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EC Tree
IUBMB Comments This is the fourth enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine . This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3,6].
The enzyme appears in viruses and cellular organisms
Synonyms
aruD, AstD, N-succinylglutamate 5-semialdehyde dehydrogenase, SGSD, succinic semialdehyde dehydrogenase, succinylglutamic semialdehyde dehydrogenase,
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N-succinylglutamate 5-semialdehyde dehydrogenase
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succinic semialdehyde dehydrogenase
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succinylglutamic semialdehyde dehydrogenase
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aruD
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N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH + 2 H+
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N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase
This is the fourth enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3,6].
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N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
additional information
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fourth enzyme of the arginine succinyltransferase pathway
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N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
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N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
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fourth enzyme of arginine succinyltransferase pathway
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N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
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N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
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fourth enzyme of arginine succinyltransferase pathway
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N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
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N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
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fourth enzyme of arginine succinyltransferase pathway
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N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
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N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
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fourth enzyme of arginine succinyltransferase pathway
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
additional information
?
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fourth enzyme of the arginine succinyltransferase pathway
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?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
-
fourth enzyme of arginine succinyltransferase pathway
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?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
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fourth enzyme of arginine succinyltransferase pathway
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?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
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fourth enzyme of arginine succinyltransferase pathway
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?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
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fourth enzyme of arginine succinyltransferase pathway
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?
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Cholelithiasis
Gender-specific association of the interleukin 18 gene with symptomatic gallstone disease.
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brenda
MK53
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brenda
MK53
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brenda
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brenda
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brenda
NCTC 10743
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brenda
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Vander Wauven, C.; Jann, A.; Haas, D.; Leisinger, T.; Stalon, V.
N2-Succinylornithine in ornithine catabolism of Pseudomonas aeruginosa
Arch. Microbiol.
150
400-404
1988
Pseudomonas aeruginosa
brenda
Tricot, C.; Vander Wauven, C.; Wattiez, R.; Falmagne, P.; Stalon, V.
Purification and properties of a succinyltransferase from Pseudomonas aeruginosa specific for both arginine and ornithine
Eur. J. Biochem.
224
853-861
1994
Pseudomonas aeruginosa
brenda
Schneider, B.L.; Kiupakis, A.K.; Reitzer, L.J.
Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli
J. Bacteriol.
180
4278-4286
1998
Escherichia coli
brenda
Vander Wauven, C.; Stalon, V.
Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia
J. Bacteriol.
164
882-886
1985
Burkholderia cepacia
brenda
Cunin, R.; Glansdorff, N.; Pierard, A.; Stalon, V.
Biosynthesis and metabolism of arginine in bacteria
Microbiol. Rev.
50
314-352
1986
Klebsiella aerogenes, Burkholderia cepacia, Klebsiella aerogenes MK53
brenda
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1.2.1.71 succinylglutamate-semialdehyde dehydrogenase
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