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EC Tree
IUBMB Comments Involved in the tyrosine degradation pathway in Arthrobacter sp.
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase, 5-carboxymethyl-2-hydroxymuconate semialdehyde:NAD+ oxidoreductase, 5-carboxymethyl-2-hydroxymuconic semialdehyde dehydrogenase, carboxymethylhydroxymuconic semialdehyde dehydrogenase,
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5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
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5-carboxymethyl-2-hydroxymuconate semialdehyde:NAD+ oxidoreductase
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5-carboxymethyl-2-hydroxymuconic semialdehyde dehydrogenase
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carboxymethylhydroxymuconic semialdehyde dehydrogenase
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5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + 2 H+
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5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase
Involved in the tyrosine degradation pathway in Arthrobacter sp.
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5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NADP+
5-carboxymethyl-2-hydroxymuconate + NADPH
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NADP+
5-carboxymethyl-2-hydroxymuconate + NADPH
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11% of the activity compared to the reduction with NAD+
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NADP+
5-carboxymethyl-2-hydroxymuconate + NADPH
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1,5% of the activity compared to reduction with NAD+
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NADP+
5-carboxymethyl-2-hydroxymuconate + NADPH
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1,5% of the activity compared to reduction with NAD+
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NADP+
5-carboxymethyl-2-hydroxymuconate + NADPH
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1,5% of the activity compared to reduction with NAD+
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NADP+
5-carboxymethyl-2-hydroxymuconate + NADPH
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18% of the activity compared to reduction with NAD+
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?
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5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
-
?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
-
?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+
5-carboxymethyl-2-hydroxymuconate + NADH
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involved in the meta-cleavage pathway of 4-hydroxyphenylacetate
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?
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NAD+
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NAD+
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can not be replaced by NADP+
NAD+
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strict dependency for NAD+ reduction
NAD+
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strict dependency for NAD+ reduction
NADP+
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98.5% lower activity compared to NAD+
NADP+
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82% lower activity compared to NAD+
NADP+
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89% lower activity compared to NAD+
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ATP
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competitive inhibition, Ki: 0.088 mM
m-hydroxybenzaldehyde
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p-Hydroxybenzaldehyde
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NADH
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competitive inhibition, Ki: 0.025 mM
NADH
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competitive inhibition with respect to NAD+, Ki: 0.027 mM
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0.005 - 0.009
5-carboxymethyl-2-hydroxymuconate semialdehyde
0.005
5-carboxymethyl-2-hydroxymuconate semialdehyde
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0.006
5-carboxymethyl-2-hydroxymuconate semialdehyde
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0.009
5-carboxymethyl-2-hydroxymuconate semialdehyde
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0.009
5-carboxymethyl-2-hydroxymuconate semialdehyde
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0.012
NAD+
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1.2
NADP+
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40
5-carboxymethyl-2-hydroxymuconate semialdehyde
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54
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7.5
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7.8
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less active in Tris-HCl buffer than in phosphate or glycine/NaOH buffers
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strict dependency for induction of enzyme synthesis of the meta-cleavage pathway by 4-hydroxyphenylacetate
brenda
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strict dependency for induction of enzyme synthesis of the meta-cleavage pathway by 4-hydroxyphenylacetate
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52500
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3 * 52500, SDS-PAGE
58000
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4 * 58000, SDS-PAGE
52000
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2 * 52000, SDS-PAGE
52000
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2 * 52000, SDS-PAGE
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dimer
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2 * 52000, SDS-PAGE
dimer
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2 * 52000, SDS-PAGE
dimer
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2 * 52000, SDS-PAGE
dimer
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2 * 52000, SDS-PAGE
tetramer
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4 * 58000, SDS-PAGE
tetramer
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3 * 52500, SDS-PAGE
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42
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loss of activity after 10 min
47
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complete loss of activity after 20 min
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heating at 50°C for 3 min and immediate chilling on ice abolishes enzyme activity in crude cell extracts
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to homogeneity, chromatography techniques
to homogeneity, chromatography techniques
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to homogeneity, chromatography techniques
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to homogeneity, chromatography techniques
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Blakley, E.R.
The catabolism of L-tyrosine by an Arthrobacter sp.
Can. J. Microbiol.
23
1128-1139
1977
Arthrobacter globiformis, Arthrobacter globiformis PRL W15
brenda
Fawcett, T.; Garrido-Pertierra, A.; Cooper, R.A.
5-Carboxymethyl-2-hydroxymuconic semialdehyde dehydrogenases of Escherichia coli C and Klebsiella pneumoniae M5a1 show very high N-terminal sequence homology
FEMS Microbiol. Lett.
57
307-312
1989
Escherichia coli, Klebsiella pneumoniae, Klebsiella pneumoniae M5a1, Escherichia coli C
brenda
Alonso, J.M.; Garrido-Pertierra, A.
Carboxymethylhydroxymuconic semialdehyde dehydrogenase in the 4-hydroxyphenylacetate catabolic pathway of Pseudomonas putida
Biochem. Cell Biol.
64
1288-1293
1986
Pseudomonas putida
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brenda
Alonso, J.M.; Garrido-Pertierra, A.
Kinetic properties of 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase from Escherichia coli
Biochimie
68
731-737
1986
Escherichia coli, Escherichia coli B / ATCC 11303
brenda
Alonso, J.M.; Garrido-Pertierra, A.
Carboxymethylhydroxymuconic semialdehyde dehydrogenase in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli
Biochim. Biophys. Acta
719
165-167
1982
Escherichia coli
brenda
Cooper, R.A.; Skinner, M.A.
Catabolism of 3- and 4-hydroxyphenylacetate by the 3,4-dihydroxyphenylacetate pathway in Escherichia coli
J. Bacteriol.
143
302-306
1980
Escherichia coli, Escherichia coli B / ATCC 11303, Escherichia coli C
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Barbour, M.G.; Bayly, R.C.
Control of meta-cleavage degradation of 4-hydroxyphenylacetate in Pseudomonas putida
J. Bacteriol.
147
844-850
1981
Pseudomonas putida, Pseudomonas putida NCIB 9865
brenda
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1.2.1.60 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
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