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Information on EC 1.3.1.108 - caffeoyl-CoA reductase

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IUBMB Comments
The enzyme, characterized from the bacterium Acetobacterium woodii, contains two [4Fe-4S] clusters and FAD. The enzyme couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant. It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction. It also reduces 4-coumaroyl-CoA and feruloyl-CoA.
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The expected taxonomic range for this enzyme is: Acetobacterium woodii
Reaction Schemes
Synonyms
caffeoyl-CoA reductase-Etf complex, electron-bifurcating caffeoyl-CoA reductase, hydrocaffeoyl-CoA:NAD+, ferredoxin oxidoreductase, more
REACTION
REACTION DIAGRAM
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UNIPROT
LITERATURE
3-(3,4-dihydroxyphenyl)propanoyl-CoA + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster
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