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IUBMB CommentsThe enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization.
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2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
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2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
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2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
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2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
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2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
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?
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
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?
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate undergoes a NAD+-dependent oxidative deamination to produce 3,7-dideoxy-D-threo-hept-2,6-diulosonic acid which cyclizes to 3-dehydroquinate
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2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate undergoes a NAD+-dependent oxidative deamination to produce 3,7-dideoxy-D-threo-hept-2,6-diulosonic acid which cyclizes to 3-dehydroquinate
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2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
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?
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
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-
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?
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
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?
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
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?
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
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?
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
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3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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White, R.H.
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii
Biochemistry
43
7618-7627
2004
Methanocaldococcus jannaschii (P81230), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (P81230)
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Morar, M.; White, R.H.; Ealick, S.E.
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids
Biochemistry
46
10562-10571
2007
Methanocaldococcus jannaschii (P81230), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (P81230)
brenda
Zhi, X.Y.; Yao, J.C.; Li, H.W.; Huang, Y.; Li, W.J.
Genome-wide identification, domain architectures and phylogenetic analysis provide new insights into the early evolution of shikimate pathway in prokaryotes
Mol. Phylogenet. Evol.
75
154-164
2014
Stigmatella aurantiaca, Streptomyces griseus, Streptomyces scabiei, Frankia casuarinae, Streptomyces griseus NBRC 13350, Streptomyces scabiei 87.22
brenda
1.4.1.24 3-dehydroquinate synthase II
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