Any feedback?
Information on EC 1.2.1.39 - phenylacetaldehyde dehydrogenase
for references in articles please use BRENDA:EC1.2.1.39Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.2.1.39 phenylacetaldehyde dehydrogenaseSpecify your search results
Word Map
- 1.2.1.39
-
phenylacetic
- monooxygenase
- phenylpyruvate
- 2-phenylethylamine
-
nad+-dependent
- 2-phenylethanol
-
denitrifying
- aromaticum
-
agrochemical
- tungstate
-
aromatoleum
- tyrosol
- 4-hydroxyphenylacetaldehyde
-
tungsten-dependent
-
dinucleotide-dependent
-
betaproteobacterium
- phenylacetyl-coa
- phenylethanols
The enzyme appears in viruses and cellular organisms
Synonyms
phenylacetaldehyde dehydrogenase, npadh, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
dehydrogenase, phenylacetaldehyde
-
-
-
-
ebA4954
feaB
NPADH
PAD
PADH
PDH
phenylacetaldehyde dehydrogenase
styD
PAD
-
-
-
-
phenylacetaldehyde dehydrogenase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+
-
-
-
-
phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+
sequential reaction mechanism in which NAD+ serves as both the leading substrate and homotropic allosteric activator, catalytic mechanism involving E169, E267, and C301, overview. The catalytic Glu has two conformations: a passive conformer that tucks away to allow hydride transfer to the nicotinamide ring, and an active conformer that abstracts a proton from the thioester-deacylating water
phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+
sequential reaction mechanism in which NAD+ serves as both the leading substrate and homotropic allosteric activator, catalytic mechanism involving E169, E267, and C301, overview. The catalytic Glu has two conformations: a passive conformer that tucks away to allow hydride transfer to the nicotinamide ring, and an active conformer that abstracts a proton from the thioester-deacylating water
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
-
-
-
-
reduction
-
-
-
-
oxidation
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
phenylacetaldehyde:NAD+ oxidoreductase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
58943-37-6
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-naphthaldehyde + NAD+ + H2O
1-naphthoate + NADH + H+
-
24% activity relative to phenylacetaldehyde
-
-
?
3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O
3,4-dihydroxyphenylacetate + NADH + H+
-
-
-
-
?
3-phenylpropionaldehyde + NAD+ + H2O
3-phenylpropionate + NADH + H+
-
34% activity relative to phenylacetaldehyde
-
-
?
decanal + NAD+ + H2O
decanoate + NADH + H+
-
17% activity relative to phenylacetaldehyde
-
-
?
indoleacetaldehyde + NAD+ + H2O
indoleacetate + NADH
Achromobacter eurydice
-
slow reaction
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetic acid + NADH + H+
-
-
-
?
1-methylphenylacetaldehyde + NAD+ + H2O
1-methylphenylacetate + NADH + 2 H+
lowest activity
-
-
?
1-methylphenylacetaldehyde + NAD+ + H2O
1-methylphenylacetate + NADH + 2 H+
-
lowest activity
-
-
?
1-methylphenylacetaldehyde + NAD+ + H2O
1-methylphenylacetate + NADH + 2 H+
-
lowest activity
-
-
?
1-methylphenylacetaldehyde + NAD+ + H2O
1-methylphenylacetate + NADH + 2 H+
-
lowest activity
-
-
?
1-methylphenylacetaldehyde + NAD+ + H2O
1-methylphenylacetate + NADH + 2 H+
-
lowest activity
-
-
?
1-methylphenylacetaldehyde + NAD+ + H2O
1-methylphenylacetate + NADH + 2 H+
lowest activity
-
-
?
1-methylphenylacetaldehyde + NAD+ + H2O
1-methylphenylacetate + NADH + 2 H+
lowest activity
-
-
?
4-chlorophenylacetaldehyde + NAD+ + H2O
4-chlorophenylacetate + NADH + 2 H+
-
-
-
?
4-chlorophenylacetaldehyde + NAD+ + H2O
4-chlorophenylacetate + NADH + 2 H+
high activity
-
-
?
4-chlorophenylacetaldehyde + NAD+ + H2O
4-chlorophenylacetate + NADH + 2 H+
-
-
-
-
?
4-chlorophenylacetaldehyde + NAD+ + H2O
4-chlorophenylacetate + NADH + 2 H+
-
-
-
-
?
4-chlorophenylacetaldehyde + NAD+ + H2O
4-chlorophenylacetate + NADH + 2 H+
-
-
-
-
?
4-chlorophenylacetaldehyde + NAD+ + H2O
4-chlorophenylacetate + NADH + 2 H+
-
-
-
-
?
4-chlorophenylacetaldehyde + NAD+ + H2O
4-chlorophenylacetate + NADH + 2 H+
highest activity
-
-
?
4-fluorophenylacetaldehyde + NAD+ + H2O
4-fluorophenylacetate + NADH + 2 H+
-
-
-
?
4-fluorophenylacetaldehyde + NAD+ + H2O
4-fluorophenylacetate + NADH + 2 H+
high activity
-
-
?
4-fluorophenylacetaldehyde + NAD+ + H2O
4-fluorophenylacetate + NADH + 2 H+
-
highest activity
-
-
?
4-fluorophenylacetaldehyde + NAD+ + H2O
4-fluorophenylacetate + NADH + 2 H+
-
highest activity
-
-
?
4-fluorophenylacetaldehyde + NAD+ + H2O
4-fluorophenylacetate + NADH + 2 H+
-
-
-
-
?
4-fluorophenylacetaldehyde + NAD+ + H2O
4-fluorophenylacetate + NADH + 2 H+
high activity
-
-
?
4-hydroxyphenylacetaldehyde + NAD+ + H2O
4-hydroxyphenylacetate + NADH + H+
-
-
-
-
?
4-hydroxyphenylacetaldehyde + NAD+ + H2O
4-hydroxyphenylacetate + NADH + H+
-
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
54% activity relative to phenylacetaldehyde
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
54% activity relative to phenylacetaldehyde
-
-
?
hexanal + NAD+ + H2O
hexanoate + NADH + H+
-
21% activity relative to phenylacetaldehyde
-
-
?
hexanal + NAD+ + H2O
hexanoate + NADH + H+
-
21% activity relative to phenylacetaldehyde
-
-
?
octanal + NAD+ + H2O
octanoate + NADH + H+
-
31% activity relative to phenylacetaldehyde
-
-
?
octanal + NAD+ + H2O
octanoate + NADH + H+
-
31% activity relative to phenylacetaldehyde
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
Achromobacter eurydice
-
inducible enzyme appears when cells are grown on L-phenylalanine or on L-tryptophan as sole source of carbon
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
inducible enzyme of 2-phenylethylamine catabolism
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
a positive regulatory protein required for expression of phenylacetaldehyde dehydrogenase is located next to the PAD gene
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
enzyme is involved in the catabolism of 2-phenylethylamine
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
involved in DL-phenylacrylic acid and phenylacetic acid catabolism
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
enzyme is involved in degradation of styrene. Low constitutive levels of NAD+-dependent phenylacetaldehyde dehydrogenase
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
enzyme is involved in degradation of styrene. Low constitutive levels of NAD+-dependent phenylacetaldehyde dehydrogenase
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
enzyme is involved in metabolism of atropine
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
enzyme is involved in metabolism of atropine
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
enzyme is involved in the anaerobic metabolism of L-phenylalanine
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
inolved in degradation of styrene oxide and 2-phenylethanol
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
inolved in degradation of styrene oxide and 2-phenylethanol
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
r
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
r
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
highest activity
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
highest activity
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
highest activity
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
highest activity
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
highest activity
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + H+
Achromobacter eurydice
-
highly specific for phenylacetaldehyde, NADP+ is about 1% as active as NAD+
-
ir
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + H+
-
best substrate
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + H+
-
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + H+
-
best substrate
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + H+
-
the enzyme participates in metabolism of phenylalanine
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + H+
-
rate-limiting step is the hydride transfer
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + H+
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + H+
-
-
-
?
phenylacetaldehyde + NADP+ + H2O
phenylacetate + NADPH + 2 H+
-
-
-
r
phenylacetaldehyde + NADP+ + H2O
phenylacetate + NADPH + 2 H+
-
-
-
r
phenylacetaldehyde + NADP+ + H2O
phenylacetate + NADPH + 2 H+
10.6% activity compared to NAD+
-
-
?
phenylacetaldehyde + NADP+ + H2O
phenylacetate + NADPH + 2 H+
11% activity compared to NAD+
-
-
?
phenylacetaldehyde + NADP+ + H2O
phenylacetate + NADPH + 2 H+
-
31.7% activity compared to NAD+
-
-
?
phenylacetaldehyde + NADP+ + H2O
phenylacetate + NADPH + 2 H+
-
31.7% activity compared to NAD+
-
-
?
phenylacetaldehyde + NADP+ + H2O
phenylacetate + NADPH + 2 H+
-
29.5% activity compared to NAD+
-
-
?
phenylacetaldehyde + NADP+ + H2O
phenylacetate + NADPH + 2 H+
-
29.5% activity compared to NAD+
-
-
?
phenylacetaldehyde + NADP+ + H2O
phenylacetate + NADPH + 2 H+
4% activity compared to NAD+
-
-
?
phenylacetaldehyde + NADP+ + H2O
phenylacetate + NADPH + 2 H+
4% activity compared to NAD+
-
-
?
additional information
?
-
enzyme is highly specific for phenylacetaldehyde, has cooperative kinetics toward the substrate, and shows considerable substrate inhibition. No activity with benzaldehyde and indole-3-carbaldehyde, substrate specificity, overview
-
-
?
additional information
?
-
-
enzyme is highly specific for phenylacetaldehyde, has cooperative kinetics toward the substrate, and shows considerable substrate inhibition. No activity with benzaldehyde and indole-3-carbaldehyde, substrate specificity, overview
-
-
?
additional information
?
-
enzyme is highly specific for phenylacetaldehyde, has cooperative kinetics toward the substrate, and shows considerable substrate inhibition. No activity with benzaldehyde and indole-3-carbaldehyde, substrate specificity, overview
-
-
?
additional information
?
-
no activity with phenazine methosulfate
-
-
-
additional information
?
-
no activity with phenazine methosulfate
-
-
-
additional information
?
-
no activity with phenazine methosulfate
-
-
-
additional information
?
-
no activity with phenazine methosulfate
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
phenylacetaldehyde + NAD+ + H2O
phenylacetic acid + NADH + H+
-
-
-
?
4-hydroxyphenylacetaldehyde + NAD+ + H2O
4-hydroxyphenylacetate + NADH + H+
-
-
-
-
?
4-hydroxyphenylacetaldehyde + NAD+ + H2O
4-hydroxyphenylacetate + NADH + H+
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
Achromobacter eurydice
-
inducible enzyme appears when cells are grown on L-phenylalanine or on L-tryptophan as sole source of carbon
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
inducible enzyme of 2-phenylethylamine catabolism
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
a positive regulatory protein required for expression of phenylacetaldehyde dehydrogenase is located next to the PAD gene
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
enzyme is involved in the catabolism of 2-phenylethylamine
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
involved in DL-phenylacrylic acid and phenylacetic acid catabolism
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
enzyme is involved in degradation of styrene. Low constitutive levels of NAD+-dependent phenylacetaldehyde dehydrogenase
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
enzyme is involved in degradation of styrene. Low constitutive levels of NAD+-dependent phenylacetaldehyde dehydrogenase
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
enzyme is involved in metabolism of atropine
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
enzyme is involved in metabolism of atropine
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
enzyme is involved in the anaerobic metabolism of L-phenylalanine
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
inolved in degradation of styrene oxide and 2-phenylethanol
-
-
?
phenylacetaldehyde + NAD+ + H2O
?
-
inolved in degradation of styrene oxide and 2-phenylethanol
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
r
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
r
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + 2 H+
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + H+
-
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + H+
-
the enzyme participates in metabolism of phenylalanine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NAD+
-
active with NAD+ and NADP+, preference for NAD+. kcat/Km for NAD+ with propionaldehyde as cosubstrate is 34700
NAD+
N-terminal NAD+-binding domain, comprising residues 1-130 and 159-269, structure analysis, overview
NADP+
-
active with NAD+ and NADP+, preference for NAD+. kcat/Km for NADP+ with propionaldehyde is 2460
additional information
enzyme PDH accepts both NAD+ and NADP+ as electron acceptors, but exhibits 86% of its maximal activity with NAD+ but only 5% of its maximal activity with NADP+
-
additional information
-
enzyme PDH accepts both NAD+ and NADP+ as electron acceptors, but exhibits 86% of its maximal activity with NAD+ but only 5% of its maximal activity with NADP+
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Cs+
Achromobacter eurydice
-
monovalent cation required. K+ , Rb+ , Na+, Li+, NH4+ and Cs+ activate in this order
K+
Achromobacter eurydice
-
monovalent cation required. K+ , Rb+ , Na+, Li+, NH4+ and Cs+ activate in this order
Li+
Achromobacter eurydice
-
monovalent cation required. K+ , Rb+ , Na+, Li+, NH4+ and Cs+ activate in this order
Mg2+
Mn2+
Na+
Achromobacter eurydice
-
monovalent cation required. K+ , Rb+ , Na+, Li+, NH4+ and Cs+ activate in this order
NH4+
Achromobacter eurydice
-
monovalent cation required. K+ , Rb+ , Na+, Li+, NH4+ and Cs+ activate in this order
Rb+
Achromobacter eurydice
-
monovalent cation required. K+ , Rb+ , Na+, Li+, NH4+ and Cs+ activate in this order
additional information