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ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosta-5,7,22-trien-3beta-ol + NADP+
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosterol + NADP+
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH
ergosterol + NADP+
ergosta-5,7,22-trien-3beta-ol + NADP+
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
additional information
?
-
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+

ergosta-5,7,22-trien-3beta-ol + NADP+
-
-
-
?
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosta-5,7,22-trien-3beta-ol + NADP+
-
-
-
?
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosta-5,7,22-trien-3beta-ol + NADP+
-
-
-
?
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosta-5,7,22-trien-3beta-ol + NADP+
-
-
-
-
?
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosta-5,7,22-trien-3beta-ol + NADP+
-
-
trivial name ergosterol
?
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosta-5,7,22-trien-3beta-ol + NADP+
-
-
-
-
?
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+

ergosterol + NADP+
-
-
-
?
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosterol + NADP+
-
-
-
?
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH

ergosterol + NADP+
-
-
-
-
?
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH
ergosterol + NADP+
-
step in the biosynthesis of ergosta-5,22-dien-3bta-ol, i.e. brassicasterol, the major sterol compound in Paracoccidioides brasiliensis
-
-
?
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH
ergosterol + NADP+
-
preferred substrate
-
-
?
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH
ergosterol + NADP+
-
terminal step in ergosterol biosynthesis, pathway overview, presursor analysis
-
-
?
ergosta-5,7,22-trien-3beta-ol + NADP+

ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
-
-
-
?
ergosta-5,7,22-trien-3beta-ol + NADP+
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
-
-
-
?
ergosta-5,7,22-trien-3beta-ol + NADP+
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
-
-
-
?
ergosta-5,7,22-trien-3beta-ol + NADP+
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
-
trivial name ergosterol
-
?
additional information

?
-
-
enzyme-deficient mutants accumulate ergosta-5,7,22,24(24 1)-tetraen-3beta-ol, ergosta-5,7,24(28)-trien-3beta-ol, ergosta-7,24(28)-dien-3beta-ol, stigmasta-5,7,22,24(28)-tetraenol, stigmasta-5,7,24(28)-trienol, stigmasta-8,24(28)-dienol, and stigmasta-7,24(28)-dienol, while ergosterol and 7-dehydroporiferasterol are absent, in contrary to the wild-type strain, overview
-
-
-
additional information
?
-
-
enzyme-deficient mutants accumulate ergosta-5,7,22,24(24 1)-tetraen-3beta-ol, ergosta-5,7,24(28)-trien-3beta-ol, ergosta-7,24(28)-dien-3beta-ol, stigmasta-5,7,22,24(28)-tetraenol, stigmasta-5,7,24(28)-trienol, stigmasta-8,24(28)-dienol, and stigmasta-7,24(28)-dienol, while ergosterol and 7-dehydroporiferasterol are absent, in contrary to the wild-type strain, overview
-
-
-
additional information
?
-
-
sterol composition with or without addition of azasterol analogue inhibitors, overview
-
-
-
additional information
?
-
the enzyme transfers either one or two methyl groups to the C-24 position of the sterol side chain producing both C28 and C29 24-alkylsterols in approximately the same proportions whereas most fungal SAM:SMT transfer only one methyl group to the side chain
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-
-
additional information
?
-
the enzyme transfers either one or two methyl groups to the C-24 position of the sterol side chain producing both C28 and C29 24-alkylsterols in approximately the same proportions whereas most fungal SAM:SMT transfer only one methyl group to the side chain
-
-
-
additional information
?
-
-
ergosta-7,22,24(28)-trien-3beta-ol, episterol, and fecosterol are poor substrates, 24,25-dihydro-24-methylene lanosterol is no substrate
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosta-5,7,22-trien-3beta-ol + NADP+
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosterol + NADP+
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH
ergosterol + NADP+
additional information
?
-
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+

ergosta-5,7,22-trien-3beta-ol + NADP+
-
-
-
?
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosta-5,7,22-trien-3beta-ol + NADP+
-
-
-
?
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosta-5,7,22-trien-3beta-ol + NADP+
-
-
-
?
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosta-5,7,22-trien-3beta-ol + NADP+
-
-
trivial name ergosterol
?
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+

ergosterol + NADP+
A0A0W4ZCX9
-
-
-
?
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
ergosterol + NADP+
A0A0W4ZCX9
-
-
-
?
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH

ergosterol + NADP+
-
step in the biosynthesis of ergosta-5,22-dien-3bta-ol, i.e. brassicasterol, the major sterol compound in Paracoccidioides brasiliensis
-
-
?
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH
ergosterol + NADP+
-
terminal step in ergosterol biosynthesis, pathway overview, presursor analysis
-
-
?
additional information

?
-
-
enzyme-deficient mutants accumulate ergosta-5,7,22,24(24 1)-tetraen-3beta-ol, ergosta-5,7,24(28)-trien-3beta-ol, ergosta-7,24(28)-dien-3beta-ol, stigmasta-5,7,22,24(28)-tetraenol, stigmasta-5,7,24(28)-trienol, stigmasta-8,24(28)-dienol, and stigmasta-7,24(28)-dienol, while ergosterol and 7-dehydroporiferasterol are absent, in contrary to the wild-type strain, overview
-
-
-
additional information
?
-
-
enzyme-deficient mutants accumulate ergosta-5,7,22,24(24 1)-tetraen-3beta-ol, ergosta-5,7,24(28)-trien-3beta-ol, ergosta-7,24(28)-dien-3beta-ol, stigmasta-5,7,22,24(28)-tetraenol, stigmasta-5,7,24(28)-trienol, stigmasta-8,24(28)-dienol, and stigmasta-7,24(28)-dienol, while ergosterol and 7-dehydroporiferasterol are absent, in contrary to the wild-type strain, overview
-
-
-
additional information
?
-
-
sterol composition with or without addition of azasterol analogue inhibitors, overview
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Neal, W.D.; Parks, L.W.
Sterol 24(28) methylene reductase in Saccharomyces cerevisiae
J. Bacteriol.
129
1375-1378
1977
Saccharomyces cerevisiae
brenda
Pierce, H.D., Jr.; Pierce, A.M.; Srinivasan, R.; Unrau, A.M.; Oehlschlager, A.C.
Azasterol inhibitors in yeast. Inhibition of the 24-methylene sterol DELTA24(28)-reductase and DELTA24-sterol methyltransferase of Saccharomyces cerevisiae by 23-azacholesterol
Biochim. Biophys. Acta
529
429-437
1978
Saccharomyces cerevisiae
brenda
Pierce, A.M.; Unrau, A.M.; Oehlschlager, A.C.; Woods, R.A.
Azasterol inhibitors in yeast. Inhibition of the DELTA24-sterol methyltransferase and the 24-methylene sterol DELTA24(28)-reductase in sterol mutants of Saccharomyces cerevisiae
Can. J. Biochem.
57
201-208
1979
Saccharomyces cerevisiae
brenda
Zweytick, D.; Hrastnik, C.; Kohlwein, S.D.; Daum, G.
Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, Erg4p, from the yeast Saccharomyces cerevisiae
FEBS Lett.
470
83-87
2000
Saccharomyces cerevisiae
brenda
Visbal, G.; Alvarez, A.; Moreno, B.; San-Blas, G.
S-adenosyl-L-methionine inhibitors DELTA24-sterol methyltransferase and DELTA24(28)-sterol methylreductase as possible agents against Paracoccidioides brasiliensis
Antimicrob. Agents Chemother.
47
2966-2970
2003
Paracoccidioides brasiliensis
brenda
Jarman, T.R.; Gunatilaka, A.A.L.; Widdowson, D.A.
Biosynthesis of steroids and terpenoids. XI. 24-Methylene sterol 24(28)-reductase of Saccharomyces cerevisiae
Bioorg. Chem.
4
202-211
1975
Saccharomyces cerevisiae
-
brenda
Salimova, E.; Boschetti, A.; Eichenberger, W.; Lutova, L.
Sterol mutants of Chlamydomonas reinhardtii: characterization of three strains deficient in C24(28) reductase
Plant Physiol. Biochem.
37
241-249
1999
Chlamydomonas reinhardtii, Chlamydomonas reinhardtii arg7cw15
-
brenda
He, X.; Guo, X.; Liu, N.; Zhang, B.
Ergosterol production from molasses by genetically modified Saccharomyces cerevisiae
Appl. Microbiol. Biotechnol.
75
55-60
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae YEH56(pHXA42)
brenda
Kaneshiro, E.; Johnston, L.; Nkinin, S.; Romero, B.; Giner, J.
Sterols of Saccharomyces cerevisiae erg6 knockout mutant expressing the Pneumocystis carinii S-adenosylmethioninesterol C-24 methyltransferase (SAMSMT)
J. Eukaryot. Microbiol.
62
298-306
2015
Pneumocystis carinii (A0A0W4ZCX9), Pneumocystis carinii, Pneumocystis carinii B80 (A0A0W4ZCX9)
brenda