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Information on EC 1.3.1.74 - 2-alkenal reductase [NAD(P)+]

for references in articles please use BRENDA:EC1.3.1.74
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IUBMB Comments
Highly specific for 4-hydroxynon-2-enal and non-2-enal. Alk-2-enals of shorter chain have lower affinities. Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one. Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid. Involved in the detoxication of alpha,beta-unsaturated aldehydes and ketones [cf. EC 1.3.1.102, 2-alkenal reductase (NADP+)].
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The enzyme appears in viruses and cellular organisms
Synonyms
2-alkenal reductase, 2AER, AER, alkenal/one oxidoreductase, alkenal/one reductase, AOR, At-AER, At5g16970, AtAOR, bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a n-alkanal + NAD(P)+ = an alk-2-enal + NAD(P)H + H+
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