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BRENDA support

Information on EC 1.3.1.14 - dihydroorotate dehydrogenase (NAD+)

for references in articles please use BRENDA:EC1.3.1.14

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IUBMB Comments

Binds FMN, FAD and a [2Fe-2S] cluster. The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit . The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes

Synonyms
dhodase, dho dehydrogenase, b-type dihydroorotate dehydrogenase, orotate reductase, dihydro-orotic dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-dihydroorotate + NAD+ = orotate + NADH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
UMP biosynthesis III