Any feedback?
Information on EC 1.2.1.48 - long-chain-aldehyde dehydrogenase
for references in articles please use BRENDA:EC1.2.1.48Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.2.1.48 long-chain-aldehyde dehydrogenaseIUBMB Comments
The best substrate is dodecylaldehyde.
Specify your search results
Word Map
- 1.2.1.48
- sls
- ichthyosis
- spastic
- faldh
- aldh3a2
-
neurocutaneous
- diplegia
- tetraplegia
-
sjogren-larsson
- amadhs
-
phytanic
- aminoaldehyde
-
photophobia
-
larsson
- quadriplegia
-
alcohol:nad+
-
glistening
- medicine
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
fatty aldehyde dehydrogenase, aldh3b2, aldh10, long-chain aldehyde dehydrogenase, aldh3b3, falddh, long-chain fatty aldehyde dehydrogenase, membrane-bound fatty aldehyde dehydrogenase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ALDH3A2
Bt-Aldh
dehydrogenase, long-chain aliphatic aldehyde
-
-
-
-
FALDH
fatty aldehyde dehydrogenase
fatty aldehyde:NAD+ oxidoreductase
-
-
-
-
long-chain aldehyde dehydrogenase
-
-
-
-
long-chain fatty aldehyde dehydrogenase
-
-
-
-
long-chain-aldehyde dehydrogenase
ALDH3A2
-
Sjögren-Larsson syndrome is caused by mutations in the ALDH3A2 gene that codes for FALDH
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a long-chain aldehyde + NAD+ + H2O = a long-chain carboxylate + NADH + H+
-
-
-
-
a long-chain aldehyde + NAD+ + H2O = a long-chain carboxylate + NADH + H+
the human enzyme FALDH shows a unique reaction mechanism that differs from other ALDHs, modelling giving an alternative model for the reaction mechanism of FALDH, overview. The first step involves the activation of the catalytic Cys241 by deprotonation and subsequent substrate binding. Once Cys241 is deprotonated, it performs a nucleophilic attack on the carbonyl carbon of the fatty aldehyde, which forms a thiohemiacetal. Asn112 supports the orientation of the polar head group by coordinating to the substrate oxygen and subsequently stabilizes a tetrahedral reaction intermediate. In a second step, the collapse of the primarily formed oxyanion then initiates a hydride transfer to the NAD cofactor in a pro-R manner. Subsequently, a water molecule is deprotonated by Glu207 or Glu331 and triggers a nucleophilic attack of the hydroxide anion on the carbonyl carbon. In a final step, a repeated collapse of the oxyanion forms the fatty acid product and releases the covalent bond to Cys241, which remains activated or can be potentially reactivated
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
reduction
-
-
-
-
redox reaction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
long-chain-aldehyde:NAD+ oxidoreductase
The best substrate is dodecylaldehyde.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
59298-89-4
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-hydroxyhexadecanal + NAD+ + H2O
2-hydroxyhexadecanoic acid + NADH + 2 H+
-
-
-
-
?
4,4'-diapolycopendial + NAD+ + H2O
4,4'-diapolycopen-4'-al-4-oic acid + NADH + H+
-
-
-
-
?
a long-chain aldehyde + NAD+ + H2O
a long-chain carboxylate + NADH + 2 H+
-
-
-
?
dihydrophytal + NAD+ + H2O
(3R,S,7R,11R)-3,7,11,15-tetramethylhexadecanoic acid + NADH
-
-
-
?
hexanal + NAD+ + H2O
hexanoic acid + NADH + H+
50% of the activity with tetradecanal
-
-
?
m-fluorobenzaldehyde + NAD+ + H2O
m-fluorobenzoic acid + NADH + H+
-
-
-
?
m-methylbenzaldehyde + NAD+ + H2O
m-methylbenzoic acid + NADH
-
36% activity toward tetradecanal
-
?
o-fluorobenzaldehyde + NAD+ + H2O
o-fluorobenzoic acid + NADH + H+
-
-
-
?
p-chlorobenzaldehyde + NAD+ + H2O
p-chlorobenzoic acid + NADH + H+
-
-
-
?
p-fluorobenzaldehyde + NAD+ + H2O
p-fluorobenzoic acid + NADH + H+
-
-
-
?
trans-2-decenal + NAD+ + H2O
trans-2-decenoic acid + NADH
-
32% activity toward tetradecanal
-
?
trans-cinnamaldehyde + NAD+ + H2O
trans-cinnamic acid + NADH
-
38% activity toward tetradecanal
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
66% activity toward tetradecanal
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
66% activity toward tetradecanal
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
major substrate
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
major substrate
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
major substrate
-
-
?
cis-9-hexadecenal + NAD+ + H2O
cis-9-hexadecenoic acid + NADH
-
31% activity toward tetradecanal
-
?
dodecanal + NAD+ + H2O
dodecanoic acid + NADH + H+
50% of the activity with tetradecanal
-
-
?
long-chain aldehyde + NAD+
?
-
the enzyme plays a significant role in n-alkane utilization, especially in intracellular wax ester synthesis
-
-
?
long-chain aldehyde + NAD+
?
-
in microsomes and mitochondria: provides long-chain fatty acids to be utilized for lipid synthesis
-
-
?
long-chain aldehyde + NAD+
?
-
in peroxisomes: provides long-chain fatty acids to be degraded via beta-oxidation to yield energy and cell constituents
-
-
?
long-chain aldehyde + NAD+
?
-
mobilization of intracellular wax esters in the cotyledon during germination
-
-
?
long-chain aldehyde + NAD+
?
-
enzyme is a functional part of the bioluminescent system
-
-
?
long-chain aldehyde + NAD+
?
-
in microsomes and mitochondria: provides long-chain fatty acids to be utilized for lipid synthesis
-
-
?
long-chain aldehyde + NAD+
?
-
in peroxisomes: provides long-chain fatty acids to be degraded via beta-oxidation to yield energy and cell constituents
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
octanal + NAD+ + H2O
octanoic acid + NADH + H+
50% of the activity with tetradecanal
-
-
?
phytenal + NAD+
phytenic acid + NADH
-
the enzyme is involved in the breakdown of phytol
-
-
?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH
-
highest activity
-
?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH
-
highest activity
-
?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH + H+
-
-
-
?
additional information
?
-
enzyme has high activity against aliphatic long-chain aldehydes such as tetradecanal, Bt-Aldh represents thermophilic aldehyde dehydrogenases responsible for degradation of long-chain alkanes
-
-
?
additional information
?
-
enzyme displays high activity against aliphatic long-chain aldehydes such as tetradecanal
-
-
?
additional information
?
-
enzyme has high activity against aliphatic long-chain aldehydes such as tetradecanal, Bt-Aldh represents thermophilic aldehyde dehydrogenases responsible for degradation of long-chain alkanes
-
-
?
additional information
?
-
enzyme displays high activity against aliphatic long-chain aldehydes such as tetradecanal
-
-
?
additional information
?
-
-
poor substrates: acetaldehyde, propionaldehyde, crotonaldehyde, glutaraldehyde, benzaldehyde, retinaldehyde
-
-
?
additional information
?
-
-
Sjögren-Larsson syndrom is an inherited neurocutaneous disease caused by mutations in the ALDH3A2 gene that codes for fatty aldehyde dehydrogenase, an enzyme involved in lipid metabolism. A rich diversity of mutations and haplotype associations is demonstrated in Sjögren-Larsson syndrom
-
-
?
additional information
?
-
-
catalytically important residues to be involved in alcohol and aldehyde oxidation are Gln-120, Glu-207, Cys-241, Phe-333, Tyr-410 and His-411
-
-
?
additional information
?
-
the C-terminal gatekeeper helix is important for directing the substrate specificity of FALDH towards long-chain fatty aldehydes. Substrate funnel properties and substrate specificity, overview
-
-
?
additional information
?
-
-
the C-terminal gatekeeper helix is important for directing the substrate specificity of FALDH towards long-chain fatty aldehydes. Substrate funnel properties and substrate specificity, overview
-
-
?
additional information
?
-
the enzyme ALDH3B2 exhibits broad substrate preferences from medium- to long-chain aldehydes
-
-
?
additional information
?
-
the enzyme ALDH3B2 exhibits broad substrate preferences from medium- to long-chain aldehydes
-
-
?
additional information
?
-
-
the enzyme ALDH3B2 exhibits broad substrate preferences from medium- to long-chain aldehydes
-
-
?
additional information
?
-
the enzyme ALDH3B3 exhibits broad substrate preferences from medium- to long-chain aldehydes
-
-
?
additional information
?
-
the enzyme ALDH3B3 exhibits broad substrate preferences from medium- to long-chain aldehydes
-
-
?
additional information
?
-
-
the enzyme ALDH3B3 exhibits broad substrate preferences from medium- to long-chain aldehydes
-
-
?
additional information
?
-
-
the enzyme plays an important role in insulin action and is deregulated in states associated with altered insulin signaling
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
a long-chain aldehyde + NAD+ + H2O
a long-chain carboxylate + NADH + 2 H+
-
-
-
?
phytenal + NAD+
phytenic acid + NADH
-
the enzyme is involved in the breakdown of phytol
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
major substrate
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
major substrate
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
major substrate
-
-
?
long-chain aldehyde + NAD+
?
-
the enzyme plays a significant role in n-alkane utilization, especially in intracellular wax ester synthesis
-
-
?
long-chain aldehyde + NAD+
?
-
in microsomes and mitochondria: provides long-chain fatty acids to be utilized for lipid synthesis
-
-
?
long-chain aldehyde + NAD+
?
-
in peroxisomes: provides long-chain fatty acids to be degraded via beta-oxidation to yield energy and cell constituents
-
-
?
long-chain aldehyde + NAD+
?
-
mobilization of intracellular wax esters in the cotyledon during germination
-
-
?
long-chain aldehyde + NAD+
?
-
enzyme is a functional part of the bioluminescent system
-
-
?
long-chain aldehyde + NAD+
?
-
in microsomes and mitochondria: provides long-chain fatty acids to be utilized for lipid synthesis
-
-
?
long-chain aldehyde + NAD+
?
-
in peroxisomes: provides long-chain fatty acids to be degraded via beta-oxidation to yield energy and cell constituents
-
-
?
additional information
?
-
enzyme has high activity against aliphatic long-chain aldehydes such as tetradecanal, Bt-Aldh represents thermophilic aldehyde dehydrogenases responsible for degradation of long-chain alkanes
-
-
?
additional information
?
-
enzyme has high activity against aliphatic long-chain aldehydes such as tetradecanal, Bt-Aldh represents thermophilic aldehyde dehydrogenases responsible for degradation of long-chain alkanes
-
-
?
additional information
?
-
-
Sjögren-Larsson syndrom is an inherited neurocutaneous disease caused by mutations in the ALDH3A2 gene that codes for fatty aldehyde dehydrogenase, an enzyme involved in lipid metabolism. A rich diversity of mutations and haplotype associations is demonstrated in Sjögren-Larsson syndrom
-
-
?
additional information
?
-
-
the enzyme plays an important role in insulin action and is deregulated in states associated with altered insulin signaling
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NAD+