Reference on EC 1.4.1.27 - glycine cleavage system
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Azize, N.A.; Ngah, W.Z.; Othman, Z.; Md Desa, N.; Chin, C.B.; Md Yunus, Z.; Mohan, A.; Hean, T.S.; Syed Zakaria, S.Z.; Lock-Hock, N.
Mutation analysis of glycine decarboxylase, aminomethyltransferase and glycine cleavage system protein-H genes in 13 unrelated families with glycine encephalopathy
J. Hum. Genet.
59
593-597
2014
Homo sapiens (P23378 and P23434 and P48728 and P09622), Homo sapiens
Varadarajan, N.M.; Sundaram, B.; Subramani, P.A.; Kalappa, D.M.; Ghosh, S.K.; Nagaraj, V.A.
Plasmodium berghei glycine cleavage system T-protein is non-essential for parasite survival in vertebrate and invertebrate hosts
Mol. Biochem. Parasitol.
197
50-55
2014
Plasmodium berghei (A0A122IGX3), Plasmodium berghei
Yoshida, T.; Kikuchi, G.
Significance of the glycine cleavage system in glycine and serine catabolism in avian liver
Arch. Biochem. Biophys.
145
658-668
1971
Columba sp., Gallus gallus (P15505)
Motokawa, Y.; Kikuchi, G.
Glycine metabolism by rat liver mitochondria. Reconstruction of the reversible glycine cleavage system with partially purified protein components
Arch. Biochem. Biophys.
164
624-633
1974
Rattus norvegicus
Kochi, H.; Seino, H.; Ono, K.
Inhibition of glycine oxidation by pyruvate, alpha-ketoglutarate, and branched-chain alpha-keto acids in rat liver mitochondria presence of interaction between the glycine cleavage system and alpha-keto acid dehydrogenase complexes
Arch. Biochem. Biophys.
249
263-272
1986
Rattus norvegicus
Fujiwara, K.; Okamura-Ikeda, K.; Motokawa, Y.
Amino acid sequence of the phosphopyridoxyl peptide from P-protein of the chicken liver glycine cleavage system
Biochem. Biophys. Res. Commun.
149
621-627
1987
Gallus gallus
Sato, K.; Yoshida, S.; Fujiwara, K.; Tada, K.; Tohyama, M.
Glycine cleavage system in astrocytes
Brain Res.
567
64-70
1991
Rattus norvegicus
Sakata, Y.; Owada, Y.; Sato, K.; Kojima, K.; Hisanaga, K.; Shinka, T.; Suzuki, Y.; Aoki, Y.; Satoh, J.; Kondo, H.; Matsubara, Y.; Kure, S.
Structure and expression of the glycine cleavage system in rat central nervous system
Brain Res. Mol. Brain Res.
94
119-130
2001
Rattus norvegicus
Zhang, H.; Li, Y.; Nie, J.; Ren, J.; Zeng, A.P.
Structure-based dynamic analysis of the glycine cleavage system suggests key residues for control of a key reaction step
Commun. Biol.
3
756
2020
Escherichia coli (P0A6T9)
Tan, Y.; Sou, N.; Tang, F.; Ko, H.; Yeh, W.; Peng, J.; Chiang, E.
Tracing metabolic fate of mitochondrial glycine cleavage system derived formate in vitro and in vivo
Int. J. Mol. Sci.
21
8808
2020
Homo sapiens (P23378 and P23434 and P48728 and P09622), Homo sapiens, Mus musculus (Q91W43 and O08749)
Steiert, P.S.; Stauffer, L.T.; Stauffer, G.V.
The lpd gene product functions as the L protein in the Escherichia coli glycine cleavage enzyme system
J. Bacteriol.
172
6142-6144
1990
Escherichia coli (P0A9P0)
Hiraga, K.; Kochi, H.; Motokawa, Y.; Kikuchi, G.
Enzyme complex nature of the reversible glycine cleavage system of cock liver mitochondria
J. Biochem.
72
1285-1289
1972
Gallus gallus (P15505)
Hayasaka, K.; Kochi, H.; Hiraga, K.; Kikuchi, G.
Purification and properties of glycine decarboxylase, a component of the glycine cleavage system, from rat liver mitochondria and immunochemical comparison of this enzyme from various sources
J. Biochem.
88
1193-1199
1980
Rattus norvegicus
Hiraga, K.; Kikuchi, G.
The mitochondrial glycine cleavage system. Purification and properties of glycine decarboxylase from chicken liver mitochondria
J. Biol. Chem.
255
11664-11670
1980
Gallus gallus (P15505), Gallus gallus (P15505 and P11183 and P28337), Gallus gallus
Okamura-Ikeda, K.; Fujiwara, K.; Motokawa, Y.
Purification and characterization of chicken liver T-protein, a component of the glycine cleavage system
J. Biol. Chem.
257
135-139
1982
Gallus gallus (P28337), Gallus gallus
Fujiwara, K.; Okamura-Ikeda, K.; Motokawa, Y.
Mechanism of the glycine cleavage reaction. Further characterization of the intermediate attached to H-protein and of the reaction catalyzed by T-protein
J. Biol. Chem.
259
10664-10668
1984
Gallus gallus (P15505)
Fujiwara, K.; Okamura-Ikeda, K.; Motokawa, Y.
Chicken liver H-protein, a component of the glycine cleavage system. Amino acid sequence and identification of the N epsilon-lipoyllysine residue
J. Biol. Chem.
261
8836-8841
1986
Gallus gallus
Fujiwara, K.; Okamura-Ikeda, K.; Motokawa, Y.
Expression of mature bovine H-protein of the glycine cleavage system in Escherichia coli and in vitro lipoylation of the apoform
J. Biol. Chem.
267
20011-20016
1992
Bos taurus (P20821), Bos taurus
Lee, H.H.; Kim, D.J.; Ahn, H.J.; Ha, J.Y.; Suh, S.W.
Crystal structure of T-protein of the glycine cleavage system. Cofactor binding, insights into H-protein recognition, and molecular basis for understanding nonketotic hyperglycinemia
J. Biol. Chem.
279
50514-50523
2004
Thermotoga maritima (Q9WY54), Thermotoga maritima
Okamura-Ikeda, K.; Hosaka, H.; Maita, N.; Fujiwara, K.; Yoshizawa, A.C.; Nakagawa, A.; Taniguchi, H.
Crystal structure of aminomethyltransferase in complex with dihydrolipoyl-H-protein of the glycine cleavage system implications for recognition of lipoyl protein substrate, disease-related mutations, and reaction mechanism
J. Biol. Chem.
285
18684-18692
2010
Escherichia coli (P0A6T9), Escherichia coli
Leung, K.Y.; De Castro, S.C.P.; Santos, C.; Savery, D.; Prunty, H.; Gold-Diaz, D.; Bennett, S.; Heales, S.; Copp, A.J.; Greene, N.D.E.
Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia
J. Inherit. Metab. Dis.
43
1186-1198
2020
Mus musculus (Q91W43), Mus musculus
Tian, S.; Feng, J.; Cao, Y.; Shen, S.; Cai, Y.; Yang, D.; Yan, R.; Wang, L.; Zhang, H.; Zhong, X.; Gao, P.
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications
Life Sci. Alliance
2
e201900413
2019
Mus musculus (Q91W43 and O08749)
Brown, M.J.; Russo, B.C.; ODee, D.M.; Schmitt, D.M.; Nau, G.J.
The contribution of the glycine cleavage system to the pathogenesis of Francisella tularensis
Microbes Infect.
16
300-309
2014
Francisella tularensis subsp. tularensis (Q5NHP0)
Kikuchi, G.; Hiraga, K.
The mitochondrial glycine cleavage system - Unique features of the glycine decarboxylation
Mol. Cell. Biochem.
45
137-149
1982
Homo sapiens (P23378 and P09622 and P48728)
Lopez-Calcagno, P.E.; Fisk, S.; Brown, K.L.; Bull, S.E.; South, P.F.; Raines, C.A.
Overexpressing the H-protein of the glycine cleavage system increases biomass yield in glasshouse and field-grown transgenic tobacco plants
Plant Biotechnol. J.
17
141-151
2019
Arabidopsis thaliana (P25855), Arabidopsis thaliana
Wittmiss, M.; Mikkat, S.; Hagemann, M.; Bauwe, H.
Stoichiometry of two plant glycine decarboxylase complexes and comparison with a cyanobacterial glycine cleavage system
Plant J.
103
801-813
2020
Pisum sativum (P31023 and P26969 and P16048 and P49364), Pisum sativum, Synechocystis sp. PCC 6803 (P72740 and P54261), Arabidopsis thaliana (Q9M5K3 and Q94B78 and P25855 and Q9LQL0 and O65396)
Vazquez, A.; Markert, E.K.; Oltvai, Z.N.
Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation
PLoS ONE
6
e25881
2011
Homo sapiens
Zubacova, Z.; Novak, L.; Bublikova, J.; Vacek, V.; Fousek, J.; Ridl, J.; Tachezy, J.; Dolezal, P.; Vlcek, C.; Hampl, V.
The mitochondrion-like organelle of Trimastix pyriformis contains the complete glycine cleavage system
PLoS ONE
8
e55417
2013
Paratrimastix pyriformis (B0F467 and B0F465 and B0F466 and B0F476 and B0F460), Paratrimastix pyriformis
Lokanath, N.; Kuroishi, C.; Okazaki, N.; Kunishima, N.
Crystal structure of a component of glycine cleavage system T-protein from Pyrococcus horikoshii OT3 at 1.5 A resolution
Proteins
58
769-773
2005
Pyrococcus horikoshii (O58888)
Yang, D.; Wang, Z.; Ma, J.; Fu, Q.; Wu, L.; Wang, H.; Wang, S.; Yan, Y.; Sun, J.
Glycine cleavage system and cAMP receptor protein co-regulate CRISPR/cas3 expression to resist bacteriophage
Viruses
12
90
2020
Escherichia coli (P27248 and P0A6T9 and P33195), Escherichia coli
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