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Information on EC 1.2.7.3 - 2-oxoglutarate synthase

for references in articles please use BRENDA:EC1.2.7.3

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IUBMB Comments

The enzyme contains thiamine diphosphate and two [4Fe-4S] clusters. Highly specific for 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.1, pyruvate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Synonyms
2-oxoglutarate:ferredoxin oxidoreductase, 2-oxoglutarate ferredoxin oxidoreductase, 2-oxoglutarate synthase, alpha-ketoglutarate synthase, alpha-ketoglutarate oxidoreductase, 2-oxoglutarate oxidoreductase, oordabc, 2-ketoglutarate ferredoxin oxidoreductase, fordabge, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-oxoglutarate + CoA + 2 oxidized ferredoxin = succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
show the reaction diagram
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