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Information on EC 1.3.1.21 - 7-dehydrocholesterol reductase

for references in articles please use BRENDA:EC1.3.1.21

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IUBMB Comments

The enzyme is part of the cholesterol biosynthesis pathway.

The enzyme appears in viruses and cellular organisms

Synonyms
dhcr7, 7-dehydrocholesterol reductase, neverland, daf-36, sterol delta7-reductase, 7-dhc reductase, 3beta-hydroxysterol delta7-reductase, 7-dehydrocholesterol delta7-reductase, 7-dhcr, 3beta-hydroxysterol-delta7-reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms), cholesterol biosynthesis (algae, late side-chain reductase), cholesterol biosynthesis (diatoms), cholesterol biosynthesis (plants, early side-chain reductase), cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), phytosterol biosynthesis (plants)