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dehydrogenase, pyruvate
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E1 component of pyruvate dehydrogenase
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E1 component of pyruvate dehydrogenase multienzyme complex
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E1 component of the pyruvate dehydrogenase multienzyme complex
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E1 component subunit alpha
E1 component subunit beta
mitochondrial pyruvate dehydrogenase
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OsI_14647
gene name, E1 component subunit alpha
OsI_31986
gene name, E1 component subunit beta
pyruvate dehydrogenase complex
pyruvate dehydrogenase complex E1 component
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pyruvate dehydrogenase complex,
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pyruvate dehydrogenase E1
pyruvate dehydrogenase E1 alpha subunit
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pyruvate dehydrogenase E1 component
pyruvate dehydrogenase E1 component subunit beta
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pyruvate dehydrogenase multienzyme complex
pyruvate dehydrogenase multienzyme complex E1
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pyruvate dehydrogenase, E1
pyruvate:NAD oxidoreductase
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pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
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pyruvic acid dehydrogenase
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pyruvic dehydrogenase
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thiamin diphosphate-dependent pyruvate dehydrogenase
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thiamin-dependent pyruvate dehydrogenase
part of the pyruvate dehydrogenase multienzyme complex PDHc as component E1
thiamine diphosphate-dependent 2-oxo acid decarboxylase
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Vegetative protein 220
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aceE
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AcoA
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CTHT_0006350
Thermochaetoides thermophila
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CTHT_0006350
Thermochaetoides thermophila DSM 1495
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CTHT_0069820
Thermochaetoides thermophila
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CTHT_0069820
Thermochaetoides thermophila DSM 1495
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E1 component subunit alpha
Thermochaetoides thermophila
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E1 component subunit alpha
Thermochaetoides thermophila DSM 1495
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E1 component subunit beta
Thermochaetoides thermophila
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E1 component subunit beta
Thermochaetoides thermophila DSM 1495
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E1alpha
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component of the pyruvate dehydrogenase multienzyme complex PDH
E1alpha
-
component of the pyruvate dehydrogenase multienzyme complex
E1ec
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E1p
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Pda1
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PDC
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PDH
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PDHa
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subunit alpha of pyruvate dehydrogenase E1
PDHC
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PDHc E1
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PDHc-E1
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PDHE1alpha
E1 alpha subunit of pyruvate dehydrogenase
PDHE1alpha
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E1 alpha subunit of pyruvate dehydrogenase
pyruvate decarboxylase
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pyruvate decarboxylase
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pyruvate dehydrogenase
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pyruvate dehydrogenase
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pyruvate dehydrogenase complex
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pyruvate dehydrogenase complex
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pyruvate dehydrogenase complex
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pyruvate dehydrogenase complex
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contains of the three catalytic components pyruvate dehydrogenase (E1p), dihydrolipoyl transacetylase (E2p), and dihydrolipoamide dehydrogenase (E3)
pyruvate dehydrogenase complex
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pyruvate dehydrogenase E1
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bound to the E1-binding domain of dihydrolipoamide acetyltransferase (E2) in pyruvate dehydrogenase complex (PDC)
pyruvate dehydrogenase E1
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pyruvate dehydrogenase E1 component
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pyruvate dehydrogenase E1 component
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pyruvate dehydrogenase multienzyme complex
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pyruvate dehydrogenase multienzyme complex
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pyruvate dehydrogenase multienzyme complex
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pyruvate dehydrogenase, E1
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pyruvate dehydrogenase, E1
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additional information
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E1 is a component of the pyruvate dehydrogenase multienzyme complex PDHc
additional information
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enzyme is a component of the pyruvate dehydrogenase multienzyme complex PDH
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pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
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pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
two-step reaction: thiamine diphosphate dependent decarboxylation of pyruvate to 2-hydroxyethylidene-thiamine diphosphate and subsequent reductive acetylation of lipoic acid residues bound to the dihydrolipoamide acetyltransferase, EC 2.3.1.12
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pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
two-step reaction: thiamine diphosphate dependent decarboxylation of pyruvate to 2-hydroxyethylidene-thiamine diphosphate and subsequent reductive acetylation of lipoic acid residues bound to the dihydrolipoamide acetyltransferase, EC 2.3.1.12
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pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
active site interactions, reaction mechanism
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
catalytic site is formed by the conserved residues Tyr281 and Arg282
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pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
reaction mechanism, role of water molecules
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
active center communication between the cofactors in the enzyme complex. Only one of the thiamine molecules bound to the two active sites is in a chemically activated state whereas the thiamin in the inactive states ionizes with a rate that is at least three orders of magnitude smaller. Model of an active site synchronization via a proton wire that keeps the two active sites in an alternating activation state
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pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
reaction with phosphonolactylthiamine diphosphate gives a covalently bound, pre-decarboxylation reaction intermediate analogue tightly held in the active site through hydrogen bonds with H407, Y599, and H640
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
substrate channelling in the multienzyme complex rests on the recognition of the lipoyl domain by enzyme. Cofactor thiamine diphosphate and substrate pyruvate have distinct effects on enzyme/lipoyl domain interaction. conformational freedom is allowed by the linker in the movement of the lipoyl domain between active sites
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2-hydroxyethylidene-thiamine diphosphate + 2,6-dichlorophenolindophenol
S-acetyldihydrolipoamide + reduced 2,6-dichlorophenolindophenol
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?
2-oxobutanoate + oxidized 2,6-dichlorophenolindophenol
propanal + CO2 + reduced 2,6-dichlorophenolindophenol
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?
2-oxoisovalerate + oxidized 2,6-dichlorophenolindophenol
2-methylpropanal + CO2 + reduced 2,6-dichlorophenolindophenol
16% of the activity with 2-oxobutanoate
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?
2-oxovalerate + oxidized 2,6-dichlorophenolindophenol
butanal + CO2 + reduced 2,6-dichlorophenolindophenol
49% of the activity with 2-oxobutanoate
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?
acetaldehyde + benzaldehyde
(R)-phenylacetylcarbinol
alpha-ketobutyrate + Fe(CN)63- + H2O
hydroxyacetate + CO2 + Fe(CN)64-
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?
alpha-ketobutyrate + lipoamide
S-propionyldihydrolipoamide + CO2
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?
pyruvate + CoA + 2,6-dichlorophenolindophenol
acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol
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?
pyruvate + CoA + ferricyanide
acetyl-CoA + CO2 + ferrocyanide
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol
acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol
pyruvate + E2p lipoyl domain
acetylated E2p lipoyl domain + CO2
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?
pyruvate + Fe(CN)63- + H2O
CO2 + Fe(CN)64-
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?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
pyruvate + lipoyl domain
acetylated lipoyl domain + CO2
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r
pyruvate + oxidized 2,6-dichlorophenolindophenol
acetaldehyde + CO2 + reduced 2,6-dichlorophenolindophenol
pyruvate + pyruvate dehydrogenase complex subunit E2p
?
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?
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine
[dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate + [dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine
[dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
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-
-
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?
additional information
?
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acetaldehyde + benzaldehyde
(R)-phenylacetylcarbinol
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?
acetaldehyde + benzaldehyde
(R)-phenylacetylcarbinol
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?
acetaldehyde + benzaldehyde
(R)-phenylacetylcarbinol
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?
acetaldehyde + benzaldehyde
(R)-phenylacetylcarbinol
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?
acetaldehyde + benzaldehyde
(R)-phenylacetylcarbinol
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-
?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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-
?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
-
?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
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-
?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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-
-
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
enzyme E1 is a component of the pyruvate dehydrogenase multienzyme complex PDHc, and catalyzes the first step of the multistep process
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
reaction of the citric acid or Krebs cycle
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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ir
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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first step of the overall reaction of the pyruvate dehydrogenase complex
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ir
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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ir
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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enzyme is the E1alpha component of the pyruvate dehydrogenase multienzyme complex, regulation via reversible phosphorylation, age-related in crease in enzyme E1alpha activity due to age-related decline in pyruvate dehydrogenase kinase PDK-4, overview
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
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?
pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol
acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol
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?
pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol
acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol
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?
pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol
acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol
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artificial electron acceptor
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?
pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol
acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol
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artifical electron acceptor
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ir
pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol
acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol
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?
pyruvate + CoA + oxidized 2,6-dichlorophenolindophenol
acetyl-CoA + CO2 + reduced 2,6-dichlorophenolindophenol
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?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
additional reactions of complex, e. g. reduction of K3Fe(CN)6
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?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
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specific for
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?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
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?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
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?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate
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?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
additional reactions of complex, e. g. reduction of K3Fe(CN)6
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
Hansenula sp.
-
additional reactions of complex, e. g. reduction of K3Fe(CN)6
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
-
-
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?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
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ir
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by hydroxypyruvate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate
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?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
low reactivity with 2-ketovalerate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
low reactivity with 2-ketoisovalerate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
low reactivity with 2-ketoisocaproate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
-
-
?
pyruvate + oxidized 2,6-dichlorophenolindophenol
acetaldehyde + CO2 + reduced 2,6-dichlorophenolindophenol
-
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-
-
?
pyruvate + oxidized 2,6-dichlorophenolindophenol
acetaldehyde + CO2 + reduced 2,6-dichlorophenolindophenol
17% of the activity with 2-oxobutanoate
-
-
?
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine
[dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
-
-
-
-
?
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine
[dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
-
-
-
?
additional information
?
-
-
conjugates of indole-3-acetic acid with amino acids act as hormones and e.g. inhibit root elongation, the sensitivity of the mutant iar4-1 plant against these conjugates and plant hormones is reduced compared to the wild-type, overview
-
-
?
additional information
?
-
non-complex-bound E1p shows the same cooperativity as found for complex-bound E1p in the pyruvate dehydrogenase complex, EC 1.2.1.104. A Hill coefficient of 1.2-1.6 is calculated for non-complex bound E1p
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-
additional information
?
-
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enzyme is essential for the tricatrboxylic cycle
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-
?
additional information
?
-
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overall reaction of the multienzyme complex, overview
-
-
?
additional information
?
-
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N-terminal residues 1-45 of the pyruvate dehydrogenase complex E1 subunit interact with the E2 subunit and are required for activity of the complex but not for reductive acetylation of the E2 subunit
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-
?
additional information
?
-
reactions performed by the whole enzyme complex, overview
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-
?
additional information
?
-
-
reactions performed by the whole enzyme complex, overview
-
-
?
additional information
?
-
-
binds to the di-domain (lipoyl domain + linker + peripheral subunit binding domain) of the dihydrolipoyl acetyltransferase (E2) component for acetylation
-
-
?
additional information
?
-
-
determination of free short-chain CoA esters in rat heart
-
-
?
additional information
?
-
-
regulatory role of pirin in the process of pyruvate catabolism through interaction with enzyme and inhibition of pyruvate dehydrogenase complex
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine
[dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
-
-
-
-
?
pyruvate + [dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine
[dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
-
-
-
-
?
additional information
?
-
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
-
-
?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
-
-
?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
enzyme E1 is a component of the pyruvate dehydrogenase multienzyme complex PDHc, and catalyzes the first step of the multistep process
-
-
?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
reaction of the citric acid or Krebs cycle
-
-
?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
first step of the overall reaction of the pyruvate dehydrogenase complex
-
-
ir
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
-
-
?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
-
?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
-
-
-
?
pyruvate + CoA + NAD+
acetyl-CoA + CO2 + NADH
-
enzyme is the E1alpha component of the pyruvate dehydrogenase multienzyme complex, regulation via reversible phosphorylation, age-related in crease in enzyme E1alpha activity due to age-related decline in pyruvate dehydrogenase kinase PDK-4, overview
-
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
additional reactions of complex, e. g. reduction of K3Fe(CN)6
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
specific for
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
additional reactions of complex, e. g. reduction of K3Fe(CN)6
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
Hansenula sp.
-
additional reactions of complex, e. g. reduction of K3Fe(CN)6
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
-
-
ir
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by hydroxypyruvate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
low reactivity with 2-ketovalerate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
low reactivity with 2-ketoisovalerate
-
?
pyruvate + lipoamide
S-acetyldihydrolipoamide + CO2
-
low reactivity with 2-ketoisocaproate
-
?
additional information
?
-
-
conjugates of indole-3-acetic acid with amino acids act as hormones and e.g. inhibit root elongation, the sensitivity of the mutant iar4-1 plant against these conjugates and plant hormones is reduced compared to the wild-type, overview
-
-
?
additional information
?
-
-
enzyme is essential for the tricatrboxylic cycle
-
-
?
additional information
?
-
-
overall reaction of the multienzyme complex, overview
-
-
?
additional information
?
-
-
determination of free short-chain CoA esters in rat heart
-
-
?
additional information
?
-
-
regulatory role of pirin in the process of pyruvate catabolism through interaction with enzyme and inhibition of pyruvate dehydrogenase complex
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
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