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Information on EC 1.2.4.1 - pyruvate dehydrogenase (acetyl-transferring)

for references in articles please use BRENDA:EC1.2.4.1
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IUBMB Comments
Contains thiamine diphosphate. It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex in which it is bound to a core of molecules of EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
pdh, pdh complex, e1alpha, mitochondrial pyruvate dehydrogenase, pyruvate dehydrogenase multienzyme complex, pdhc-e1, pyruvate dehydrogenase e1, mtpdc, pdhc e1, pdh e1alpha, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
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