Information on EC 1.2.1.86 - geranial dehydrogenase
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
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geranial + H2O + NAD+ = geranate + NADH + H+
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beta myrcene degradation
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geraniol and nerol degradation
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Biosynthesis of antibiotics
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geranial:NAD+ oxidoreductase
Does not act on neral.
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NAD+-dependent citral dehydrogenase
GADH

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geoB

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gene name
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NAD+-dependent citral dehydrogenase

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NAD+-dependent citral dehydrogenase
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metabolism

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the enzyme contributes to the formation of geranic acid
metabolism
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the enzyme contributes to the formation of geranic acid
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geranial + H2O + NAD+
geranate + NADH + H+
geranial + H2O + NAD+

geranate + NADH + H+
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geranial + H2O + NAD+
geranate + NADH + H+
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geranial + H2O + NAD+
geranate + NADH + H+
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geranial + H2O + NAD+
geranate + NADH + H+
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geranial is partially transformed into geranic acid by NAD+-dependent citral dehydrogenase activity
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geranial + H2O + NAD+
geranate + NADH + H+
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geranial is partially transformed into geranic acid by NAD+-dependent citral dehydrogenase activity
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additional information
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enzyme activity is independent of coenzyme A
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53000
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x * 53000, SDS-PAGE
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expressed in Escherichia coli BL21 Star(DE3) cells
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GEOB_CASDE
478
50637
Swiss-Prot
A0A231GZA7_9NOCA
495
52238
TrEMBL
A0A1Q2ZCR4_9ACTN
482
51685
TrEMBL
A0A0M2HC86_9MICO
488
51360
TrEMBL
A0A075V1L4_9PSEU
481
50588
TrEMBL
A0A0K2YNC3_9NOCA
497
52496
TrEMBL
A0A222TFS2_GORRU
499
52414
TrEMBL
A0A2X3KRH9_9ACTN
483
49760
TrEMBL
A0A178WWR3_9PSEU
479
51147
TrEMBL
A0A221K356_9RHOB
576
62743
TrEMBL
A0A259U974_9FIRM
482
52430
TrEMBL
A0A2N9BFQ7_STRCX
483
51589
TrEMBL
A0A0J6VQF5_9MYCO
490
51956
TrEMBL
A0A0U5LQ82_STRRE
483
50427
TrEMBL
A0A202FJ39_MYCPC
493
51983
TrEMBL
A0A177HQ79_9ACTN
500
53035
TrEMBL
A0A231GXH9_9NOCA
481
50770
TrEMBL
W0Z6S0_9MICO
488
51661
TrEMBL
A0A1B9EQ67_9ACTN
487
50965
TrEMBL
A0A0J6WK36_9MYCO
490
52224
TrEMBL
A0A1Y2MJ19_PSEAH
342
35991
TrEMBL
A0A177HWE8_9ACTN
485
51374
TrEMBL
A0A0E4A3G3_RHOER
481
50632
TrEMBL
A0A2H1SBC5_XANCI
489
52420
TrEMBL
A0A084FU31_9PEZI
496
54254
TrEMBL
A0A075UU98_9PSEU
486
51809
TrEMBL
A0A1B1K0Q2_RHOOP
482
50817
TrEMBL
A0A221VYP8_9PSEU
476
49052
TrEMBL
A0A2S8BM70_9MYCO
221
23468
TrEMBL
A0A2I2KPZ7_9ACTN
486
50960
TrEMBL
A0A2I2KT84_9ACTN
486
52060
TrEMBL
A0A222TIL4_GORRU
483
50493
TrEMBL
A0A1Y5PKF3_9MYCO
484
50319
TrEMBL
A0A1V2MQT2_9ACTN
488
51133
TrEMBL
A0A0G3H5J1_9CORY
481
50579
TrEMBL
A0A1B9EQ82_9ACTN
489
52853
TrEMBL
A0A2S8BM25_9MYCO
252
27259
TrEMBL
A0A1Y2MIZ1_PSEAH
496
52756
TrEMBL
A0A0F7KXH1_9SPHN
490
51911
TrEMBL
A0A1Y5PA77_9MYCO
493
52446
TrEMBL
A0A1A9GET0_9ACTN
497
52578
TrEMBL
A0A1Y2MPM6_PSEAH
491
51127
TrEMBL
A0A1X7A4R9_9RHOB
486
51974
TrEMBL
A0A200GUX2_MYCPC
284
29571
TrEMBL
A0A0K2YDI5_9NOCA
482
50935
TrEMBL
A0A2I2KI34_9ACTN
488
50662
TrEMBL
A0A222TE36_GORRU
497
52956
TrEMBL
A0A202FRV5_MYCPC
193
20523
TrEMBL
A0A231GXH5_9NOCA
479
50235
TrEMBL
A0A231GZA2_9NOCA
489
51455
TrEMBL
A0A1Y2N001_PSEAH
480
49794
TrEMBL
A0A1Y2MJQ8_PSEAH
166
18307
TrEMBL
A0A1V2RLF5_9ACTN
476
50957
TrEMBL
A0A0U5M5F5_STRRE
483
51633
TrEMBL
A0A200GN83_MYCPC
493
51997
TrEMBL
A0A178WTN7_9PSEU
332
34994
TrEMBL
A0A2X3KD52_9ACTN
483
50879
TrEMBL
A0A0F0LKL2_9MICO
479
50045
TrEMBL
A0A1S1NM28_9MYCO
489
51230
TrEMBL
A0A231H3C8_9NOCA
476
49898
TrEMBL
W0Z6B1_9MICO
494
52394
TrEMBL
A0A0K2W6H9_MESPL
478
51238
TrEMBL
A0A0J6YD10_9MYCO
490
51958
TrEMBL
A0A1X9MGN7_9BACI
481
52681
TrEMBL
A0A0K2YNB5_9NOCA
480
50014
TrEMBL
A0A2I2KI23_9ACTN
495
51947
TrEMBL
A0A2K8RBI3_9ACTN
488
51913
TrEMBL
A0A1F2PVG1_RHOER
481
49901
TrEMBL
A0A222TJ29_GORRU
497
51096
TrEMBL
A0A222TE12_GORRU
479
49651
TrEMBL
A0A1Y5NX74_9MYCO
491
52471
TrEMBL
A0A200GZX7_MYCPC
488
52515
TrEMBL
A0A098BU31_9NOCA
482
50808
TrEMBL
A0A098BIA1_9NOCA
484
51806
TrEMBL
A0A1Y5P7A3_9MYCO
412
43142
TrEMBL
A0A231H313_9NOCA
478
48633
TrEMBL
W0ZB59_9MICO
485
51580
TrEMBL
A0A124C4Y1_STRSC
497
53412
TrEMBL
A0A1V2MWL1_9ACTN
489
52602
TrEMBL
A0A0F0L3Z5_9MICO
481
50260
TrEMBL
A0A222TGP9_GORRU
477
50143
TrEMBL
A0A1Y2N1Y3_STRPT
483
51129
TrEMBL
A0A1B1KF92_RHOOP
482
51243
TrEMBL
A0A231HDK8_9NOCA
491
51803
TrEMBL
A0A117EAY9_9ACTN
482
51719
TrEMBL
A0A2P9FEG8_9ACTN
480
51176
TrEMBL
A0A202FRU0_MYCPC
284
29541
TrEMBL
A0A2X3KMJ9_9ACTN
482
51030
TrEMBL
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Lueddeke, F.; Wuelfing, A.; Timke, M.; Germer, F.; Weber, J.; Dikfidan, A.; Rahnfeld, T.; Linder, D.; Meyerdierks, A.; Harder, J.
Geraniol and geranial dehydrogenases induced in anaerobic monoterpene degradation by Castellaniella defragrans
Appl. Environ. Microbiol.
78
2128-2136
2012
Castellaniella defragrans
brenda
Wolken, W.; Van Der Werf, M.
Geraniol biotransformation-pathway in spores of Penicillium digitatum
Appl. Microbiol. Biotechnol.
57
731-737
2001
Penicillium digitatum, Penicillium digitatum ATCC 201167
brenda
Lueddeke, F.; Dikfidan, A.; Harder, J.
Physiology of deletion mutants in the anaerobic beta-myrcene degradation pathway in Castellaniella defragrans
BMC Microbiol.
12
192
2012
Castellaniella defragrans, Castellaniella defragrans 65Phen
brenda
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