Any feedback?
Information on EC 1.5.1.34 - 6,7-dihydropteridine reductase
for references in articles please use BRENDA:EC1.5.1.34Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.5.1.34 6,7-dihydropteridine reductaseIUBMB Comments
The substrate is the quinonoid form of dihydropteridine. Not identical with EC 1.5.1.3 dihydrofolate reductase.
Specify your search results
Word Map
- 1.5.1.34
- tetrahydrobiopterin
- hydroxylase
- bh4
- hyperphenylalaninemia
-
neurotransmitter
- phenylketonuria
- biopterin
- pterins
- dopamine
-
quinonoid
- sepiapterin
-
1.6.99.7
-
cyclohydrolase
- 6-pyruvoyl-tetrahydropterin
- 5-hydroxytryptophan
- tetrahydropterin
- dihydrobiopterin
- l-dopa
- ptp
-
folinic
-
nadh-specific
-
homovanillic
-
pterin-4a-carbinolamine
-
guthrie
-
6-pyruvoyl
- dihydropterins
- gtpch
- medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
dihydropteridine reductase, quinoid dihydropteridine reductase, nadph-specific dihydropteridine reductase, bmdhpr, dicdhpr, 6,7-dihydropteridine reductase, npra nitroreductase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
DHPR
dihydropteridine reductase
dihydropteridine reductase (NADH)
-
-
-
-
EC 1.6.99.10
-
-
formerly
-
EC 1.6.99.7
NADH-dihydropteridine reductase
-
-
-
-
NADPH-dihydropteridine reductase
-
-
-
-
NADPH-specific dihydropteridine reductase
-
-
-
-
NprA nitroreductase
-
enzyme shows nitroreductase activity with a wide range of nitroaromatic compounds, but highest activity is detected with the quinonoid form of 6,7-dimethyl-7,8-dihydropterine as substrate, in vivo role as dihydropteridine reductase involved in aromatic amino acids metabolism suggested
quinoid dihydropteridine reductase
reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide)
-
-
-
-
additional information
DHPR
-
-
-
-
EC 1.6.99.7
-
-
formerly
-
additional information
-
NADPH-specific dihydropteridine reductase and NADH-dihydropteridine reductase have no common antigenic determinants, and show different physicochemical properties
additional information
-
NADPH-specific dihydropteridine reductase and NADH-dihydropteridine reductase have no common antigenic determinants, and show different physicochemical properties
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+
-
-
-
-
a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+
ordered bi-bi mechanism, binding of NADH first and dissociation of NAD+ last
-
a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+
structural and mechanistic characteristics
-
a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+
catalytic triad consists of Y182, K186, and D169
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase
The substrate is the quinonoid form of dihydropteridine. Not identical with EC 1.5.1.3 dihydrofolate reductase.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
70851-99-9
-
9074-11-7
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(6R,S)-6-hydroxy-methyltetrahydropterin + NAD(P)+
?
low activity
-
-
r
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
2-amino-4-hydroxy-6-methyl-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6-methyl-tetrahydropteridine + NAD(P)+
-
-
-
?
2-amino-4-hydroxy-7-methyl-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-7-methyl-tetrahydropteridine + NAD(P)+
-
-
-
?
5,6,7,8-tetrahydrobiopterin + NAD+
quinonoid dihydrobiopterin + NADH + H+
-
-
-
-
r
5,6,7,8-tetrahydropteridine + NAD(P)+
6,7-dihydropteridine + NAD(P)H
enzyme is required for recycling of 6,7-dihydropteridine, in vivo regulation is related to growth phase
-
-
r
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD+
6,7-dimethyl-7,8-dihydropterin + NADH + H+
-
-
-
-
r
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD+
quinonoid 6,7-dimethyl dihydropteridine + NADH + H+
-
-
-
-
r
6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+
6,7-dimethyl-7,8-dihydropterin + NADPH + H+
-
-
-
-
r
6,7-dimethyl-7,8-dihydropteridine + NADH + H+
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD+
-
NADH is preferred in vitro compared to NADPH
-
-
?
6,7-dimethyl-7,8-dihydropteridine + NADPH
(6R)-L-erythro-6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + NADP+
6,7-dimethyldihydropterin + NADH + H+
6,7-dimethyltetrahydropterin + NAD+
-
-
-
?
6-methyl-dihydropterin + NADH + H+
6-methyl-tetrahydropterin + NAD+
-
-
-
-
r
6-methyldihydropterin + NADH + H+
quinoid 6,6-dimethyldihydropterin + NAD+
-
-
-
-
r
a 6,7-dihydropteridine + NAD(P)H + H+
a 5,6,7,8-tetrahydropteridine + NAD(P)+
-
-
-
-
?
a 6,7-dihydropteridine + NADPH + H+
a 5,6,7,8-tetrahydropteridine + NADP+
-
-
-
-
?
dihydropteroylglutamic acid + NAD(P)H
tetrahydropteroylglutamate + NAD(P)+
-
-
-
?
quinoid 6-methyl-7,8-dihydropterin + NADH + H+
6-methyl-5,6,7,8-tetrahydropterin + NAD+
-
-
-
-
r
quinoid 7,8-(6H)-dihydropterin + NADH + H+
5,6,7,8-tetrahydropterin + NAD+
non-enzymatic reaction of quinoid 7,8-(6H)-dihydropterine to 7,8-dihydropterin
-
-
?
quinonoid (6R)-D-threo-dihydrobiopterin + NADH + H+
?
-
-
-
?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
quinonoid 6,7-dimethyl-7,8-dihydropteridine + NADH + H+
6,7-dimethyl-5,6,7,8-tetrahydropteridine + NAD+
-
-
-
-
r
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
quinonoid 6-methyl-7,8-dihydropterin + NADH + H+
6-methyl-5,6,7,8-tetrahydropterin + NAD+
-
-
-
-
r
quinonoid 7,8-(6H)-dihydropterin + NADH + H+
5,6,7,8-tetrahydropterin + NAD+
-
-
-
-
r
quinonoid 7,8-dihydropterin + NADH + H+
5,6,7,8-tetrahydropterin + NAD+
-
-
-
-
r
quinonoid dihydro-2-methylamino-4-hydroxy-6,7-dimethylpteridine + NAD(P)H
tetrahydro-2-methylamino-4-hydroxy-6,7-dimethylpteridine + NAD(P)+
-
approx. one-third of activity with 2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropterid
-
?
quinonoid dihydro-L-threo-neopterin + NAD(P)H
tetrahydro-L-threo-neopterin + NAD(P)+
-
-
-
?
quinonoid dihydrobiopterin + NADH + H+
5,6,7,8-tetrahydrobiopterin + NAD+
-
-
-
-
r
quinonoid dihydromonapterin + NAD(P)H
tetrahydromonapterin + NAD(P)+
-
-
-
?
quinonoid dihydroneopterin + NAD(P)H
tetrahydroneopterin + NAD(P)+
-
-
-
?
quinonoid-6-methyl-7,8-dihydrobiopterin + NADH + H+
6-methyl-7,8-dihydropterin + NAD+
-
-
-
-
r
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
-
-
-
-
?
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
-
NADH is 20fold more effective than NADPH
-
?
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
-
-
-
?
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
-
3% activity with NADPH
-
?
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
-
-
-
?
6,7-dihydropteridine + NADH
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
-
-
-
-
?
6,7-dihydropteridine + NADH
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
-
-
-
?
6,7-dihydropteridine + NADH
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
last step of recycling of the cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopteridine essential for aromatic amino acid hydroxylases and nitric oxide synthases, regulatory mechanism involve H2O2, enzyme inactivation because of H2O2 accumulation in the epidermis contributes to the pathomechanism of vitiligo
-
-
?
6,7-dihydropteridine + NADPH + H+
5,6,7,8-tetrahydropteridine + NADP+
-
-
-
r
6,7-dihydropteridine + NADPH + H+
5,6,7,8-tetrahydropteridine + NADP+
-
-
-
r
6,7-dimethyl-7,8-dihydropteridine + NADPH
(6R)-L-erythro-6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + NADP+
-
-
-
-
?
6,7-dimethyl-7,8-dihydropteridine + NADPH
(6R)-L-erythro-6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + NADP+
-
-
-
-
?
6,7-dimethyl-7,8-dihydropteridine + NADPH
(6R)-L-erythro-6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + NADP+
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
-
-
-
?
6,7-dimethyl-7,8-dihydropterin + NADPH + H+
6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+
-
-
-
-
?
6,7-dimethyl-7,8-dihydropterin + NADPH + H+
6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+
-
-
-
-
?
6,7-dimethyl-7,8-dihydropterin + NADPH + H+
6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+
-
as the quinonoid forms of pterines are very unstable, the reaction is carried out with a dimethyl analogue in the presence of H2O2 and radish peroxidase to allow the continuous formation of 6,7-dimethyl-7,8-dihydropterine, activity is 25fold higher than the nitroreductase activity 2,4-dinitrophenol
-
-
?
dihydrobiopterin + NADH + H+
tetrahydrobiopterin + NAD+
-
pH 7.4, 37°C
-
-
?
dihydrofolate + NADPH
tetrahydrofolate + NADP+
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
-
-
-
?
quinoid dihydrobiopterin + NAD(P)H
tetrahydrobiopterin + NAD(P)+
-
-
-
-
?
quinoid dihydrobiopterin + NAD(P)H
tetrahydrobiopterin + NAD(P)+
-
NADH is 2.5fold more effective than NADPH
-
?
quinoid dihydrobiopterin + NAD(P)H
tetrahydrobiopterin + NAD(P)+
-
specific for NADH
-
?
quinoid dihydrobiopterin + NAD(P)H
tetrahydrobiopterin + NAD(P)+
-
-
-
-
?
quinonoid 6,6-dimethyldihydropterin + NAD(P)H
6,6-dimethyltetrahydropterin + NAD(P)+
-
-
-
?
quinonoid 6,6-dimethyldihydropterin + NAD(P)H
6,6-dimethyltetrahydropterin + NAD(P)+
-
-
-
?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
-
-
?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
-
-
?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
enzyme from adrenal medulla
-
?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
-
-
?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
-
-
?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
-
-
?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
no activity with 6,6,8-trimethyl-7,8-(6H)-dihydropterin
-
?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
-
-
?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
-
-
-
?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
-
-
?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
-
-
-
?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
NADPH-specific enzyme from liver, NADPH is 660times more effective than NADH
-
-
?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
-
-
?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
-
-
-
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
-
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
-
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
-
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
-
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
-
-
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
may also have an important role in regulation of catecholamine synthesis
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
more specific for NADH, 50% activity with NADPH, no activity with biopterin and 7,8-dihydrobiopterin
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
enzyme also has pterin-independent NADH and NADPH oxidoreductase activity with potassium ferricyanide
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
-
-
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
-
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
-
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
-
-
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
enzyme prefers NADH
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
absolutely specific for quinonoid dihydro-isomer corresponding to 7,8-dihydropterins
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
essential component of the hepatic phenylalanine hydroxylating system
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
no marked specificity for the pteridine cofactor that occurs naturally in this organism L-threo-neopterin
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
essential component of catecholamine biosynthetic metabolism
-
?
quinonoid 7,8-(6H)-dihydropterin + NADPH + H+
5,6,7,8-tetrahydropterin + NADP+
-
-
-
-
r
quinonoid 7,8-(6H)-dihydropterin + NADPH + H+
5,6,7,8-tetrahydropterin + NADP+
-
-
-
-
r
quinonoid 7,8-dihydropterin + NADPH + H+
5,6,7,8-tetrahydropterin + NADP+
-
-
-
-
r
quinonoid 7,8-dihydropterin + NADPH + H+
5,6,7,8-tetrahydropterin + NADP+
-
-
-
-
r
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
-
-
-
-
?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
-
-
-
-
?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
-
-
-
-
?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
-
-
-
-
?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
-
-
-
-
?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
-
-
-
-
?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
-
-
-
-
?
additional information
?
-
-
essential part of the hydroxylating system of the aromatic amino acids phenylalanine, tyrosine and tryptophan, reduces quinonoid dihydropterine to regenerate tetrahydrobiopterin, main metabolic derangements caused by DHPR deficiency are hyperphenylalaninaemia and impaired production of the monoamine neurotransmitters dopamine, noradrenaline and serotonin, DHPR deficiency patients can develop severe and progressive neurological damage
-
-
?
additional information
?
-
substrate specificity, enzyme shows selectivity for pterin substrates with a 6-(1', 2'-dihydroxypropyl) substitution
-
-
?
additional information
?
-
-
substrate specificity, enzyme shows selectivity for pterin substrates with a 6-(1', 2'-dihydroxypropyl) substitution
-
-
?
additional information
?
-
-
in vivo role as dihydropteridine reductase involved in aromatic amino acids metabolism suggested
-
-
?
additional information
?
-
-
enzyme shows nitroreductase activity with several different substrates such as 2,4-dinitrophenol, 2,4-dinitrobenzoate and nitrofurazone
-
-
?
additional information
?
-
-
no activity with potassium ferricyanide, 6-biopterin, and 6-methyl-7,8-dihydropterine
-
-
?
additional information
?
-
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
no activity with potassium ferricyanide, 6-biopterin, and 6-methyl-7,8-dihydropterine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5,6,7,8-tetrahydropteridine + NAD(P)+
6,7-dihydropteridine + NAD(P)H
enzyme is required for recycling of 6,7-dihydropteridine, in vivo regulation is related to growth phase
-
-
r
6,7-dihydropteridine + NADH
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
last step of recycling of the cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopteridine essential for aromatic amino acid hydroxylases and nitric oxide synthases, regulatory mechanism involve H2O2, enzyme inactivation because of H2O2 accumulation in the epidermis contributes to the pathomechanism of vitiligo
-
-
?
a 6,7-dihydropteridine + NAD(P)H + H+
a 5,6,7,8-tetrahydropteridine + NAD(P)+
-
-
-
-
?
dihydrobiopterin + NADH + H+
tetrahydrobiopterin + NAD+
-
pH 7.4, 37°C
-
-
?
quinoid 7,8-(6H)-dihydropterin + NADH + H+
5,6,7,8-tetrahydropterin + NAD+
non-enzymatic reaction of quinoid 7,8-(6H)-dihydropterine to 7,8-dihydropterin
-
-
?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
-
-
-
-
?
6,7-dihydropteridine + NADPH + H+
5,6,7,8-tetrahydropteridine + NADP+
-
-
-
r
6,7-dihydropteridine + NADPH + H+
5,6,7,8-tetrahydropteridine + NADP+
-
-
-
r
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
-
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
may also have an important role in regulation of catecholamine synthesis
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
-
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
essential component of the hepatic phenylalanine hydroxylating system
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
no marked specificity for the pteridine cofactor that occurs naturally in this organism L-threo-neopterin
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
essential component of catecholamine biosynthetic metabolism
-
?
additional information
?
-
-
essential part of the hydroxylating system of the aromatic amino acids phenylalanine, tyrosine and tryptophan, reduces quinonoid dihydropterine to regenerate tetrahydrobiopterin, main metabolic derangements caused by DHPR deficiency are hyperphenylalaninaemia and impaired production of the monoamine neurotransmitters dopamine, noradrenaline and serotonin, DHPR deficiency patients can develop severe and progressive neurological damage
-
-
?
additional information
?
-
-
in vivo role as dihydropteridine reductase involved in aromatic amino acids metabolism suggested
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NADH
-
liver: 2 distinct dihydropteridine reductases which catalyze the conversion of the quinonoid dihydropteridine to tetrahydropterin: NADH-dihydropteridine reductase, DPR, utilizes NADH as a better substrate than NADPH, NADPH-specific dihydropteridine reductase, TPR, shows strict specificity for NADPH