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Information on EC 1.2.5.3 - aerobic carbon monoxide dehydrogenase

for references in articles please use BRENDA:EC1.2.5.3

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IUBMB Comments

This enzyme, found in carboxydotrophic bacteria, catalyses the oxidation of CO to CO2 under aerobic conditions. The enzyme contains a binuclear Mo-Cu cluster in which the copper is ligated to a molybdopterin center via a sulfur bridge. The enzyme also contains two [2Fe-2S] clusters and FAD, and belongs to the xanthine oxidoreductase family. The CO2 that is produced is assimilated by the Calvin-Benson-Basham cycle, while the electrons are transferred to a quinone via the FAD site, and continue through the electron transfer chain to a dioxygen terminal acceptor . cf. EC 1.2.7.4, anaerobic carbon monoxide dehydrogenase.

The enzyme appears in viruses and cellular organisms
Reaction Schemes

Synonyms
mocu-codh, aerobic carbon monoxide dehydrogenase, mo-cu carbon monoxide dehydrogenase, molybdenum-containing co dehydrogenase, molybdoenzyme carbon monoxide dehydrogenase, molybdenum-containing carbon monoxide dehydrogenase, molybdenum- and copper-dependent co dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CO + a quinone + H2O = CO2 + a quinol
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
carbon monoxide oxidation to CO2