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Information on EC 1.2.7.5 - aldehyde ferredoxin oxidoreductase
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1.2.7.5 aldehyde ferredoxin oxidoreductaseIUBMB Comments
This is an oxygen-sensitive enzyme that contains tungsten-molybdopterin and iron-sulfur clusters. Catalyses the oxidation of aldehydes (including crotonaldehyde, acetaldehyde, formaldehyde and glyceraldehyde) to their corresponding acids. However, it does not oxidize glyceraldehyde 3-phosphate [see EC 1.2.7.6, glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)]. Can use ferredoxin or methyl viologen but not NAD(P)+ as electron acceptor.
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Word Map
- 1.2.7.5
- furiosus
- pyrococcus
-
hyperthermophilic
- pterins
-
acetogenic
-
tungstoenzymes
-
wood-ljungdahl
-
energy-conserving
- molybdopterin
-
tungsten-dependent
- ljungdahlii
- crotonaldehyde
-
molybdoenzymes
- litoralis
- analysis
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
aldehyde ferredoxin oxidoreductase, aldehyde:ferredoxin oxidoreductase, tungsten-containing aldehyde ferredoxin oxidoreductases, glyceraldehyde 3-phosphate oxidoreductase, tungsten-containing aldehyde:ferredoxin oxidoreductase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
aldehyde ferredoxin oxidoreductase
aldehyde oxidase (ferredoxin)
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-
-
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aldehyde oxidoreductase
AOR
Aor1
Aor2
Aor3
aorA
AORAa
Athe_0820
Athe_0821
ebA5355
FOR
glyceraldehyde 3-phosphate oxidoreductase
Gor
oxidase, aldehyde (ferredoxin)
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-
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tungsten-containing aldehyde ferredoxin oxidoreductases
additional information
AOR
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-
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additional information
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formaldehyde ferredoxin oxidoreductase and aldehyde ferredoxin oxidoreductase are 2 separate enzymes
additional information
-
formaldehyde ferredoxin oxidoreductase and aldehyde ferredoxin oxidoreductase are 2 separate enzymes
additional information
-
formaldehyde ferredoxin oxidoreductase and aldehyde ferredoxin oxidoreductase are 2 separate enzymes
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an aldehyde + H2O + oxidized ferredoxin = a carboxylate + 2 H+ + reduced ferredoxin
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-
-
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an aldehyde + H2O + oxidized ferredoxin = a carboxylate + 2 H+ + reduced ferredoxin
active site structure
-
an aldehyde + H2O + oxidized ferredoxin = a carboxylate + 2 H+ + reduced ferredoxin
active site structure
-
an aldehyde + H2O + oxidized ferredoxin = a carboxylate + 2 H+ + reduced ferredoxin
intermolecular interaction analysis
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an aldehyde + H2O + oxidized ferredoxin = a carboxylate + 2 H+ + reduced ferredoxin
substrate binding, catalytic site and reaction mechanism including cofactor action
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
aldehyde:ferredoxin oxidoreductase
This is an oxygen-sensitive enzyme that contains tungsten-molybdopterin and iron-sulfur clusters. Catalyses the oxidation of aldehydes (including crotonaldehyde, acetaldehyde, formaldehyde and glyceraldehyde) to their corresponding acids. However, it does not oxidize glyceraldehyde 3-phosphate [see EC 1.2.7.6, glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)]. Can use ferredoxin or methyl viologen but not NAD(P)+ as electron acceptor.
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CAS REGISTRY NUMBER
COMMENTARY
138066-90-7
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-aminobenzaldehyde + H2O + 2 oxidized benzyl viologen
2-aminobenzoate + 2 H+ + 2 reduced benzyl viologen
4-hydroxybenzaldehyde + H2O + 2 oxidized benzyl viologen
4-hydroxybenzoate + 2 H+ + 2 reduced benzyl viologen
acetaldehyde + H2O + 2 oxidized benzyl viologen
acetate + 2 H+ + 2 reduced benzyl viologen
acetaldehyde + H2O + oxidized benzyl viologen
acetate + reduced benzyl viologen
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at 5% of the activity with crotonaldehyde
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-
?
benzaldehyde + H2O + 2 oxidized benzyl viologen
benzoate + 2 H+ + 2 reduced benzyl viologen
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-
-
?
benzaldehyde + H2O + oxidized benzyl viologen
benzoate + H+ + reduced benzyl viologen
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144% activity compared to phenylacetaldehyde
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-
?
benzaldehyde + H2O + oxidized benzyl viologen
benzoate + reduced benzyl viologen
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at 149% of the activity with crotonaldehyde
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-
?
benzaldehyde + H2O + oxidized ferredoxin
benzoic acid + H+ + reduced ferredoxin
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-
-
-
?
benzoate + Ti(III) citrate + 2 H+
benzaldehyde + Ti(I) citrate + H2O
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-
-
?
butyraldehyde + H2O + oxidized benzyl viologen
butanoate + H+ + reduced benzyl viologen
-
-
-
?
cinnamaldehyde + H2O + oxidized benzyl viologen
cinnamate + reduced benzyl viologen
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at 139% of the activity with crotonaldehyde
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-
?
crotonaldehyde + CoA + 2 oxidized ferredoxin
crotonate + CO2 + 2 reduced ferredoxin + 2 H+
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the ability of the 4Fe-ferredoxin to accept electrons is not absolutely dependent upon Asp14 (of ferredoxin), as this residue can be effectively replaced by Cys. However, the efficiency of electron transfer is compromised if Asp14 is replaced by Ser, or if the 4Fe-cluster is converted to the 3Fe-form, but Asp14 does not appear to offer any kinetic advantage over the expected Cys
-
-
?
crotonaldehyde + H2O + 2 NAD+
crotonate + 2 NADH + 2 H+
-
-
-
?
crotonaldehyde + H2O + 2 oxidized benzyl viologen
crotonate + 2 H+ + 2 reduced benzyl viologen
-
-
-
?
crotonaldehyde + H2O + oxidized benzyl viologen
crotonate + reduced benzyl viologen
-
-
-
-
?
crotonaldehyde + H2O + oxidized benzyl viologen
crotonate + reduced benzyl viologen + H+
-
-
-
?
crotonaldehyde + H2O + oxidized methyl viologen
crotonate + reduced methyl viologen + H+
-
-
-
?
formaldehyde + H2O + 2 oxidized benzyl viologen
formate + 2 H+ + 2 reduced benzyl viologen
-
-
-
?
formaldehyde + H2O + oxidized benzyl viologen
formate + reduced benzyl viologen
-
-
-
-
?
formaldehyde + H2O + oxidized methyl viologen
formate + H+ + reduced methyl viologen
-
specific activity is 17% compared to the activity with crotonaldehyde
-
-
?
glutaraldehyde + H2O + oxidized methyl viologen
glutarate + H+ + reduced methyl viologen
-
-
-
?
glutardialdehyde + H2O + oxidized benzyl viologen
? + H+ + reduced benzyl viologen
-
111% activity compared to phenylacetaldehyde
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-
?
glutaric dialdehyde + H2O + oxidized benzyl viologen
?
-
formaldehyde ferredoxin oxidoreductase
-
-
ir
glyceraldehyde + H2O + 2 oxidized benzyl viologen
glycerate + 2 H+ + 2 reduced benzyl viologen
-
-
-
?
glyceraldehyde 3-phosphate + H2O + oxidized ferredoxin
glycerate 3-phosphate + H+ + reduced ferredoxin
hexanal + H2O + oxidized methyl viologen
hexanoate + H+ + reduced methyl viologen
-
specific activity is 5.7% compared to the activity with crotonaldehyde
-
-
?
indoleacetaldehyde + H2O + oxidized benzyl viologen
indoleacetate + H+ + reduced benzyl viologen
isobutyraldehyde + H2O + oxidized benzyl viologen
isobutanoate + H+ + reduced benzyl viologen
-
-
-
?
isovalerylaldehyde + H2O + oxidized benzyl viologen
isovalerate + H+ + reduced benzyl viologen
phenylacetaldehyde + H2O + 2 NAD+
phenylacetate + 2 NADH + 2 H+
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-
-
?
phenylacetaldehyde + H2O + 2 oxidized benzyl viologen
phenylacetate + 2 H+ + 2 reduced benzyl viologen
-
-
-
?
phenylacetaldehyde + H2O + oxidized benzyl viologen
phenylacetate + H+ + reduced benzyl viologen
phenylacetaldehyde + H2O + oxidized ferredoxin
phenylacetate + H+ + reduced ferredoxin
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-
-
-
?
phenylpropionaldehyde + H2O + oxidized benzyl viologen
phenylpropanoate + H+ + reduced benzyl viologen
propionaldehyde + H2O + 2 oxidized benzyl viologen
propionate + 2 H+ + 2 reduced benzyl viologen
-
-
-
?
propionaldehyde + H2O + oxidized benzyl viologen
propanoate + H+ + reduced benzyl viologen
-
-
-
?
propionaldehyde + H2O + oxidized benzyl viologen
propionate + H+ + reduced benzyl viologen
salicylaldehyde + H2O + oxidized benzyl viologen
salicylic acid + H+ + reduced benzyl viologen
-
-
-
-
ir
succinic semialdehyde + H2O + oxidized benzyl viologen
succinic acid + H+ + reduced benzyl viologen
2-aminobenzaldehyde + H2O + 2 oxidized benzyl viologen
2-aminobenzoate + 2 H+ + 2 reduced benzyl viologen
-
-
-
?
2-aminobenzaldehyde + H2O + 2 oxidized benzyl viologen
2-aminobenzoate + 2 H+ + 2 reduced benzyl viologen
-
-
-
?
4-hydroxybenzaldehyde + H2O + 2 oxidized benzyl viologen
4-hydroxybenzoate + 2 H+ + 2 reduced benzyl viologen
-
-
-
?
4-hydroxybenzaldehyde + H2O + 2 oxidized benzyl viologen
4-hydroxybenzoate + 2 H+ + 2 reduced benzyl viologen
-
-
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?
acetaldehyde + H2O + 2 NAD+
acetate + 2 NADH + 2 H+
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-
-
?
acetaldehyde + H2O + 2 oxidized benzyl viologen
acetate + 2 H+ + 2 reduced benzyl viologen
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-
-
?
acetaldehyde + H2O + 2 oxidized benzyl viologen
acetate + 2 H+ + 2 reduced benzyl viologen
-
-
-
?
acetaldehyde + H2O + oxidized benzyl viologen
acetate + H+ + reduced benzyl viologen
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52% activity compared to phenylacetaldehyde
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-
?
acetaldehyde + H2O + oxidized benzyl viologen
acetate + H+ + reduced benzyl viologen
-
formaldehyde ferredoxin oxidoreductase
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ir
acetaldehyde + H2O + oxidized benzyl viologen
acetate + H+ + reduced benzyl viologen
formaldehyde ferredoxin oxidoreductase
-
ir
acetaldehyde + H2O + oxidized benzyl viologen
acetate + H+ + reduced benzyl viologen
-
-
-
?
acetaldehyde + H2O + oxidized benzyl viologen
acetate + H+ + reduced benzyl viologen
-
formaldehyde ferredoxin oxidoreductase
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ir
acetaldehyde + H2O + oxidized benzyl viologen
acetate + H+ + reduced benzyl viologen
-
-
-
ir
acetaldehyde + H2O + oxidized benzyl viologen
acetate + H+ + reduced benzyl viologen
-
-
-
ir
acetaldehyde + H2O + oxidized benzyl viologen
acetate + H+ + reduced benzyl viologen
-
-
-
ir
acetaldehyde + H2O + oxidized ferredoxin
acetate + H+ + reduced ferredoxin
-
-
-
-
?
acetaldehyde + H2O + oxidized ferredoxin
acetate + H+ + reduced ferredoxin
-
-
-
ir
acetaldehyde + H2O + oxidized ferredoxin
acetate + H+ + reduced ferredoxin
-
formaldehyde ferredoxin oxidoreductase
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ir
acetaldehyde + H2O + oxidized ferredoxin
acetate + H+ + reduced ferredoxin
-
best substrate
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ir
acetate + H+ + reduced ferredoxin
acetaldehyde + H2O + oxidized ferredoxin
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-
-
-
?
acetate + H+ + reduced ferredoxin
acetaldehyde + H2O + oxidized ferredoxin
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-
-
?
acetate + H+ + reduced ferredoxin
acetaldehyde + H2O + oxidized ferredoxin
-
-
-
-
?
acetate + H+ + reduced ferredoxin
acetaldehyde + H2O + oxidized ferredoxin
-
-
-
-
?
acetate + H+ + reduced methyl viologen
acetaldehyde + H2O + oxidized methyl viologen
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very low activity
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ir
acetate + H+ + reduced methyl viologen
acetaldehyde + H2O + oxidized methyl viologen
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below pH 6.0
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ir
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
?
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
ir
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
ir
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
?
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
?
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
?
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
ir
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
ir
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
ir
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
ir
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
ir
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
formaldehyde ferredoxin oxidoreductase, C1-C3 aldehydes
-
ir
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
formaldehyde ferredoxin oxidoreductase, C1-C3 aldehydes
-
ir
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
formaldehyde ferredoxin oxidoreductase, enzyme plays a role in peptide fermentation in hyperthermophilic archaea
-
?
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
ir
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
formaldehyde ferredoxin oxidoreductase, enzyme plays a role in peptide fermentation in hyperthermophilic archaea
-
?
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
?
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
ir
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
ir
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
enzyme oxidizes aldehydes generated during amino acid catabolism
-
-
?
an aldehyde + H2O + oxidized ferredoxin
an acid + H+ + reduced ferredoxin
-
-
-
?, ir
benzaldehyde + H2O + oxidized benzyl viologen
benzoic acid + H+ + reduced benzyl viologen
-
no activity
-
-
?
benzaldehyde + H2O + oxidized benzyl viologen
benzoic acid + H+ + reduced benzyl viologen
-
-
-
-
ir
butyraldehyde + H2O + oxidized ferredoxin
butyrate + H+ + reduced ferredoxin
-
-
-
ir
butyraldehyde + H2O + oxidized ferredoxin
butyrate + H+ + reduced ferredoxin
-
low activity
-
ir
butyraldehyde + H2O + oxidized ferredoxin
butyrate + H+ + reduced ferredoxin
-
formaldehyde ferredoxin oxidoreductase
-
ir
crotonaldehyde + H2O + oxidized benzyl viologen
crotonate + H+ + reduced benzyl viologen
-
48% activity compared to phenylacetaldehyde
-
-
?
crotonaldehyde + H2O + oxidized benzyl viologen
crotonate + H+ + reduced benzyl viologen
-
-
-
ir
crotonaldehyde + H2O + oxidized benzyl viologen
crotonate + H+ + reduced benzyl viologen
-
-
-
?
crotonaldehyde + H2O + oxidized benzyl viologen
crotonate + H+ + reduced benzyl viologen
-
low activity, formaldehyde ferredoxin oxidoreductase
-
-
ir
crotonaldehyde + H2O + oxidized benzyl viologen
crotonate + H+ + reduced benzyl viologen
-
no activity
-
-
?
crotonaldehyde + H2O + oxidized benzyl viologen
crotonate + H+ + reduced benzyl viologen
-
-
-
-
ir
crotonaldehyde + H2O + oxidized benzyl viologen
crotonate + H+ + reduced benzyl viologen
-
-
-
-
ir
crotonaldehyde + H2O + oxidized ferredoxin
crotonate + H+ + reduced ferredoxin
-
best substrate
-
-
ir
crotonaldehyde + H2O + oxidized ferredoxin
crotonate + H+ + reduced ferredoxin
-
-
-
-
r
crotonaldehyde + H2O + oxidized ferredoxin
crotonate + reduced ferredoxin
-
utilizes a 7Fe ferredoxin as the putative physiological redox partner, instead of a 4Fe ferredoxin as in Pyrococcus furiosus, 17% of the activity with benzyl viologen
-
-
?
crotonaldehyde + H2O + oxidized ferredoxin
crotonate + reduced ferredoxin
-
-
-
-
?
crotonaldehyde + H2O + oxidized methyl viologen
crotonate + H+ + reduced methyl viologen
-
-
-
-
?
crotonaldehyde + H2O + oxidized methyl viologen
crotonate + H+ + reduced methyl viologen
-
artifical electron acceptor
-
-
ir
formaldehyde + H2O + oxidized benzyl viologen
formate + H+ + reduced benzyl viologen
-
26% activity compared to phenylacetaldehyde
-
-
?
formaldehyde + H2O + oxidized benzyl viologen
formate + H+ + reduced benzyl viologen
-
formaldehyde ferredoxin oxidoreductase
-
ir
formaldehyde + H2O + oxidized benzyl viologen
formate + H+ + reduced benzyl viologen
formaldehyde ferredoxin oxidoreductase
-
ir
formaldehyde + H2O + oxidized benzyl viologen
formate + H+ + reduced benzyl viologen
-
formaldehyde ferredoxin oxidoreductase
-
ir
formaldehyde + H2O + oxidized benzyl viologen
formate + H+ + reduced benzyl viologen
-
-
-
ir
formaldehyde + H2O + oxidized benzyl viologen
formate + H+ + reduced benzyl viologen
-
-
-
ir
formaldehyde + H2O + oxidized benzyl viologen
formate + H+ + reduced benzyl viologen
-
-
-
ir
formaldehyde + H2O + oxidized ferredoxin
formate + H+ + reduced ferredoxin
-
-
-
ir
formaldehyde + H2O + oxidized ferredoxin
formate + H+ + reduced ferredoxin
-
-
-
?
formaldehyde + H2O + oxidized ferredoxin
formate + H+ + reduced ferredoxin
-
formaldehyde and aldehyde ferredoxin oxidoreductases
-
ir
glyceraldehyde + H2O + oxidized ferredoxin
glycerate + H+ + reduced ferredoxin
B9MQI2; B9MQI1
-
-
-
?
glyceraldehyde + H2O + oxidized ferredoxin
glycerate + H+ + reduced ferredoxin
B9MQI2; B9MQI1
-
-
-
?
glyceraldehyde + H2O + oxidized ferredoxin
glycerate + H+ + reduced ferredoxin
-
-
-
ir
glyceraldehyde + H2O + oxidized ferredoxin
glycerate + H+ + reduced ferredoxin
-
involved in glycolysis
-
ir
glyceraldehyde + H2O + oxidized methyl viologen
glycerate + H+ + reduced methyl viologen
-
-
-
ir
glyceraldehyde + H2O + oxidized methyl viologen
glycerate + H+ + reduced methyl viologen
-
very poor substrate
-
-
?
glyceraldehyde 3-phosphate + H2O + oxidized ferredoxin
glycerate 3-phosphate + H+ + reduced ferredoxin
B9MQI2; B9MQI1
-
-
-
?
glyceraldehyde 3-phosphate + H2O + oxidized ferredoxin
glycerate 3-phosphate + H+ + reduced ferredoxin
B9MQI2; B9MQI1
-
-
-
?
indoleacetaldehyde + H2O + oxidized benzyl viologen
indoleacetate + H+ + reduced benzyl viologen
-
-
-
?
indoleacetaldehyde + H2O + oxidized benzyl viologen
indoleacetate + H+ + reduced benzyl viologen
-
formaldehyde ferredoxin oxidoreductase
-
-
ir
indoleacetaldehyde + H2O + oxidized benzyl viologen
indoleacetate + H+ + reduced benzyl viologen
-
-
-
-
ir
isovalerylaldehyde + H2O + oxidized benzyl viologen
isovalerate + H+ + reduced benzyl viologen
-
formaldehyde ferredoxin oxidoreductase, no activity
-
-
?
isovalerylaldehyde + H2O + oxidized benzyl viologen
isovalerate + H+ + reduced benzyl viologen
formaldehyde ferredoxin oxidoreductase, no activity
-
-
?
isovalerylaldehyde + H2O + oxidized benzyl viologen
isovalerate + H+ + reduced benzyl viologen
-
formaldehyde ferredoxin oxidoreductase, no activity
-
-
?
isovalerylaldehyde + H2O + oxidized benzyl viologen
isovalerate + H+ + reduced benzyl viologen
-
-
-
-
ir
phenylacetaldehyde + H2O + oxidized benzyl viologen
phenylacetate + H+ + reduced benzyl viologen
-
100% activity
-
-
?
phenylacetaldehyde + H2O + oxidized benzyl viologen
phenylacetate + H+ + reduced benzyl viologen
-
no activity
-
-
?
phenylacetaldehyde + H2O + oxidized benzyl viologen
phenylacetate + H+ + reduced benzyl viologen
-
-
-
-
ir
phenylpropionaldehyde + H2O + oxidized benzyl viologen
phenylpropanoate + H+ + reduced benzyl viologen
-
-
-
r
phenylpropionaldehyde + H2O + oxidized benzyl viologen
phenylpropanoate + H+ + reduced benzyl viologen
-
formaldehyde ferredoxin oxidoreductase
-
-
ir
propionaldehyde + H2O + oxidized benzyl viologen
propionate + H+ + reduced benzyl viologen
-
36% activity compared to phenylacetaldehyde
-
-
?
propionaldehyde + H2O + oxidized benzyl viologen
propionate + H+ + reduced benzyl viologen
-
formaldehyde ferredoxin oxidoreductase
-
ir
propionaldehyde + H2O + oxidized benzyl viologen
propionate + H+ + reduced benzyl viologen
formaldehyde ferredoxin oxidoreductase
-
ir
propionaldehyde + H2O + oxidized benzyl viologen
propionate + H+ + reduced benzyl viologen
-
formaldehyde ferredoxin oxidoreductase
-
ir
propionaldehyde + H2O + oxidized benzyl viologen
propionate + H+ + reduced benzyl viologen
-
-
-
ir
propionaldehyde + H2O + oxidized benzyl viologen
propionate + H+ + reduced benzyl viologen
-
-
-
ir
propionaldehyde + H2O + oxidized ferredoxin
propionate + H+ + reduced ferredoxin
-
-
-
-
?
propionaldehyde + H2O + oxidized ferredoxin
propionate + H+ + reduced ferredoxin
-
formaldehyde ferredoxin oxidoreductase
-
ir
succinic semialdehyde + H2O + oxidized benzyl viologen
succinic acid + H+ + reduced benzyl viologen
-
-
-
r
succinic semialdehyde + H2O + oxidized benzyl viologen
succinic acid + H+ + reduced benzyl viologen
-
formaldehyde ferredoxin oxidoreductase
-
-
ir
additional information
?
-
enzyme AORAa catalyzes the oxidation of a broad variety of aldehydes to the respective acids with either viologen dyes or NAD+ as electron acceptors, about twofold higher kcat values with benzyl viologen than with NAD+ as electron acceptor. Enzyme AORAa is also catalyzing the reverse reaction, reduction of benzoate to benzaldehyde, albeit at very low rates and under conditions strongly favoring acid reduction, e.g. low pH and using Ti(III) citrate as electron donor of very low redox potential. Substrate specificity, overview
-
-
-
additional information
?
-
enzyme AORAa catalyzes the oxidation of a broad variety of aldehydes to the respective acids with either viologen dyes or NAD+ as electron acceptors, about twofold higher kcat values with benzyl viologen than with NAD+ as electron acceptor. Enzyme AORAa is also catalyzing the reverse reaction, reduction of benzoate to benzaldehyde, albeit at very low rates and under conditions strongly favoring acid reduction, e.g. low pH and using Ti(III) citrate as electron donor of very low redox potential. Substrate specificity, overview
-
-
-
additional information
?
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no activity towards xanthine, allopurinol, and isoquinoline, inactive towards N-heterolytic compounds
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additional information
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no activity towards xanthine, allopurinol, and isoquinoline, inactive towards N-heterolytic compounds
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additional information
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the enzyme is expressed under microaerobic conditions. The non-magnetic mutant, NMA21 is defective in aldehyde ferredoxin oxidoreductase gene. The enzyme may contribute to ferric iron reduction during synthesis of bacterial magnetic particles under microaerobic respiration
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additional information
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the enzyme is expressed under microaerobic conditions. The non-magnetic mutant, NMA21 is defective in aldehyde ferredoxin oxidoreductase gene. The enzyme may contribute to ferric iron reduction during synthesis of bacterial magnetic particles under microaerobic respiration
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additional information
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enzyme shows an active and an inactive form
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additional information
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enzyme shows an active and an inactive form
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no oxidizing activity with glyceraldehyde-3-phosphate, glyoxylate, glucose, glucose 6-phosphate, CO, H2, formate, pyruvate, 2-oxoglutarate
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no H2 evolution from reduced methyl viologen
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the enzyme is most active on aldehydes derived from amino acids
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acid reduction is strongly dependent on the overall reduction potential, therfore reverse reaction is only possible with reduced methyl viologen at a low rate
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