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IUBMB Comments The enzyme, characterized from the bacteria Streptomyces griseus and Streptomyces coelicolor, is involved in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.
The expected taxonomic range for this enzyme is: Streptomyces griseus
Reaction Schemes
a [(3S)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate
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Synonyms
bprA , butenolide phosphate reductase,
scbB ,
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butenolide phosphate reductase
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bprA
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a [(3S)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP+ = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + NADPH + H+
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[(3S)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate:NADP+ oxidoreductase
The enzyme, characterized from the bacteria Streptomyces griseus and Streptomyces coelicolor, is involved in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.
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[4-(6-methylheptanoyl)-5-oxo-2,5-dihydrofuran-3-yl]methyl phosphate + NADPH + H+
[(3S)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP+
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additional information
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no activity with NADH
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brenda
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BPRA_STRGG
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
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30055
Swiss-Prot
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Kato, J.; Funa, N.; Watanabe, H.; Ohnishi, Y.; Horinouchi, S.
Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces
Proc. Natl. Acad. Sci. USA
104
2378-2383
2007
Streptomyces griseus
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brenda
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