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precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
sirohydrochlorin + Fe2+
siroheme + H+
-
-
-
?
additional information
?
-
-
large multifunctional protein that catalyzes four diverse reactions, 2 S-adensyl-L-methionine-dependent methylations, NAD+-dependent tetrapyrrole dehydrogenation and metal chelation
-
?
precorrin-2 + NAD+

sirohydrochlorin + NADH + H+
-
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
multifunctional protein involved in S-adenosyl-L-methionine-dependent methylation, pyridine dinucleotide dependent dehydrogenation, and ferrochelation, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
multifunctional protein involved in S-adenosyl-L-methionine-dependent methylation, pyridine dinucleotide dependent dehydrogenation, and ferrochelation, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
unlike Met8p and CysG, SirC has no chelatase activity
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
siroheme and cobalamin biosynthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
unlike Met8p and CysG, SirC has no chelatase activity
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
siroheme and cobalamin biosynthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
bifunctional dehydrogenase and ferrochelatase, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
siroheme and cobalamin biosynthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
tetrapyrrole and cobalamin biosynthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
precorrin-2 is the precursor of both siroheme and B12, first reaction specific to B12 synthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
sirohydrochlorin + Fe2+
siroheme + H+
-
-
-
?
precorrin-2 + NAD+

sirohydrochlorin + NADH + H+
-
multifunctional protein involved in S-adenosyl-L-methionine-dependent methylation, pyridine dinucleotide dependent dehydrogenation, and ferrochelation, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
multifunctional protein involved in S-adenosyl-L-methionine-dependent methylation, pyridine dinucleotide dependent dehydrogenation, and ferrochelation, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
siroheme and cobalamin biosynthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
siroheme and cobalamin biosynthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
bifunctional dehydrogenase and ferrochelatase, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
siroheme and cobalamin biosynthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
tetrapyrrole and cobalamin biosynthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
precorrin-2 is the precursor of both siroheme and B12, first reaction specific to B12 synthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
?
precorrin-2 + NAD+
sirohydrochlorin + NADH + H+
-
-
-
?
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CYSG_EDWI9
Edwardsiella ictaluri (strain 93-146)
461
0
49998
Swiss-Prot
-
CYSG_ENT38
Enterobacter sp. (strain 638)
457
0
50458
Swiss-Prot
-
CYSG_ESCF3
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)
457
0
50041
Swiss-Prot
-
CYSG_GLUDA
Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5)
470
0
50124
Swiss-Prot
-
CYSG_GLUOX
Gluconobacter oxydans (strain 621H)
473
0
51101
Swiss-Prot
-
CYSG_HAHCH
Hahella chejuensis (strain KCTC 2396)
469
0
51442
Swiss-Prot
-
CYSG_HYDCU
Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2)
473
0
51899
Swiss-Prot
-
CYSG_MANSM
Mannheimia succiniciproducens (strain MBEL55E)
476
0
52268
Swiss-Prot
-
CYSG_METCA
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
474
0
50893
Swiss-Prot
-
CYSG_METFK
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
467
0
50652
Swiss-Prot
-
CYSG_NEIM0
Neisseria meningitidis serogroup C (strain 053442)
480
0
51867
Swiss-Prot
-
CYSG_NEIMA
Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)
486
0
52484
Swiss-Prot
-
CYSG_NEIMB
Neisseria meningitidis serogroup B (strain MC58)
483
0
52111
Swiss-Prot
-
CYSG_NEIMF
Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
483
0
52308
Swiss-Prot
-
CYSG_NITEC
Nitrosomonas eutropha (strain DSM 101675 / C91 / Nm57)
476
0
52002
Swiss-Prot
-
CYSG_NITEU
Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
475
0
52234
Swiss-Prot
-
CYSG_NITMU
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
472
0
51911
Swiss-Prot
-
CYSG_NITOC
Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)
468
0
51081
Swiss-Prot
-
CYSG_PHOLL
Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
470
0
51343
Swiss-Prot
-
CYSG_PHOPR
Photobacterium profundum (strain SS9)
469
0
51363
Swiss-Prot
-
CYSG3_AERHH
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)
468
0
49807
Swiss-Prot
-
CYSG_ACIAD
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
457
0
50431
Swiss-Prot
-
CYSG_ACTP7
Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
486
0
53272
Swiss-Prot
-
CYSG_ACTPJ
Actinobacillus pleuropneumoniae serotype 3 (strain JL03)
486
0
53152
Swiss-Prot
-
CYSG_ACTSZ
Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z)
476
0
52367
Swiss-Prot
-
CYSG_ALCBS
Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)
461
0
49741
Swiss-Prot
-
CYSG_ALKEH
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
481
0
52927
Swiss-Prot
-
CYSG_AZOVD
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
464
0
50227
Swiss-Prot
-
CYSG_BAUCH
Baumannia cicadellinicola subsp. Homalodisca coagulata
462
0
51049
Swiss-Prot
-
CYSG_BLOFL
461
0
51478
Swiss-Prot
-
CYSG_BLOPB
Blochmannia pennsylvanicus (strain BPEN)
474
0
52601
Swiss-Prot
-
CYSG_BORA1
Bordetella avium (strain 197N)
461
0
49690
Swiss-Prot
-
CYSG_BORBR
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
473
0
50648
Swiss-Prot
-
CYSG_BORPA
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
473
0
50648
Swiss-Prot
-
CYSG_BORPD
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
474
0
51002
Swiss-Prot
-
CYSG_BORPE
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
473
0
50524
Swiss-Prot
-
CYSG_BUCAI
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
473
0
52874
Swiss-Prot
-
CYSG_CHRVO
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
470
0
50153
Swiss-Prot
-
CYSG_CITK8
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
457
0
49822
Swiss-Prot
-
CYSG_ECO24
Escherichia coli O139:H28 (strain E24377A / ETEC)
457
0
49981
Swiss-Prot
-
PC2DH_METBF
Methanosarcina barkeri (strain Fusaro / DSM 804)
224
0
24736
Swiss-Prot
-
PC2DH_METJA
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
206
0
23989
Swiss-Prot
-
CYSG1_AERHH
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)
463
0
50392
Swiss-Prot
-
CYSG1_AERS4
Aeromonas salmonicida (strain A449)
468
0
49834
Swiss-Prot
-
CYSG1_CROS8
Cronobacter sakazakii (strain ATCC BAA-894)
471
0
50673
Swiss-Prot
-
CYSG1_HALHL
Halorhodospira halophila (strain DSM 244 / SL1)
484
0
52541
Swiss-Prot
-
HEMA_RUMJO
515
0
58368
Swiss-Prot
-
MET8_SCHPO
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
264
0
29444
Swiss-Prot
other Location (Reliability: 4)
MET8_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
274
0
31918
Swiss-Prot
other Location (Reliability: 2)
SIRC_BACSU
Bacillus subtilis (strain 168)
162
0
18004
Swiss-Prot
-
SIRC_PRIMG
202
0
22970
Swiss-Prot
-
CYSG_SHIBS
Shigella boydii serotype 4 (strain Sb227)
457
0
50041
Swiss-Prot
-
CYSG_SHIDS
Shigella dysenteriae serotype 1 (strain Sd197)
457
0
50008
Swiss-Prot
-
CYSG_SHIF8
Shigella flexneri serotype 5b (strain 8401)
457
0
50011
Swiss-Prot
-
CYSG_SHIFL
457
0
50011
Swiss-Prot
-
CYSG_SHISS
Shigella sonnei (strain Ss046)
457
0
50011
Swiss-Prot
-
CYSG_SODGM
Sodalis glossinidius (strain morsitans)
471
0
50590
Swiss-Prot
-
CYSG_THIDA
Thiobacillus denitrificans (strain ATCC 25259)
479
0
51742
Swiss-Prot
-
CYSG_THISH
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
489
0
53653
Swiss-Prot
-
CYSG_TOLAT
Tolumonas auensis (strain DSM 9187 / TA4)
468
0
50336
Swiss-Prot
-
CYSG_VESOH
Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
466
0
51511
Swiss-Prot
-
CYSG_XYLF2
Xylella fastidiosa (strain M23)
478
0
51958
Swiss-Prot
-
CYSG_XYLFA
Xylella fastidiosa (strain 9a5c)
476
0
51598
Swiss-Prot
-
CYSG_XYLFM
Xylella fastidiosa (strain M12)
476
0
51691
Swiss-Prot
-
CYSG_XYLFT
478
0
51958
Swiss-Prot
-
CYSG_YERPA
Yersinia pestis bv. Antiqua (strain Antiqua)
470
0
51664
Swiss-Prot
-
CYSG_YERPE
470
0
51664
Swiss-Prot
-
CYSG_ZYMMO
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
471
0
51585
Swiss-Prot
-
CYSG_ECO27
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
457
0
49977
Swiss-Prot
-
CYSG_ECO45
Escherichia coli O45:K1 (strain S88 / ExPEC)
457
0
50007
Swiss-Prot
-
CYSG_ECO55
Escherichia coli (strain 55989 / EAEC)
457
0
49951
Swiss-Prot
-
CYSG_ECO57
457
0
49951
Swiss-Prot
-
CYSG_ECO5E
Escherichia coli O157:H7 (strain EC4115 / EHEC)
457
0
49932
Swiss-Prot
-
CYSG_ECO7I
Escherichia coli O7:K1 (strain IAI39 / ExPEC)
457
0
49967
Swiss-Prot
-
CYSG_ECO81
Escherichia coli O81 (strain ED1a)
457
0
49991
Swiss-Prot
-
CYSG_ECO8A
Escherichia coli O8 (strain IAI1)
457
0
49981
Swiss-Prot
-
CYSG_ECOBW
Escherichia coli (strain K12 / MC4100 / BW2952)
457
0
49951
Swiss-Prot
-
CYSG_ECODH
Escherichia coli (strain K12 / DH10B)
457
0
49951
Swiss-Prot
-
CYSG_ECOHS
Escherichia coli O9:H4 (strain HS)
457
0
49951
Swiss-Prot
-
CYSG_ECOK1
457
0
50007
Swiss-Prot
-
CYSG_ECOL5
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
457
0
49993
Swiss-Prot
-
CYSG_ECOL6
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
457
0
49977
Swiss-Prot
-
CYSG_ECOLC
Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)
457
0
49951
Swiss-Prot
-
CYSG_ECOLI
Escherichia coli (strain K12)
457
0
49951
Swiss-Prot
-
CYSG_ECOLU
Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
457
0
49932
Swiss-Prot
-
CYSG_ECOSE
Escherichia coli (strain SE11)
457
0
49981
Swiss-Prot
-
CYSG_ECOSM
Escherichia coli (strain SMS-3-5 / SECEC)
457
0
49951
Swiss-Prot
-
CYSG_ECOUT
Escherichia coli (strain UTI89 / UPEC)
457
0
50007
Swiss-Prot
-
CYSG_PSYIN
Psychromonas ingrahamii (strain 37)
472
0
51193
Swiss-Prot
-
CYSG_PSYWF
Psychrobacter sp. (strain PRwf-1)
487
0
52938
Swiss-Prot
-
CYSG_RUTMC
Ruthia magnifica subsp. Calyptogena magnifica
472
0
52011
Swiss-Prot
-
CYSG_SACD2
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
458
0
50119
Swiss-Prot
-
CYSG_SALA4
Salmonella agona (strain SL483)
459
0
50437
Swiss-Prot
-
CYSG_SALAR
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
457
0
49970
Swiss-Prot
-
CYSG_SALCH
Salmonella choleraesuis (strain SC-B67)
457
0
50159
Swiss-Prot
-
CYSG_SALDC
Salmonella dublin (strain CT_02021853)
457
0
50158
Swiss-Prot
-
CYSG_SALEP
Salmonella enteritidis PT4 (strain P125109)
457
0
50159
Swiss-Prot
-
CYSG_SALG2
Salmonella gallinarum (strain 287/91 / NCTC 13346)
457
0
50177
Swiss-Prot
-
CYSG_SALHS
Salmonella heidelberg (strain SL476)
457
0
50173
Swiss-Prot
-
CYSG_SALNS
Salmonella newport (strain SL254)
457
0
50133
Swiss-Prot
-
CYSG_SALPA
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
457
0
50160
Swiss-Prot
-
CYSG_SALPB
457
0
50159
Swiss-Prot
-
CYSG_SALPC
Salmonella paratyphi C (strain RKS4594)
457
0
50159
Swiss-Prot
-
CYSG_SALPK
Salmonella paratyphi A (strain AKU_12601)
457
0
50160
Swiss-Prot
-
CYSG_SALSV
Salmonella schwarzengrund (strain CVM19633)
457
0
50114
Swiss-Prot
-
CYSG_SALTI
457
0
50170
Swiss-Prot
-
CYSG_SALTY
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
457
0
50147
Swiss-Prot
-
CYSG_SHIB3
Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
457
0
50041
Swiss-Prot
-
CYSG1_KLEP7
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
471
0
50986
Swiss-Prot
-
CYSG1_PECAS
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
480
0
51737
Swiss-Prot
-
CYSG1_SERP5
Serratia proteamaculans (strain 568)
476
0
51267
Swiss-Prot
-
CYSG1_YERE8
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
472
0
50883
Swiss-Prot
-
CYSG1_YERP3
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
472
0
50901
Swiss-Prot
-
CYSG1_YERPN
Yersinia pestis bv. Antiqua (strain Nepal516)
472
0
50904
Swiss-Prot
-
CYSG1_YERPP
Yersinia pestis (strain Pestoides F)
473
0
51946
Swiss-Prot
-
CYSG1_YERPS
Yersinia pseudotuberculosis serotype I (strain IP32953)
472
0
50874
Swiss-Prot
-
CYSG2_AERHH
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)
470
0
50861
Swiss-Prot
-
CYSG2_AERS4
Aeromonas salmonicida (strain A449)
480
0
51976
Swiss-Prot
-
CYSG2_CROS8
Cronobacter sakazakii (strain ATCC BAA-894)
457
0
50052
Swiss-Prot
-
CYSG2_HALHL
Halorhodospira halophila (strain DSM 244 / SL1)
495
0
53848
Swiss-Prot
-
CYSG2_KLEP7
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
457
0
49979
Swiss-Prot
-