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IUBMB Comments The enzyme from the bacterium Mycobacterium tuberculosis reduces the beta-isoprene unit of menaquinone-9, forming the predominant form of menaquinone found in mycobacteria. Contains FAD.
The enzyme appears in viruses and cellular organisms
Synonyms
MenJ , MSMEG1132, Rv0561c,
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MenJ
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MSMEG1132
locus name
Rv0561c
locus name
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menaquinone-9 + reduced acceptor = beta-dihydromenaquinone-9 + acceptor
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redox reaction
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menaquinone-9 oxidoreductase (beta-dihydromenaquinone-9-forming)
The enzyme from the bacterium Mycobacterium tuberculosis reduces the beta-isoprene unit of menaquinone-9, forming the predominant form of menaquinone found in mycobacteria. Contains FAD.
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menaquinone-9 + reduced acceptor
beta-dihydromenaquinone-9 + acceptor
menaquinone-9 + reduced acceptor
beta-dihydromenaquinone-9 + acceptor
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beta dihaydromenaquinone-9 i.e. menaquinone with 9 isoprene units in the side chain, with the one in the second (beta) position saturated
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menaquinone-9 + reduced acceptor
beta-dihydromenaquinone-9 + acceptor
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beta dihaydromenaquinone-9 i.e. menaquinone with 9 isoprene units in the side chain, with the one in the second (beta) position saturated
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?
menaquinone-9 + reduced acceptor
beta-dihydromenaquinone-9 + acceptor
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beta dihaydromenaquinone-9 i.e. menaquinone with 9 isoprene units in the side chain, with the one in the second (beta) position saturated
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?
menaquinone-9 + reduced acceptor
beta-dihydromenaquinone-9 + acceptor
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beta dihaydromenaquinone-9 i.e. menaquinone with 9 isoprene units in the side chain, with the one in the second (beta) position saturated
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FAD
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Tuberculosis
Partial Saturation of Menaquinone in Mycobacterium tuberculosis: Function and Essentiality of a Novel Reductase, MenJ.
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SwissProt
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SwissProt
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SwissProt
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SwissProt
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MENJ_MYCS2
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
409
0
43404
Swiss-Prot
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MENJ_MYCTO
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
408
0
43870
Swiss-Prot
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MENJ_MYCTU
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
408
0
43870
Swiss-Prot
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A0A6I1Z0Z3_9ACTN
430
0
47006
TrEMBL
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A0A5D3ICJ9_MOOTH
378
0
41250
TrEMBL
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A0A5S9PAG7_9GAMM
408
0
45120
TrEMBL
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A0A5P9Q840_9MICO
442
0
46107
TrEMBL
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A0A5S9Q0K0_MYCVN
416
0
44078
TrEMBL
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A0A5E6URH8_PSEFL
347
0
38519
TrEMBL
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A0A5S9NMP8_9GAMM
408
0
45133
TrEMBL
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A0A6I5ZTD3_9THEO
290
0
30891
TrEMBL
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A0A653Q4R5_9ACTN
417
0
45077
TrEMBL
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A0A7K0CXU5_9NOCA
424
0
45394
TrEMBL
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A0A5E7BSW9_PSEFL
347
0
38477
TrEMBL
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A0A7K0BXX5_9ACTN
418
0
45903
TrEMBL
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A0A653WFE3_9ACTN
415
0
44426
TrEMBL
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A0A6N7CYJ9_9NOCA
420
0
44195
TrEMBL
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A0A5S9R2V3_MYCVN
394
0
42892
TrEMBL
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A0A7K0DWV3_9NOCA
425
0
45326
TrEMBL
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A0A7K0CIZ1_9ACTN
425
0
46320
TrEMBL
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A0A7J5WWL2_9ACTN
424
0
44338
TrEMBL
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J774A
the mutant is capable of infecting host cell but incapable of surviving in the macrophage
J774A
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the mutant is capable of infecting host cell but incapable of surviving in the macrophage
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expressed in Escherichia coli BL21
expressed in Escherichia coli BL21
expressed in Escherichia coli BL21
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pharmacology
menaquinone synthesis may be a drug target in Mycobacteria
pharmacology
menaquinone synthesis may be a drug target in Mycobacterium tuberculosis
pharmacology
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menaquinone synthesis may be a drug target in Mycobacteria
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pharmacology
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menaquinone synthesis may be a drug target in Mycobacterium tuberculosis
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Upadhyay, A.; Fontes, F.L.; Gonzalez-Juarrero, M.; McNeil, M.R.; Crans, D.C.; Jackson, M.; Crick, D.C.
Partial saturation of menaquinone in Mycobacterium tuberculosis: function and essentiality of a novel reductase, MenJ
ACS Cent. Sci.
1
292-302
2015
Mycobacterium tuberculosis (P9WNY9), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNY9), Mycolicibacterium smegmatis (A0QRI8), Mycolicibacterium smegmatis ATCC 700084 (A0QRI8)
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