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(2E)-but-2-enoyl-[acyl carrier protein] + NADPH + H+
butanoyl-[acyl-carrier protein] + NADP+
1-cyclohexenylcarbonyl-CoA + NADPH
1-cyclohexylcarbonyl-CoA + NADP+
-
reaction in ansatrienin biosynthesis out of shikimic acid
-
?
2-decenoyl-[acyl-carrier protein] + NADPH
decanoyl-[acyl-carrier protein] + NADP+
-
syn addition of hydrogen via a 2-Re,3-Si attack on the double bond
-
?
2-hexenoyl-[acyl-carrier protein] + NADPH
hexanoyl-[acyl-carrier protein] + NADP+
2-trans-hexenoyl-CoA + NADPH
?
-
assay at pH 7.5, 23ưC
-
-
?
5-hydroxycyclohex-1-enecarbonyl-CoA + NADPH
5-hydroxycyclohexylcarbonyl-CoA + NADP+
-
reaction in ansatrienin biosynthesis out of shikimic acid
-
?
acyl-[acyl-carrier protein] + NADP+
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
an acyl-[acyl-carrier protein] + NADP+
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
beta-ketoacyl-[acyl-carrier protein] + NADH + H+
beta-hydroxyacyl-[acyl-carrier protein] + NAD+
-
-
-
-
?
crotonyl-CoA + NADPH + H+
?
crotonyl-N-acetyl-cysteamine + NADPH
butyryl-N-acetyl-cysteamine + NADP+
crotonyl-N-acetyl-cysteamine + NADPH + H+
butyryl-N-acetyl-cysteamine + NADP+
-
-
-
-
?
crotonyl-[acyl-carrier protein] + NADPH
butyryl-[acyl-carrier protein] + NADP+
crotonyl-[acyl-carrier protein] + NADPH + H+
?
crotonyl-[acyl-carrier protein] + NADPH + H+
butyryl-[acyl-carrier protein] + NADP+
crotonyl-[Staphylococcus aureus acyl carrier protein] + NADPH + H+
butyryl-[Staphylococcus aureus acyl carrier protein] + NADP+
-
-
-
-
?
dodec-2-enoyl-CoA + NADPH + H+
dodecanoyl-CoA + NADP+
-
-
-
-
r
dodecenoyl-CoA + NADPH + H+
dodecanoyl-CoA + NADP+
-
-
-
-
?
dodecenoyl-N-acetyl-cysteamine + NADPH + H+
dodecanoyl-N-acetyl-cysteamine + NADP+
-
-
-
-
?
dodecenoyl-[Staphylococcus aureus acyl carrier protein] + NADPH + H+
dodecanoyl-[Staphylococcus aureus acyl carrier protein] + NADP+
-
-
-
-
?
hexanoyl-CoA + NADH + H+
?
-
-
-
-
?
hexanoyl-[acyl-carrier protein] + NADH + H+
?
-
-
-
-
?
octenoyl-N-acetyl-cysteamine + NADPH
octanoyl-N-acetyl-cysteamine + NADP+
S-((2E)-oct-2-enoyl)-N-acetylcysteamine + NADPH + H+
S-octanoyl-N-acetylcysteamine + NADP+
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH
acyl-[acyl-carrier protein] + NADP+
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
acyl-[acyl-carrier protein] + NADP+
-
prefers acyl carrier protein substrates carrying fatty acids with long acyl chains
-
-
?
trans-2-hexenoyl-CoA + NADPH
hexanoyl-CoA + NADP+
-
-
-
-
?
trans-3,4-dihydroxycyclohexa-1,5-dienecarbonyl-CoA + NADPH
trans-4,5-dihydroxycyclohexa-2-enecarbonyl-CoA + NADP+
-
reaction in ansatrienin biosynthesis out of shikimic acid
-
?
additional information
?
-
(2E)-but-2-enoyl-[acyl carrier protein] + NADPH + H+

butanoyl-[acyl-carrier protein] + NADP+
-
-
-
?
(2E)-but-2-enoyl-[acyl carrier protein] + NADPH + H+
butanoyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
2-hexenoyl-[acyl-carrier protein] + NADPH

hexanoyl-[acyl-carrier protein] + NADP+
-
-
-
?
2-hexenoyl-[acyl-carrier protein] + NADPH
hexanoyl-[acyl-carrier protein] + NADP+
-
-
-
?
acyl-[acyl-carrier protein] + NADP+

trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
-
-
-
-
?
acyl-[acyl-carrier protein] + NADP+
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
-
-
-
-
?
an acyl-[acyl-carrier protein] + NADP+

a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
-
-
-
?
an acyl-[acyl-carrier protein] + NADP+
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
assay method by consumption of beta-nicotinamide adenine dinucleotide phosphate during reduction of trans-2-octenoyl-N-acetylcysteamine as the substrate
-
-
?
an acyl-[acyl-carrier protein] + NADP+
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
-
-
-
-
?
an acyl-[acyl-carrier protein] + NADP+
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
-
assay method by consumption of beta-nicotinamide adenine dinucleotide phosphate during reduction of trans-2-octenoyl-N-acetylcysteamine as the substrate
-
-
?
an acyl-[acyl-carrier protein] + NADP+
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
-
-
-
?
crotonyl-CoA + NADPH + H+

?
-
-
-
-
?
crotonyl-CoA + NADPH + H+
?
-
-
-
-
?
crotonyl-N-acetyl-cysteamine + NADPH

butyryl-N-acetyl-cysteamine + NADP+
-
stereochemistry
-
?
crotonyl-N-acetyl-cysteamine + NADPH
butyryl-N-acetyl-cysteamine + NADP+
-
-
?
crotonyl-[acyl-carrier protein] + NADPH

butyryl-[acyl-carrier protein] + NADP+
-
-
?
crotonyl-[acyl-carrier protein] + NADPH
butyryl-[acyl-carrier protein] + NADP+
-
-
-
?
crotonyl-[acyl-carrier protein] + NADPH
butyryl-[acyl-carrier protein] + NADP+
-
-
-
?
crotonyl-[acyl-carrier protein] + NADPH
butyryl-[acyl-carrier protein] + NADP+
-
-
-
?
crotonyl-[acyl-carrier protein] + NADPH
butyryl-[acyl-carrier protein] + NADP+
-
anti addition of hydrogen via a 2-Si,3-Si attack on the double bond
-
?
crotonyl-[acyl-carrier protein] + NADPH
butyryl-[acyl-carrier protein] + NADP+
-
anti addition of hydrogen via a 2-Si,3-Si attack on the double bond
-
?
crotonyl-[acyl-carrier protein] + NADPH
butyryl-[acyl-carrier protein] + NADP+
-
substrate created by E. coli enzymes during assay
-
?
crotonyl-[acyl-carrier protein] + NADPH + H+

?
-
-
-
-
?
crotonyl-[acyl-carrier protein] + NADPH + H+
?
-
-
-
-
?
crotonyl-[acyl-carrier protein] + NADPH + H+

butyryl-[acyl-carrier protein] + NADP+
-
-
-
?
crotonyl-[acyl-carrier protein] + NADPH + H+
butyryl-[acyl-carrier protein] + NADP+
-
-
-
?
octenoyl-N-acetyl-cysteamine + NADPH

octanoyl-N-acetyl-cysteamine + NADP+
-
-
?
octenoyl-N-acetyl-cysteamine + NADPH
octanoyl-N-acetyl-cysteamine + NADP+
-
-
?
S-((2E)-oct-2-enoyl)-N-acetylcysteamine + NADPH + H+

S-octanoyl-N-acetylcysteamine + NADP+
-
-
-
?
S-((2E)-oct-2-enoyl)-N-acetylcysteamine + NADPH + H+
S-octanoyl-N-acetylcysteamine + NADP+
-
-
-
-
?
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH

acyl-[acyl-carrier protein] + NADP+
-
-
-
-
?
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH
acyl-[acyl-carrier protein] + NADP+
-
reaction within the fatty acid synthase complex, indispensable for respiratory function in mitochondria
-
-
?
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH
acyl-[acyl-carrier protein] + NADP+
-
-
-
?
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH
acyl-[acyl-carrier protein] + NADP+
reaction within the fatty acid synthase complex, indispensable for respiratory function in mitochondria
-
-
?
additional information

?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters of both N-acetylcysteamine and acyl-carrier protein
-
-
?
additional information
?
-
catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters of both N-acetylcysteamine and acyl-carrier protein
-
-
?
additional information
?
-
-
catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters of both N-acetylcysteamine and acyl-carrier protein
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
active on substrates with acyl chain length C4-C16
-
-
?
additional information
?
-
-
active on substrates with acyl chain length C4-C16
-
-
?
additional information
?
-
-
inactive with enoyl-CoA substrates
-
-
?
additional information
?
-
-
inactive with enoyl-CoA substrates
-
-
?
additional information
?
-
-
inactive with enoyl-CoA substrates
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
enzyme possesses intrinsic NADPH oxidase activity in the absence of the crotonyl-CoA substrate
-
-
?
additional information
?
-
-
enzyme possesses intrinsic NADPH oxidase activity in the absence of the crotonyl-CoA substrate
-
-
?
additional information
?
-
enzyme possesses intrinsic NADPH oxidase activity in the absence of the crotonyl-CoA substrate
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
no activity with crotonyl-CoA and NADH
-
-
?
additional information
?
-
-
activity measurement by reduction of the trans-2-octenoyl N-acetylcysteamine as substrate and NADPH as cofactor
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-cyclohexenylcarbonyl-CoA + NADPH
1-cyclohexylcarbonyl-CoA + NADP+
-
reaction in ansatrienin biosynthesis out of shikimic acid
-
?
5-hydroxycyclohex-1-enecarbonyl-CoA + NADPH
5-hydroxycyclohexylcarbonyl-CoA + NADP+
-
reaction in ansatrienin biosynthesis out of shikimic acid
-
?
an acyl-[acyl-carrier protein] + NADP+
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
beta-ketoacyl-[acyl-carrier protein] + NADH + H+
beta-hydroxyacyl-[acyl-carrier protein] + NAD+
-
-
-
-
?
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH
acyl-[acyl-carrier protein] + NADP+
trans-3,4-dihydroxycyclohexa-1,5-dienecarbonyl-CoA + NADPH
trans-4,5-dihydroxycyclohexa-2-enecarbonyl-CoA + NADP+
-
reaction in ansatrienin biosynthesis out of shikimic acid
-
?
additional information
?
-
an acyl-[acyl-carrier protein] + NADP+

a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
-
-
-
?
an acyl-[acyl-carrier protein] + NADP+
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
-
-
-
-
?
an acyl-[acyl-carrier protein] + NADP+
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
-
-
-
?
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH

acyl-[acyl-carrier protein] + NADP+
-
reaction within the fatty acid synthase complex, indispensable for respiratory function in mitochondria
-
-
?
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH
acyl-[acyl-carrier protein] + NADP+
reaction within the fatty acid synthase complex, indispensable for respiratory function in mitochondria
-
-
?
additional information

?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters of both N-acetylcysteamine and acyl-carrier protein
-
-
?
additional information
?
-
catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters of both N-acetylcysteamine and acyl-carrier protein
-
-
?
additional information
?
-
-
catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters of both N-acetylcysteamine and acyl-carrier protein
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
additional information
?
-
-
part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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0.025
1-cyclohexenylcarbonyl-CoA
-
vmax 0.0075 mmol/mg/min
0.03
5-hydroxycyclohex-1-enecarbonyl-CoA
-
vmax 0.0053 mmol/mg/min
0.008 - 8
Crotonyl-N-acetyl-cysteamine
0.0478
crotonyl-[acyl-carrier protein]
pH 7.5, 25ưC
0.0115
crotonyl-[Staphylococcus aureus acyl carrier protein]
-
wild type enzyme, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
0.0241
dodec-2-enoyl-CoA
-
wild type enzyme, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
0.0233
dodecenoyl-N-acetyl-cysteamine
-
wild type enzyme, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
0.0045 - 0.0184
dodecenoyl-[Staphylococcus aureus acyl carrier protein]
additional information
NADPH
0.008
Crotonyl-N-acetyl-cysteamine

-
wild type enzyme, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
8
Crotonyl-N-acetyl-cysteamine
Vmax 0.0003 nmol/min/mg
0.0045
dodecenoyl-[Staphylococcus aureus acyl carrier protein]

-
wild type enzyme, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
0.0114
dodecenoyl-[Staphylococcus aureus acyl carrier protein]
-
mutant enzyme A95V, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
0.0184
dodecenoyl-[Staphylococcus aureus acyl carrier protein]
-
mutant enzyme F204S, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
0.016
NADPH

-
0.016
NADPH
no cooperativity in binding NADPH
0.0171
NADPH
pH 7.5, 25ưC
0.2694
NADPH
-
mutant enzyme A95V, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
0.4296
NADPH
-
mutant enzyme F204S, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
1
NADPH
-
Km above 1 mM, mutant enzyme I193S, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
additional information
NADPH

-
value above 2 mM
additional information
NADPH
half-maximal rate at 0.065 mM NADPH
additional information
NADPH
-
half-maximal rate at 0.065 mM NADPH
additional information
NADPH
cooperative binding with Hill coefficient 2.2
additional information
NADPH
-
cooperative binding with Hill coefficient 2.2
additional information
trans-3,4-dihydroxycyclohexa-1,5-dienecarbonyl-CoA
-
only impure solution available, KM and vmax in same order of magnitude as with 1-cyclohexenylcarbonyl-CoA
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1.5
Crotonyl-N-acetyl-cysteamine
-
wild type enzyme, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
0.038 - 0.51
crotonyl-[acyl-carrier protein]
11.6
crotonyl-[Staphylococcus aureus acyl carrier protein]
-
wild type enzyme, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
18
dodec-2-enoyl-CoA
-
wild type enzyme, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
30.4
dodecenoyl-N-acetyl-cysteamine
-
wild type enzyme, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
18.4 - 157.3
dodecenoyl-[Staphylococcus aureus acyl carrier protein]
130.2
NADPH
-
wild type enzyme, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
0.038
crotonyl-[acyl-carrier protein]

-
mutant enzyme Y147F, pH and temperature not specified in the publication
0.038
crotonyl-[acyl-carrier protein]
-
mutant enzyme Y147H, pH and temperature not specified in the publication
0.51
crotonyl-[acyl-carrier protein]
-
wild type enzyme, pH and temperature not specified in the publication
18.4
dodecenoyl-[Staphylococcus aureus acyl carrier protein]

-
mutant enzyme A95V, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
130.2
dodecenoyl-[Staphylococcus aureus acyl carrier protein]
-
wild type enzyme, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
157.3
dodecenoyl-[Staphylococcus aureus acyl carrier protein]
-
mutant enzyme F204S, at 25ưC, in 100 mM Na2HPO4 buffer (pH 7.8)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Shimakata, T.; Stumpf, P.K.
The procaryotic nature of the fatty acid synthetase of developing Carthamus tinctorius L. (Safflower) seeds
Arch. Biochem. Biophys.
217
144-154
1982
Carthamus tinctorius
brenda
Saito, K.; Kawaguchi, A.; Seyama, Y.; Yamakawa, T.; Okuda, S.
Steric course of reaction catalyzed by the enoyl acyl-carrier-protein reductase of Escherichia coli
Eur. J. Biochem.
116
581-586
1981
Escherichia coli
brenda
Sedgwick, B.; Morris, C.
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