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3,4-Dimethoxy-5-hydroxy-benzaldehyde + carbamoyl methyl viologen
3,4-Dimethoxy-5-hydroxy-benzoate + reduced carbamoyl methyl viologen
-
-
-
-
?
3,5-Dimethoxy-4-hydroxy-benzaldehyde + carbamoyl methyl viologen
3,5-Dimethoxy-4-hydroxy-benzoate + reduced carbamoyl methyl viologen
-
-
-
-
?
3-Chlorobenzoate + reduced carbamoyl methyl viologen
3-Chlorobenzaldehyde + carbamoyl methyl viologen
3-Fluorobenzoate + reduced carbamoyl methyl viologen
3-Fluorobenzaldehyde + carbamoyl methyl viologen
3-Hydroxybenzoate + reduced carbamoyl methyl viologen
3-Hydroxybenzaldehyde + carbamoyl methyl viologen
3-Methoxybenzoate + reduced carbamoyl methyl viologen
3-Methoxybenzaldhyde + carbamoyl methyl viologen
3-Methylbenzoate + reduced carbamoyl methyl viologen
3-Methylbenzaldehyde + carbamoyl methyl viologen
4-(Hydroxymethyl)benzoate + reduced carbamoyl methyl viologen
4-(Hydroxymethyl)benzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Chlorobenzoate + reduced carbamoyl methyl viologen
4-Chlorobenzaldehyde + carbamoyl methyl viologen
4-Fluorobenzoate + reduced carbamoyl methyl viologen
4-Fluorobenzaldehyde + carbamoyl methyl viologen
4-Hydroxy-3-methoxy-benzaldehyde + carbamoyl methyl viologen
4-Hydroxy-3-methoxy-benzoate + reduced carbamoyl methyl viologen
-
-
-
-
?
4-Hydroxybenzaldehyde + carbamoyl methyl viologen
4-Hydroxybenzoate + reduced carbamoyl methyl viologen
-
r
-
?
4-Hydroxybenzoate + reduced carbamoyl methyl viologen
4-Hydroxybenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Methoxybenzaldehyde + benzyl viologen
4-Methoxybenzoate + reduced carbamoyl methyl viologen
4-Methoxybenzoate + reduced carbamoyl methyl viologen
4-Methoxybenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Methylbenzoate + reduced carbamoyl methyl viologen
4-Methylbenzaldehyde + carbamoyl methyl viologen
5-Phenyl-2,4-pentadienate + reduced carbamoyl methyl viologen
? + carbamoyl methyl viologen
-
-
-
-
?
Acetaldehyde + 2,6-dichlorophenol-indophenol
acetate + reduced 2,6-dichlorophenol-indophenol
Acetaldehyde + 3-(4',5'-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide
acetate + reduced 3-(4',5'-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide
Acetaldehyde + benzyl viologen
acetate + reduced benzyl viologen
acetaldehyde + benzyl viologen
acetic acid + reduced benzyl viologen
-
-
-
-
?
Acetaldehyde + carbamoyl methyl viologen
acetate + reduced carbamoyl methyl viologen
-
r
-
?
Acetaldehyde + methyl viologen
acetate + reduced methyl viologen
acetaldehyde + methyl viologen + H2O
acetate + reduced methyl viologen
-
-
-
-
r
benzaldehyde + 2,6-dichlorophenol indophenol
benzoate + reduced 2,6-dichlorophenol indophenol
Megalodesulfovibrio gigas
-
-
-
-
?
Benzaldehyde + benzyl viologen
Benzoate + reduced benzyl viologen
benzaldehyde + benzyl viologen
benzoic acid + reduced benzyl viologen
-
96% of activity compared to acetaldehyde
-
-
?
Benzaldehyde + carbamoyl methyl viologen
Benzoate + reduced carbamoyl methyl viologen
Butanal + methyl viologen
Butanoate + reduced methyl viologen
-
-
-
-
?
Butanal + NH2CO-methyl viologen
Butanoate + reduced NH2CO-methyl viologen
Butyraldehyde + benzyl viologen
Butanoate + reduced benzyl viologen
Cinnamaldehyde + carbamoyl methyl viologen
Cinnamate + reduced carbamoyl methyl viologen
-
r
-
?
crotonaldehyde + benzyl viologen
crotonic acid + reduced benzyl viologen
-
47% of activity compared to acetaldehyde
-
-
?
Crotonaldehyde + benzyl viologen
E-2-Butenoate + reduced benzyl viologen
-
at less than 1% of the activity with benzyl viologen
-
-
?
Crotonaldehyde + ES-1 ferredoxin
Crotonate + reduced ES-1 ferredoxin
-
-
-
-
?
Crotonaldehyde + methyl viologen
Crotonate + reduced methyl viologen
decylaldehyde + 2,6-dichlorophenol indophenol
decanoate + reduced 2,6-dichlorophenol indophenol
Megalodesulfovibrio gigas
-
-
-
-
?
DL-glyceraldehyde + benzyl viologen
alpha,beta-dihydroxypropionic acid + reduced benzyl viologen
-
9% of activity compared to acetaldehyde
-
-
?
formaldehyde + benzyl viologen
formic acid + reduced benzyl viologen
-
2% of activity compared to acetaldehyde
-
-
?
Furfural + benzyl viologen
2-Furancarboxylic acid + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 77% of the activity relative to acetaldehyde
-
-
?
Glutaraldehyde + benzyl viologen
Glutarate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 16% of the activity relative to acetaldehyde
-
-
?
glutaraldehyde + benzyl viologen
glutaric acid + reduced benzyl viologen
-
19% of activity compared to acetaldehyde
-
-
?
Glyceraldehyde + benzyl viologen
Glycerate + reduced benzyl viologen
-
-
-
-
?
Glyceraldehyde + methyl viologen
Glycerate + reduced methyl viologen
-
-
-
-
?
Glycolaldehyde + benzyl viologen
Glycolate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 23% of the activity relative to acetaldehyde
-
-
?
glyoxylate + benzyl viologen
oxalic acid + reduced benzyl viologen
-
6% of activity compared to acetaldehyde
-
-
?
Hexanal + benzyl viologen
Hexanoate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 6% of the activity relative to acetaldehyde
-
-
?
Indoleacetaldehyde + benzyl viologen
Indoleacetate + reduced benzyl viologen
isovaleraldehyde + benzyl viologen
isopentanoic acid + reduced benzyl viologen
-
66% of activity compared to acetaldehyde
-
-
?
Isovaleraldehyde + benzyl viologen
Isovalerate + reduced benzyl viologen
Methanal + benzyl viologen
Formate + reduced benzyl viologen
Methanal + carbamoyl methyl viologen
Formate + reduced methyl viologen
-
-
-
-
?
Methanal + methyl viologen
Formate + reduced carbamoyl methyl viologen
-
-
-
-
?
octanal + 2,6-dichlorophenol indophenol
octanoate + reduced 2,6-dichlorophenol indophenol
Megalodesulfovibrio gigas
-
-
-
-
?
Pentanal + benzyl viologen
Pentanoate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 9% of the activity relative to acetaldehyde
-
-
?
Phenylacetaldehyde + benzyl viologen
Phenylacetate + reduced benzyl viologen
phenylacetaldehyde + benzyl viologen
phenylacetic acid + reduced benzyl viologen
-
20% of activity compared to acetaldehyde
-
-
?
Propanal + benzyl viologen
Propanoate + reduced benzyl viologen
Propanal + methyl viologen
Propanoate + reduced methyl viologen
Propanal + NH2CO-methyl viologen
Propanoate + reduced carbamoyl methyl viologen
Propanal + reduced 1,1',2,2'-tetramethylviologen
Propanoate + 1,1',2,2'-tetramethylviologen
-
-
-
-
?
propionaldehyde + benzyl viologen
propionic acid + reduced benzyl viologen
-
119% of activity compared to acetaldehyde
-
-
?
Pyridine 4-carboxylate + reduced carbamoyl methyl viologen
Pyridine 4-carboxaldehyde + carbamoyl methyl viologen
-
-
-
-
?
Salicylaldehyde + benzyl viologen
Salicylate + reduced benzyl viologen
salicylaldehyde + benzyl viologen
salicylic acid + reduced benzyl viologen
-
4% of activity compared to acetaldehyde
-
-
?
terephthalaldehyde + carbamoyl methyl viologen
terephthalate + reduced carbamoyl methyl viologen
-
r
-
?
additional information
?
-
3-Chlorobenzoate + reduced carbamoyl methyl viologen
3-Chlorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Chlorobenzoate + reduced carbamoyl methyl viologen
3-Chlorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Fluorobenzoate + reduced carbamoyl methyl viologen
3-Fluorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Fluorobenzoate + reduced carbamoyl methyl viologen
3-Fluorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Hydroxybenzoate + reduced carbamoyl methyl viologen
3-Hydroxybenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Hydroxybenzoate + reduced carbamoyl methyl viologen
3-Hydroxybenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Methoxybenzoate + reduced carbamoyl methyl viologen
3-Methoxybenzaldhyde + carbamoyl methyl viologen
-
-
-
-
?
3-Methoxybenzoate + reduced carbamoyl methyl viologen
3-Methoxybenzaldhyde + carbamoyl methyl viologen
-
-
-
-
?
3-Methylbenzoate + reduced carbamoyl methyl viologen
3-Methylbenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Methylbenzoate + reduced carbamoyl methyl viologen
3-Methylbenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Chlorobenzoate + reduced carbamoyl methyl viologen
4-Chlorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Chlorobenzoate + reduced carbamoyl methyl viologen
4-Chlorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Fluorobenzoate + reduced carbamoyl methyl viologen
4-Fluorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Fluorobenzoate + reduced carbamoyl methyl viologen
4-Fluorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Methoxybenzaldehyde + benzyl viologen
4-Methoxybenzoate + reduced carbamoyl methyl viologen
Megalodesulfovibrio gigas
-
at 19% of the activity relative to acetaldehyde
-
-
?
4-Methoxybenzaldehyde + benzyl viologen
4-Methoxybenzoate + reduced carbamoyl methyl viologen
-
-
-
?
4-Methylbenzoate + reduced carbamoyl methyl viologen
4-Methylbenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Methylbenzoate + reduced carbamoyl methyl viologen
4-Methylbenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
Acetaldehyde + 2,6-dichlorophenol-indophenol
acetate + reduced 2,6-dichlorophenol-indophenol
Megalodesulfovibrio gigas
-
at 1.3% of the activity relative to benzyl viologen
-
-
?
Acetaldehyde + 2,6-dichlorophenol-indophenol
acetate + reduced 2,6-dichlorophenol-indophenol
Megalodesulfovibrio gigas NCIMB 9332
-
at 1.3% of the activity relative to benzyl viologen
-
-
?
Acetaldehyde + 3-(4',5'-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide
acetate + reduced 3-(4',5'-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide
Megalodesulfovibrio gigas
-
at 5% of the activity relative to benzyl viologen
-
-
?
Acetaldehyde + 3-(4',5'-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide
acetate + reduced 3-(4',5'-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide
Megalodesulfovibrio gigas NCIMB 9332
-
at 5% of the activity relative to benzyl viologen
-
-
?
Acetaldehyde + benzyl viologen
acetate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
-
-
-
?
Acetaldehyde + benzyl viologen
acetate + reduced benzyl viologen
Megalodesulfovibrio gigas NCIMB 9332
-
-
-
-
?
Acetaldehyde + benzyl viologen
acetate + reduced benzyl viologen
-
r
-
-
?
Acetaldehyde + benzyl viologen
acetate + reduced benzyl viologen
-
r
-
-
?
Acetaldehyde + benzyl viologen
acetate + reduced benzyl viologen
-
r
-
-
?
Acetaldehyde + methyl viologen
acetate + reduced methyl viologen
Megalodesulfovibrio gigas
-
at 19% of the activity relative to benzyl viologen
-
-
?
Acetaldehyde + methyl viologen
acetate + reduced methyl viologen
Megalodesulfovibrio gigas NCIMB 9332
-
at 19% of the activity relative to benzyl viologen
-
-
?
Acetaldehyde + methyl viologen
acetate + reduced methyl viologen
-
-
-
-
?
Benzaldehyde + benzyl viologen
Benzoate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 93% of the activity relative to acetaldehyde
-
-
?
Benzaldehyde + benzyl viologen
Benzoate + reduced benzyl viologen
Megalodesulfovibrio gigas NCIMB 9332
-
at 93% of the activity relative to acetaldehyde
-
-
?
Benzaldehyde + benzyl viologen
Benzoate + reduced benzyl viologen
-
-
-
-
?
Benzaldehyde + benzyl viologen
Benzoate + reduced benzyl viologen
-
-
-
-
?
Benzaldehyde + benzyl viologen
Benzoate + reduced benzyl viologen
-
-
-
-
?
Benzaldehyde + carbamoyl methyl viologen
Benzoate + reduced carbamoyl methyl viologen
-
-
-
-
?
Benzaldehyde + carbamoyl methyl viologen
Benzoate + reduced carbamoyl methyl viologen
-
only reverse reaction described
-
-
?
Benzaldehyde + carbamoyl methyl viologen
Benzoate + reduced carbamoyl methyl viologen
-
r
-
?
Butanal + NH2CO-methyl viologen
Butanoate + reduced NH2CO-methyl viologen
-
-
-
-
?
Butanal + NH2CO-methyl viologen
Butanoate + reduced NH2CO-methyl viologen
-
only reverse reaction described
-
-
?
Butanal + NH2CO-methyl viologen
Butanoate + reduced NH2CO-methyl viologen
-
-
-
-
?
Butyraldehyde + benzyl viologen
Butanoate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 16% of the activity relative to acetaldehyde
-
-
?
Butyraldehyde + benzyl viologen
Butanoate + reduced benzyl viologen
-
101% of activity compared to acetaldehyde
-
-
?
Crotonaldehyde + methyl viologen
Crotonate + reduced methyl viologen
-
-
-
-
?
Crotonaldehyde + methyl viologen
Crotonate + reduced methyl viologen
-
-
-
-
?
Indoleacetaldehyde + benzyl viologen
Indoleacetate + reduced benzyl viologen
-
-
-
-
?
Indoleacetaldehyde + benzyl viologen
Indoleacetate + reduced benzyl viologen
-
-
-
-
?
Isovaleraldehyde + benzyl viologen
Isovalerate + reduced benzyl viologen
-
-
-
-
?
Isovaleraldehyde + benzyl viologen
Isovalerate + reduced benzyl viologen
-
-
-
-
?
Isovaleraldehyde + benzyl viologen
Isovalerate + reduced benzyl viologen
-
-
-
-
?
Methanal + benzyl viologen
Formate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 16% of the activity relative to acetaldehyde
-
-
?
Methanal + benzyl viologen
Formate + reduced benzyl viologen
-
-
-
-
?
Phenylacetaldehyde + benzyl viologen
Phenylacetate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 31% of the activity relative to acetaldehyde
-
-
?
Phenylacetaldehyde + benzyl viologen
Phenylacetate + reduced benzyl viologen
-
-
-
-
?
Phenylacetaldehyde + benzyl viologen
Phenylacetate + reduced benzyl viologen
-
-
-
-
?
Phenylacetaldehyde + benzyl viologen
Phenylacetate + reduced benzyl viologen
-
-
-
-
?
Propanal + benzyl viologen
Propanoate + reduced benzyl viologen
-
only reverse reaction described
-
?
Propanal + benzyl viologen
Propanoate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 117% of the activity relative to acetaldehyde
-
-
?
Propanal + benzyl viologen
Propanoate + reduced benzyl viologen
-
-
-
-
?
Propanal + methyl viologen
Propanoate + reduced methyl viologen
-
only reverse reaction described
-
?
Propanal + methyl viologen
Propanoate + reduced methyl viologen
-
-
-
-
?
Propanal + NH2CO-methyl viologen
Propanoate + reduced carbamoyl methyl viologen
-
-
-
-
?
Propanal + NH2CO-methyl viologen
Propanoate + reduced carbamoyl methyl viologen
-
only reverse reaction described
-
?
Propanal + NH2CO-methyl viologen
Propanoate + reduced carbamoyl methyl viologen
-
r
-
-
?
Salicylaldehyde + benzyl viologen
Salicylate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 14% of the activity relative to acetaldehyde
-
-
?
Salicylaldehyde + benzyl viologen
Salicylate + reduced benzyl viologen
-
-
-
-
?
additional information
?
-
-
in contast to the dimeric enzyme form the heptameric enzyme form also catalyzes the reversible reduction of the oxidized carbamoyl methyl viologen with NADPH
-
-
?
additional information
?
-
-
its physiological role is proposed as the oxidation of glyceraldehyde to glycerate in a unique, partially nonphosphorylated glycolytic pathway that generates acetyl-CoA from glucose without participation of nicotinamide nucleotides
-
-
?
additional information
?
-
-
the enzyme possibly functions to oxidize aldehydes generated during amino acid catabolism, it is also possible that the enzyme generates aldehydes from organic acids produced by fermentation
-
-
?
additional information
?
-
-
the enzyme possibly functions to oxidize aldehydes generated during amino acid catabolism, it is also possible that the enzyme generates aldehydes from organic acids produced by fermentation
-
-
?
additional information
?
-
-
the enzyme possibly functions to oxidize aldehydes generated during amino acid catabolism, it is also possible that the enzyme generates aldehydes from organic acids produced by fermentation
-
-
?
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Acquired Immunodeficiency Syndrome
Direct enzyme assay evidence confirms aldehyde reductase function of Ydr541cp and Ygl039wp from Saccharomyces cerevisiae.
Ascorbic Acid Deficiency
Vitamin C. Biosynthesis, recycling and degradation in mammals.
Astrocytoma
The role of aldehyde reductase AKR1A1 in the metabolism of gamma-hydroxybutyrate in 1321N1 human astrocytoma cells.
Carcinogenesis
A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant.
Carcinogenesis
Glutathione-S-transferase, alcohol dehydrogenase and aldehyde reductase activities during diethylnitrosamine-carcinogenesis in rat liver.
Carcinogenesis
Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat.
Carcinoma
Increased resistance of tumor cells to daunorubicin after transfection of cDNAs coding for anthracycline inactivating enzymes.
Carcinoma, Hepatocellular
Glutathione-S-transferase, alcohol dehydrogenase and aldehyde reductase activities during diethylnitrosamine-carcinogenesis in rat liver.
Carcinoma, Hepatocellular
Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1).
Carcinoma, Hepatocellular
Role of aldehyde metabolizing enzymes in mediating effects of aldehyde products of lipid peroxidation in liver cells.
Carcinoma, Hepatocellular
Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue.
Cataract
Lens aldehyde reductase and dehydrogenase, and their possible involvement in diabetes and cataract formation.
Colorectal Neoplasms
Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.
Diabetes Complications
Aldose and aldehyde reductase in animal tissues.
Diabetes Complications
All in the family.
Diabetes Complications
Expression of human aldose and aldehyde reductases. Site-directed mutagenesis of a critical lysine 262.
Diabetes Complications
Molecular modelling and synthesis of spiroimidazolidine-2,4-diones with dual activities as hypoglycemic agents and selective inhibitors of aldose reductase.
Diabetes Complications
Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.
Diabetes Complications
Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies.
Diabetes Complications
Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications.
Diabetes Mellitus
Coumarin-thiazole and -oxadiazole derivatives: Synthesis, bioactivity and docking studies for aldose/aldehyde reductase inhibitors.
Diabetic Neuropathies
X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: Implications for inhibitor binding and selectivity.
Hepatitis
Induction of aldose reductase gene expression in LEC rats during the development of the hereditary hepatitis and hepatoma.
Hypernatremia
The role of polyols in cerebral cell volume regulation in hypernatremic and hyponatremic states.
Hyponatremia
The role of polyols in cerebral cell volume regulation in hypernatremic and hyponatremic states.
Infections
Genome sequence and transcriptome profiles of pathogenic fungus Paecilomyces penicillatus reveal its interactions with edible fungus Morchella importuna.
Laryngeal Neoplasms
Increased aldehyde reductase expression mediates acquired radioresistance of laryngeal cancer cells via modulating p53.
Leukemia, Myeloid
NADPH-dependent reductases and polyol formation in human leukemia cell lines.
Leukemia, Myeloid, Acute
[Induction of cell differentiation and development of new anticancer drugs]
Metabolic Diseases
Coumarin-thiazole and -oxadiazole derivatives: Synthesis, bioactivity and docking studies for aldose/aldehyde reductase inhibitors.
Neoplasms
Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.
Neoplasms
Differential protein expression in honeybee (Apis mellifera L.) larvae: underlying caste differentiation.
Neoplasms
Genetic variation of Aflatoxin B(1) aldehyde reductase genes (AFAR) in human tumour cells.
Neoplasms
In silico designing of novel inhibitors for triple inhibition of Aldose Reductase, Aldose Reductase like protein 1, and Aldehyde Reductase.
Neoplasms
Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma.
Neoplasms
Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.
Obesity
[Aldehyde reductase activity and blood aldo-keto reductase spectrum in adolescents with neuroendocrine obesity].
Pancreatic Neoplasms
Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma.
Sarcoma, Experimental
Purification and properties of aldose reductase and aldehyde reductase from EHS tumor cells.
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10
3,5-dimethoxy-4-hydroxybenzaldehyde
-
with carbamoyl methyl viologen as cosubstrate
2.4 - 3.8
3-chlorobenzoate
3.5
3-Fluorobenzoate
-
with reduced carbamoyl methyl viologen as cosubstrate
50.4 - 78
3-hydroxybenzoate
44.9
3-Methoxybenzoate
-
-
6.1 - 12.8
3-methylbenzoate
8
4-(hydroxymethyl)benzoate
-
with reduced carbamoyl methyl viologen as cosubstrate
3
4-hydroxy-3-methoxybenzaldehyde
12
4-hydroxybenzaldehyde
-
with carbamoyl methyl viologen as cosubstrate
130 - 382
4-hydroxybenzoate
0.005
4-methoxybenzaldehyde
2.1
4-Methoxybenzoate
-
-
0.1
5-Phenyl-2,4-pentadienate
-
with reduced carbamoyl methyl viologen as cosubstrate
0.0125 - 0.019
acetaldehyde
0.0014 - 0.057
benzaldehyde
0.169 - 0.55
benzyl viologen
0.012
cinnamaldehyde
-
with carbamoyl methyl viologen as cosubstrate
1.7
cinnamate
-
with reduced carbamoyl methyl viologen as cosubstrate
0.04 - 0.136
crotonaldehyde
0.016
DL-glyceraldehyde
-
-
0.0308
furfural
Megalodesulfovibrio gigas
-
with benzyl viologen as cosubstrate
0.196
glyceraldehyde
-
with benzyl viologen as cosubstrate, at 45°C
0.028 - 0.033
Isovaleraldehyde
0.067 - 0.076
phenylacetaldehyde
0.017
propionaldehyde
-
-
0.03 - 0.16
reduced carbamoyl methyl viologen
0.065
Salicylaldehyde
-
with benzyl viologen as cosubstrate, at 85°C
4
terephthalate
-
with reduced carbamoyl methyl viologen as cosubstrate
2.4
3-chlorobenzoate
-
with reduced carbamoyl methyl viologen as cosubstrate
50.4
3-hydroxybenzoate
-
-
78
3-hydroxybenzoate
-
with reduced carbamoyl methyl viologen as cosubstrate
78
3-hydroxybenzoate
-
pyridine-4-carboxylate, with reduced carbamoyl methyl viologen as cosubstrate
6.1
3-methylbenzoate
-
with reduced carbamoyl methyl viologen as cosubstrate
12.8
3-methylbenzoate
-
-
1
4-Chlorobenzoate
-
with reduced carbamoyl methyl viologen as cosubstrate
3
4-hydroxy-3-methoxybenzaldehyde
-
with carbamoyl methyl viologen as cosubstrate
3
4-hydroxy-3-methoxybenzaldehyde
-
4-methylbenzoate, with reduced carbamoyl methyl viologen as cosubstrate
130
4-hydroxybenzoate
-
with reduced carbamoyl methyl viologen as cosubstrate
382
4-hydroxybenzoate
-
-
0.005
4-methoxybenzaldehyde
-
terephthalaldehyde, with carbamoyl methyl viologen as cosubstrate
0.005
4-methoxybenzaldehyde
-
with carbamoyl methyl viologen as cosubstrate
0.0125
acetaldehyde
Megalodesulfovibrio gigas
-
with benzyl viologen as cosubstrate
0.015
acetaldehyde
-
with NH2CO-methyl viologen as cosubstrate, molybdenum-containing enzyme
0.016
acetaldehyde
-
with benzyl viologen as cosubstrate, at 85°C
1.8
acetate
-
with methylviologen as cosubstrate
5.6
acetate
-
with reduced carbamoyl methyl viologen as cosubstrate
0.0014
benzaldehyde
-
-
0.009
benzaldehyde
-
with carbamoyl methyl viologen as cosubstrate
0.02
benzaldehyde
Megalodesulfovibrio gigas
-
with benzyl viologen as cosubstrate
0.02
benzaldehyde
-
3,4-dimethoxy-5-hydroxybenzaldehyde, with carbamoyl methyl viologen as cosubstrate
0.057
benzaldehyde
-
with benzyl viologen as cosubstrate, at 85°C
16.7
benzoate
-
-
31
benzoate
-
with reduced carbamoyl methyl viologen as cosubstrate, pH 4.5
53
benzoate
-
with reduced carbamoyl methyl viologen as cosubstrate, pH 5.5
0.169
benzyl viologen
-
with crotonaldehyde as cosubstrate, at 85°C
0.55
benzyl viologen
Megalodesulfovibrio gigas
-
-
0.002
Butanal
-
-
0.006
Butanal
-
with carbamoyl methyl viologen as cosubstrate
0.022
Butanal
-
with NH2CO-methyl viologen as cosubstrate, tungsten-containing enzyme
0.04
crotonaldehyde
-
-
0.13
crotonaldehyde
-
with benzyl viologen as cosubstrate, at 45°C
0.136
crotonaldehyde
-
with benzyl viologen as cosubstrate, at 85°C
0.01
ES-1 ferredoxin
-
acetaldehyde, with carbamoyl methyl viologen as cosubstrate
-
0.01
ES-1 ferredoxin
-
with crotonaldehyde as cosubstrate, at 85°C
-
0.05
Indoleacetaldehyde
-
with benzyl viologen as cosubstrate, at 85°C
0.05
Indoleacetaldehyde
-
reduced carbamoyl methyl viologen, with benzoate as cosubstrate
0.028
Isovaleraldehyde
-
with benzyl viologen as cosubstrate, at 85°C
0.033
Isovaleraldehyde
-
-
1.422
methanal
-
with benzyl viologen as cosubstrate, at 85°C
1.6
methanal
-
with carbamoyl methyl viologen as cosubstrate
1.6
methanal
-
4-fluorobenzoate, with reduced carbamoyl methyl viologen as cosubstrate
1.6
methanal
-
4-methoxybenzoate, with reduced carbamoyl methyl viologen as cosubstrate
2.9
methyl viologen
-
3-methoxybenzoate, with reduced carbamoyl methyl viologen as cosubstrate
2.9
methyl viologen
-
with crotonaldehyde as cosubstrate
0.067
phenylacetaldehyde
-
-
0.076
phenylacetaldehyde
-
with benzyl viologen as cosubstrate, at 85°C
0.0055
propanal
-
-
0.008
propanal
-
with carbamoyl methyl viologen as cosubstrate
0.0108
propanal
Megalodesulfovibrio gigas
-
with benzyl viologen as cosubstrate
0.15
propanal
-
with benzyl viologen as cosubstrate, at 85°C
6.3
propanoate
-
with reduced carbamoyl methyl viologen as cosubstrate
6.3
propanoate
-
3-fluorobenzoate
0.03
reduced carbamoyl methyl viologen
-
with propanoate as cosubstrate
0.16
reduced carbamoyl methyl viologen
-
with benzoate as cosubstrate
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Heider, J.; Ma, K.; Adams, M.W.W.
Purification, characterization, and metabolic function of tungsten-containing aldehyde ferredoxin oxidoreductase from the hyperthermophilic and proteolytic archaeon Thermococcus strain ES-1
J. Bacteriol.
177
4757-4764
1995
Thermococcus sp., Thermococcus sp. ES-1
brenda
Hensgens, C.M.H.; Hagen, W.R.; Hansen, T.A.
Purification and characterization of a benzylviologen-linked tungsten-containing aldehyde oxidoreductase from Desulfovibrio gigas
J. Bacteriol.
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6195-6200
1995
Megalodesulfovibrio gigas, Megalodesulfovibrio gigas NCIMB 9332
brenda
White, H.; Strobl, G.; Feicht, R.; Simon, H.
Carboxylic acid reductase: a new tungsten enzyme catalyses the reduction of non-activated carboxylic acids to aldehydes
Eur. J. Biochem.
184
89-96
1989
Moorella thermoacetica
brenda
Mukund, S.; Adams, M.W.W.
The novel tungsten-iron-sulfur protein of the hyperthermophilic archaebacterium, Pyrococcus furiosus, is an aldehyde ferredoxin oxidoreductase. Evidence for its participation in a unique glycolytic pathway
J. Biol. Chem.
266
14208-14216
1991
Pyrococcus furiosus
brenda
Huber, C.; Skopan, H.; Feicht, R.; White, H.; Simon, H.
Pterin cofactor, substrate specificity, and observations on the kinetics of the reversible tungsten-containing aldehyde oxidoreductase from Clostridium thermoaceticum
Arch. Microbiol.
164
110-118
1995
Moorella thermoacetica
-
brenda
Huber, C.; Caldeira, J.; Jongejan, J.A.; Simon, H.
Further characterization of two different, reversible aldehyde oxidoreductases from Clostridium formicoaceticum, one containing tungsten and the other molybdenum
Arch. Microbiol.
162
303-309
1994
Clostridium formicaceticum
-
brenda
White, H.; Simon, H.
The role of tungstate and/or molybdate in the formation of aldehyde oxidoreductase in Clostridium thermoaceticum and other acetogens, immunological distances of such enzymes
Arch. Microbiol.
158
81-84
1992
Moorella thermoacetica, no activity in Butyribacterium methylotrophicum, no activity in Clostridium aceticum, no activity in Eubacterium limosum
brenda
Strobl, G.; Feicht, R.; White, H.; Lottspeich, F.; Simon, H.
The tungsten-containing aldehyde oxidoreductase from Clostridium thermoaceticum and its complex with a viologen-accepting NADPH oxidoreductase
Biol. Chem. Hoppe-Seyler
373
123-132
1992
Moorella thermoacetica
brenda
White, H.; Feicht, R.; Huber, C.; Lottspeich, F.; Simon, H.
Purification and some properties of the tungsten-containing carboxylic acid reductase from Clostridium formicoaceticum
Biol. Chem. Hoppe-Seyler
372
999-1005
1991
Clostridium formicaceticum
brenda
Andrade, S.L.A.; Brondino, C.D.; Kamenskaya, E.O.; Levashov, A.V.; Moura, J.J.G.
Kinetic behavior of Desulfovibrio gigas aldehyde oxidoreductase encapsulated in reverse micelles
Biochem. Biophys. Res. Commun.
308
73-78
2003
Megalodesulfovibrio gigas
brenda
Rauh, D.; Graentzdoerffer, A.; Granderath, K.; Andreesen, J.R.; Pich, A.
Tungsten-containing aldehyde oxidoreductase of Eubacterium acidaminophilum. Isolation, characterization and molecular analysis
Eur. J. Biochem.
271
212-219
2004
Peptoclostridium acidaminophilum
brenda