reductase) in the Algerian population: evidence for defective alleles.
Recessive congenital methemoglobinemia caused by a rare mechanism: maternal uniparental heterodisomy with segmental isodisomy of a chromosome 22.
Recessive congenital methemoglobinemia due to NADH-cytochrome b5 reductase deficiency associated with recurrent early pregnancy loss (REPL) in an Indian family.
Recessive congenital methemoglobinemia type II: Hypoplastic basal ganglia in two siblings with a novel mutation of the cytochrome b5 reductase gene.
Recessive hereditary methemoglobinemia: two novel mutations in the NADH-cytochrome b5 reductase gene.
Reexamining the risks of drinking-water nitrates on public health.
Serine-proline replacement at residue 127 of NADH-cytochrome b5 reductase causes hereditary methemoglobinemia, generalized type.
Severe mental retardation and recessive congenital methemoglobinemia in three Indian patients: compound heterozygous for NADH-cytochrome b5 reductase gene mutations.
Severe Methemoglobinemia Secondary to Ferula asafoetida Ingestion in an Infant: A Case Report.
Soluble and microsomal forms of NADH-cytochrome beta 5 reductase from human placenta. Similarity with NADH-methemoglobin reductase from human erythrocytes.
Structural analysis of NADH-cytochrome b5 reductase in relation to hereditary methemoglobinemia.
The Acute Treatment of Methemoglobinemia in Pregnancy.
The structure of the S127P mutant of cytochrome b5 reductase that causes methemoglobinemia shows the AMP moiety of the flavin occupying the substrate binding site.
Two novel mutations in the reduced nicotinamide adenine dinucleotide (NADH)-cytochrome b5 reductase gene of a patient with generalized type, hereditary methemoglobinemia.
Unstable variant of NADH methemoglobin reductase in Puerto Ricans with hereditary methemoglobinemia.
[A NEW CASE OF RECESSIVE CONGENITAL METHEMOGLOBINEMIA LINKED WITH A DIAPHORASE I DEFICIENCY.]
[A search for mutations in the DIA1 gene in case of hereditary methemoglobinemia type I in the iakut population]
[Adaptation of rats following sodium-nitrite-induced methemoglobinemia]
[An infant with hereditary methemoglobinemia]
[Arginine-glutamine replacement at residue 57 of NADH-cytochrome b5 reductase in Chinese hereditary methemoglobinemia]
[Clinical and biological forms of cytochrome b5 reductase deficiency]
[Congenital deficiency of NADH dependent methemoglobin reductase in erythrocytes of two children with methemoglobinemia]
[Congenital methemoglobinemia caused by the absence of NADH-dependent methemoglobin reductase in the red blood cells]
[Congenital methemoglobinemia due to NADH (DPNH) dependent methemoglobin reductase deficiency]
[Congenital methemoglobinemia with central nervous system damage caused by generalized deficiency of NADH-dependent methemoglobin reductase in a 2-year-old Polish girl]
[Congenital methemoglobinemia with cytochrome-b5-reductase deficiency: 4th Swiss family]
[Cyanosis in children caused by inherited methemoglobinemia due to deficiency of NADH-dependent methemoglobin reductase in erythrocytes]
[Familial case of methemoglobinemia associated with glucose-4-phosphate dehydrogenase deficiency]
[Genetic injuries in 2 families with congenital methemoglobinemia caused by diaphorase I deficiency]
[Hereditary methemoglobinemia caused by NADH methemoglobin reductase deficiency]
[Hereditary methemoglobinemias]
[Leu 72 Pro mutation in the NADH-cytochrome b5 reductase gene found in a Chinese hereditary methemoglobinemia patient]
[Methemoglobinemia in an infant due to the transient deficiency of NADH-dependent methemoglobin reductase in erythrocytes]
[Molecular analysis of the structure of the mutant NADH-cytochrome b5 reductase gene causing methemoglobinemia]
[Novel large deletion c.22-1320_633+1224del in the CYB5R3 gene from patients with hereditary methemoglobinemia].
[Population frequency and age of c.806C > T mutation in CYB5R3 gene as cause of recessive congenital methemoglobinemia in Yakutia].
[Prenatal diagnosis of generalized cytochrome b5 reductase deficiency (congenital methemoglobinemia with mental retardation, type II) (author's transl)]
[Studies on congenital methemoglobinemia due to a dificiency of methemoglobin reductase in the red blood cells]
Microcephaly
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Movement Disorders
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Nasopharyngeal Carcinoma
Cytochrome b5 reductase 2 is a novel candidate tumor suppressor gene frequently inactivated by promoter hypermethylation in human nasopharyngeal carcinoma.
Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis.
Neoplasm Metastasis
Cytochrome b5 reductase 2 is a novel candidate tumor suppressor gene frequently inactivated by promoter hypermethylation in human nasopharyngeal carcinoma.
Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis.
Microsomal reductase activity in patients with thyroid neoplasms.
NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer.
Neoplasms
Capsaicin alleviates the imbalance in xenobiotic metabolizing enzymes and tumor markers during experimental lung tumorigenesis.
Cytochrome b5 reductase 2 is a novel candidate tumor suppressor gene frequently inactivated by promoter hypermethylation in human nasopharyngeal carcinoma.
Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis.
Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells.
Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors.
DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?
Enhancement of the antineoplastic effect of mitomycin C by dietary fat.
Evaluation of sulfonamide detoxification pathways in haematologic malignancy patients prior to intermittent trimethoprim-sulfamethoxazole prophylaxis.
Microsomal reductase activity in patients with thyroid neoplasms.
Monooxygenase system in Guerin’s carcinoma of rats under conditions of ?-3 polyunsaturated fatty acids administration.
NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer.
Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women.
Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) in tumor cells.
[Functional activity of NADH-dependent reductase system in the liver microsomal fraction and Guerin's carcinoma in rats exposed to preliminary irradiation].
Nervous System Diseases
Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II.
Membrane-Bound CYB5R3 Is a Common Effector of Nutritional and Oxidative Stress Response Through FOXO3a and Nrf2.
Neuroblastoma
Cytochrome b5 reductase, a plasma membrane redox enzyme, protects neuronal cells against metabolic and oxidative stress through maintaining redox state and bioenergetics.
Neurologic Manifestations
Hereditary methemoglobinemia due to cytochrome b5 reductase deficiency in blood cells without associated neurologic and mental disorders.
Ovarian Neoplasms
Genome-wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma.
Parasitemia
Effect of beta-arteether treatment on erythrocytic methemoglobin reductase system in Plasmodium yoelii nigeriensis infected mice.
Pneumonia
Methemoglobinemia in children with acute lymphoblastic leukemia (ALL) receiving dapsone for pneumocystis carinii pneumonia (PCP) prophylaxis: a correlation with cytochrome b5 reductase (Cb5R) enzyme levels.
Pneumonia, Pneumocystis
Methemoglobinemia in children with acute lymphoblastic leukemia (ALL) receiving dapsone for pneumocystis carinii pneumonia (PCP) prophylaxis: a correlation with cytochrome b5 reductase (Cb5R) enzyme levels.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Methemoglobinemia in children with acute lymphoblastic leukemia (ALL) receiving dapsone for pneumocystis carinii pneumonia (PCP) prophylaxis: a correlation with cytochrome b5 reductase (Cb5R) enzyme levels.
Protein Deficiency
Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice.
Pulmonary Disease, Chronic Obstructive
Profiling the erythrocyte membrane proteome isolated from patients diagnosed with chronic obstructive pulmonary disease.
Riboflavin Deficiency
Lipid metabolism in riboflavin-deficient rats. 2. Mitochondrial fatty acid oxidation and the microsomal desaturation pathway.
Sarcoma
Effect of extra-hepatic Walker sarcoma 256 on the synthesis and degradation of liver cytochromes P-450 and b5.
Spondylosis
New variant of cytochrome b5 reductase deficiency (b5RKurashiki) in red cells, platelets, lymphocytes, and cultured fibroblasts with congenital methemoglobinemia, mental and neurological retardation, and skeletal anomalies.
Starvation
NCB5OR Deficiency in the Cerebellum and Midbrain Leads to Dehydration and Alterations in Thirst Response, Fasted Feeding Behavior, and Voluntary Exercise in Mice.
Stomatitis
Epidemiological evaluation of recurrent stomatitis, nitrates in drinking water, and cytochrome b5 reductase activity.
Sulfhemoglobinemia
Evaluation of the methemoglobinemia associated with sulofenur.
Thyroid Cancer, Papillary
Microsomal reductase activity in patients with thyroid neoplasms.
Thyroid Neoplasms
Microsomal reductase activity in patients with thyroid neoplasms.
Tremor
Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice.