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Information on EC 1.5.1.1 - 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

for references in articles please use BRENDA:EC1.5.1.1
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IUBMB Comments
The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.21, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.
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The enzyme appears in viruses and cellular organisms
Synonyms
ketimine reductase, pyr2c reductase, p2c/pyr2c reductase, delta1-pyrroline-2-carboxylate reductase, p2c reductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-pipecolate + NAD(P)+ = 1-piperideine-2-carboxylate + NAD(P)H + H+
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(1)
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L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+
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