Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 1.2.1.71 - succinylglutamate-semialdehyde dehydrogenase

for references in articles please use BRENDA:EC1.2.1.71

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

This is the fourth enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine . This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3,6].

The enzyme appears in viruses and cellular organisms

Synonyms
sgsd, n-succinylglutamate 5-semialdehyde dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH + H+
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
Highest Expressing Human Cell Lines
Cell Line Links Gene Links