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2-ketocaproate + NH3 + NADH
2-aminocaproate + H2O + NAD+
2-oxo-3-methylbutanoate + NH3 + NADH
L-Val + NAD+ + H2O
-
-
-
-
?
2-oxobutanoate + NH3 + NADH
2-aminobutanoate + H2O + NAD+
2-oxoglutarate + NH3 + NADH
L-Gln + NAD+ + H2O
3-bromopyruvate + NH3 + NADH
2-amino-3-bromopropanoate + NAD+ + H2O
-
5.3% of the activity with pyruvate
-
-
?
3-fluoropyruvate + NH3 + NADH
3-fluoro-L-alanine + H2O + NAD+
3-fluoropyruvate + NH3 + NADH
? + H2O + NAD+
3-fluoropyruvate + NH3 + NADH + H+
3-fluoro-L-alanine + H2O + NAD+
-
-
-
-
?
3-hydroxypyruvate + NH3 + NADH
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
Ser + H2O + NAD+
-
15.4% of the activity with pyruvate
-
-
?
4-methyl-2-oxopentanoate + NH3 + NADH
2-amino-4-methylpentanoate + NAD+ + H2O
D-Ala + H2O + NAD+
pyruvate + NH3 + NADH
D-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
DL-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
-
r
Gly + H2O + NAD+
glyoxylate + NH3 + NADH
-
-
-
r
glycine + H2O + NAD+
glyoxylate + NH3 + NADH + H+
-
-
-
-
r
glyoxalate + NH3 + NADH + H+
aminoacetate + H2O + NAD+
-
-
-
-
r
glyoxylate + NH3 + NADH
aminoacetate + NAD+ + H2O
hydroxypyruvate + NH3 + NADH
L-Ser + NAD+ + H2O
ketovalerate + NH3 + NADH
2-aminovalerate + H2O + NAD+
-
-
-
-
?
L-2-amino-4-pentenoate + H2O + NAD+
2-oxo-4-pentenoate + NH3 + NADH
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NH3 + NADH
-
-
-
-
r
L-Ala + H2O + 1,N6-etheno-NAD+
pyruvate + NH3 + 1,N6-etheno-NADH
L-Ala + H2O + 3-acetylpyridine-NAD+
pyruvate + H2O + 3-acetylpyridine-NADH
L-Ala + H2O + 3-pyridinealdehyde-NAD+
?
-
5.0% of the activity with NAD+
-
-
?
L-Ala + H2O + deamino-NAD+
pyruvate + NH3 + deamino-NADH
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
L-Ala + H2O + NADP+
pyruvate + NH3 + NADPH
L-Ala + H2O + nicotinamide guanine dinucleotide
?
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
L-alanine + NAD+ + H2O
pyruvate + NH3 + NADH + H+
L-Asp + H2O + NAD+
oxaloacetate + NH3 + NADH
-
-
-
-
r
L-homophenylalanine + H2O + NADH + H+
2-oxo-4-phenylbutanoate + NH3 + NAD+
-
-
-
?
L-homoserine + H2O + NAD+
4-hydroxy-2-oxobutanoate + NH3 + NADH
-
-
-
?
L-Ile + H2O + NAD+
2-oxo-3-methylpentanoate + NH3 + NADH
L-isoleucine + H2O + NAD+
2-oxo-3-methylpentanoate + NH3 + NADH + H+
-
-
-
-
r
L-leucine + H2O + NAD+
4-methyl-2-oxopentanoate + NH3 + NADH
-
-
-
?
L-methionine + H2O + NAD+
4-(methylsulfanyl)-2-oxobutanoate + NH3 + NADH
-
-
-
?
L-norleucine + H2O + NADH + H+
2-oxohexanoate + NH3 + NAD+
-
-
-
?
L-norvaline + H2O + NAD+
2-oxopentanoate + NH3 + NADH
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
L-serine + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
L-serine + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH + NH3 + NADH + H+
-
-
-
-
r
L-Thr + H2O + NAD+
3-hydroxy-2-oxobutyrate + NH3 + NADH
-
-
-
-
?
L-threonine + H2O + NAD+
3-hydroxy-2-oxobutyrate + NH3 + NADH + H+
-
-
-
-
r
L-Val + H2O + NAD+
3-methyl-2-oxobutanoate + NH3 + NADH
L-valine + H2O + NAD+
3-methyl-2-oxobutanoate + NH3 + NADH
oxaloacetate + NH3 + NADH
L-Asp + H2O + NAD+
phenylpyruvate + NH3 + NADH
L-phenylalanine + H2O + NAD+
-
-
-
-
?
pyruvate + NH3 + NADH
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
L-Ala + NAD+ + H2O
-
primary route for alanine synthesis in isolated bacteroids, alanine synthesis and secretion contributes to the efficiency of N2-fixation and therefore biomass accumulation
-
-
?
pyruvate + NH3 + NADH
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
L-Ala + H2O + NAD+
-
-
-
-
?
pyruvate + NH3 + NADH + H+
L-alanine + H2O + NAD+
pyruvate + NH3 + NADPH + H+
L-Ala + H2O + NADP+
-
NADPH is a poor cofactor for wild-type
-
-
?
additional information
?
-
2-ketocaproate + NH3 + NADH

2-aminocaproate + H2O + NAD+
-
-
-
-
?
2-ketocaproate + NH3 + NADH
2-aminocaproate + H2O + NAD+
-
-
-
-
?
2-oxobutanoate + NH3 + NADH

2-aminobutanoate + H2O + NAD+
-
-
-
-
r
2-oxobutanoate + NH3 + NADH
2-aminobutanoate + H2O + NAD+
-
-
-
-
r
2-oxobutanoate + NH3 + NADH
2-aminobutanoate + H2O + NAD+
-
-
-
-
?
2-oxobutanoate + NH3 + NADH
2-aminobutanoate + H2O + NAD+
-
-
-
-
r
2-oxobutanoate + NH3 + NADH
2-aminobutanoate + H2O + NAD+
-
62% of the activity with pyruvate
-
-
?
2-oxobutanoate + NH3 + NADH
2-aminobutanoate + H2O + NAD+
-
4.1% of the activity with pyruvate
-
-
?
2-oxobutanoate + NH3 + NADH
2-aminobutanoate + H2O + NAD+
-
no activity
-
-
?
2-oxobutanoate + NH3 + NADH
2-aminobutanoate + H2O + NAD+
-
3.7% of the activity with pyruvate
-
-
?
2-oxobutanoate + NH3 + NADH
2-aminobutanoate + H2O + NAD+
-
15% of maximal activity
-
-
?
2-oxobutanoate + NH3 + NADH
2-aminobutanoate + H2O + NAD+
-
15.8% of the activity with pyruvate
-
-
?
2-oxoglutarate + NH3 + NADH

L-Gln + NAD+ + H2O
-
no activity
-
-
?
2-oxoglutarate + NH3 + NADH
L-Gln + NAD+ + H2O
-
11.7% of the activity with pyruvate
-
-
?
3-fluoropyruvate + NH3 + NADH

3-fluoro-L-alanine + H2O + NAD+
-
-
-
?
3-fluoropyruvate + NH3 + NADH
3-fluoro-L-alanine + H2O + NAD+
-
97% of the activity with pyruvate
-
-
?
3-fluoropyruvate + NH3 + NADH

? + H2O + NAD+
-
-
-
-
?
3-fluoropyruvate + NH3 + NADH
? + H2O + NAD+
74% of the activity with pyruvate
-
-
?
3-hydroxypyruvate + NH3 + NADH

L-Ser + H2O + NAD+
-
-
-
-
?
3-hydroxypyruvate + NH3 + NADH
L-Ser + H2O + NAD+
-
123% of the activity with pyruvate
-
-
?
3-hydroxypyruvate + NH3 + NADH
L-Ser + H2O + NAD+
-
-
-
-
?
3-hydroxypyruvate + NH3 + NADH
L-Ser + H2O + NAD+
-
6.9% of the activity with pyruvate
-
-
?
3-hydroxypyruvate + NH3 + NADH
L-Ser + H2O + NAD+
-
32.3% of the activity with pyruvate
-
-
?
3-hydroxypyruvate + NH3 + NADH
L-Ser + H2O + NAD+
54% of the activity with pyruvate
-
-
?
4-methyl-2-oxopentanoate + NH3 + NADH

2-amino-4-methylpentanoate + NAD+ + H2O
-
-
-
-
?
4-methyl-2-oxopentanoate + NH3 + NADH
2-amino-4-methylpentanoate + NAD+ + H2O
-
-
-
-
?
4-methyl-2-oxopentanoate + NH3 + NADH
2-amino-4-methylpentanoate + NAD+ + H2O
-
1.6% of the activity with pyruvate
-
-
?
D-Ala + H2O + NAD+

pyruvate + NH3 + NADH
3.5% of the activity with L-Ala
-
-
?
D-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
32.3% of the activity with L-Ala
-
-
?
D-Ser + H2O + NAD+

3-hydroxypyruvate + NH3 + NADH
4.4% of the activity with L-Ala
-
r
D-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
in the reverse reaction the enzyme reacts at 9.3% of the activity with pyruvate
-
r
D-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
1.3% of the activity with L-Ser
-
-
?
glyoxylate + NH3 + NADH

aminoacetate + NAD+ + H2O
-
-
-
?
glyoxylate + NH3 + NADH
aminoacetate + NAD+ + H2O
-
-
-
-
?
glyoxylate + NH3 + NADH
aminoacetate + NAD+ + H2O
-
-
-
-
?
glyoxylate + NH3 + NADH
aminoacetate + NAD+ + H2O
-
1.2% of the activity with pyruvate
-
-
?
glyoxylate + NH3 + NADH
aminoacetate + NAD+ + H2O
-
6.2% of the activity with pyruvate
-
-
?
glyoxylate + NH3 + NADH
aminoacetate + NAD+ + H2O
-
-
-
-
?
glyoxylate + NH3 + NADH
aminoacetate + NAD+ + H2O
-
5.6% of the activity with pyruvate
-
-
?
glyoxylate + NH3 + NADH
aminoacetate + NAD+ + H2O
-
13.3% of the activity with pyruvate
-
-
?
hydroxypyruvate + NH3 + NADH

L-Ser + NAD+ + H2O
-
-
-
-
?
hydroxypyruvate + NH3 + NADH
L-Ser + NAD+ + H2O
-
-
-
-
?
L-2-amino-4-pentenoate + H2O + NAD+

2-oxo-4-pentenoate + NH3 + NADH
-
-
-
?
L-2-amino-4-pentenoate + H2O + NAD+
2-oxo-4-pentenoate + NH3 + NADH
-
-
-
?
L-2-aminobutanoate + H2O + NAD+

2-oxobutanoate + NH3 + NADH
-
-
-
-
?
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
-
13.3% of the activity with L-Ala
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
in the reverse reaction the enzyme reacts at 15.3% of the activity with pyruvate
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
10.4% of the activity with L-Ala
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
-
7.5% of the activity with L-Ala
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
-
in the reverse reaction 2-oxobutanoate reacts with 79% of the activity with pyruvate
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
-
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
-
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
-
8.7% of the activity with L-Ala
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
-
in the reverse reaction 2-oxobutanoate reacts with 2.0% of the activity with pyruvate
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
-
-
-
-
?
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
-
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
-
2.4% of the activity with L-Ala
-
-
?
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
-
in the reverse reaction 2-oxobutanoate reacts with 1.2% of the activity with pyruvate
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
-
0.7% of the activity with L-Ala
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH
-
1.6% of the activity with L-Ala
-
-
?
L-Ala + H2O + 1,N6-etheno-NAD+

pyruvate + NH3 + 1,N6-etheno-NADH
-
45% of the activity with NAD+
-
-
?
L-Ala + H2O + 1,N6-etheno-NAD+
pyruvate + NH3 + 1,N6-etheno-NADH
-
59% of the activity with NAD+
-
-
?
L-Ala + H2O + 3-acetylpyridine-NAD+

pyruvate + H2O + 3-acetylpyridine-NADH
-
as active as NAD+
-
-
?
L-Ala + H2O + 3-acetylpyridine-NAD+
pyruvate + H2O + 3-acetylpyridine-NADH
-
43% of the activity with NAD+
-
-
?
L-Ala + H2O + 3-acetylpyridine-NAD+
pyruvate + H2O + 3-acetylpyridine-NADH
-
62% of the activity with NAD+
-
-
?
L-Ala + H2O + deamino-NAD+

pyruvate + NH3 + deamino-NADH
-
90.2% of the activity with NAD+
-
-
?
L-Ala + H2O + deamino-NAD+
pyruvate + NH3 + deamino-NADH
-
4.4% of the activity with NAD+
-
-
?
L-Ala + H2O + deamino-NAD+
pyruvate + NH3 + deamino-NADH
-
77% of the activity with NAD+
-
-
?
L-Ala + H2O + NAD+

pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
highly specific for L-Ala
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
Bacillus japonicum
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
the physiological role is to catabolize L-Ala to pyruvate and NH3, inducible by L-Ala, D-Ala and 11 other D-amino acids. The enzyme catabolizes L-Ala, and thereby limits the amount of L-Ala available to alanine racemase for the synthesis of D-Ala
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
enzyme is involved in primary ammonium assimilation and the rapid formation of key metabolites pyruvate and NH3 from L-Ala and also in cell differentiation
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
absolutely specific for L-Ala in oxidative deamination
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
NH4+ assimilating enzyme
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
highly specific for L-Ala
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
physiological role in nitrogen metabolism in Streptomycetes
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
the reaction rate for deamination of pyruvate at the optimum is about 2.8times higher than that for amination of L-Ala at the optimum
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
specific for L-Ala
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
Micromonospora melanosporea
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
highly specific for L-Ala
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
since the physiological environment of the organism has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-Ala
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
Mycobacterium tuberculosis displays less Ald activity than the complemented Mycobacterium bovis BCG strain
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
enzyme is required for utilization of alanine as a sole nitrogen source, enzyme is required for optimal growth under anaerobic conditions
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
key enzyme in the metabolism of alanine, Ala is onyl fermented after lactate exhaustion and then at a slow rate
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
rate of the deaminating reaction is only 2.2% of the aminating reaction
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
role in NH3 assimilation and alanine catabolism
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
rate of the deaminating reaction is only 2.2% of the aminating reaction
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
role in NH3 assimilation and alanine catabolism
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
no function in NH4+-assimilation but rather is required to supply the cells with the appropriate quantities of organic carbon when the organism grows at the expense of L-Ala as C-source and N-source
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
alternative route for ammonia assimilation when glutamine synthetase is inactivated
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
involved in taurine catabolism
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
enzyme formation is effectively induced by Ala
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
NH4+ assimilating enzyme
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
highly specific for L-Ala
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
r
L-Ala + H2O + NADP+

pyruvate + NH3 + NADPH
-
7% of the activity with NAD+
-
-
?
L-Ala + H2O + NADP+
pyruvate + NH3 + NADPH
-
in the reverse direction NADPH reacts at 1.6% of the activity with NADH
-
-
r
L-Ala + H2O + NADP+
pyruvate + NH3 + NADPH
-
2.5% of the activity with NAD+
-
-
r
L-Ala + H2O + NADP+
pyruvate + NH3 + NADPH
wild-type enzyme and mutant enzyme R199I acts specifically on NAD+, mutant enzyme I198R is also active with NADP+
-
-
?
L-Ala + H2O + NADP+
pyruvate + NH3 + NADPH
wild-type enzyme and mutant enzyme R199I acts specifically on NAD+, mutant enzyme I198R is also active with NADP+
-
-
?
L-Ala + H2O + NADP+
pyruvate + NH3 + NADPH
-
wild-type enzyme shows high activity with NAD+ and low activity with NADP+. The mutant enzymes D198G, D198A, D198V and D198L show higher efficiency with NADP+ than with NAD+ as coenzyme
-
-
?
L-Ala + H2O + NADP+
pyruvate + NH3 + NADPH
-
wild-type enzyme shows high activity with NAD+ and low activity with NADP+. The mutant enzymes D198G, D198A, D198V and D198L show higher efficiency with NADP+ than with NAD+ as coenzyme
-
-
?
L-Ala + H2O + nicotinamide guanine dinucleotide

?
-
59.9% of the activity with NAD+
-
-
?
L-Ala + H2O + nicotinamide guanine dinucleotide
?
-
69.7% of the activity with NAD+
-
-
?
L-Ala + H2O + nicotinamide guanine dinucleotide
?
-
71% of the activity with NAD+
-
-
?
L-alanine + H2O + NAD+

pyruvate + NH3 + NADH + H+
-
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
?
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
-
?
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
?
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
-
r
L-alanine + NAD+ + H2O

pyruvate + NH3 + NADH + H+
-
-
-
-
r
L-alanine + NAD+ + H2O
pyruvate + NH3 + NADH + H+
-
-
-
-
r
L-alanine + NAD+ + H2O
pyruvate + NH3 + NADH + H+
-
-
-
-
r
L-Ile + H2O + NAD+

2-oxo-3-methylpentanoate + NH3 + NADH
-
-
-
-
?
L-Ile + H2O + NAD+
2-oxo-3-methylpentanoate + NH3 + NADH
-
5% of the activity with L-Ala
-
-
?
L-Ile + H2O + NAD+
2-oxo-3-methylpentanoate + NH3 + NADH
-
-
-
?
L-Ile + H2O + NAD+
2-oxo-3-methylpentanoate + NH3 + NADH
-
0.1% of the activity with L-Ala
-
-
?
L-norvaline + H2O + NAD+

2-oxopentanoate + NH3 + NADH
-
-
-
-
?
L-norvaline + H2O + NAD+
2-oxopentanoate + NH3 + NADH
-
-
-
r
L-norvaline + H2O + NAD+
2-oxopentanoate + NH3 + NADH
at 4.6% of the activity with L-Ala
-
-
?
L-norvaline + H2O + NAD+
2-oxopentanoate + NH3 + NADH
-
1.5% of the activity with L-Ala
-
r
L-norvaline + H2O + NAD+
2-oxopentanoate + NH3 + NADH
-
in the reverse reaction 2-oxopentanoate reacts with 6.6% of the activity of pyruvate
-
r
L-norvaline + H2O + NAD+
2-oxopentanoate + NH3 + NADH
-
in the reverse reaction 2-oxopentanoate reacts with 0.12% of the activity of pyruvate
-
r
L-norvaline + H2O + NAD+
2-oxopentanoate + NH3 + NADH
-
-
-
-
r
L-norvaline + H2O + NAD+
2-oxopentanoate + NH3 + NADH
-
-
-
r
L-norvaline + H2O + NAD+
2-oxopentanoate + NH3 + NADH
-
-
-
?
L-norvaline + H2O + NAD+
2-oxopentanoate + NH3 + NADH
-
-
-
?
L-Ser + H2O + NAD+

3-hydroxypyruvate + NH3 + NADH
-
-
-
-
r
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
-
-
-
?
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
3.5% of the activity with L-Ala
-
r
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
in the reverse reaction 3-hydroxypyruvate reacts with 0.4% of the activity with pyruvate
-
r
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
in the reverse reaction 3-hydroxypyruvate reacts with 14.2% of the activity with pyruvate
-
-
r
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
4.1% of the activity with L-Ala
-
-
r
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
-
-
-
?
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
-
-
r
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
no activity
-
-
?
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
7.9% of the activity with L-Ala
-
-
?
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
no activity
-
-
?
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
2.4% of the activity with L-Ala
-
-
?
L-Ser + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
-
-
-
?
L-serine + H2O + NAD+

3-hydroxypyruvate + NH3 + NADH
-
-
-
?
L-serine + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH
-
-
-
?
L-Val + H2O + NAD+

3-methyl-2-oxobutanoate + NH3 + NADH
-
-
-
-
?
L-Val + H2O + NAD+
3-methyl-2-oxobutanoate + NH3 + NADH
-
9% of the activity with L-Ala
-
-
?
L-Val + H2O + NAD+
3-methyl-2-oxobutanoate + NH3 + NADH
4.8% of the activity with L-Ala
-
-
?
L-Val + H2O + NAD+
3-methyl-2-oxobutanoate + NH3 + NADH
-
1.5% of the activity with L-Ala
-
-
?
L-Val + H2O + NAD+
3-methyl-2-oxobutanoate + NH3 + NADH
-
-
-
-
?
L-Val + H2O + NAD+
3-methyl-2-oxobutanoate + NH3 + NADH
-
0.2% of the activity with L-Ala
-
-
?
L-valine + H2O + NAD+

3-methyl-2-oxobutanoate + NH3 + NADH
-
-
-
?
L-valine + H2O + NAD+
3-methyl-2-oxobutanoate + NH3 + NADH
-
-
-
?
oxaloacetate + NH3 + NADH

L-Asp + H2O + NAD+
-
-
-
-
?
oxaloacetate + NH3 + NADH
L-Asp + H2O + NAD+
-
-
-
?
oxaloacetate + NH3 + NADH
L-Asp + H2O + NAD+
-
-
-
-
?
oxaloacetate + NH3 + NADH
L-Asp + H2O + NAD+
-
-
-
-
?
oxaloacetate + NH3 + NADH
L-Asp + H2O + NAD+
-
-
-
-
?
oxaloacetate + NH3 + NADH
L-Asp + H2O + NAD+
-
99% of the activity with pyruvate
-
-
?
oxaloacetate + NH3 + NADH
L-Asp + H2O + NAD+
-
94% of maximal activity
-
-
?
oxaloacetate + NH3 + NADH
L-Asp + H2O + NAD+
-
43.1% of the activity with pyruvate
-
-
?
pyruvate + NH3 + NADH

L-Ala + H2O + NAD+
-
-
-
?
pyruvate + NH3 + NADH
L-Ala + H2O + NAD+
-
-
-
r
pyruvate + NH3 + NADH

L-alanine + H2O + NAD+
-
-
-
?
pyruvate + NH3 + NADH
L-alanine + H2O + NAD+
the structural analysis leads to the identification of a water molecule which is hydrogen bonded to the active site His 96 and probably drives the conversion of the iminopyruvate intermediate to a carbinolamine
-
-
?
pyruvate + NH3 + NADH
L-alanine + H2O + NAD+
the structural analysis leads to the identification of a water molecule which is hydrogen bonded to the active site His 96 and probably drives the conversion of the iminopyruvate intermediate to a carbinolamine
-
-
?
pyruvate + NH3 + NADH + H+

L-alanine + H2O + NAD+
-
-
-
-
?
pyruvate + NH3 + NADH + H+
L-alanine + H2O + NAD+
-
-
-
-
?
pyruvate + NH3 + NADH + H+
L-alanine + H2O + NAD+
-
-
-
-
r
pyruvate + NH3 + NADH + H+
L-alanine + H2O + NAD+
-
-
-
-
r
additional information

?
-
-
Aâspecific enzyme with regard to stereochemistry of the hydrogen transfer to NAD+
-
-
?
additional information
?
-
-
the enzyme is required for normal sporulation
-
-
?
additional information
?
-
-
transfer of hydride is a partially limiting step and the reaction rate is limited by the release of product NADH. The fluorine constituent doesn't cause a significant change in the area of bonds that are being converted, and deuteriated solvent present in the reaction medium only slightly affects the conversion of [E-S] complex into [E-P] complex
-
-
?
additional information
?
-
no activity with taurine
-
-
?
additional information
?
-
-
no activity with taurine
-
-
?
additional information
?
-
enzyme is involved in taurine metabolism
-
-
?
additional information
?
-
-
enzyme is involved in taurine metabolism
-
-
?
additional information
?
-
-
circadian oscillations in alanine dehydrogenase
-
-
?
additional information
?
-
-
circadian oscillations in alanine dehydrogenase
-
-
?
additional information
?
-
-
enzyme Ald has both pyruvate and glyoxylate aminating activities
-
-
?
additional information
?
-
-
enzyme Ald has both pyruvate and glyoxylate aminating activities
-
-
?
additional information
?
-
-
strong induction immediately after deflection from aerobic growth suggests that alanine dehydrogenase may be required for the adaption from aerobic growth to anaerobic dormacy, the induction of alanine dehydrogenase may also support the maintenance of the NAD+ pool when oxygen as the terminal electron acceptor becomes limiting
-
-
?
additional information
?
-
the enzyme is induced by carboxylic acids (succinate, malate and pyruvate), although the best induer is alanine. The role of the enzyme may be to balance the alanine level for optimal functioning of bacteroid metabolism rather than to synthesize alanine as the sole product of N2 reduction
-
-
?
additional information
?
-
the enzyme is induced by carboxylic acids (succinate, malate and pyruvate), although the best induer is alanine. The role of the enzyme may be to balance the alanine level for optimal functioning of bacteroid metabolism rather than to synthesize alanine as the sole product of N2 reduction
-
-
?
additional information
?
-
-
important role in biosynthesis of erythromycin
-
-
?
additional information
?
-
-
enzyme activity during production phase of the antibiotic A 6599, enzyme induction by an excess of alanine or ammonia
-
-
?
additional information
?
-
-
substrate specifiicty, overview. The enzyme is also active with substrates DL-alanine, L-serine, L-isoleucine, L-threonine, and glycine, with L-serine giving the highest activity rate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DL-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
-
r
glycine + H2O + NAD+
glyoxylate + NH3 + NADH + H+
-
-
-
-
r
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
L-alanine + NAD+ + H2O
pyruvate + NH3 + NADH + H+
L-isoleucine + H2O + NAD+
2-oxo-3-methylpentanoate + NH3 + NADH + H+
-
-
-
-
r
L-serine + H2O + NAD+
3-hydroxypyruvate + NH3 + NADH + NH3 + NADH + H+
-
-
-
-
r
L-threonine + H2O + NAD+
3-hydroxy-2-oxobutyrate + NH3 + NADH + H+
-
-
-
-
r
pyruvate + NH3 + NADH
L-Ala + NAD+ + H2O
-
primary route for alanine synthesis in isolated bacteroids, alanine synthesis and secretion contributes to the efficiency of N2-fixation and therefore biomass accumulation
-
-
?
pyruvate + NH3 + NADH + H+
L-alanine + H2O + NAD+
additional information
?
-
L-Ala + H2O + NAD+

pyruvate + NH3 + NADH
-
the physiological role is to catabolize L-Ala to pyruvate and NH3, inducible by L-Ala, D-Ala and 11 other D-amino acids. The enzyme catabolizes L-Ala, and thereby limits the amount of L-Ala available to alanine racemase for the synthesis of D-Ala
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
enzyme is involved in primary ammonium assimilation and the rapid formation of key metabolites pyruvate and NH3 from L-Ala and also in cell differentiation
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
NH4+ assimilating enzyme
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
physiological role in nitrogen metabolism in Streptomycetes
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
since the physiological environment of the organism has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-Ala
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
enzyme is required for utilization of alanine as a sole nitrogen source, enzyme is required for optimal growth under anaerobic conditions
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
key enzyme in the metabolism of alanine, Ala is onyl fermented after lactate exhaustion and then at a slow rate
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
role in NH3 assimilation and alanine catabolism
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
role in NH3 assimilation and alanine catabolism
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
no function in NH4+-assimilation but rather is required to supply the cells with the appropriate quantities of organic carbon when the organism grows at the expense of L-Ala as C-source and N-source
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
alternative route for ammonia assimilation when glutamine synthetase is inactivated
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
involved in taurine catabolism
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
enzyme formation is effectively induced by Ala
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
NH4+ assimilating enzyme
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
?
L-Ala + H2O + NAD+
pyruvate + NH3 + NADH
-
-
-
?
L-alanine + H2O + NAD+

pyruvate + NH3 + NADH + H+
-
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
-
-
-
r
L-alanine + NAD+ + H2O

pyruvate + NH3 + NADH + H+
-
-
-
-
r
L-alanine + NAD+ + H2O
pyruvate + NH3 + NADH + H+
-
-
-
-
r
L-alanine + NAD+ + H2O
pyruvate + NH3 + NADH + H+
-
-
-
-
r
pyruvate + NH3 + NADH + H+

L-alanine + H2O + NAD+
-
-
-
-
?
pyruvate + NH3 + NADH + H+
L-alanine + H2O + NAD+
-
-
-
-
?
pyruvate + NH3 + NADH + H+
L-alanine + H2O + NAD+
-
-
-
-
r
pyruvate + NH3 + NADH + H+
L-alanine + H2O + NAD+
-
-
-
-
r
additional information

?
-
-
the enzyme is required for normal sporulation
-
-
?
additional information
?
-
enzyme is involved in taurine metabolism
-
-
?
additional information
?
-
-
enzyme is involved in taurine metabolism
-
-
?
additional information
?
-
-
circadian oscillations in alanine dehydrogenase
-
-
?
additional information
?
-
-
circadian oscillations in alanine dehydrogenase
-
-
?
additional information
?
-
-
enzyme Ald has both pyruvate and glyoxylate aminating activities
-
-
?
additional information
?
-
-
enzyme Ald has both pyruvate and glyoxylate aminating activities
-
-
?
additional information
?
-
-
strong induction immediately after deflection from aerobic growth suggests that alanine dehydrogenase may be required for the adaption from aerobic growth to anaerobic dormacy, the induction of alanine dehydrogenase may also support the maintenance of the NAD+ pool when oxygen as the terminal electron acceptor becomes limiting
-
-
?
additional information
?
-
the enzyme is induced by carboxylic acids (succinate, malate and pyruvate), although the best induer is alanine. The role of the enzyme may be to balance the alanine level for optimal functioning of bacteroid metabolism rather than to synthesize alanine as the sole product of N2 reduction
-
-
?
additional information
?
-
the enzyme is induced by carboxylic acids (succinate, malate and pyruvate), although the best induer is alanine. The role of the enzyme may be to balance the alanine level for optimal functioning of bacteroid metabolism rather than to synthesize alanine as the sole product of N2 reduction
-
-
?
additional information
?
-
-
important role in biosynthesis of erythromycin
-
-
?
additional information
?
-
-
enzyme activity during production phase of the antibiotic A 6599, enzyme induction by an excess of alanine or ammonia
-
-
?
additional information
?
-
-
substrate specifiicty, overview. The enzyme is also active with substrates DL-alanine, L-serine, L-isoleucine, L-threonine, and glycine, with L-serine giving the highest activity rate
-
-
?
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1-(isonicotinamido)-N2,N4-bis(benzo[d]thiazol-2-yl)azetidine-2,4-dicarboxamide
compound shows 100fold reduction in nutrient starved dormant Mycobacterium tuberculosis model and MIC of 11.81 microM in actively replicative Mycobacterium tuberculosis
1-(isonicotinamido)-N2,N4-bis(phenyl)azetidine-2,4-dicarboxamide
lead compound for inhibitor screening, involved in hydrophobic interactions with residues Pro242, Val241, Ala176, Leu130, Ile267, Ala179, Ile199 and Ile174
2,4,6-Trinitrobenzenesulfonic acid
-
inactivation follows pseudo first-order kinetics with a 1:1 stoichiometric ratio between the reagent and the enzyme subunit. Partial protection by each of the substrates, NADH or pyruvate. Complete protection only in presence of the ternary complex enzyme-NADH-pyruvate
3-(2-pyridyldithio)propionate
-
inactivation follows pseudo first-order kinetics with a 1:1 stoichiometric ratio between the reagent and the enzyme subunit. Partial protection by each of the substrates, NADH or pyruvate. Complete protection only in presence of the ternary complex enzyme-NADH-pyruvate
3-hydroxypyruvate
-
competitive with respect to pyruvate
5'-(p-(fluorosulfonyl)-benzoyl)adenosine
-
inactivation follows pseudo-first-order kinetics, complete inactivation of the enzyme can not be obtained even at high reagent concentration
5,5'-dithiobis(2-nitrobenzoate)
-
-
5-(4-(benzyloxy)benzylidene)-3-(2,5-dimethylphenyl)-2-iminothiazolidin-4-one
compound shows potency, selectivity, and no cytotoxicity up to 50 microM in a mouse macrophage cell line
5-(4-(benzyloxy)benzylidene)-3-(2,6-dimethylphenyl)-2-iminothiazolidin-4-one
compound shows potency, selectivity, and no cytotoxicity up to 50 microM in a mouse macrophage cell line
6-acetyl-2-(4-chlorobenzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
compound shows potency, selectivity, and no cytotoxicity up to 50 microM in a mouse macrophage cell line
AgNO3
-
0.1 mM, 57% inhibition
Cibacron blue F3GA
0.1 mM, 70% inhibition
DTNB
7% inhibition with 0.01 M and 40% inhibition with 0.1 mM
Fe3+
-
10 mM, 85% inhibition of reductive amination
L-Phe
-
reductive amination of pyruvate, 10 mM, 28% inhibition
L-Trp
-
reductive amination of pyruvate, 10 mM, 29% inhibition
methyl p-nitrobenzenesulfonate
0.1 mM, complete inhibition
Mn2+
-
10 mM, 60% inhibition of reductive amination
MnSO4
-
10 mM, 50% inhibition
NADPH
-
inhibition of reductive amination
Ni2+
-
10 mM, 60% inhibition of reductive amination
p-hydroxymercuribenzoate
-
no effect on aminating activity, inhibition of deaminating activity
pyridoxal 5'-phosphate
-
-
tert-butyl 3-carbamoyl-2-(4-chlorobenzamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
compound shows potency, selectivity, and no cytotoxicity up to 50 microM in a mouse macrophage cell line
CaCl2

-
10 mM, 22% inhibition
CaCl2
1 mM, 15% inhibition
Cd2+

-
10 mM, 36% inhibition of reductive amination
Cibacron blue

-
-
Co2+

-
10 mM, 60% inhibition of reductive amination
Co2+
-
17% inhibition at 10 mM, 23.75% at 20 mM
CoCl2

-
0.1 mM, 53% inhibition
Cu2+

-
10 mM, 60% inhibition of reductive amination
CuCl2

-
1 mM, 52% inhibition
CuSO4

-
10 mM, 36% inhibition
CuSO4
-
50.7% inhibition by 1 mM, 96.3% inhibition by 20 mM, EDTA in a 10fold molar excess restores activity almost completely, recombinant enzyme
D-Ala

-
-
D-Ala
-
aminating reaction, competitive with respect to NADH, noncompetitive with respect to NH4+ and pyruvate
D-Cys

-
-
Fe2+

-
10 mM, 85% inhibition of reductive amination
glycine

-
-
Hg2+

-
-
HgCl2

-
0.003 mM, complete inhibition
HgCl2
-
1 mM, 38% inhibition
HgCl2
1 mM, complete inhibition
Hydroxypyruvate

-
-
iodoacetate

-
-
iodoacetate
-
23.75% inhibition at 10 mM
L-Ala

-
-
L-Ala
-
reductive amination of pyruvate
L-Ala
-
uncompetitive inhibition with respect to NADH
L-Ala
-
substrate inhibition
L-Ala
-
5 mM, 34% inhibition
L-Ala
-
reductive amination of pyruvate
L-Cys

-
-
L-Cys
10 mM, 40% inhibition
L-Ser

-
-
L-Ser
-
inhibition of aminating activity
L-Ser
-
inhibition of aminating activity
L-Ser
-
reductive amination of pyruvate
L-Ser
-
10 mM, 26% inhibition; inhibition of aminating activity
L-Ser
-
inhibition of aminating activity
L-Thr

-
inhibition of aminating activity
L-Thr
-
reductive amination of pyruvate, 10 mM, 37% inhibition
Mercurials

-
-
-
MgCl2

-
inhibitory at a concentration above 2.13 mM
MnCl2

-
10 mM, 12% inhibition
MnCl2
1 mM, 10% inhibition
NAD+

-
product inhibition
NAD+
-
0.1 mM, 35% inhibition
NADH

-
-
NADH
-
product inhibition
NADH
-
product inhibition
NH4+

-
-
NH4+
-
product inhibition
NH4+
-
inhibition of aminating activity
Pb2+

-
-
PCMB

-
-
PCMB
-
0.3 mM, 52% inhibition
PCMB
0.1 mM, 97% inhibition
pyruvate

-
-
pyruvate
-
product inhibition
pyruvate
-
substrate inhibition
pyruvate
-
inhibition at pH 7.5 greater than at pH 9.5; product inhibition
pyruvate
-
substrate inhibition
pyruvate
-
product inhibition
Zn2+

-
-
Zn2+
-
10 mM, 62% inhibition
Zn2+
-
allosteric competitive inhibitor, reversible, inducing conformational change through the intersubunit interaction, positive cooperative binding of the substrate in presence of Zn2+
Zn2+
-
26.5% inhibition by 1 mM ZnCl2, 90.1% inhibition by 20 mM ZnCl2, EDTA in a 10fold molar excess restores activity almost completely, recombinant enzyme
Zn2+
-
57% inhibition at 10 mM, 72.75% at 20 mM
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