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Information on EC 1.2.7.11 - 2-oxoacid oxidoreductase (ferredoxin)

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IUBMB Comments
Contains thiamine diphosphate and [4Fe-4S] clusters . This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For example, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).
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The expected taxonomic range for this enzyme is: Archaea, Bacteria
Synonyms
2-oxoacid:ferredoxin oxidoreductase, 2-oxoacid:ferredoxin oxidoreductases, stofor, ape1473/1472, stofor2, stofor1, 2-oxoacid ferredoxin oxidoreductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 2-oxocarboxylate + CoA + 2 oxidized ferredoxin = an acyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
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