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Information on EC 1.2.1.4 - aldehyde dehydrogenase (NADP+)
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EC Tree
1.2.1.4 aldehyde dehydrogenase (NADP+)Specify your search results
Word Map
- 1.2.1.4
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voltage-gated
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kvbeta1
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voltage-dependent
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pore-forming
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juxtaparanodal
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paranodal
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caspr
- medicine
- retinaldehyde
- synthesis
The enzyme appears in viruses and cellular organisms
Synonyms
kvbeta2, aldh6, nadp-dependent aldehyde dehydrogenase, taaldh, aldehyde dehydrogenase (nadp+), aldhpyr1147, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ALD6
aldehyde dehydrogenase (NADP+)
aldehyde dehydrogenase 3A1
aldehyde dehydrogenase 6
ALDH
ALDH1F1
ALDH3A1
ALDH6
AlDHPyr1147
dehydrogenase, aldehyde (nicotinamide adenine dinucleotide phosphate)
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NADP+-dependent Ald6
NADP-acetaldehyde dehydrogenase
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NADP-dependent aldehyde dehydrogenase
Ta0439
TaAlDH
NADP-dependent aldehyde dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an aldehyde + NADP+ + H2O = a carboxylate + NADPH + H+
random kinetic mechanism
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an aldehyde + NADP+ + H2O = a carboxylate + NADPH + H+
random kinetic mechanism
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an aldehyde + NADP+ + H2O = a carboxylate + NADPH + H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
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reduction
oxidation
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reduction
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
aldehyde:NADP+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
9028-87-9
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97162-78-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-cyanobenzaldehyde + NADP+ + H2O
2-cyanobenzoate + NADPH + H+
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3% activity compared to 4-nitrobenzaldehyde
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-
?
2-methlybutyraldehyde + NADP+ + H2O
2-methylbutanoate + NADPH + H+
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16% activity compared to 4-nitrobenzaldehyde
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-
?
2-nitrobenzaldehyde + NADP+ + H2O
2-nitrobenzoate + NADPH + H+
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22% activity compared to 4-nitrobenzaldehyde
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-
?
3-nitrobenzaldehyde + NADP+ + H2O
3-nitrobenzoate + NADPH + H+
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53% activity compared to 4-nitrobenzaldehyde
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-
?
4-cyanobenzaldehyde + NADP+ + H2O
4-cyanobenzoate + NADPH + H+
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6% activity compared to 4-nitrobenzaldehyde
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?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
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20% activity compared to 4-nitrobenzaldehyde
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?
4-nitroacetophenone + NADP+ + H2O
?
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2% activity compared to 4-nitrobenzaldehyde
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?
4-nitrobenzaldehyde + NADP+ + H2O
4-nitrobenzoate + NADPH + H+
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100% activity
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?
butanal + NADP+ + H2O
butanoate + NADPH + H+
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5% activity compared to 4-nitrobenzaldehyde
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?
chloroacetaldehyde + NADP+ + H2O
chloroacetate + NADPH + H+
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most effective substrate in the absence of Mg2+
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?
crotonaldehyde + NADP+ + H2O
crotonate + NADPH + H+
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2% activity compared to 4-nitrobenzaldehyde
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?
glutaraldehyde + NADP+ + H2O
glutarate + NADPH + H+
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-
-
-
?
hexanal + NADP+ + H2O
hexanoate + NADPH + H+
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1% activity compared to 4-nitrobenzaldehyde
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-
?
isobutanal + NADP+
isobutyrate + NADPH
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19% of the activity with acetaldehyde
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ir
methylglyoxal + NADP+ + H2O
?
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7% activity compared to 4-nitrobenzaldehyde
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?
phenylglyoxal + NADP+ + H2O
?
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3% activity compared to 4-nitrobenzaldehyde
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?
succinic semialdehyde + NADP+ + H2O
?
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5% activity compared to 4-nitrobenzaldehyde
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?
trans,trans-muconaldehyde + NADP+ + H2O
trans,trans-muconic acid + NADPH + H+
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?
valeraldehyde + NADP+ + H2O
pentanoate + NADPH + H+
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1% activity compared to 4-nitrobenzaldehyde
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?
4-hydroxy-2-nonenal + NADP+ + H2O
(2E)-4-hydroxynon-2-enoate + NADPH + H+
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?
4-hydroxy-2-nonenal + NADP+ + H2O
(2E)-4-hydroxynon-2-enoate + NADPH + H+
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?
4-hydroxy-2-nonenal + NADP+ + H2O
(2E)-4-hydroxynon-2-enoate + NADPH + H+
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?
acetaldehyde + NADP+
?
Acetobacter acetigenus
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enzyme is involved in assimilation of ethanol
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?
acetaldehyde + NADP+
?
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enzyme is involved in assimilation of ethanol
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?
acetaldehyde + NADP+
?
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enzyme is involved in assimilation of ethanol
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?
acetaldehyde + NADP+
?
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enzyme is involved in assimilation of ethanol
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?
acetaldehyde + NADP+
?
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enzyme is involved in assimilation of ethanol
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?
acetaldehyde + NADP+
?
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enzyme is involved in assimilation of ethanol
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?
acetaldehyde + NADP+
?
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enzyme is involved in assimilation of ethanol
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?
acetaldehyde + NADP+
?
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enzyme is involved in assimilation of ethanol
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?
acetaldehyde + NADP+
?
Gluconobacter gluconicus
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enzyme is involved in assimilation of ethanol
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?
acetaldehyde + NADP+
?
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enzyme is involved in assimilation of ethanol
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?
acetaldehyde + NADP+
?
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enzyme is involved in assimilation of ethanol
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?
acetaldehyde + NADP+
?
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enzyme is involved in assimilation of ethanol
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?
acetaldehyde + NADP+
acetate + NADPH + H+
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?
acetaldehyde + NADP+ + H2O
acetate + NADPH + H+
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enzyme a, b, c, d and e
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?
acetaldehyde + NADP+ + H2O
acetate + NADPH + H+
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131% of the activity with isovaleraldehyde
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?
an aldehyde + NADP+ + H2O
an acid + NADPH + H+
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removal of aldehydes and alcohols in cells under stress
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?
benzaldehyde + NADP+
benzoate + NADPH
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l40% of the activity with acetaldehyde
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?
benzaldehyde + NADP+
benzoate + NADPH
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6% of the activity with isovaleraldehyde
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?
benzaldehyde + NADP+ + H2O
benzoate + NADPH + H+
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8% activity compared to 4-nitrobenzaldehyde
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?
butanal + NADP+ + H2O
butyrate + NADPH + H+
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n-butanal, enzyme a, b, c, d and e
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?
butanal + NADP+ + H2O
butyrate + NADPH + H+
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n-butanal, 2% of the activity with acetaldehyde
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ir
D-glyceraldehyde + NADP+
D-glycerate + NADPH + H+
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?
D-glyceraldehyde + NADP+
D-glycerate + NADPH + H+
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?
D-glyceraldehyde + NADP+
D-glycerate + NADPH + H+
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?
D-glyceraldehyde + NADP+
D-glycerate + NADPH + H+
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?
formaldehyde + NADP+
formate + NADPH + H+
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?
formaldehyde + NADP+ + H2O
formate + NADPH + H+
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weak activity with enzyme a, b, d and e
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?
formaldehyde + NADP+ + H2O
formate + NADPH + H+
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low activity
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?
formaldehyde + NADP+ + H2O
formate + NADPH + H+
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low activity
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?
formaldehyde + NADP+ + H2O
formate + NADPH + H+
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2% of the activity with acetaldehyde
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ir
glyceraldehyde + NADP+ + H2O
glycerate + NADPH + H+
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?
glyceraldehyde + NADP+ + H2O
glycerate + NADPH + H+
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ir
glyceraldehyde + NADP+ + H2O
glycerate + NADPH + H+
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ir
isobutyraldehyde + NADP+ + H2O
isobutyrate + NADPH + H+
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ir
isobutyraldehyde + NADP+ + H2O
isobutyrate + NADPH + H+
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ir
octanal + NADP+ + H2O
octanoate + NADPH + H+
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n-octanal, enzyme b, c, d and e
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?
pentanal + NADP+
pentanoate + NADPH
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n-pentanal, enzyme a, b, c, d and e
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?
propanal + NADP+ + H2O
propionate + NADPH + H+
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enzyme a, b, c, d and e
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?
propanal + NADP+ + H2O
propionate + NADPH + H+
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much lower activity than with acetaldehyde
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?
propanal + NADP+ + H2O
propionate + NADPH + H+
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102% of the activity with acetaldehyde
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ir
propanal + NADP+ + H2O
propionate + NADPH + H+
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181% of the activity with isovaleraldehyde
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?
propionaldehyde + NADP+ + H2O
propanoate + NADPH + H+
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?
propionaldehyde + NADP+ + H2O
propanoate + NADPH + H+
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ir
propionaldehyde + NADP+ + H2O
propanoate + NADPH + H+
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ir
additional information
?
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the constitutive enzyme may function in the intracellular detoxification of short chain aldehydes by conversion to corresponding fatty acids
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?
additional information
?
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the constitutive enzyme may function in the intracellular detoxification of short chain aldehydes by conversion to corresponding fatty acids
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?
additional information
?
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enzyme is involved in the oxidation of alkanes
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?
additional information
?
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no activity with glycolaldehyde and glyceraldehyde
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?
additional information
?
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no activity with phenylacetaldehyde, chlorobenzaldehyde, betaine aldehyde and succinic semialdehyde
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?
additional information
?
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no activity with phenylacetaldehyde, chlorobenzaldehyde, betaine aldehyde and succinic semialdehyde
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?
additional information
?
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no activity with 4-chlorobenzaldehyde, 4-fluorbenzaldehyde, tolualdehyde, anisaldehyde, formaldehyde, octanal, cinnamaldehyde, and isatin
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?
additional information
?
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enzyme is partly repressed during growth on glucose
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?
additional information
?
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NADH/formaldehyde detection by luminescence assay using Vibrio fischeri
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additional information
?
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NADH/formaldehyde detection by luminescence assay using Vibrio fischeri
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additional information
?
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no activity with acetaldehyde
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additional information
?
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no activity with acetaldehyde
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additional information
?
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no activity with acetaldehyde
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additional information
?
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no activity with acetaldehyde
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