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Information on EC 1.3.1.54 - precorrin-6A reductase

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EC Tree
     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.54 precorrin-6A reductase
IUBMB Comments
The enzyme, which participates in the aerobic (late cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses the reduction of the double bond between C-18 and C-19 of precorrin-6A. See EC 1.3.1.106, cobalt-precorrin-6A reductase, for the corresponding enzyme that participates in the anaerobic cobalamin biosynthesis pathway.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
precorrin 6-X reductase, precorrin-6 reductase, precorrin-6A reductase, precorrin-6x reductase, precorrin-6Y:NADP+ oxidoreductase, Reductase, precorrin 6x (Pseudomonas denitrificans clone pXL367 gene cobK), more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
precorrin-6B + NADP+ = precorrin-6A + NADPH + H+
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