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Reference on EC 1.5.1.33 - pteridine reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nare, B.; Hardy, L.W.; Beverley, S.M.
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major
J. Biol. Chem.
272
13883-13891
1997
Leishmania major, Leishmania tarentolae
Manually annotated by BRENDA team
Robello, C.; Navarro, P.; Castanys, S.; Gamarro, F.
A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi
Mol. Biochem. Parasitol.
90
525-535
1997
Trypanosoma cruzi, Trypanosoma cruzi Y
Manually annotated by BRENDA team
Nare, B.; Luba, J.; Hardy, L.W.; Beverley, S.
New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity
Parasitology
114
101-110
1997
Leishmania major
-
Manually annotated by BRENDA team
Hardy, L.W.; Matthews, W.; Nare, B.; Beverley, S.M.
Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways
Exp. Parasitol.
87
157-169
1997
Leishmania major
Manually annotated by BRENDA team
Leblanc, E.; Papadopoulou, B.; Bernatchez, C.; Ouellette, M.
Residues involved in co-factor and substrate binding of the short-chain dehydrogenase/reductase PTR1 producing methotrexate resistance in Leishmania
Eur. J. Biochem.
251
768-774
1998
Leishmania tarentolae
Manually annotated by BRENDA team
Bello, A.R.; Nare, B.; Freedman, D.; Hardy, L.; Beverly, S.M.
PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major
Proc. Natl. Acad. Sci. USA
91
11442-11446
1994
Leishmania major
Manually annotated by BRENDA team
Wang, J.; Leblanc, E.; Chang, C.F.; Papadopoulou, B.; Bray, T.; Witheley, J.M.; Lin, S.X.; Quellette, M.
Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1
Arch. Biochem. Biophys.
342
197-202
1997
Leishmania tarentolae
Manually annotated by BRENDA team
Luba, J.; Nare, B.; Liang, P.H.; Anderson, K.S.; Beverley, S.M.; Hardy, L.W.
Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence
Biochemistry
37
4093-4104
1998
Leishmania major
Manually annotated by BRENDA team
Zhao, H.; Bray, T.; Ouellette, M.; Zhao, M.; Ferre, R.A.; Matthews, D.; Whiteley, J.M.; Varughese, K.I.
Structure of pteridine reductase (PTR1) from Leishmania tarentolae
Acta Crystallogr. Sect. D
59
1539-1544
2003
Leishmania tarentolae (P42556), Leishmania tarentolae
Manually annotated by BRENDA team
McLuskey, K.; Gibellini, F.; Carvalho, P.; Avery, M.A.; Hunter, W.N.
Inhibition of Leishmania major pteridine reductase by 2,4,6-triaminoquinazoline: structure of the NADPH ternary complex
Acta Crystallogr. Sect. D
60
1780-1785
2004
Leishmania major (Q01782), Leishmania major
Manually annotated by BRENDA team
Kumar, P.; Kothari, H.; Singh, N.
Overexpression in Escherichia coli and purification of pteridine reductase (PTR1) from a clinical isolate of Leishmania donovani
Protein Expr. Purif.
38
228-236
2004
Leishmania donovani (Q6QDB5), Leishmania donovani
Manually annotated by BRENDA team
Schuettelkopf, A.W.; Hardy, L.W.; Beverley, S.M.; Hunter, W.N.
Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design
J. Mol. Biol.
352
105-116
2005
Leishmania major
Manually annotated by BRENDA team
Dawson, A.; Gibellini, F.; Sienkiewicz, N.; Tulloch, L.B.; Fyfe, P.K.; McLuskey, K.; Fairlamb, A.H.; Hunter, W.N.
Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate
Mol. Microbiol.
61
1457-1468
2006
Trypanosoma brucei
Manually annotated by BRENDA team
Kumar, P.; Sundar, S.; Singh, N.
Degradation of pteridine reductase 1 (PTR1) enzyme during growth phase in the protozoan parasite Leishmania donovani
Exp. Parasitol.
116
182-189
2007
Leishmania donovani (Q6QDB5), Leishmania donovani
Manually annotated by BRENDA team
Kumar, P.; Kumar, A.; Verma, S.S.; Dwivedi, N.; Singh, N.; Siddiqi, M.I.; Tripathi, R.P.; Dube, A.; Singh, N.
Leishmania donovani pteridine reductase 1: biochemical properties and structure-modeling studies
Exp. Parasitol.
120
73-79
2008
Leishmania donovani
Manually annotated by BRENDA team
Cavazzuti, A.; Paglietti, G.; Hunter, W.N.; Gamarro, F.; Piras, S.; Loriga, M.; Allecca, S.; Corona, P.; McLuskey, K.; Tulloch, L.; Gibellini, F.; Ferrari, S.; Costi, M.P.
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
Proc. Natl. Acad. Sci. USA
105
1448-1453
2008
Trypanosoma cruzi, Leishmania major (Q01782), Leishmania major
Manually annotated by BRENDA team
Shanks, E.J.; Ong, H.B.; Robinson, D.A.; Thompson, S.; Sienkiewicz, N.; Fairlamb, A.H.; Frearson, J.A.
Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase
Anal. Biochem.
396
194-203
2010
Trypanosoma brucei (O76290), Trypanosoma brucei
Manually annotated by BRENDA team
Kaur, J.; Singh, B.K.; Tripathi, R.P.; Singh, P.; Singh, N.
Leishmania donovani: a glycosyl dihydropyridine analogue induces apoptosis like cell death via targeting pteridine reductase 1 in promastigotes
Exp. Parasitol.
123
258-264
2009
Leishmania donovani (Q6QDB5), Leishmania donovani
Manually annotated by BRENDA team
Mpamhanga, C.P.; Spinks, D.; Tulloch, L.B.; Shanks, E.J.; Robinson, D.A.; Collie, I.T.; Fairlamb, A.H.; Wyatt, P.G.; Frearson, J.A.; Hunter, W.N.; Gilbert, I.H.; Brenk, R.
One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening
J. Med. Chem.
52
4454-4465
2009
Trypanosoma brucei (O76290)
Manually annotated by BRENDA team
Singh, N.; Kaur, J.; Kumar, P.; Gupta, S.; Singh, N.; Ghosal, A.; Dutta, A.; Kumar, A.; Tripathi, R.; Siddiqi, M.I.; Mandal, C.; Dube, A.
An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1
Parasitol. Res.
105
1317-1325
2009
Leishmania donovani
Manually annotated by BRENDA team
Nare, B.; Garraway, L.A.; Vickers, T.J.; Beverley, S.M.
PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major
Curr. Genet.
55
287-299
2009
Leishmania major
Manually annotated by BRENDA team
Kaur, J.; Singh, N.; Singh, B.K.; Dube, A.; Tripathi, R.P.; Singh, P.; Singh, N.
Leishmania donovani: oral therapy with glycosyl 1,4-dihydropyridine analogue showing apoptosis like phenotypes targeting pteridine reductase 1 in intracellular amastigotes
Exp. Parasitol.
125
310-314
2010
Leishmania major
Manually annotated by BRENDA team
Kaur, J.; Sundar, S.; Singh, N.
Molecular docking, structure-activity relationship and biological evaluation of the anticancer drug monastrol as a pteridine reductase inhibitor in a clinical isolate of Leishmania donovani
J. Antimicrob. Chemother.
65
1742-1748
2010
Leishmania donovani
Manually annotated by BRENDA team
Tulloch, L.B.; Martini, V.P.; Iulek, J.; Huggan, J.K.; Lee, J.H.; Gibson, C.L.; Smith, T.K.; Suckling, C.J.; Hunter, W.N.
Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases
J. Med. Chem.
53
221-229
2010
Leishmania major, Trypanosoma brucei (Q581W1), Trypanosoma brucei
Manually annotated by BRENDA team
Sienkiewicz, N.; Ong, H.B.; Fairlamb, A.H.
Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice
Mol. Microbiol.
77
658-671
2010
Trypanosoma brucei
Manually annotated by BRENDA team
Barrack, K.L.; Tulloch, L.B.; Burke, L.A.; Fyfe, P.K.; Hunter, W.N.
Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site
Acta Crystallogr. Sect. F
67
33-37
2011
Leishmania donovani (Q6QDB5), Leishmania donovani
Manually annotated by BRENDA team
Spinks, D.; Ong, H.B.; Mpamhanga, C.P.; Shanks, E.J.; Robinson, D.A.; Collie, I.T.; Read, K.D.; Frearson, J.A.; Wyatt, P.G.; Brenk, R.; Fairlamb, A.H.; Gilbert, I.H.
Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1
ChemMedChem
6
302-308
2011
Trypanosoma brucei
Manually annotated by BRENDA team
Kazemi, B.; Tohidi, F.; Bandehpour, M.; Yarian, F.
Molecular cloning, expression and enzymatic assay of pteridine reductase 1 from Iranian lizard Leishmania
Iran. Biomed. J.
14
97-102
2010
Leishmania sp. (A2TEY0), Leishmania sp. BK-2007 (A2TEY0)
Manually annotated by BRENDA team
Ong, H.B.; Sienkiewicz, N.; Wyllie, S.; Fairlamb, A.H.
Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major
J. Biol. Chem.
286
10429-10438
2011
Leishmania major, Trypanosoma brucei
Manually annotated by BRENDA team
Sahi, S.; Tewatia, P.; Ghosal, S.
Leishmania donovani pteridine reductase 1: comparative protein modeling and protein-ligand interaction studies of the leishmanicidal constituents isolated from the fruits of Piper longum
J. Mol. Model.
18
5065-5073
2012
Leishmania donovani
Manually annotated by BRENDA team
Leite, F.H.A.; Froes, T.Q.; da Silva, S.G.; de Souza, E.I.M.; Vital-Fujii, D.G.; Trossini, G.H.G.; Pita, S.S.D.R.; Castilho, M.S.
An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors
Eur. J. Med. Chem.
132
322-332
2017
Leishmania major
Manually annotated by BRENDA team
de Souza Moreira, D.; Ferreira, R.F.; Murta, S.M.
Molecular characterization and functional analysis of pteridine reductase in wild-type and antimony-resistant Leishmania lines
Exp. Parasitol.
160
60-66
2016
Leishmania amazonensis (O09352), Leishmania amazonensis, Leishmania braziliensis (A4HCP1), Leishmania braziliensis, Leishmania guyanensis (A0A1E1IZ95), Leishmania guyanensis, Leishmania infantum (A4I067), Leishmania infantum
Manually annotated by BRENDA team
Khalaf, A.I.; Huggan, J.K.; Suckling, C.J.; Gibson, C.L.; Stewart, K.; Giordani, F.; Barrett, M.P.; Wong, P.E.; Barrack, K.L.; Hunter, W.N.
Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1
J. Med. Chem.
57
6479-6494
2014
Trypanosoma brucei
Manually annotated by BRENDA team
Di Pisa, F.; Landi, G.; Dello Iacono, L.; Pozzi, C.; Borsari, C.; Ferrari, S.; Santucci, M.; Santarem, N.; Cordeiro-Da-Silva, A.; Moraes, C.; Alcantara, L.; Fontana, V.; Freitas-Junior, L.; Gul, S.; Kuzikov, M.; Behrens, B.; Poehner, I.; Wade, R.; Costi,
Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity
Molecules
22
E426
2017
no activity in Homo sapiens, Trypanosoma brucei (O76290), Leishmania major (Q01782)
Manually annotated by BRENDA team
Landi, G.; Linciano, P.; Tassone, G.; Costi, M.P.; Mangani, S.; Pozzi, C.
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor
Acta Crystallogr. Sect. D
76
558-564
2020
Trypanosoma brucei brucei (O76290)
Manually annotated by BRENDA team
Shamshad, H.; Hafiz, A.; Althagafi, I.I.; Saeed, M.; Mirza, A.Z.
Characterization of the Trypanosoma brucei pteridine reductase active-site using computational docking and virtual screening techniques
Curr. Comput. aided Drug Des.
16
583-598
2020
Trypanosoma brucei brucei (O76290), Leishmania major (Q01782), Leishmania major
Manually annotated by BRENDA team
Linciano, P.; Cullia, G.; Borsari, C.; Santucci, M.; Ferrari, S.; Witt, G.; Gul, S.; Kuzikov, M.; Ellinger, B.; Santarem, N.; Cordeiro da Silva, A.; Conti, P.; Bolognesi, M.L.; Roberti, M.; Prati, F.; Bartoccini, F.; Retini, M.; Piersanti, G.; Cavalli, A.; Goldoni, L.; Bertozzi, S.M.; Bertozzi, F.; , B.
Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign
Eur. J. Med. Chem.
189
112047
2020
Trypanosoma brucei brucei (O76290), Leishmania major (Q01782), Leishmania major
Manually annotated by BRENDA team
Phadke, S.; Somani, R.; Pathak, D.
New benzimidazole derivatives as inhibitors of Pteridine reductase 1 design, molecular docking study and ADMET prediction
J. Appl. Pharm. Sci.
10
30-39
2020
Leishmania major (Q01782)
-
Manually annotated by BRENDA team
Labine, M.; DePledge, L.; Feirer, N.; Greenwich, J.; Fuqua, C.; Allen, K.
Enzymatic and mutational analysis of the PruA pteridine reductase required for pterin-dependent control of biofilm formation in Agrobacterium tumefaciens
J. Bacteriol.
202
e00098-20
2020
Leishmania major (Q01782), Agrobacterium fabrum (Q7CZX3), Agrobacterium fabrum C58 (Q7CZX3), Agrobacterium fabrum ATCC 33970 (Q7CZX3)
Manually annotated by BRENDA team
Herrmann, F.C.; Sivakumar, N.; Jose, J.; Costi, M.P.; Pozzi, C.; Schmidt, T.J.
In silico identification and in vitro evaluation of natural inhibitors of Leishmania major pteridine reductase I
Molecules
22
2166
2017
Leishmania major (Q01782), Leishmania major
Manually annotated by BRENDA team
Kimuda, M.P.; Laming, D.; Hoppe, H.C.; Tastan Bishop, Oe.
Identification of novel potential inhibitors of pteridine reductase 1 in Trypanosoma brucei via computational structure-based approaches and in vitro inhibition assays
Molecules
24
142
2019
Trypanosoma cruzi (O44029), Trypanosoma brucei brucei (O76290)
Manually annotated by BRENDA team
Herrera-Acevedo, C.; Flores-Gaspar, A.; Scotti, L.; Mendonca-Junior, F.J.B.; Scotti, M.T.; Coy-Barrera, E.
Identification of kaurane-type diterpenes as inhibitors of Leishmania pteridine reductase I
Molecules
26
0000
2021
Leishmania panamensis (A0A088SA10), Leishmania panamensis, Leishmania braziliensis (A4HCP1), Leishmania amazonensis (O09352), Leishmania major (Q01782), Leishmania major
Manually annotated by BRENDA team
Tassone, G.; Landi, G.; Linciano, P.; Francesconi, V.; Tonelli, M.; Tagliazucchi, L.; Costi, M.P.; Mangani, S.; Pozzi, C.
Evidence of pyrimethamine and cycloguanil analogues as dual inhibitors of Trypanosoma brucei pteridine reductase and dihydrofolate reductase
Pharmaceuticals
14
636
2021
Trypanosoma brucei brucei (O76290)
Manually annotated by BRENDA team
Bhattacharya, A.; Leprohon, P.; Ouellette, M.
Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
PLoS Negl. Trop. Dis.
15
e0009377
2021
Leishmania infantum (A4I067), Leishmania infantum, Leishmania infantum MHOM/MA/67/ITMAP-263 (A4I067)
Manually annotated by BRENDA team