Information on EC 1.4.1.B5 - glutamate synthase (NAD(P)H)

for references in articles please use BRENDA:EC1.4.1.B5
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The enzyme appears in viruses and cellular organisms

top print hide
EC NUMBER
COMMENTARY hide
1.4.1.B5
preliminary BRENDA-supplied EC number
top print hide
RECOMMENDED NAME
GeneOntology No.
glutamate synthase (NAD(P)H)
-
top print hide
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+
show the reaction diagram
-
-
-
-
top print hide
SYSTEMATIC NAME
IUBMB Comments
L-glutamate:NAD(P)+ oxidoreductase (transaminating)
-
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top print hide
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
top print hide
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 L-glutamate + NAD+
L-glutamine + 2-oxoglutarate + NADH + H+
show the reaction diagram
2 L-glutamate + NADP+
L-glutamine + 2-oxoglutarate + NADPH + H+
show the reaction diagram
top print hide
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 L-glutamate + NAD+
L-glutamine + 2-oxoglutarate + NADH + H+
show the reaction diagram
2 L-glutamate + NADP+
L-glutamine + 2-oxoglutarate + NADPH + H+
show the reaction diagram
top print hide
top print hide
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NH4Cl
-
activates
top print hide
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
azaserine
top print hide
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NH4Cl
-
activates
top print hide
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.6 - 0.9
2-oxoglutarate
0.6 - 1.5
L-glutamine
top print hide
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.024 - 0.041
-
pH 7.5, 30°C, L3 stage
0.033 - 0.059
-
pH 7.5, 30°C, adult worm
0.051 - 0.095
-
pH 7.5, 30°C, adult worm
top print hide
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
top print hide
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
top print hide
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
-
no activity in L3 stage
Manually annotated by BRENDA team
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LINKS TO OTHER DATABASES (specific for EC-Number 1.4.1.B5)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)