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IUBMB Comments A molybdenum—iron—sulfur flavoprotein with molybdopterin cytosine dinucleotide as the molybdenum cofactor. Quinoline, 4-methylquinoline and 4-chloroquinoline can also serve as substrates for the enzyme from Agrobacterium sp. 1B. Iodonitrotetrazolium chloride, thionine, menadione and 2,6-dichlorophenolindophenol can act as electron acceptors.
Synonyms
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2-Carboxyquinoline 4-monooxygenase
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Oxygenase, 2-quinolinecarboxylate 4-mono
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Quinaldate 4-monooxygenase
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Quinaldic acid 4-monooxygenase
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Quinaldic acid 4-oxidoreductase
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Quinoline-4-carboxylic acid oxidoreductase
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quinoline-4-carboxylate + acceptor + H2O = 2-oxo-1,2-dihydroquinoline-4-carboxylate + reduced acceptor
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quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)
A molybdenum---iron---sulfur flavoprotein with molybdopterin cytosine dinucleotide as the molybdenum cofactor. Quinoline, 4-methylquinoline and 4-chloroquinoline can also serve as substrates for the enzyme from Agrobacterium sp. 1B. Iodonitrotetrazolium chloride, thionine, menadione and 2,6-dichlorophenolindophenol can act as electron acceptors.
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4-chloroquinoline + acceptor
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4-methylquinoline + acceptor
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quinoline-4-carboxylate + 2-(4-iodophenyl)-3-nitrophenyl-5-phenyltetrazolium chloride + H2O
2-oxo-1,2-dihydroquinoline-4-carboxylate + reduced 2-(4-iodophenyl)-3-nitrophenyl-5-phenyltetrazolium chloride
quinoline-4-carboxylate + acceptor
2-oxo-1,2-dihydroquinoline-4-carboxylic acid + reduced acceptor
4-chloroquinoline + acceptor
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Substrates: with 4% of the activity relative to quinoline-4-carboxylate
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4-chloroquinoline + acceptor
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Substrates: with 4% of the activity relative to quinoline-4-carboxylate
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4-methylquinoline + acceptor
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Substrates: with 24% of the activity relative to quinoline-4-carboxylate
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4-methylquinoline + acceptor
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Substrates: with 24% of the activity relative to quinoline-4-carboxylate
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quinoline + acceptor
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Substrates: with 34% of the activity relative to quinoline-4-carboxylate
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quinoline + acceptor
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Substrates: with 34% of the activity relative to quinoline-4-carboxylate
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quinoline-4-carboxylate + 2-(4-iodophenyl)-3-nitrophenyl-5-phenyltetrazolium chloride + H2O
2-oxo-1,2-dihydroquinoline-4-carboxylate + reduced 2-(4-iodophenyl)-3-nitrophenyl-5-phenyltetrazolium chloride
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Substrates: -
r
quinoline-4-carboxylate + 2-(4-iodophenyl)-3-nitrophenyl-5-phenyltetrazolium chloride + H2O
2-oxo-1,2-dihydroquinoline-4-carboxylate + reduced 2-(4-iodophenyl)-3-nitrophenyl-5-phenyltetrazolium chloride
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Substrates: -
r
quinoline-4-carboxylate + acceptor
2-oxo-1,2-dihydroquinoline-4-carboxylic acid + reduced acceptor
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Substrates: acceptors: 2-(4-iodophenyl)-3-nitrophenyl-5-phenyltetrazolium chloride, thionin, menadione, benzoquinone, 2,6-dichlorophenol-indophenol
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quinoline-4-carboxylate + acceptor
2-oxo-1,2-dihydroquinoline-4-carboxylic acid + reduced acceptor
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Substrates: acceptors: 2-(4-iodophenyl)-3-nitrophenyl-5-phenyltetrazolium chloride, thionin, menadione, benzoquinone, 2,6-dichlorophenol-indophenol
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FAD
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enzyme contains 1.7 mol of FAD per mol of enzyme
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Iron
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enzyme contains 8.3 g-atoms of iron and 7.2 mol of acid-labile sulfur per mol of enzyme
Molybdenum
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enzyme contains 2.1 mol of molybdenum per mol of enzyme
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4-chloromercuribenzoate
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molybdopterin cytosine dinucleotide
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cofactor
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0.00008
2-(4-iodophenyl)-3-nitrophenyl-5-phenyltetrazolium chloride
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with quinoline-4-carboxylate as cosubstrate
0.0093
Quinoline-4-carboxylate
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with 2-(4-iodophenyl)-3-nitrophenyl-5-phenyltetrazolium chloride as cosubstrate
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1B
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brenda
1B
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brenda
Highest Expressing Human Cell Lines
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21000
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or hexamer, 1 * or 2 * 21000 + 1 * or 2 * 35000 + 1 * or 2 * 85000, SDS-PAGE
35000
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or hexamer, 1 * or 2 * 21000 + 1 * or 2 * 35000 + 1 * or 2 * 85000, SDS-PAGE
85000
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or hexamer, 1 * or 2 * 21000 + 1 * or 2 * 35000 + 1 * or 2 * 85000, SDS-PAGE
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trimer
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or hexamer, 1 * or 2 * 21000 + 1 * or 2 * 35000 + 1 * or 2 * 85000, SDS-PAGE
trimer
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or hexamer, 1 * or 2 * 21000 + 1 * or 2 * 35000 + 1 * or 2 * 85000, SDS-PAGE
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Bauer, G.; Lingens, F.
Microbial metabolism of quinoline and related compounds. XV. Quinoline-4-carboxylic acid oxidoreductase from Agrobacterium spec. 1B: a molybdenum-containing enzyme
Biol. Chem. Hoppe-Seyler
373
699-705
1992
Agrobacterium sp., Agrobacterium sp. 1B
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