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Information on EC 1.3.1.94 - polyprenol reductase

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EC Tree
     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.94 polyprenol reductase
IUBMB Comments
The reaction occurs in the reverse direction with reduction of the terminal double bond next to the alcohol group. Isolated from human fetal brain tissue but present in all eukaryotes. In mammalian cells dolichols are predominantly 18-21 isoprene units in length.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
srd5a3, steroid 5alpha-reductase type 3, dfg10, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH + H+
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