Information on EC 1.3.1.115 - 3-oxocholoyl-CoA 4-desaturase

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The expected taxonomic range for this enzyme is: Clostridium scindens

EC NUMBER
COMMENTARY hide
1.3.1.115
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RECOMMENDED NAME
GeneOntology No.
3-oxocholoyl-CoA 4-desaturase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
(1)
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7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
(2)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
bile acids degradation
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Secondary bile acid biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
3-oxocholoyl-CoA DELTA4-oxidoreductase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+
7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+
7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+
7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+
7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8
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assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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