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Information on EC 1.5.1.46 - agroclavine dehydrogenase

for references in articles please use BRENDA:EC1.5.1.46
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IUBMB Comments
The enzyme participates in the biosynthesis of ergotamine, an ergot alkaloid produced by some fungi of the Clavicipitaceae family. The reaction is catalysed in the opposite direction to that shown. The substrate for the enzyme is an iminium intermediate that is formed spontaneously from chanoclavine-I aldehyde in the presence of glutathione.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
agroclavine synthase, EasG, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
agroclavine + NADP+ = 6,8-dimethyl-6,7,8,9-tetradehydroergoline + NADPH + H+
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