Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
acetyl coenzyme A synthase/carbon monoxide dehydrogenase
-
-
acetyl-CoA synthase/carbon monoxide dehydrogenase
-
bifunctional enzyme
Carbon dioxide/carbon monoxide oxidoreductase
-
-
-
-
Carbon monoxide dehydrogenase
carbon monoxide dehydrogenase-corrinoid enzyme complex
-
-
-
-
carbon monoxide dehydrogenase/acetyl-CoA synthase
Carbon monoxide oxidoreductase
-
-
-
-
CO dehydrogenase complex
-
-
CO dehydrogenase complex II
-
CO dehydrogenase/acetyl-CoA synthase
-
-
-
-
CODHACS
-
bifunctional enzyme, CODHACS is a macromolecular machine that catalyzes the last step of the Wood-Ljungdahl pathway of anaerobic carbon dioxide fixation
Dehydrogenase, carbon monoxide
-
-
-
-
EC 1.2.99.2
-
-
formerly
-
monoxide dehydrogenase/acetyl-CoA synthase
Ni,Fe-dependent carbon monoxide dehydrogenase
-
-
Ni-containing carbon monoxide dehydrogenase
-
-
Ni-Fe carbon monoxide dehydrogenase II
ACS/CODH

-
-
ACS/CODH
-
bifunctional enzyme
ACS/CODH
-
bifunctional enzyme with ACS alpha subunits and CODH beta subunits
Carbon monoxide dehydrogenase

-
-
-
-
Carbon monoxide dehydrogenase
-
-
carbon monoxide dehydrogenase/acetyl-CoA synthase

-
bifunctional enzyme
carbon monoxide dehydrogenase/acetyl-CoA synthase
bifunctional enzyme
CO dehydrogenase

-
-
-
-
CO dehydrogenase
Mycobacterium tuberculosis TMC 326 / H37Ra-INH-R / ATCC 35835
-
-
-
CO-DH

-
-
CO-DH
-
possesses also nitric oxid dehydrogenase activity in mycobacteria
CO-DH
D5G1Y2; D5G1Y0; D5G1Y1
-
CO-DH
-
possesses also nitric oxid dehydrogenase activity in mycobacteria
-
CO-DH
D5G1Y2; D5G1Y0; D5G1Y1
-
-
CO-DH
-
possesses also nitric oxid dehydrogenase activity in mycobacteria
CO-DH
-
possesses also nitric oxid dehydrogenase activity in mycobacteria
-
CO-DH
Mycobacterium tuberculosis TMC 326 / H37Ra-INH-R / ATCC 35835
-
-
-
CO-DH
Mycobacterium tuberculosis TMC 326 / H37Ra-INH-R / ATCC 35835
-
possesses also nitric oxid dehydrogenase activity in mycobacteria
-
CO-DH
-
possesses also nitric oxid dehydrogenase activity in mycobacteria
CODH

-
-
-
-
CODH
Leadbettera azotonutricia
-
CODH
Leadbettera azotonutricia ZAS-9
-
-
CODH
-
beta subunit of the bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase complex
CODH
-
beta subunit of the bifunctional acetyl coenzyme A synthase/carbon monoxide dehydrogenase complex
CODH
-
forms a complex with acetyl-CoA synthase
CODH
Roseibium aggregatum
-
CODH II

-
CODH/ACS

-
-
CODH/ACS
-
bifunctional enzyme carbon monoxide dehydrogenase/acetyl-CoA synthase
CODH/ACS
bifunctional enzyme
CODHII

-
-
coos

-
catalytic subunit
coos
-
catalytic subunit
-
coos
Leadbettera azotonutricia
-
coos
Leadbettera azotonutricia
gene encoding the catalytic (beta) subunit of the anaerobic CODH enzyme complex
coos
Leadbettera azotonutricia ZAS-9
-
-
coos
Leadbettera azotonutricia ZAS-9
gene encoding the catalytic (beta) subunit of the anaerobic CODH enzyme complex
-
coos
gene encoding the catalytic (beta) subunit of the anaerobic CODH enzyme complex
coos
gene encoding the catalytic (beta) subunit of the anaerobic CODH enzyme complex
coos
gene encoding the catalytic (beta) subunit of the anaerobic CODH enzyme complex
-
coos
gene encoding the catalytic (beta) subunit of the anaerobic CODH enzyme complex
-
coos
gene encoding the catalytic (beta) subunit of the anaerobic CODH enzyme complex
coos
gene encoding the catalytic (beta) subunit of the anaerobic CODH enzyme complex
coos
gene encoding the catalytic (beta) subunit of the anaerobic CODH enzyme complex
coos
gene encoding the catalytic (beta) subunit of the anaerobic CODH enzyme complex
-
coos
gene encoding the catalytic (beta) subunit of the anaerobic CODH enzyme complex
-
coos
gene encoding the catalytic (beta) subunit of the anaerobic CODH enzyme complex
-
monoxide dehydrogenase/acetyl-CoA synthase

-
-
monoxide dehydrogenase/acetyl-CoA synthase
-
-
Ni-Fe carbon monoxide dehydrogenase II

-
-
Ni-Fe carbon monoxide dehydrogenase II
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+

ping-pong mechanism
-
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
ping-pong mechanism
-
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
CO may react with OH- rather than with H2O
-
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
enzyme also catalyzes acetyl-CoA/CoA and acetyl-CoA/CO exchange reaction, enzyme has both CO-dehydrogenase and acetyl-CoA synthase activity
-
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
CO2/CO tunnel gating mechanism
-
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
kinetics, oxidation state of Fe-S cluster during catalysis
-
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
mechanism, CO binding labilizes the hydroxyl bridging Ni and Fe and increases the nucleophilic tendency toward attacking Ni-bound carbonyl
-
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
mechanism, CO binding labilizes the hydroxyl bridging Ni and Fe and increases the nucleophilic tendency toward attacking Ni-bound carbonyl
-
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
mechanism, enzyme is capable of producing formate
-
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
mechnaism via thiocarbonate-like intermediate state
-
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
CO and CO2 enter and exit the enzyme at the water channel along the betabeta subunit interface. CO either enters the enzyme and migrates through the tunnel before binding at the A-cluster, or it binds the A-cluster directly from solvent
-
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
anaerobic CO dehydrogenases catalyze the reversible oxidation of CO to CO2 at a complex Ni-, Fe-, and S-containing metal center called cluster C
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
acetyl-SCoA + CO
acetyl-SCoA + CO
-
acetyl-CoA/CO exchange reaction, 14C experiments prove that the enzyme can cleave both the carbon-carbon and carbon-sulfur bonds of acetyl-CoA as well as to store methyl, CO, and CoA fragments at the active site
-
r
acetyl-SCoA + CoASH
acetyl-SCoA + CoASH
-
acetyl-CoA/CoA exchange reaction
-
r
CO + ferredoxin
?
-
ferredoxin is the direct electron acceptor, the carbon-monoxide dehydrogenase complex reduces a ferredoxin which, together with membranes and associated hydrogenase, reconstitutes a CO-oxidizing:H2-evolving system
-
-
?
CO + H2O
CO2 + H2
-
-
-
?
CO + H2O + 1,1'-trimethylene-4,4'-dimethyl-2,2'dipyridylium dibromide
CO2 + reduced 1,1'-trimethylene-4,4'-dimethyl-2,2'dipyridylium dibromide
-
-
-
?
CO + H2O + 2 oxidized ferredoxin
CO2 + 2 reduced ferredoxin + 2 H+
-
-
-
-
r
CO + H2O + 2,3,5-triphenyltetrazolium chloride
CO2 + reduced 2,3,5-triphenyltetrazolium chloride
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO + H2O + acceptor
CO2 + reduced acceptor
CO + H2O + acceptor
CO2 + reduced acceptor + H+
-
-
-
?
CO + H2O + benzyl viologen
CO2 + reduced benzyl viologen
-
-
-
-
?
CO + H2O + coenzyme F420
CO2 + reduced coenzyme F420
CO + H2O + cytochrome b
CO2 + reduced cytochrome b
-
-
-
?
CO + H2O + cytochrome c3
CO2 + reduced cytochrome c3
-
cytochrome 3 from Desulfovibrio vulgaris
-
?
CO + H2O + electron acceptor
?
CO + H2O + electron acceptor
CO2 + reduced electron acceptor
-
a proton gradient across the cytoplasmic membrane is generated by channeling the electrons formed via cytochrome b561 into a CO-insensitive respiratory chain
-
?
CO + H2O + FAD
CO2 + FADH2
CO + H2O + ferredoxin
CO2 + reduced ferredoxin
CO + H2O + flavodoxin
CO2 + reduced flavodoxin
-
-
-
?
CO + H2O + FMN
CO2 + FMNH2
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
CO + H2O + methyl viologen
CO2 + reduced methyl viologen + H+
CO + H2O + methylene blue
CO2 + reduced methylene blue
CO + H2O + NAD+
CO2 + NADH + H+
CO + H2O + NADP+
CO2 + NADPH + H+
CO + H2O + oxidized 2,3,5-triphenyltetrazolium chloride
CO2 + reduced 2,3,5-triphenyltetrazolium chloride
-
-
-
-
?
CO + H2O + oxidized 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO + H2O + oxidized cytochrome b
CO2 + reduced cytochrome b
-
membrane-bound b-type, native electron carrier
-
-
?
CO + H2O + oxidized cytochrome c3
CO2 + reduced cytochrome c3
-
Desulfovibrio vulgaris cytochrome c3
-
-
?
CO + H2O + oxidized ferredoxin
CO2 + reduced ferredoxin
CO + H2O + oxidized ferredoxin
CO2 + reduced ferredoxin + H+
CO + H2O + oxidized flavodoxin
CO2 + reduced flavodoxin
CO + H2O + oxidized methyl viologen
CO2 + reduced methyl viologen
CO + H2O + oxidized methyl viologen
CO2 + reduced methyl viologen + H+
CO + H2O + oxidized methylene blue
CO2 + reduced methylene blue
-
-
-
-
?
CO + H2O + oxidized phenazine methosulfate
CO2 + reduced phenazine methosulfate
-
-
-
-
?
CO + H2O + oxidized rubredoxin
CO2 + reduced rubredoxin
-
most efficient electron acceptor
-
-
?
CO + H2O + oxidized viologen
CO2 + reduced viologen
-
-
-
-
?
CO + H2O + phenazine methosulfate
CO2 + reduced phenazine methosulfate
-
-
-
?
CO + H2O + rubredoxin
CO2 + reduced rubredoxin
CO2 + 2 reduced ferredoxin + 2 H+
CO + H2O + 2 oxidized ferredoxin
-
-
-
-
r
H2 + reduced methyl viologen
methyl viologen
-
-
-
-
r
propionyl-SCoA + CoASH
propionyl-SCoA + CoASH
-
acetyl-CoA/CoA exchange reaction
-
r
tetrahydrosarcinapterin + acetyl-SCoA + H2O
methyltetrahydrosarcinapterin + CO2 + CoASH
trichloroethylene + ?
cis-dichloroethylene + trans-dichlororethylene + 1,1-dichloroethylene + vinyl chloride + ethylene
-
-
-
?
additional information
?
-
CO + H2O + 2,3,5-triphenyltetrazolium chloride

CO2 + reduced 2,3,5-triphenyltetrazolium chloride
-
-
-
?
CO + H2O + 2,3,5-triphenyltetrazolium chloride
CO2 + reduced 2,3,5-triphenyltetrazolium chloride
-
-
-
?
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride

CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
-
-
-
-
?
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
-
-
-
-
?
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
-
-
-
-
?
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
-
-
-
-
?
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
Mycobacterium tuberculosis TMC 326 / H37Ra-INH-R / ATCC 35835
-
-
-
-
?
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
-
-
-
-
?
CO + H2O + acceptor

CO2 + reduced acceptor
-
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
-
r
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
r
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
-
r
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
-
r
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
D5G1Y2; D5G1Y0; D5G1Y1
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
D5G1Y2; D5G1Y0; D5G1Y1
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
-
r
CO + H2O + acceptor
CO2 + reduced acceptor
Roseibium aggregatum
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + coenzyme F420

CO2 + reduced coenzyme F420
-
-
-
?
CO + H2O + coenzyme F420
CO2 + reduced coenzyme F420
-
1.5% of the activity with methyl viologen
-
?
CO + H2O + electron acceptor

?
-
-
-
-
?
CO + H2O + electron acceptor
?
-
the physiological role of the enzyme in acetyl-CoA synthesis is the reduction of CO2 to a bound CO, the physiological electron acceptor is not known and may be different in different organisms
-
-
?
CO + H2O + electron acceptor
?
-
key enzyme in C1-pathway of acetyl-CoA degradation
-
-
?
CO + H2O + electron acceptor
?
Autotrophic methanogenic bacterium
-
the enzyme is required for autotrophic CO2 fixation in methanogens, the enzyme is also involved in methanogenesis from acetate, not required for methanogenesis
-
-
?
CO + H2O + electron acceptor
?
-
the carbon monoxide dehydrogenase-corrinoid enzyme complex catalyzes the methylation of tetrahydrosarcinapterin in a reaction involving net cleavage of acetyl-CoA
-
-
?
CO + H2O + electron acceptor
?
-
enzyme may also be involved in the formation of acetyl-CoA from methanol in methanogens
-
-
?
CO + H2O + electron acceptor
?
-
extensive role of the enzyme in the acetyl-CoA pathway, it is proposed that the enzyme serves as the CO, CH3, SCoA acceptor and catalyzes the final steps of the synthesis of acetyl-CoA
-
-
?
CO + H2O + electron acceptor
?
-
the enzyme is involved in the Wood pathway of acetyl-CoA synthesis
-
-
?
CO + H2O + electron acceptor
?
-
delivery of a low-potential electron to the CO-bound NiFe complex is the physiological function of the CO oxidation reaction catalyzed by the enzyme
-
-
?
CO + H2O + electron acceptor
?
-
the formation of acetyl-CoA from methyltetrahydrofolate requires several enzymes, including CO dehydrogenase
-
-
?
CO + H2O + electron acceptor
?
-
ferredoxin and a membrane-bound b-type cytochrome are considered to be the native electron carriers
-
-
?
CO + H2O + electron acceptor
?
-
catalyzes the final step in the synthesis of acetyl-CoA
-
-
?
CO + H2O + electron acceptor
?
-
the physiological role of the enzyme in acetyl-CoA synthesis is the reduction of CO2 to a bound CO, the physiological electron acceptor is not known and may be different in different organisms
-
-
?
CO + H2O + electron acceptor
?
-
key role of the enzyme in the synthesis of acetyl-CoA
-
-
?
CO + H2O + FAD

CO2 + FADH2
-
-
-
?
CO + H2O + FAD
CO2 + FADH2
-
-
-
?
CO + H2O + FAD
CO2 + FADH2
-
at 15% of the specific activity compared to methyl viologen
-
-
?
CO + H2O + FAD
CO2 + FADH2
-
at 15% of the specific activity compared to methyl viologen
-
-
?
CO + H2O + FAD
CO2 + FADH2
-
0.3% of the activity with methyl viologen
-
?
CO + H2O + ferredoxin

CO2 + reduced ferredoxin
-
-
-
?
CO + H2O + ferredoxin
CO2 + reduced ferredoxin
-
-
-
?
CO + H2O + ferredoxin
CO2 + reduced ferredoxin
-
-
-
?
CO + H2O + ferredoxin
CO2 + reduced ferredoxin
-
-
-
?
CO + H2O + ferredoxin
CO2 + reduced ferredoxin
-
-
-
?
CO + H2O + ferredoxin
CO2 + reduced ferredoxin
-
active with ferredoxin obtained from Clostridium thermoaceticum, no activity with ferredoxin from spinach
-
?
CO + H2O + FMN

CO2 + FMNH2
-
-
-
?
CO + H2O + FMN
CO2 + FMNH2
-
-
-
?
CO + H2O + FMN
CO2 + FMNH2
-
at 15% of the specific activity compared to methyl viologen
-
-
?
CO + H2O + FMN
CO2 + FMNH2
-
at 15% of the specific activity compared to methyl viologen
-
-
?
CO + H2O + FMN
CO2 + FMNH2
-
0.6% of the activity with methyl viologen
-
?
CO + H2O + FMN
CO2 + FMNH2
-
-
-
-
?
CO + H2O + FMN
CO2 + FMNH2
-
-
-
?
CO + H2O + FMN
CO2 + FMNH2
-
-
-
?
CO + H2O + methyl viologen

CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
r
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
catalyzes an exchange reaction between CO and the carbonyl group of acetyl-CoA
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
-
r
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
optimal concentration of CO 5% in headspace
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
no activity with NAD+ and NADP+
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
the enzyme fails to reduce NAD+, NADP+, or 8-hydroxy-5-deazaflavin cofactor 420
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?