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Information on EC 1.3.99.22 - coproporphyrinogen dehydrogenase

for references in articles please use BRENDA:EC1.3.99.22

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transferred to EC 1.3.98.3
IUBMB Comments

This enzyme differs from EC 1.3.3.3, coproporphyrinogen oxidase, by using S-adenosyl-L-methionine (AdoMet) instead of oxygen as oxidant. It occurs mainly in bacteria, whereas eukaryotes use the oxygen-dependent oxidase. The reaction starts by using an electron from the reduced form of the enzyme’s [4Fe-4S] cluster to split AdoMet into methionine and the radical 5′-deoxyadenosin-5′-yl. This radical initiates attack on the 2-carboxyethyl groups, leading to their conversion into vinyl groups. This conversion, —·CH-CH2-COO- → —CH=CH2 + CO2 + e- replaces the electron initially used.

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