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Enzyme Nomenclature
Information on EC 1.2.1.71 - succinylglutamate-semialdehyde dehydrogenase
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.2.1.71
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RECOMMENDED NAME
GeneOntology No.
succinylglutamate-semialdehyde dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH + 2 H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase
This is the fourth enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3,6].
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CAS REGISTRY NUMBER
COMMENTARY
201426-13-3
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
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fourth enzyme of the arginine succinyltransferase pathway
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-
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N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
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-
-
-
?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
-
fourth enzyme of arginine succinyltransferase pathway
-
-
?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
-
-
-
-
?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
-
fourth enzyme of arginine succinyltransferase pathway
-
-
?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
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-
-
-
?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
-
fourth enzyme of arginine succinyltransferase pathway
-
-
?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
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-
-
-
?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
-
fourth enzyme of arginine succinyltransferase pathway
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-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
fourth enzyme of the arginine succinyltransferase pathway
-
-
-
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
-
fourth enzyme of arginine succinyltransferase pathway
-
-
?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + 2 H+
-
fourth enzyme of arginine succinyltransferase pathway
-
-
?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
-
fourth enzyme of arginine succinyltransferase pathway
-
-
?
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O
N-succinyl-L-glutamate + NADH + H+
-
fourth enzyme of arginine succinyltransferase pathway
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-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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PDB
SCOP
CATH
UNIPROT
ORGANISM
Q2SXN9
Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264);
Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8);
O50174
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1);
A1U5W8
Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8);
A1U5W8
Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8);
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LINKS TO OTHER DATABASES (specific for EC-Number 1.2.1.71)
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