Reference on EC 1.2.4.2 - oxoglutarate dehydrogenase (succinyl-transferring)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Guest, J.R.; Darlison, M.G.; Spencer, M.E.; Stephens, P.E.
Cloning and sequence analysis of the pyruvate and 2-oxoglutarate dehydrogenase complex genes of Escherichia coli
Biochem. Soc. Trans.
12
220-223
1984
Escherichia coli
Schulze, E.; Westphal, A.H.; Hanemaaijer, R.; de Kok A.
The 2-oxoglutarate dehydrogenase complex from Azotobacter vinelandii. 1. Molecular cloning and sequence analysis of the gene encoding the 2-oxoglutarate dehydrogenase component
Eur. J. Biochem.
187
229-234
1990
Azotobacter vinelandii
Carlsson, P.; Hederstedt, L.
Genetic characterization of Bacillus subtilis odhA and odhB, encoding 2-oxoglutarate dehydrogenase and dihydrolipoamide transsuccinylase, respectively
J. Bacteriol.
171
3667-3672
1989
Bacillus subtilis
Repetto, B.; Tzagoloff, A.
Structure and regulation of KGD1, the structural gene for yeast alpha-ketoglutarate dehydrogenase
Mol. Cell. Biol.
9
2695-2705
1989
Saccharomyces cerevisiae
Karam, G.A.; Bishop, S.H.
alpha-Ketoglutarate dehydrogenase from cauliflower mitochondria: preparation and reactivity with substrates
Phytochemistry
28
3291-3293
1989
Brassica oleracea
-
Dry, I.B.; Wiskich, J.T.
2-Oxoglutarate dehydrogenase and pyruvate dehydrogenase activities in plant mitochondria: interaction via a common coenzyme a pool
Arch. Biochem. Biophys.
257
92-99
1987
Brassica rapa, Pisum sativum
Burke, L.A.; Heffron, J.J.A.
Isocitrate and oxoglutarate dehydrogenase activities of murine dystrophic skeletal muscle
Biochem. Soc. Trans.
15
233-234
1987
Mus musculus
-
De Marcucci, O.G.L.; Hunter, A.; Lindsay, J.G.
Precursor forms of the constituent polypeptides of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes from ox heart
Biochem. Soc. Trans.
14
870
1986
Bos taurus
-
Hunter, A.; Lindsay, J.G.
Immunological and biosynthetic studies on the mammalian 2-oxoglutarate dehydrogenase multienzyme complex
Eur. J. Biochem.
155
103-109
1986
Bos taurus
Hein, S.; Steinbuechel, A.
Cloning and characterization of the Alcaligenes eutrophus 2-oxoglutarate dehydrogenase complex
FEMS Microbiol. Lett.
136
231-238
1996
Cupriavidus necator
Nichols, B.J.; Rigoulet, M.; Denton, R.M.
Comparison of the effects of Ca2+, adenine nucleotides and pH on the kinetic properties of mitochondrial NAD+-isocitrate dehydrogenase and oxoglutarate dehydrogenase from the yeast Saccharomyces cerevisiae and rat heart
Biochem. J.
303
461-465
1994
Saccharomyces cerevisiae, Rattus norvegicus
Nulton-Persson, A.C.; Starke, D.W.; Mieyal, J.J.; Szweda, L.I.
Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status
Biochemistry
42
4235-4242
2003
Rattus norvegicus
Kim, C.H.
Catalytic domain of Salmonella typhimurium 2-oxoglutarate dehydrogenase is localized in N-terminal region
J. Mol. Catal. B
26
193-200
2003
Salmonella enterica subsp. enterica serovar Typhimurium (O87668)
-
Tretter, L.; Adam-Vizi, V.
Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase
J. Neurosci.
24
7771-7778
2004
Cavia porcellus, Sus scrofa
Starkov, A.A.; Fiskum, G.; Chinopoulos, C.; Lorenzo, B.J.; Browne, S.E.; Patel, M.S.; Beal, M.F.
Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species
J. Neurosci.
24
7779-7788
2004
Mus musculus, Rattus norvegicus
McMillan, P.J.; Stimmler, L.M.; Foth, B.J.; McFadden, G.I.; Mueller, S.
The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases
Mol. Microbiol.
55
27-38
2005
Plasmodium falciparum
Solien, J.; Haynes, V.; Giulivi, C.
Differential requirements of calcium for oxoglutarate dehydrogenase and mitochondrial nitric-oxide synthase under hypoxia: Impact on the regulation of mitochondrial oxygen consumption
Comp. Biochem. Physiol. A
142A
111-117
2005
Rattus norvegicus
-
Niebisch, A.; Kabus, A.; Schultz, C.; Weil, B.; Bott, M.
Corynebacterial protein kinase G controls 2-oxoglutarate dehydrogenase activity via the phosphorylation status of the OdhI protein
J. Biol. Chem.
281
12300-12307
2006
Corynebacterium glutamicum
Tian, J.; Bryk, R.; Shi, S.; Erdjument-Bromage, H.; Tempst, P.; Nathan, C.
Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes
Mol. Microbiol.
57
859-868
2005
no activity in Mycobacterium tuberculosis
Jones, D.D.; Perham, R.N.
The role of loop and beta-turn residues as structural and functional determinants for the lipoyl domain from the Escherichia coli 2-oxoglutarate dehydrogenase complex
Biochem. J.
409
357-366
2008
Escherichia coli
Frank, R.A.; Price, A.J.; Northrop, F.D.; Perham, R.N.; Luisi, B.F.
Crystal structure of the E1 component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex
J. Mol. Biol.
368
639-651
2007
Escherichia coli (P0AFG3), Escherichia coli
Shi, Q.; Karuppagounder, S.S.; Xu, H.; Pechman, D.; Chen, H.; Gibson, G.E.
Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability
Neurochem. Int.
50
921-931
2007
Mus musculus
Bunik, V.I.; Fernie, A.R.
Metabolic control exerted by the 2-oxoglutarate dehydrogenase reaction: a cross-kingdom comparison of the crossroad between energy production and nitrogen assimilation
Biochem. J.
422
405-421
2009
Rattus norvegicus
Bunik, V.; Kaehne, T.; Degtyarev, D.; Shcherbakova, T.; Reiser, G.
Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart
FEBS J.
275
4990-5006
2008
Rattus norvegicus
Mailloux, R.J.; Singh, R.; Brewer, G.; Auger, C.; Lemire, J.; Appanna, V.D.
alpha-Ketoglutarate dehydrogenase and glutamate dehydrogenase work in tandem to modulate the antioxidant alpha-ketoglutarate during oxidative stress in Pseudomonas fluorescens
J. Bacteriol.
191
3804-3810
2009
Pseudomonas fluorescens
Graf, A.; Kabysheva, M.; Klimuk, E.; Trofimova, L.; Dunaeva, T.; Z1/4ndorf, G.; Kahlert, S.; Reiser, G.; Storozhevykh, T.; Pinelis, V.; Sokolova, N.; Bunik, V.
Role of 2-oxoglutarate dehydrogenase in brain pathologies involving glutamate neurotoxicity
J. Mol. Catal. B
61
80-87
2009
Rattus norvegicus
-
Ambrus, A.; Tretter, L.; Adam-Vizi, V.
Inhibition of the alpha-ketoglutarate dehydrogenase-mediated reactive oxygen species generation by lipoic acid
J. Neurochem.
109 Suppl 1
222-229
2009
Cavia porcellus
Hoffelder, M.; Raasch, K.; van Ooyen, J.; Eggeling, L.
The E2 domain of OdhA of Corynebacterium glutamicum has succinyltransferase activity dependent on lipoyl residues of the acetyltransferase AceF
J. Bacteriol.
192
5203-5211
2010
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032
Mailloux, R.J.; Gardiner, D.; OBrien, M.
2-Oxoglutarate dehydrogenase is a more significant source of O2(-)/H2O2 than pyruvate dehydrogenase in cardiac and liver tissue
Free Radic. Biol. Med.
97
501-512
2016
Sus scrofa
Zakharchenko, M.; Zakharchenko, A.; Khunderyakova, N.; Tutukina, M.; Simonova, M.; Vasilieva, A.; Romanova, O.; Fedotcheva, N.; Litvinova, E.; Maevsky, E.; Zinchenko, V.; Berezhnov, A.; Morgunov, I.; Gulayev, A.; Kondrashova, M.
Burst of succinate dehydrogenase and alpha-ketoglutarate dehydrogenase activity in concert with the expression of genes coding for respiratory chain proteins underlies short-term beneficial physiological stress in mitochondria
Int. J. Biochem. Cell Biol.
45
190-200
2013
Rattus norvegicus
Nemeria, N.S.; Ambrus, A.; Patel, H.; Gerfen, G.; Adam-Vizi, V.; Tretter, L.; Zhou, J.; Wang, J.; Jordan, F.
Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate
J. Biol. Chem.
289
29859-29873
2014
Homo sapiens
Lei, G.; Wang, X.; Lai, C.; Li, Z.M.; Zhang, W.; Xie, C.; Wang, F.; Wu, X.; Li, Z.
Expression and biochemical characterization of alpha-ketoglutarate decarboxylase from cyanobacterium Synechococcus sp. PCC7002
Int. J. Biol. Macromol.
114
188-193
2018
Synechococcus sp. PCC 7002 (B1XMM5)
Choi, S.; Pfleger, J.; Jeon, Y.; Yang, Z.; He, M.; Shin, H.; Sayed, D.; Astrof, S.; Abdellatif, M.
Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications
Biochim. Biophys. Acta
1862
194436
2019
Homo sapiens (Q02218), Homo sapiens, Mus musculus (Q60597), Mus musculus
Nemeria, N.S.; Gerfen, G.; Guevara, E.; Nareddy, P.R.; Szostak, M.; Jordan, F.
The human Krebs cycle 2-oxoglutarate dehydrogenase complex creates an additional source of superoxide/hydrogen peroxide from 2-oxoadipate as alternative substrate
Free Radic. Biol. Med.
108
644-654
2017
Homo sapiens, Homo sapiens (Q02218)
Kinugawa, H.; Kondo, N.; Komine-Abe, A.; Tomita, T.; Nishiyama, M.; Kosono, S.
In vitro reconstitution and characterization of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase hybrid complex from Corynebacterium glutamicum
MicrobiologyOpen
9
e1113
2020
Corynebacterium glutamicum (Q8NRC3), Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13869 (Q8NRC3)
Condori-Apfata, J.A.; Batista-Silva, W.; Medeiros, D.B.; Vargas, J.R.; Valente, L.M.L.; Heyneke, E.; Perez-Diaz, J.L.; Fernie, A.R.; Araujo, W.L.; Nunes-Nesi, A.
The Arabidopsis E1 subunit of the 2-oxoglutarate dehydrogenase complex modulates plant growth and seed production
Plant Mol. Biol.
101
183-202
2019
Arabidopsis thaliana (F4IWV2), Arabidopsis thaliana (Q9FLH2), Arabidopsis thaliana
Chakraborty, J.; Nemeria, N.; Zhang, X.; Nareddy, P.; Szostak, M.; Farinas, E.; Jordan, F.
Engineering 2-oxoglutarate dehydrogenase to a 2-oxo aliphatic dehydrogenase complex by optimizing consecutive components
AIChE J.
66
e16769
2020
Escherichia coli
-
Nagy, B.; Polak, M.; Ozohanics, O.; Zambo, Z.; Szabo, E.; Hubert, A.; Jordan, F.; Novacek, J.; Adam-Vizi, V.; Ambrus, A.
Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry Implications for the overall hKGDHc structure
Biochim. Biophys. Acta Gen. Subj.
1865
129889
2021
Homo sapiens
Choi, S.; Pfleger, J.; Jeon, Y.H.; Yang, Z.; He, M.; Shin, H.; Sayed, D.; Astrof, S.; Abdellatif, M.
Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications
Biochim. Biophys. Acta Gene Regul. Mech.
1862
194436
2019
Homo sapiens, Mus musculus, Rattus norvegicus
Green, S.R.; Storey, K.B.
Regulation of the alpha-ketoglutarate dehydrogenasecomplex during hibernation in a small mammal, the Richardsons ground squirrel (Urocitellus richardsonii)
Biochim. Biophys. Acta Proteins Proteom.
1868
140448
2020
Urocitellus richardsonii
Burch, J.S.; Marcero, J.R.; Maschek, J.A.; Cox, J.E.; Jackson, L.K.; Medlock, A.E.; Phillips, J.D.; Dailey, H.A.
Glutamine via alpha-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis
Blood
132
987-998
2018
Homo sapiens, Mus musculus (Q60597)
Nemeria, N.S.; Gerfen, G.; Nareddy, P.R.; Yang, L.; Zhang, X.; Szostak, M.; Jordan, F.
The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species
Free Radic. Biol. Med.
115
136-145
2018
Homo sapiens, Homo sapiens (Q96HY7 and Q02218)
Artiukhov, A.; Kazantsev, A.; Lukashev, N.; Bellinzoni, M.; Bunik, V.
Selective inhibition of 2-oxoglutarate and 2-oxoadipate dehydrogenases by the phosphonate analogs of their 2-oxo acid substrates
Front. Chem.
8
596187
2021
Rattus norvegicus (Q4KLP0), Rattus norvegicus (Q5XI78)
Wagner, T.; Boyko, A.; Alzari, P.M.; Bunik, V.I.; Bellinzoni, M.
Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate From a Michaelis-like complex to ThDP adducts
J. Struct. Biol.
208
182-190
2019
Mycolicibacterium smegmatis (A0R2B1), Mycolicibacterium smegmatis ATCC 700084 (A0R2B1), Mycolicibacterium smegmatis mc(2)155 (A0R2B1)
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