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Information on EC 1.4.1.3 - glutamate dehydrogenase [NAD(P)+]
for references in articles please use BRENDA:EC1.4.1.3
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EC Tree 1 Oxidoreductases
1.4 Acting on the CH-NH2 group of donors
1.4.1 With NAD+ or NADP+ as acceptor
1.4.1.3 glutamate dehydrogenase [NAD(P)+]
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
showSynonyms
hgdh2, glutamate dehydrogenase 1, gdhii, nad(p)-dependent glutamate dehydrogenase, nad(p)+-dependent glutamate dehydrogenase, legdh1, nad(p)-glutamate dehydrogenase, nad(p)h-dependent glutamate dehydrogenase, ttgdh, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
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-
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dual-coenzyme specific glutamate dehydrogenase
GDH
GDH1
GDH2
GdhA
GLUD1
GLUD2
GluDH
glutamate dehydrogenase
glutamate dehydrogenase 1
glutamate dehydrogenase 2
glutamic acid dehydrogenase
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glutamic dehydrogenase
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hGDH1
hGDH2
L-glutamate dehydrogenase
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L-glutamic acid dehydrogenase
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Legdh1
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Membrane protein 50
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MP50
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NAD(P)-glutamate dehydrogenase
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NAD(P)H-dependent glutamate dehydrogenase
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NAD(P)H-utilizing glutamate dehydrogenase
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dual-coenzyme specific glutamate dehydrogenase
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
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GDH
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+
mechanism
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L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+
alternative order mechanism at pH 9.5
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L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+
kinetic data suggest either a rapid-equilibrium random mechanism or a compulsory mechanism with binding sequence NH4+, NAD(P)H, 2-oxoglutarate
dogfish
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L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+
compulsory order mechanism at pH 8.8
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L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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reductive amination
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PATHWAY SOURCE
PATHWAYS
KEGG
MetaCyc
GABA shunt I, L-glutamate biosynthesis II, L-glutamate degradation X, L-ornithine biosynthesis II
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SYSTEMATIC NAME
IUBMB Comments
L-glutamate:NAD(P)+ oxidoreductase (deaminating)
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CAS REGISTRY NUMBER
COMMENTARY
9029-12-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-aminobutyrate + H2O + NADP+
2-oxobutyrate + NH3 + NADPH
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Substrates: 3% of activity with L-glutamate
Products: -
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?
2-oxoglutarate + NH3 + NAD(P)H + H+
L-glutamate + H2O + NAD(P)+
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADPH
L-glutamate + H2O + NADP+
-
Substrates: -
Products: -
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r
L-glutamate + H2O + 2-azido-NAD+
2-oxoglutarate + NH3 + 2-azido-NADH
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Substrates: -
Products: -
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?
L-glutamate + H2O + N6-(2-aminoethyl)-NAD(P)+
2-oxoglutarate + NH3 + N6-(2-aminoethyl)-NAD(P)H
-
Substrates: -
Products: -
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?
L-glutamate + H2O + N6-(2-aminoethyl)-NAD+
2-oxoglutarate + NH3 + N6-(2-aminoethyl)-NADH + H+
-
Substrates: -
Products: -
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r
L-glutamate + H2O + N6-(2-hydroxy-3-trimethylammoniumpropyl)-NAD+
2-oxoglutarate + NH3 + N6-(2-hydroxy-3-trimethylammoniumpropyl)-NADH
-
Substrates: -
Products: -
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?
L-glutamate + H2O + N6-(2-hydroxy-3-trimethylammoniumpropyl)-NAD+
2-oxoglutarate + NH3 + N6-(2-hydroxy-3-trimethylammoniumpropyl)-NADH + H+
-
Substrates: -
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r
L-glutamate + H2O + N6-(3-sulfonatopropyl)-NAD+
2-oxoglutarate + NH3 + N6-(2-sulfonatopropyl)-NADH
-
Substrates: -
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?
L-glutamate + H2O + N6-poly(ethyleneglycol)-N6-(2-aminoethyl)-NAD+
2-oxoglutarate + NH3 + )poly(ethyleneglycol)-N6-(2-aminoethyl)-NADH + H+
-
Substrates: -
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NADPH + H+
-
Substrates: -
Products: -
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?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH
-
Substrates: -
Products: -
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r
L-glutamate + H2O + poly(ethyleneglycol)-N6-(2-aminoethyl)-NADP+
2-oxoglutarate + NH3 + poly(ethyleneglycol)-N6-(2-aminoethyl)-NADPH + H+
-
Substrates: -
Products: -
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r
L-glutamate + H2O + polyethylenglycol-N6-(2-aminoethyl)-NAD(P)+
2-oxoglutarate + NH3 + polyethylenglycol-N6-(2-aminoethyl)-NAD(P)H
-
Substrates: -
Products: -
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?
L-glutamate + NADP+ + H2O
2-oxoglutarate + NADPH + NH3
-
Substrates: -
Products: -
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r
norvaline + H2O + NAD(P)+
2-oxopentanoate + NH3 + NAD(P)H
-
Substrates: -
Products: -
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?
norvaline + H2O + NADP+
2-oxovalerate + NH3 + NADPH
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Substrates: activity is 20% of that observed in the presence of 2-oxoglutarate and L-glutamate
Products: -
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r
oxaloacetate + NH3 + NADH + H+
L-aspartate + H2O + NAD+
-
Substrates: -
Products: -
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r
valine + H2O + NADP+
2-oxovalerate + NH3 + NADPH
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Substrates: 3% of activity with L-glutamate
Products: -
Products: -
?
2-oxoglutarate + NAD(P)H + NH3
L-glutamate + NAD(P)+ + H2O
-
Substrates: -
Products: -
Products: -
?
2-oxoglutarate + NAD(P)H + NH3
L-glutamate + NAD(P)+ + H2O
-
Substrates: -
Products: -
Products: -
?
2-oxoglutarate + NADH + NH3
L-glutamate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
2-oxoglutarate + NADH + NH3
L-glutamate + NAD+ + H2O
-
Substrates: -
Products: -
Products: -
?
2-oxoglutarate + NADH + NH3
L-glutamate + NAD+ + H2O
Substrates: -
Products: -
Products: -
?
2-oxoglutarate + NADH + NH3
L-glutamate + NAD+ + H2O
Substrates: -
Products: -
Products: -
?
2-oxoglutarate + NADH + NH3
L-glutamate + NAD+ + H2O
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Substrates: no activity with NAD+ as cofactor
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ir
2-oxoglutarate + NADH + NH3
L-glutamate + NAD+ + H2O
-
Substrates: -
Products: -
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?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
Substrates: -
Products: -
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?
2-oxoglutarate + NADPH + NH3
L-glutamate + NADP+ + H2O
-
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADH
L-glutamate + H2O + NAD+
-
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADH
L-glutamate + H2O + NAD+
-
Substrates: -
Products: -
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?
2-oxoglutarate + NH3 + NADH
L-glutamate + H2O + NAD+
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Substrates: specific activity in the presence of NADH is about 30% of that with NADPH
Products: -
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r
2-oxoglutarate + NH3 + NADH
L-glutamate + H2O + NAD+
-
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: NH4Cl used in enzyme assay
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: NH4Cl used in enzyme assay
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: NH4Cl used in enzyme assay
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: NH4Cl used in enzyme assay
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: -
Products: -
Products: -
r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: NH4Cl used in enzyme assay
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
-
Substrates: NH4Cl used in enzyme assay
Products: -
Products: -
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
Substrates: NH4Cl used in enzyme assay
Products: -
Products: -
r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
Substrates: NH4Cl used in enzyme assay
Products: -
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r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
-
Substrates: -
Products: -
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r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
Substrates: -
Products: -
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?
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
Substrates: -
Products: -
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r
alanine + H2O + NAD(P)+
pyruvate + NH3 + NAD(P)H
-
Substrates: very low activity
Products: -
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?
alanine + H2O + NAD(P)+
pyruvate + NH3 + NAD(P)H
-
Substrates: very low activity
Products: -
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?
alanine + H2O + NAD(P)+
pyruvate + NH3 + NAD(P)H
-
Substrates: very low activity
Products: -
Products: -
?
alanine + H2O + NAD(P)+
pyruvate + NH3 + NAD(P)H
-
Substrates: very low activity
Products: -
Products: -
?
alanine + H2O + NAD(P)+
pyruvate + NH3 + NAD(P)H
-
Substrates: very low activity
Products: -
Products: -
?
alanine + H2O + NAD(P)+
pyruvate + NH3 + NAD(P)H
-
Substrates: very low activity
Products: -
Products: -
?
alanine + H2O + NAD(P)+
pyruvate + NH3 + NAD(P)H
-
Substrates: very low activity
Products: -
Products: -
?
alanine + H2O + NAD(P)+
pyruvate + NH3 + NAD(P)H
-
Substrates: very low activity
Products: -
Products: -
?
alanine + H2O + NAD(P)+
pyruvate + NH3 + NAD(P)H
-
Substrates: very low activity
Products: -
Products: -
?
alanine + H2O + NAD(P)+
pyruvate + NH3 + NAD(P)H
-
Substrates: very low activity
Products: -
Products: -
?
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: highly specific for 2-oxoglutarate and glutamate
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: enzyme for the main route for ammonia assimilation at low concentrations of ammonia
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
391593, 391595, 391597, 391599, 391601, 391602, 391603, 391612, 391613, 391614, 391616, 391617, 391626, 391628, 391633, 391636
Substrates: -
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: very low activity with: leucine, alpha-aminobutyrate, valine, isoleucine and methionine
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: rate of glutamate synthesis is several-fold higher than the rate for the reverse reaction
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
dogfish
-
Substrates: -
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: highly specific for 2-oxoglutarate and glutamate
Products: -
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L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
-
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
-
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
-
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
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r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
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r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
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L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
Products: -
ir
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
-
Substrates: -
Products: -
Products: -
ir
L-glutamate + NAD+ + H2O
2-oxoglutarate + NADH + NH3
-
Substrates: -
Products: -
Products: -
?
L-glutamate + NAD+ + H2O
2-oxoglutarate + NADH + NH3
Substrates: -
Products: -
Products: -
r
additional information
?
-
-
Substrates: the similarity in relative activation when both cofactors are present, combined with consistently greater GDH product formation from equimolar NADH than with NADPH, does not support the idea that there is a preferential utilization of NADPH by bovine GDH
Products: -
Products: -
?
additional information
?
-
-
Substrates: the glutamate formation activity is 3fold higher than the glutamate deamination activity
Products: -
Products: -
?
additional information
?
-
Substrates: in vitro, the thermodynamic equilibrium of mammalian GDH favors glutamate synthesis. Because the GDH-catalyzed reaction is reversible, its direction is expected to depend on the concentration of the substrates and the affinity of the enzyme (Km value) for these substrates. In addition to substrate concentrations, the GDH catalysis is affected by the pH, the ionic strength and the composition of the buffer
Products: -
Products: -
-
additional information
?
-
Substrates: in vitro, the thermodynamic equilibrium of mammalian GDH favors glutamate synthesis. Because the GDH-catalyzed reaction is reversible, its direction is expected to depend on the concentration of the substrates and the affinity of the enzyme (Km value) for these substrates. In addition to substrate concentrations, the GDH catalysis is affected by the pH, the ionic strength and the composition of the buffer
Products: -
Products: -
-
additional information
?
-
-
Substrates: in vitro, the thermodynamic equilibrium of mammalian GDH favors glutamate synthesis. Because the GDH-catalyzed reaction is reversible, its direction is expected to depend on the concentration of the substrates and the affinity of the enzyme (Km value) for these substrates. In addition to substrate concentrations, the GDH catalysis is affected by the pH, the ionic strength and the composition of the buffer
Products: -
Products: -
-
additional information
?
-
Substrates: the binding affinity of L-glutamate is lower than that of 2-oxoglutarate. Hence, L-glutamate has a weaker affinity than 2-oxoglutarate in binding to the active site of GDH. A comparison of binding site in 2-oxoglutarate and L-glutamate indicate three residues which include Arg401, Trp88, and Arg12 that have important role in interaction between these ligands with active site of GDH
Products: -
Products: -
-
additional information
?
-
-
Substrates: no activity in the amination reaction direction with NADH or NADPH, 2-oxoglutarate and ammonia
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-oxoglutarate + NH3 + NAD(P)H + H+
L-glutamate + H2O + NAD(P)+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
-
Substrates: enzyme for the main route for ammonia assimilation at low concentrations of ammonia
Products: -
Products: -
r
additional information
?
-
-
Substrates: the similarity in relative activation when both cofactors are present, combined with consistently greater GDH product formation from equimolar NADH than with NADPH, does not support the idea that there is a preferential utilization of NADPH by bovine GDH
Products: -
Products: -
?
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
-
Substrates: -
Products: -
Products: -
?
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
Products: -
r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
-
Substrates: -
Products: -
Products: -
r