Reference on EC 1.2.3.1 - aldehyde oxidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kishore, G.S.; Boutwell, R.K.
Enzymatic oxidation and reduction of retinal by mouse epidermis
Biochem. Biophys. Res. Commun.
94
1381-1386
1980
Mus musculus
Coleman, M.; Vontas, J.G.; Hemingway, J.
Molecular characterization of the amplified aldehyde oxidase from insecticide resistant Culex quinquefasciatus
Eur. J. Biochem.
269
768-779
2002
Culex quinquefasciatus (Q9NCL9), Culex quinquefasciatus
Maia, L.; Mira, L.
Xanthine oxidase and aldehyde oxidase: A simple procedure for the simultaneous purification from rat liver
Arch. Biochem. Biophys.
400
48-53
2002
Rattus norvegicus
Al-Salmy, H.S.
Individual variation in hepatic aldehyde oxidase activity
IUBMB Life
51
249-253
2001
Homo sapiens
Bittner, F.; Oreb, M.; Mendel, R.R.
ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana
J. Biol. Chem.
276
40381-40384
2001
Arabidopsis thaliana
Seo, M.; Peeters, A.J.M.; Koiwai, H.; Oritani, T.; Marion-Poll, A.; Zeevaart, J.A.D.; Koornneef, M.; Kamiya, Y.; Koshiba, T.
The Arabidopsis aldehyde oxidase 3 (AAO3) gene product catalyzes the final step in abscisic acid biosynthesis in leaves
Proc. Natl. Acad. Sci. USA
97
12908-12913
2000
Arabidopsis thaliana
Wroczynski, P.; Wierzchowski, J.
Aromatic aldehydes as fluorogenic indicators for human aldehyde dehydrogenases and oxidases: substrate and isozyme specificity
Analyst
125
511-516
2000
Rattus norvegicus
Duarte, R.O.; Archer, M.; Dias, J.M.; Bursakov, S.; Huber, R.; Moura, I.; Romao, M.J.; Moura, J.J.G.
Biochemical/spectroscopic characterization and preliminary x-ray analysis of a new aldehyde oxidoreductase isolated from Desulfovibrio desulfuricans ATCC 27774
Biochem. Biophys. Res. Commun.
268
745-749
2000
Desulfovibrio desulfuricans
Sugihara, K.; Katsuma, Y.; Tanaka, C.; Kitamura, S.
Purification and some properties of hamster liver aldehyde oxidase
Biol. Pharm. Bull.
22
1246-1248
1999
Cavia porcellus, Oryctolagus cuniculus, Mesocricetus auratus
Kurosaki, M.; Demontis, S.; Barzago, M.M.; Garattini, E.; Terao, M.
Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone
Biochem. J.
341
71-80
1999
Mus musculus (O54754), Mus musculus
Wright, R.M.; Clayton, D.A.; Riley, M.G.; McManaman, J.L.; Repine, J.E.
cDNA cloning, sequencing, and characterization of male and female rat liver aldehyde oxidase (rAOX1)
J. Biol. Chem.
274
3878-3886
1999
Rattus norvegicus (Q9Z0U5)
Yoshihara, S.i.; Tatsumi, K.
Purification and characterization of hepatic aldehyde oxidase in male and female mice
Arch. Biochem. Biophys.
338
29-34
1997
Mus musculus
Acheampong, A.A.; Chien, D.S.; Lam, S.; Vekich, S.; Breau, A.; Usansky, J.; Harcourt, D.; Munk, S.A.; Nguyen, H.; Garst, M.; Tang-Liu, D.
Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase
Xenobiotica
26
1035-1055
1996
Canis lupus familiaris, Oryctolagus cuniculus, Macaca fascicularis, Rattus norvegicus
Koshiba, T.; Saito, E.; Ono, N.; Yamamoto, N.; Sato, M.
Purification and properties of flavin- and molybdenum-containing aldehyde oxidase from coleoptiles of maize
Plant Physiol.
110
781-789
1996
Zea mays
Calzi, M.L.; Raviolo, C.; Ghibaudi, E.; de Gioia, L.; Salmona, M.; Cazzaniga, G.; Kurosaki, M.; Terao, M.; Garattini, E.
Purification, cDNA cloning, and tissue distribution of bovine liver aldehyde oxidase
J. Biol. Chem.
270
31037-31045
1995
Bos taurus (P48034), Bos taurus
Tasayco, M.L.; Prestwich, G.D.
A specific affinity reagent to distinguish aldehyde dehydrogenases and oxidases. Enzymes catalyzing aldehyde oxidation in an adult moth
J. Biol. Chem.
265
3094-3101
1990
Heliothis virescens
Tasayco, M.L.; Prestwich, G.D.
Aldehyde-oxidizing enzymes in an adult moth: in vitro study of aldehyde metabolism in Heliothis virescens
Arch. Biochem. Biophys.
278
444-451
1990
Heliothis virescens
Stell, J.G.P.; Warne, A.J.; Lee-Woolley, C.
Purification of rabbit liver aldehyde oxidase by affinity chromatography on benzamidine sepharose 6B
J. Chromatogr.
475
363-372
1989
Oryctolagus cuniculus
Turner, N.; Barata, B.; Bray, R.C.; Deistung, J.; Le Gall, J.; Moura, J.J.G.
The molybdenum iron-sulphur protein from Desulfovibrio gigas as a form of aldehyde oxidase
Biochem. J.
243
755-761
1987
Megalodesulfovibrio gigas
Cabre, F.; Canela, E.I.
Purification and properties of bovine liver aldehyde oxidase: comparison with xanthine oxidase
Biochem. Soc. Trans.
15
882-883
1987
Bos taurus
-
Tatsumi, K.; Ishigai, M.
Oxime-metabolizing activity of liver aldehyde oxidase
Arch. Biochem. Biophys.
253
413-418
1987
Cavia porcellus, Oryctolagus cuniculus, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Sus scrofa
Banks, R.B.; Barnett, S.D.
Tropylium tetrafluoroborate, a novel substrate for aldehyde oxidase
Biochem. Biophys. Res. Commun.
140
609-615
1986
Oryctolagus cuniculus
Yoshihara, S.; Tatsumi, K.
Kinetic and inhibition studies on reduction of diphenyl sulfoxide by guinea pig liver aldehyde oxidase
Arch. Biochem. Biophys.
249
8-14
1986
Cavia porcellus
Banks, R.B.; Cooke, R.T.
Chromate reduction by rabbit liver aldehyde oxidase
Biochem. Biophys. Res. Commun.
137
8-14
1986
Oryctolagus cuniculus
Tatsumi, K.; Kitamura, S.
N-Hydroxy-2-acetylaminofluorene as effective inhibitor of aldehyde oxidase
Biochem. Biophys. Res. Commun.
138
312-317
1986
Oryctolagus cuniculus
Hall, W.W.; Krenitsky, T.A.
Aldehyde oxidase from rabbit liver: specificity toward purines and their analogs
Arch. Biochem. Biophys.
251
36-46
1986
Oryctolagus cuniculus
Chanteux, B.; Libion-Mannaert, M.; Dernoncourt-Sterpin, C.; Wattiaux-De Cininck, S.; Elens, A.
Ethanol metabolizing system in Drosophila melanogaster: subcellular distribution of some main enzymes
Experientia
41
1543-1546
1985
Drosophila melanogaster
-
Yoshihara, S.; Tatsumi, K.
Guinea pig liver aldehyde oxidase as a sulfoxide reductase: its purification and characterization
Arch. Biochem. Biophys.
242
213-224
1985
Cavia porcellus
Thomas, H.G.; Silverman, D.N.
Oxidation in H2O and D2O of 6-ethyl-5H-dibenz(c,e)azepine and 1-methylnicotinamide by aldehyde oxidase from rabbit liver
Arch. Biochem. Biophys.
241
649-655
1985
Oryctolagus cuniculus
Angelino, S.A.G.F.; Muller, F.; Van der Plas, H.C.
Purification and immobilization of rabbit liver aldehyde oxidase
Biotechnol. Bioeng.
27
447-455
1985
Oryctolagus cuniculus
Kitamura, S.; Tatsumi, K.
Involvement of liver aldehyde oxidase in the reduction of nicotinamide N-oxide
Biochem. Biophys. Res. Commun.
120
602-606
1984
Cavia porcellus, Mesocricetus auratus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Kitamura, S.; Tatsumi, K.
Reduction of tertiary amine N-oxides by liver preparations: function of aldehyde oxidase as a major N-oxide reductase
Biochem. Biophys. Res. Commun.
121
749-754
1984
Oryctolagus cuniculus
Taylor, S.M.; Stubley-Beedham, C.; Stell, J.G.P.
Simultaneous formation of 2- and 4-quinolones from quinolinium cations catalysed by aldehyde oxidase
Biochem. J.
220
67-74
1984
Cavia porcellus, Oryctolagus cuniculus
Tatsumi, K.; Kitamura, S.; Yamada, H.
Sulfoxide reductase activity of liver aldehyde oxidase
Biochim. Biophys. Acta
747
86-92
1983
Cavia porcellus, Oryctolagus cuniculus
Gormley, P.E.; Rossitch, E.; D'Anna, M.E.; Cysyk, R.
An extremely potent anilinoacridine inhibitor of aldehyde oxidase
Biochem. Biophys. Res. Commun.
116
759-764
1983
Oryctolagus cuniculus
Barber, M.J.; Coughlan, M.P.; Rajagopalan, K.V.; Siegel, L.M.
Properties of the prosthetic groups of rabbit liver aldehyde oxidase: a comparison of molybdenum hydroxylase enzymes
Biochemistry
21
3561-3568
1982
Oryctolagus cuniculus
Badwey, J.A.; Robinson, J.M.; Karnovsky, M.J.; Karnovsky, M.L.
Superoxide production by an unusual aldehyde oxidase in guinea pig granulocytes. Characterization and cytochemical localization
J. Biol. Chem.
256
3479-3486
1981
Cavia porcellus
Warner, C.K.; Finnerty, V.
Molybdenum hydroxylases in Drosophila. II. Molybdenum cofactor in xanthine dehydrogenase, aldehyde oxidase and pyridoxal oxidase
Mol. Gen. Genet.
184
92-96
1981
Drosophila melanogaster
Brandnge, S.; Lindblom, L.
The enzyme aldehyde oxidase is an iminium oxidase. Reaction with nicotine delta 1(5) iminium ion
Biochem. Biophys. Res. Commun.
91
991-996
1979
Oryctolagus cuniculus
Takahashi, N.; Sasaki, R.; Chiba, H.
Enzymatic improvement of food flavor IV. Oxidation of aldehydes in soybean extracts by aldehyde oxidase
Agric. Biol. Chem.
43
2557-2561
1979
Bos taurus
-
Kuhn, D.T.; Cunningham, G.N.
Aldehyde oxidase compartmentalization in Drosophila melanogaster wing imaginal disks
Science
196
875-877
1977
Drosophila melanogaster
Andres, R.Y.
Aldehyde oxidase and xanthine dehydrogenase from wild-type Drosophila melanogaster and immunologically cross-reacting material from ma-1 mutants. Purification by immunoadsorption and characterization
Eur. J. Biochem.
62
591-600
1976
Drosophila melanogaster
Romeo, J.; Pinphanichakarn, V.; Iwamoto, Y.; Folkers, K.
Absence of coenzyme Q10 as an intrinsic component of aldehyde oxidase
Biochem. Biophys. Res. Commun.
59
1286-1291
1974
Oryctolagus cuniculus
Felsted, R.L.; Chu, A.E.Y.; Chaykin, S.
Purification and properties of the aldehyde oxidases from hog and rabbit livers
J. Biol. Chem.
248
2580-2587
1973
Oryctolagus cuniculus, Sus scrofa
Massey, V.
Iron-sulfur flavoprotein hydrolases
Iron-Sulfur Proteins (Lovenberg, W. , ed. )
1
301-360
1973
Oryctolagus cuniculus
-
Krenitsky, T.A.; Neil, S.M.; Elion, G.B.; Hitchings, G.H.
A comparison of the specificities of xanthine oxidase and aldehyde oxidase
Arch. Biochem. Biophys.
150
585-599
1972
Oryctolagus cuniculus
Stanulovic, M.; Chaykin, S.
Aldehyde oxidase: catalysis of the oxidation of N 1 -methylnicotinamide and pyridoxal
Arch. Biochem. Biophys.
145
27-34
1971
Mus musculus, Rattus norvegicus
Arneson, R.M.
Substrate-induced chemiluminescence of xanthine oxidase and aldehyde oxidase
Arch. Biochem. Biophys.
136
352-360
1970
Oryctolagus cuniculus
Rajagopalan, K.V.; Handler, P.
Aldehyde oxidase
Methods Enzymol.
9
364-368
1968
Oryctolagus cuniculus
-
Loo, T.L.; Lim, C.; Johns, D.G.
Enzymic hydroxylation of 6-methylthiopurine by hepatic aldehyde oxidase
Biochim. Biophys. Acta
134
467-469
1967
Oryctolagus cuniculus
-
Huang, D.Y.; Furukawa, A.; Ichikawa, Y.
Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in E. coli
Arch. Biochem. Biophys.
364
264-272
1999
Oryctolagus cuniculus, Mus musculus
Tomita, S.; Tsujita, M.; Ichikawa, Y.
Retinal oxidase is identical to aldehyde oxidase
FEBS Lett.
336
272-274
1993
Oryctolagus cuniculus
Hupert, J.; Mobarhan, S.; Layden, T.J.; Papa, V.M.; Lucchesi, D.
In vitro formation of retinoic acid from retinal in rat liver
Biochem. Cell Biol.
69
509-514
1991
Rattus sp.
Bhat, P.; Poissant, L.; Lacroix, A.
Properties of retinal-oxidizing enzyme activity in rat kidney
Biochim. Biophys. Acta
967
211-217
1988
Rattus sp.
Mandal, S.K.; Chaudhuri, B.D.
Enzymic oxidation of vitamin A aldehyde to vitamin A acid by rat livers of experimental thyroid disorders
Indian J. Exp. Biol.
25
796-797
1987
Rattus sp.
Bhat, P.V.; Poissant, L.; Falardeau, P.; Lacroix, A.
Enzymatic oxidation of all-trans retinal to retinoic acid in rat tissues
Biochem. Cell Biol.
66
735-740
1988
Rattus sp.
Uchida, H.; Kondo, D.; Yamashita, A.; Nagaosa, Y.; Sakurai, T.; Fujii, Y.; Fujishiro, K.; Aisaka, K.; Uwajima, T.
Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690
FEMS Microbiol. Lett.
229
31-36
2003
Pseudomonas sp., Pseudomonas sp. KY 4690
Panoutsopoulos, G.I.; Beedham, C.
Kinetics and specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase towards substituted benzaldehydes
Acta Biochim. Pol.
51
649-663
2004
Cavia porcellus
Panoutsopoulos, G.I.; Beedham, C.
Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin
Acta Biochim. Pol.
51
943-951
2004
Cavia porcellus
Uchida, H.; Fukuda, T.; Satoh, Y.; Okamura, Y.; Toriyama, A.; Yamashita, A.; Aisaka, K.; Sakurai, T.; Nagaosa, Y.; Uwajima, T.
Characterization and potential application of purified aldehyde oxidase from Pseudomonas stutzeri IFO12695
Appl. Microbiol. Biotechnol.
68
53-56
2005
Pseudomonas stutzeri, Pseudomonas stutzeri 12695
Prabhu, R.; Thomas, S.; Balasubramanian, K.A.
Surgical stress-induced alterations in retinoid metabolism in the small intestine: role of oxygen free radicals
Arch. Biochem. Biophys.
434
299-305
2005
Rattus norvegicus
Al-Salmy, H.S.
Inter-strain variability in aldehyde oxidase activity in the mouse
Comp. Biochem. Physiol. C
132
341-347
2002
Mus musculus
Kurosaki, M.; Terao, M.; Barzago, M.M.; Bastone, A.; Bernardinello, D.; Salmona, M.; Garattini, E.
The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa
J. Biol. Chem.
279
50482-50498
2004
Mus musculus
Vila, R.; Kurosaki, M.; Barzago, M.M.; Kolek, M.; Bastone, A.; Colombo, L.; Salmona, M.; Terao, M.; Garattini, E.
Regulation and biochemistry of mouse molybdo-flavoenzymes. The DBA/2 mouse is selectively deficient in the expression of aldehyde oxidase homologues 1 and 2 and represents a unique source for the purification and characterization of aldehyde oxidase
J. Biol. Chem.
279
8668-8683
2004
Mus musculus, Mus musculus CD-1, Mus musculus DBA/2
Yasuhara, A.; Akiba-Goto, M.; Fujishiro, K.; Uchida, H.; Uwajima, T.; Aisaka, K.
Production of aldehyde oxidases by microorganisms and their enzymatic properties
J. Biosci. Bioeng.
94
124-129
2002
Methylobacillus sp., Pseudomonas sp., Streptomyces moderatus
Obach, R.S.; Huynh, P.; Allen, M.C.; Beedham, C.
Human liver aldehyde oxidase: inhibition by 239 drugs
J. Clin. Pharmacol.
44
7-19
2004
Homo sapiens
Taylor, N.J.; Cowan, A.K.
Xanthine dehydrogenase and aldehyde oxidase impact plant hormone homeostasis and affect fruit size in 'Hass' avocado
J. Plant Res.
117
121-130
2004
Persea americana
Omarov, R.; Drager, D.; Tischner, R.; Lips, H.
Aldehyde oxidase isoforms and subunit composition in roots of barley as affected by ammonium and nitrate
Physiol. Plant.
117
337-342
2003
Hordeum vulgare
Yesbergenova, Z.; Yang, G.; Oron, E.; Soffer, D.; Fluhr, R.; Sagi, M.
The plant Mo-hydroxylases aldehyde oxidase and xanthine dehydrogenase have distinct reactive oxygen species signatures and are induced by drought and abscisic acid
Plant J.
42
862-876
2005
Solanum lycopersicum
Merlin, C.; Francois, M.C.; Bozzolan, F.; Pelletier, J.; Jacquin-Joly, E.; Maibeche-Coisne, M.
A new aldehyde oxidase selectively expressed in chemosensory organs of insects
Biochem. Biophys. Res. Commun.
332
4-10
2005
Mamestra brassicae (Q4VGM3), Mamestra brassicae
Neumeier, M.; Weigert, J.; Schaeffler, A.; Weiss, T.S.; Schmidl, C.; Buettner, R.; Bollheimer, C.; Aslanidis, C.; Schoelmerich, J.; Buechler, C.
Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro
Biochem. Biophys. Res. Commun.
350
731-735
2006
Rattus norvegicus
Klecker, R.W.; Cysyk, R.L.; Collins, J.M.
Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: influence of sex and inhibitors
Bioorg. Med. Chem.
14
62-66
2006
Canis lupus familiaris, Macaca fascicularis, Homo sapiens, Mus musculus, Rattus norvegicus, Mus musculus CD-1
Sasaki, T.; Masubuchi, A.; Yamamura, M.; Watanabe, N.; Hiratsuka, M.; Mizugaki, M.; Itoh, K.; Tanaka, Y.
Rat strain differences in stereospecific 2-oxidation of RS-8359, a reversible and selective MAO-A inhibitor, by aldehyde oxidase
Biopharm. Drug Dispos.
27
247-255
2006
Rattus norvegicus (Q9Z0U5)
Saieed, P.; Reza, R.M.; Abbas, D.; Seyyedvali, R.; Aliasghar, H.
Inhibitory effects of Ruta graveolens L. extract on guinea pig liver aldehyde oxidase. [Erratum to document cited in CA144:381924]
Chem. Pharm. Bull.
54
925
2006
Cavia porcellus
-
Dick, R.A.; Kanne, D.B.; Casida, J.E.
Identification of aldehyde oxidase as the neonicotinoid nitroreductase
Chem. Res. Toxicol.
18
317-323
2005
Gallus gallus, Homo sapiens, Macaca fascicularis, Oryctolagus cuniculus, Rattus norvegicus
Dick, R.A.; Kanne, D.B.; Casida, J.E.
Substrate specificity of rabbit aldehyde oxidase for nitroguanidine and nitromethylene neonicotinoid insecticides
Chem. Res. Toxicol.
19
38-43
2006
Rattus norvegicus
Sugihara, K.; Tayama, Y.; Shimomiya, K.; Yoshimoto, D.; Ohta, S.; Kitamura, S.
Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats
Drug Metab. Dispos.
34
208-212
2006
Rattus norvegicus
Yamaguchi, Y.; Matsumura, T.; Ichida, K.; Okamoto, K.; Nishino, T.
Human Xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate
J. Biochem.
141
513-524
2007
Homo sapiens
Yang, Y.M.; Huang, D.Y.; Liu, G.F.; Zhong, J.C.; Du, K.; Li, Y.F.; Song, X.H.
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A metabolism in mice
J. Biochem. Mol. Toxicol.
19
327-335
2005
Mus musculus
Terao, M.; Kurosaki, M.; Barzago, M.M.; Varasano, E.; Boldetti, A.; Bastone, A.; Fratelli, M.; Garattini, E.
Avian and canine aldehyde oxidases. Novel insights into the biology and evolution of molybdo-flavoenzymes
J. Biol. Chem.
281
19748-19761
2006
Canis lupus familiaris (Q2QB47), Canis lupus familiaris (Q2QB48), Canis lupus familiaris, Gallus gallus (Q2QB49), Gallus gallus (Q2QB50), Gallus gallus
Al-Omar, M.A.; Al-Rashood, S.T.; El-Subbagh, H.I.; Abdel Hamide, S.G.
Interaction of 2-thio-4-oxo-quinazoline derivatives with guinea pig liver molybdenum hydroxylases, xanthine oxidase and aldehyde oxidase
J. Biol. Sci.
5
370-378
2005
Cavia porcellus
-
Al-Omar, M.A.; Al-Arifi, M.N.
Comparative effects of scopoletin and menadione on aldehyde oxidase activity of guinea pig liver
J. Biol. Sci.
5
525-531
2005
Cavia porcellus
-
Thapper, A.; Rivas, M.G.; Brondino, C.D.; Ollivier, B.; Fauque, G.; Moura, I.; Moura, J.J.
Biochemical and spectroscopic characterization of an aldehyde oxidoreductase isolated from Desulfovibrio aminophilus
J. Inorg. Biochem.
100
44-50
2006
Desulfovibrio aminophilus
Al-Omar, M.A.
Effect of 2-hydroxy-1, 4-naphthoquinone, a natural dye of Henna, on aldehyde oxidase activity in guinea pig liver
J. Med. Sci.
5
163-168
2005
Cavia porcellus
-
Fedorova, E.; Redondo, F.J.; Koshiba, T.; Pueyo, J.J.; de Felipe, M.R.; Lucas, M.M.
Aldehyde oxidase (AO) in the root nodules of Lupinus albus and Medicago truncatula: identification of AO in meristematic and infection zones
Mol. Plant Microbe Interact.
18
405-413
2005
Lupinus albus, Medicago truncatula
Al-Omar, M.A.
In vitro inhibitory effect of quinolinic acid on aldehyde oxidase activity of guinea pig liver: A proposed mechanism
Saudi Pharm. J.
13
164-170
2005
Cavia porcellus
-
Honda, H.; Tomizawa, M.; Casida, J.E.
Neo-nicotinoid metabolic activation and inactivation established with coupled nicotinic receptor-CYP3A4 and -aldehyde oxidase systems
Toxicol. Lett.
161
108-114
2006
Oryctolagus cuniculus
Rivera, S.P.; Choi, H.H.; Chapman, B.; Whitekus, M.J.; Terao, M.; Garattini, E.; Hankinson, O.
Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes
Toxicology
207
401-409
2005
Mus musculus
Uchida, H.; Okamura, Y.; Yamanaka, H.; Fukuda, T.; Haneda, S.; Aisaka, K.; Fujii, Y.
Purification and some properties of an aldehyde oxidase from Streptomyces rimosus ATCC10970
World J. Microbiol. Biotechnol.
22
469-474
2006
Streptomyces rimosus, Streptomyces rimosus ATCC 10970
Kundu, T.K.; Hille, R.; Velayutham, M.; Zweier, J.L.
Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues
Arch. Biochem. Biophys.
460
113-121
2007
Rattus norvegicus (Q9Z0U5)
Hoshino, K.; Itoh, K.; Masubuchi, A.; Adachi, M.; Asakawa, T.; Watanabe, N.; Kosaka, T.; Tanaka, Y.
Cloning, expression, and characterization of male cynomolgus monkey liver aldehyde oxidase
Biol. Pharm. Bull.
30
1191-1198
2007
Rattus norvegicus, Macaca fascicularis (Q5FB27), Macaca fascicularis
Garattini, E.; Fratelli, M.; Terao, M.
Mammalian aldehyde oxidases: genetics, evolution and biochemistry
Cell. Mol. Life Sci.
65
1019-1048
2008
Danio rerio, Drosophila melanogaster, Drosophila melanogaster (Q9VF53), Equus caballus, Homo sapiens, Macaca mulatta, Mus musculus, Mus musculus (O54754), Mus musculus (Q5SGK3), Mus musculus (Q6V956), Mus musculus (Q8VJ15), Pan troglodytes, Pongo pygmaeus, Rattus norvegicus, Rattus norvegicus (Q5QE78), Rattus norvegicus (Q5QE79), Rattus norvegicus (Q5QE80), Rattus norvegicus (Q9Z0U5), Takifugu rubripes, Monodelphis domestica, Tetraodon nigroviridis, no activity in Aspergillus nidulans, Zea mays (O23887), Zea mays (O23888), Caenorhabditis elegans (O61198), Caenorhabditis elegans (Q960A1), Bos taurus (P48034), Oryctolagus cuniculus (P80456), Canis lupus familiaris (Q2QB47), Canis lupus familiaris (Q2QB48), Gallus gallus (Q2QB49), Gallus gallus (Q2QB50), Mamestra brassicae (Q4VGM3), Macaca fascicularis (Q5FB27), Xenopus laevis (Q6GMC5), Arabidopsis thaliana (Q7G191), Arabidopsis thaliana (Q7G192), Arabidopsis thaliana (Q7G193), Solanum lycopersicum (Q9FV23), Solanum lycopersicum (Q9FV24), Solanum lycopersicum (Q9FV25)
Tayama, Y.; Miyake, K.; Sugihara, K.; Kitamura, S.; Kobayashi, M.; Morita, S.; Ohta, S.; Kihira, K.
Developmental changes of aldehyde oxidase activity in young Japanese children
Clin. Pharmacol. Ther.
81
567-572
2007
Homo sapiens
Tayama, Y.; Moriyasu, A.; Sugihara, K.; Ohta, S.; Kitamura, S.
Developmental changes of aldehyde oxidase in postnatal rat liver
Drug Metab. Pharmacokinet.
22
119-124
2007
Rattus norvegicus
Rashidi, M.R.; Beedham, C.; Smith, J.S.; Davaran, S.
In vitro study of 6-mercaptopurine oxidation catalysed by aldehyde oxidase and xanthine oxidase
Drug Metab. Pharmacokinet.
22
299-306
2007
Cavia porcellus
Pelletier, J.; Bozzolan, F.; Solvar, M.; Francois, M.C.; Jacquin-Joly, E.; Maibeche-Coisne, M.
Identification of candidate aldehyde oxidases from the silkworm Bombyx mori potentially involved in antennal pheromone degradation
Gene
404
31-40
2007
Bombyx mori (A8TUB4), Bombyx mori (A8TUC0), Bombyx mori, Bombyx mori Nistari (A8TUB4), Bombyx mori Nistari (A8TUC0)
Graessler, J.; Fischer, S.
The dual substrate specificity of aldehyde oxidase 1 for retinal and acetaldehyde and its role in ABCA1 mediated efflux
Horm. Metab. Res.
39
775-776
2007
Homo sapiens, Rattus norvegicus, Bos taurus (P48034), Oryctolagus cuniculus (P80456), Gallus gallus (Q2QB50)
Sigruener, A.; Buechler, C.; Orso, E.; Hartmann, A.; Wild, P.J.; Terracciano, L.; Roncalli, M.; Bornstein, S.R.; Schmitz, G.
Human aldehyde oxidase 1 interacts with ATP-binding cassette transporter-1 and modulates its activity in hepatocytes
Horm. Metab. Res.
39
781-789
2007
Homo sapiens (Q06278), Homo sapiens
Li, H.; Cui, H.; Kundu, T.K.; Alzawahra, W.; Zweier, J.L.
Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase
J. Biol. Chem.
283
17855-17863
2008
Rattus norvegicus
Torres, R.A.; Korzekwa, K.R.; McMasters, D.R.; Fandozzi, C.M.; Jones, J.P.
Use of density functional calculations to predict the regioselectivity of drugs and molecules metabolized by aldehyde oxidase
J. Med. Chem.
50
4642-4647
2007
synthetic construct
Itoh, K.; Maruyama, H.; Adachi, M.; Hoshino, K.; Watanabe, N.; Tanaka, Y.
Lack of dimer formation ability in rat strains with low aldehyde oxidase activity
Xenobiotica
37
709-716
2007
Rattus norvegicus
Itoh, K.; Adachi, M.; Sato, J.; Shouji, K.; Fukiya, K.; Fujii, K.; Tanaka, Y.
Effects of selenium deficiency on aldehyde oxidase 1 in rats
Biol. Pharm. Bull.
32
190-194
2009
Rattus norvegicus
Itoh, K.; Asakawa, T.; Hoshino, K.; Adachi, M.; Fukiya, K.; Watanabe, N.; Tanaka, Y.
Functional analysis of aldehyde oxidase using expressed chimeric enzyme between monkey and rat
Biol. Pharm. Bull.
32
31-35
2009
Macaca fascicularis, Rattus norvegicus
Alfaro, J.F.; Joswig-Jones, C.A.; Ouyang, W.; Nichols, J.; Crouch, G.J.; Jones, J.P.
Purification and mechanism of human aldehyde oxidase (Aox1) expressed in E. coli
Drug Metab. Dispos.
37
2393-2398
2009
Homo sapiens
Weigert, J.; Neumeier, M.; Bauer, S.; Mages, W.; Schnitzbauer, A.A.; Obed, A.; Groeschl, B.; Hartmann, A.; Schaeffler, A.; Aslanidis, C.; Schoelmerich, J.; Buechler, C.
Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release
FEBS Lett.
582
2965-2972
2008
Homo sapiens, Mus musculus
Kadam, R.; Iyer, K.
Isolation of liver aldehyde oxidase containing fractions from different animals and determination of kinetic parameters for benzaldehyde
Indian J. Pharm. Sci.
70
85-88
2008
Cavia porcellus, Oryctolagus cuniculus, Mus musculus, Rattus norvegicus
Sasaki, Y.; Isobe, K.; Kataoka, M.; Ogawa, J.; Iwasaki, A.; Hasegawa, J.; Shimizu, S.
Purification and characterization of a new aldehyde oxidase from Pseudomonas sp. AIU 362
J. Biosci. Bioeng.
106
297-302
2008
Pseudomonas sp., Pseudomonas sp. AIU 362
Pirouzpanah, S.; Hanaee, J.; Razavieh, S.V.; Rashidi, M.R.
Inhibitory effects of flavonoids on aldehyde oxidase activity
J. Enzyme Inhib. Med. Chem.
24
14-21
2009
Cavia porcellus
Alfaro, J.; Jones, J.
Studies on the mechanism of aldehyde oxidase and xanthine oxidase
J. Org. Chem.
73
9469-9472
2008
synthetic construct
Ibdah, M.; Chen, Y.T.; Wilkerson, C.G.; Pichersky, E.
An aldehyde oxidase in developing seeds of Arabidopsis converts benzaldehyde to benzoic acid
Plant Physiol.
150
416-423
2009
Arabidopsis thaliana
Schumann, S.; Terao, M.; Garattini, E.; Saggu, M.; Lendzian, F.; Hildebrandt, P.; Leimkuehler, S.
Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1
PLoS ONE
4
e5348
2009
Mus musculus (O54754), Mus musculus
Maeda, Y.; Doubayashi, D.; Ootake, T.; Oki, M.; Mikami, B.; Uchida, H.
Crystallization and preliminary X-ray analysis of formate oxidase, an enzyme of the glucose-methanol-choline oxidoreductase family
Acta Crystallogr. Sect. F
66
1064-1066
2010
Aspergillus oryzae, Aspergillus oryzae RIB 40
Sorouraddin, M.H.; Amini, K.; Naseri, A.; Asgari, D.; Rashidi, M.R.
Study of aldehyde oxidase-catalyzed metabolic pathway of phenanthridine using MCR-ALS method
Bioprocess Biosyst. Eng.
34
173-177
2010
Rattus norvegicus
Zientek, M.; Jiang, Y.; Youdim, K.; Obach, R.S.
In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase
Drug Metab. Dispos.
38
1322-1327
2010
Homo sapiens
Fukiya, K.; Itoh, K.; Yamaguchi, S.; Kishiba, A.; Adachi, M.; Watanabe, N.; Tanaka, Y.
A single amino acid substitution confers high cinchonidine oxidation activity comparable with that of rabbit to monkey aldehyde oxidase 1
Drug Metab. Dispos.
38
302-307
2010
Macaca fascicularis, Oryctolagus cuniculus
Dalvie, D.; Zhang, C.; Chen, W.; Smolarek, T.; Obach, R.S.; Loi, C.M.
Cross-species comparison of the metabolism and excretion of zoniporide: contribution of aldehyde oxidase to interspecies differences
Drug Metab. Dispos.
38
641-654
2010
Homo sapiens
Li, H.; Kundu, T.K.; Zweier, J.L.
Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite
J. Biol. Chem.
284
33850-33858
2009
Rattus norvegicus
Zdunek-Zastocka, E.
The activity pattern and gene expression profile of aldehyde oxidase during the development of Pisum sativum seeds
Plant Sci.
179
543-548
2010
Pisum sativum, Pisum sativum (B0LAZ9), Pisum sativum (B0LB00), Pisum sativum (B0LB01)
Rashidi, M.R.; Dehghany, M.; Dehghan, G.; Jouyban, A.; Faridi, A.
Aldehyde oxidase activity and stability in water-miscible organic solvents
Appl. Biochem. Biotechnol.
169
901-910
2013
Oryctolagus cuniculus (P80456), Oryctolagus cuniculus
Mahro, M.; Coelho, C.; Trincao, J.; Rodrigues, D.; Terao, M.; Garattini, E.; Saggu, M.; Lendzian, F.; Hildebrandt, P.; Romao, M.J.; Leimkuehler, S.
Characterization and crystallization of mouse aldehyde oxidase 3: from mouse liver to Escherichia coli heterologous protein expression
Drug Metab. Dispos.
39
1939-1945
2011
Mus musculus
Hutzler, J.M.; Yang, Y.S.; Albaugh, D.; Fullenwider, C.L.; Schmenk, J.; Fisher, M.B.
Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes
Drug Metab. Dispos.
40
267-275
2012
Homo sapiens
Barr, J.T.; Jones, J.P.
Evidence for substrate-dependent inhibition profiles for human liver aldehyde oxidase
Drug Metab. Dispos.
41
24-29
2013
Homo sapiens
Coelho, C.; Mahro, M.; Trincao, J.; Carvalho, A.T.; Ramos, M.J.; Terao, M.; Garattini, E.; Leimkuehler, S.; Romao, M.J.
The first mammalian aldehyde oxidase crystal structure: insights into substrate specificity
J. Biol. Chem.
287
40690-40702
2012
Mus musculus (G3X982)
Choo, Y.M.; Pelletier, J.; Atungulu, E.; Leal, W.S.
Identification and characterization of an antennae-specific aldehyde oxidase from the navel orangeworm
PLoS ONE
8
e67794
2013
Amyelois transitella (S5FPI8), Amyelois transitella
Hamzeh-Mivehroud, M.; Rahmani, S.; Rashidi, M.R.; Hosseinpour Feizi, M.A.; Dastmalchi, S.
Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids
Xenobiotica
43
661-670
2013
Rattus norvegicus, Rattus norvegicus SpragueDawley
Choughule, K.V.; Joswig-Jones, C.A.; Jones, J.P.
Interspecies differences in the metabolism of methotrexate: An insight into the active site differences between human and rabbit aldehyde oxidase
Biochem. Pharmacol.
96
288-295
2015
Homo sapiens (Q06278), Homo sapiens, Oryctolagus cuniculus (O54754), Oryctolagus cuniculus
Siah, M.; Farzaei, M.H.; Ashrafi-Kooshk, M.R.; Adibi, H.; Arab, S.S.; Rashidi, M.R.; Khodarahmi, R.
Inhibition of guinea pig aldehyde oxidase activity by different flavonoid compounds: An in vitro study
Bioorg. Chem.
64
74-84
2016
Cavia porcellus
Li, Y.; Liu, L.; Tian, P.
NAD(+)-independent aldehyde oxidase catalyzes cofactor balanced 3-hydroxypropionic acid production in Klebsiella pneumoniae
Biotechnol. Lett.
36
2215-2221
2014
Pseudomonas sp., Pseudomonas sp. AIU 362
Barr, J.T.; Jones, J.P.; Oberlies, N.H.; Paine, M.F.
Inhibition of human aldehyde oxidase activity by diet-derived constituents: structural influence, enzyme-ligand interactions, and clinical relevance
Drug Metab. Dispos.
43
34-41
2015
Homo sapiens
Cerqueira, N.M.; Coelho, C.; Bras, N.F.; Fernandes, P.A.; Garattini, E.; Terao, M.; Romao, M.J.; Ramos, M.J.
Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases
J. Biol. Inorg. Chem.
20
209-217
2015
Mus musculus (Q148T8), Mus musculus (Q5SGK3), Mus musculus (Q8R387), Mus musculus (Q8VI15), Mus musculus
Yamada, M.; Adachi, K.; Ogawa, N.; Kishino, S.; Ogawa, J.; Kataoka, M.; Shimizu, S.; Isobe, K.
A new aldehyde oxidase catalyzing the conversion of glycolaldehyde to glycolate from Burkholderia sp. AIU 129
J. Biosci. Bioeng.
119
410-415
2015
Burkholderia sp. AIU 129
Xu, Y.; Li, L.; Wang, Y.; Xing, J.; Zhou, L.; Zhong, D.; Luo, X.; Jiang, H.; Chen, K.; Zheng, M.; Deng, P.; Chen, X.
Aldehyde oxidase mediated metabolism in drug-like molecules: a combined computational and experimental study
J. Med. Chem.
60
2973-2982
2017
Homo sapiens
Srivastava, S.; Brychkova, G.; Yarmolinsky, D.; Soltabayeva, A.; Samani, T.; Sagi, M.
Aldehyde oxidase 4 plays a critical role in delaying silique senescence by catalyzing aldehyde detoxification
Plant Physiol.
173
1977-1997
2017
Arabidopsis thaliana (Q7G191)
Mahro, M.; Bras, N.F.; Cerqueira, N.M.; Teutloff, C.; Coelho, C.; Romao, M.J.; Leimkuehler, S.
Identification of crucial amino acids in mouse aldehyde oxidase 3 that determine substrate specificity
PLoS ONE
8
e82285
2013
Mus musculus (G3X982), Mus musculus
Nirogi, R.; Kandikere, V.; Palacharla, R.C.; Bhyrapuneni, G.; Kanamarlapudi, V.B.; Ponnamaneni, R.K.; Manoharan, A.K.
Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions
Xenobiotica
44
197-204
2014
Homo sapiens
Ferreira, P.; Cerqueira, N.; Fernandes, P.; Romao, M.; Ramos, M.
Catalytic Mechanism of human aldehyde oxidase
ACS Catal.
10
9276-9286
2020
Homo sapiens (Q06278)
-
Montefiori, M.; Jorgensen, F.S.; Olsen, L.
Aldehyde oxidase reaction mechanism and prediction of site of metabolism
ACS Omega
2
4237-4244
2017
Homo sapiens (Q06278)
Ogiso, T.; Fukami, T.; Mishiro, K.; Konishi, K.; Jones, J.P.; Nakajima, M.
Substrate selectivity of human aldehyde oxidase 1 in reduction of nitroaromatic drugs
Arch. Biochem. Biophys.
659
85-92
2018
Homo sapiens (Q06278), Homo sapiens
Paragas, E.M.; Humphreys, S.C.; Min, J.; Joswig-Jones, C.A.; Jones, J.P.
The two faces of aldehyde oxidase Oxidative and reductive transformations of 5-nitroquinoline
Biochem. Pharmacol.
145
210-217
2017
Homo sapiens (Q06278), Homo sapiens
Takei, M.; Kogure, S.; Yokoyama, C.; Kouzuma, Y.; Suzuki, Y.
Identification of an aldehyde oxidase involved in indole-3-acetic acid synthesis in Bombyx mori silk gland
Biosci. Biotechnol. Biochem.
83
129-136
2019
Bombyx mori (Q17209), Bombyx mori
Uehara, S.; Uno, Y.; Okamoto, E.; Inoue, T.; Sasaki, E.; Yamazaki, H.
Molecular cloning and characterization of marmoset aldehyde oxidase
Drug Metab. Dispos.
45
883-886
2017
Callithrix jacchus (F6Y8K6)
Kuecuekgoeze, G.; Terao, M.; Garattini, E.; Leimkuehler, S.
Direct comparison of the enzymatic characteristics and superoxide production of the four aldehyde oxidase enzymes present in mouse
Drug Metab. Dispos.
45
947-955
2017
Mus musculus (G3X982), Mus musculus (O54754), Mus musculus (Q3TYQ9), Mus musculus (Q5SGK3), Mus musculus
Zhang, J.W.; Xiao, W.; Gao, Z.T.; Yu, Z.T.; Zhang, J.Y.J.
Metabolism of c-Met kinase inhibitors containing quinoline by aldehyde oxidase, electron donating, and steric hindrance effect
Drug Metab. Dispos.
46
1847-1855
2018
Homo sapiens, Macaca fascicularis, Mus musculus, Rattus norvegicus
Uchida, H.; Mikami, B.; Yamane-Tanabe, A.; Ito, A.; Hirano, K.; Oki, M.
Crystal structure of an aldehyde oxidase from Methylobacillus sp. KY4400
J. Biochem.
163
321-328
2018
Methylobacillus sp. KY4400 (Q84IX9 and Q84IY0 andQ84IX8)
Zhang, Y.; Yang, Y.; Shen, G.; Mao, X.; Jiao, M.; Lin, Y.
Identification and characterization of aldehyde oxidase 5 in the pheromone gland of the silkworm (Lepidoptera Bombycidae)
J. Insect Sci.
20
31-41
2020
Bombyx mori (A0A1U9X1S0), Bombyx mori
Okamura, Y.; Inada, M.; Elshopakey, G.E.; Itami, T.
Characterization of xanthine dehydrogenase and aldehyde oxidase of Marsupenaeus japonicus and their response to microbial pathogen
Mol. Biol. Rep.
45
419-432
2018
Penaeus japonicus (A0A336UZ51), Penaeus japonicus
Xu, W.; Liao, Y.
Identification and characterization of aldehyde oxidases (AOXs) in the cotton bollworm
Naturwissenschaften
104
94
2017
Helicoverpa armigera
Wang, M.M.; He, M.; Wang, H.; Ma, Y.F.; Dewer, Y.; Zhang, F.; He, P.
A candidate aldehyde oxidase in the antennae of the diamondback moth, Plutella xylostella (L.), is potentially involved in the degradation of pheromones, plant-derived volatiles and the detoxification of xenobiotics
Pestic. Biochem. Physiol.
171
104726
2021
Plutella xylostella (A0A1L8D6P5), Plutella xylostella
Abu-Zaitoon, Y.; Al Tawaha, A.; Alnaimat, S.; Al-Rawashdeh, I.; Abu-Zaiton, A.; Khalifat, A.
Investigation of the potential role of aldehyde oxidase in indole-3-acetic acid synthesis of developing rice grains
Plant Cell Biotechnol. Mol. Biol.
20
6-13
2019
Oryza sativa Japonica Group (Q7XH05)
-
Kuecuekgoeze, G.; Leimkuehler, S.
Direct comparison of the four aldehyde oxidase enzymes present in mouse gives insight into their substrate specificities
PLoS ONE
13
e0191819
2018
Mus musculus (G3X982), Mus musculus (O54754), Mus musculus (Q3TYQ9), Mus musculus (Q5SGK3), Mus musculus
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