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Information on EC 1.3.98.1 - dihydroorotate dehydrogenase (fumarate)

for references in articles please use BRENDA:EC1.3.98.1
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IUBMB Comments
Binds FMN. The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. Molecular oxygen can replace fumarate in vitro. Other class 1 dihydroorotate dehydrogenases use either NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
dhodh, dhodehase, dhoda, tcdhod, (dho) dehydrogenase, class 1a dhod, lmdhodh, class 1a dhodh, dhod1, dhod2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-dihydroorotate + fumarate = orotate + succinate
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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