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Information on EC 1.5.1.20 - methylenetetrahydrofolate reductase [NAD(P)H]

for references in articles please use BRENDA:EC1.5.1.20
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IUBMB Comments
A flavoprotein (FAD). Menadione can also serve as an electron acceptor.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
10-methylenetetrahydrofolate reductase, 5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methylenetetrahydrofolate:NADP+ oxidoreductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, 5-methyltetrahydrofolate:NAD oxidoreductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+
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