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The enzyme, found in many Gram negative bacteria, also slowly reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate (cf. EC 126.96.36.199, dihydrofolate reductase). The enzyme has no activity with NADH.
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The enzyme appears in viruses and cellular organisms
dihydromonapterin reductase, more
5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+
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