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Information on EC 1.4.1.3 - glutamate dehydrogenase [NAD(P)+]
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EC Tree
1.4.1.3 glutamate dehydrogenase [NAD(P)+]Specify your search results
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
hgdh2, glutamate dehydrogenase 1, gdhii, nad(p)-dependent glutamate dehydrogenase, legdh1, nad(p)+-dependent glutamate dehydrogenase, nad(p)-glutamate dehydrogenase, nad(p)h-dependent glutamate dehydrogenase, ttgdh, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
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dual-coenzyme specific glutamate dehydrogenase
GDH
GDH1
GDH2
GdhA
GLUD1
GLUD2
GluDH
glutamate dehydrogenase
glutamate dehydrogenase 1
glutamate dehydrogenase 2
glutamic acid dehydrogenase
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glutamic dehydrogenase
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hGDH1
hGDH2
L-glutamate dehydrogenase
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L-glutamic acid dehydrogenase
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Legdh1
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Membrane protein 50
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MP50
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NAD(P)-glutamate dehydrogenase
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NAD(P)H-dependent glutamate dehydrogenase
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NAD(P)H-utilizing glutamate dehydrogenase
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dual-coenzyme specific glutamate dehydrogenase
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
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GDH
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+
mechanism
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L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+
alternative order mechanism at pH 9.5
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L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+
kinetic data suggest either a rapid-equilibrium random mechanism or a compulsory mechanism with binding sequence NH4+, NAD(P)H, 2-oxoglutarate
dogfish
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L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+
compulsory order mechanism at pH 8.8
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L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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reductive amination
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
L-glutamate:NAD(P)+ oxidoreductase (deaminating)
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CAS REGISTRY NUMBER
COMMENTARY
9029-12-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-aminobutyrate + H2O + NADP+
2-oxobutyrate + NH3 + NADPH
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3% of activity with L-glutamate
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?
2-oxoglutarate + NH3 + NAD(P)H + H+
L-glutamate + H2O + NAD(P)+
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r
L-glutamate + H2O + 2-azido-NAD+
2-oxoglutarate + NH3 + 2-azido-NADH
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?
L-glutamate + H2O + N6-(2-aminoethyl)-NAD(P)+
2-oxoglutarate + NH3 + N6-(2-aminoethyl)-NAD(P)H
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?
L-glutamate + H2O + N6-(2-aminoethyl)-NAD+
2-oxoglutarate + NH3 + N6-(2-aminoethyl)-NADH + H+
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r
L-glutamate + H2O + N6-(2-hydroxy-3-trimethylammoniumpropyl)-NAD+
2-oxoglutarate + NH3 + N6-(2-hydroxy-3-trimethylammoniumpropyl)-NADH
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?
L-glutamate + H2O + N6-(2-hydroxy-3-trimethylammoniumpropyl)-NAD+
2-oxoglutarate + NH3 + N6-(2-hydroxy-3-trimethylammoniumpropyl)-NADH + H+
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r
L-glutamate + H2O + N6-(3-sulfonatopropyl)-NAD+
2-oxoglutarate + NH3 + N6-(2-sulfonatopropyl)-NADH
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?
L-glutamate + H2O + N6-poly(ethyleneglycol)-N6-(2-aminoethyl)-NAD+
2-oxoglutarate + NH3 + )poly(ethyleneglycol)-N6-(2-aminoethyl)-NADH + H+
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r
L-glutamate + H2O + poly(ethyleneglycol)-N6-(2-aminoethyl)-NADP+
2-oxoglutarate + NH3 + poly(ethyleneglycol)-N6-(2-aminoethyl)-NADPH + H+
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r
L-glutamate + H2O + polyethylenglycol-N6-(2-aminoethyl)-NAD(P)+
2-oxoglutarate + NH3 + polyethylenglycol-N6-(2-aminoethyl)-NAD(P)H
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?
norvaline + H2O + NADP+
2-oxovalerate + NH3 + NADPH
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activity is 20% of that observed in the presence of 2-oxoglutarate and L-glutamate
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r
valine + H2O + NADP+
2-oxovalerate + NH3 + NADPH
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3% of activity with L-glutamate
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?
2-oxoglutarate + NADH + NH3
L-glutamate + NAD+ + H2O
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?
2-oxoglutarate + NADH + NH3
L-glutamate + NAD+ + H2O
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no activity with NAD+ as cofactor
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ir
2-oxoglutarate + NH3 + NADH
L-glutamate + H2O + NAD+
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specific activity in the presence of NADH is about 30% of that with NADPH
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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r
2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NAD+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
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NH4Cl used in enzyme assay
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r
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
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?
2-oxoglutarate + NH3 + NADPH + H+
L-glutamate + H2O + NADP+
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r
alanine + H2O + NAD(P)+
pyruvate + NH3 + NAD(P)H
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very low activity
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?
alanine + H2O + NAD(P)+
pyruvate + NH3 + NAD(P)H
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very low activity
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?
alanine + H2O + NAD(P)+
pyruvate + NH3 + NAD(P)H
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very low activity
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?
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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highly specific for 2-oxoglutarate and glutamate
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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enzyme for the main route for ammonia assimilation at low concentrations of ammonia
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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very low activity with: leucine, alpha-aminobutyrate, valine, isoleucine and methionine
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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rate of glutamate synthesis is several-fold higher than the rate for the reverse reaction
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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highly specific for 2-oxoglutarate and glutamate
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
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?
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
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?
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
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?
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
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r
L-glutamate + H2O + NAD(P)+
2-oxoglutarate + NH3 + NAD(P)H + H+
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r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
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r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
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r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
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r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
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r
L-glutamate + H2O + NAD+
2-oxoglutarate + NH3 + NADH + H+
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r
L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+