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Disease on EC 1.2.1.3 - aldehyde dehydrogenase (NAD+)

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DISEASE
TITLE OF PUBLICATION
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Achlorhydria
Deficient aldehyde dehydrogenase 2 is associated with increased risk for esophageal squamous cell carcinoma in the presence of gastric hypochlorhydria.
Acute Coronary Syndrome
Aldehyde dehydrogenase 2 Glu504Lys variant predicts a worse prognosis of acute coronary syndrome patients.
Alpha-lipoic acid ameliorates oxidative stress by increasing aldehyde dehydrogenase-2 activity in patients with acute coronary syndrome.
Role of Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism in Acute Coronary Syndrome.
Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome.
The role of MTHFR C677T and ALDH2 Glu504Lys polymorphism in acute coronary syndrome in a Hakka population in southern China.
Acute Kidney Injury
Aldehyde dehydrogenase 2 protects against acute kidney injury by regulating autophagy via the Beclin-1 pathway.
Inhibition of ALDH2 expression aggravates renal injury in a rat sepsis syndrome model.
Adenocarcinoma
Aggressive tumor microenvironment of solid predominant lung adenocarcinoma subtype harboring with epidermal growth factor receptor mutations.
Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study.
Aldehyde dehyderogenase (ALDH1A1) delineating the normal and cancer stem cells in spectral lung lesions: An immunohistochemical appraisal.
Aldehyde dehydrogenase 1A1 confers intrinsic and acquired resistance to gemcitabine in human pancreatic adenocarcinoma MIA PaCa-2 cells.
Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer.
Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma.
Aldehyde dehydrogenase 1B1 is a potential marker of colorectal tumors.
Aldehyde Dehydrogenase 1B1 Is Associated with Altered Cell Morphology, Proliferation, Migration and Chemosensitivity in Human Colorectal Adenocarcinoma Cells.
Aldehyde dehydrogenase 3A1 promotes multi-modality resistance and alters gene expression profile in human breast adenocarcinoma MCF-7 cells.
ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line.
ALDH1 expression correlates with an epithelial-like phenotype and favorable prognosis in lung adenocarcinoma: a study based on immunohistochemistry and mRNA expression data.
ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis.
ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors.
Association of genotypes of rs671 withinALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas.
Bioinformatic analysis of potential hub genes in gastric adenocarcinoma.
Cancer stem cell markers in adenocarcinoma of the salivary glands - reliable prognostic markers?
Cancer stem cell markers in prostate cancer: an immunohistochemical study of ALDH1, SOX2 and EZH2.
Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis.
Correction to: Identification of ALDH3A2 as a novel prognostic biomarker in gastric adenocarcinoma using integrated bioinformatics analysis.
Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer.
Expression of cancer stem cell markers is prognostic in metastatic gastroesophageal adenocarcinoma.
Expression of PD-L1, cancer stem cell and epithelial-mesenchymal transition phenotype in non-small cell lung cancer.
Identification of ALDH3A2 as a novel prognostic biomarker in gastric adenocarcinoma using integrated bioinformatics analysis.
Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma.
Loss of CD44 and SOX2 Expression is Correlated with a Poor Prognosis in Esophageal Adenocarcinoma Patients.
Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer.
Musashi-1 Expression is a Prognostic Factor in Ovarian Adenocarcinoma and Correlates with ALDH-1 Expression.
Prognosis genes in gastric adenocarcinoma identified by cross talk genes in disease?related pathways.
Prognostic Significance of CD44v6, CD133, CD166, and ALDH1 Expression in Small Intestinal Adenocarcinoma.
Prognostic significance of stem cell-related marker expression and its correlation with histologic subtypes in lung adenocarcinoma.
Proteome Profiling of Primary Pancreatic Ductal Adenocarcinomas Undergoing Additive Chemoradiation Link ALDH1A1 to Early Local Recurrence and Chemoradiation Resistance.
Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate model.
Role of stem cells in colorectal cancer progression and prognostic and predictive characteristics of stem cells markers in colorectal cancer.
Smad4 Decreases the Population of Pancreatic Cancer-Initiating Cells through Transcriptional Repression of ALDH1A1.
Spectrum of ALDH1 mRNA in smokers and non-smokers with adenocarcinoma or squamous cell lung carcinoma.
The different pathogeneses of sporadic adenoma and adenocarcinoma in non-ampullary lesions of the proximal and distal duodenum.
The expression of ALDH1 in cervical carcinoma.
Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5'-upstream regions of these genes.
Transcriptional Regulation of Aldehyde Dehydrogenase 1A1 Gene by Alternative Spliced Forms of Nuclear Factor Y in Tumorigenic Population of Endometrial Adenocarcinoma.
Value of CagA, HER2, ALDH1, and KiSS-1 in predicting metastasis and prognosis for gastric adenocarcinoma.
Verification of ALDH Activity as a Biomarker in Colon Cancer Stem Cells-Derived HT-29 Cell Line.
[Expression and Clinical Significance of ALDH1 and Twist in Gastric Adenocarcinoma].
[Proliferation of cancer stem cells in colorectal adenocarcinoma].
Adenocarcinoma of Lung
?-catenin/POU5F1/SOX2 transcription factor complex mediates IGF-1 receptor signaling and predicts poor prognosis in lung adenocarcinoma.
?-Escin Inhibits NNK-Induced Lung Adenocarcinoma and ALDH1A1 and RhoA/Rock Expression in A/J Mice and Growth of H460 Human Lung Cancer Cells.
Aldehyde dehydrogenase 1A1 confers erlotinib resistance via facilitating the reactive oxygen species-reactive carbonyl species metabolic pathway in lung adenocarcinomas.
ALDH1 and SALL4 Expression in Cell Block Samples from Patients with Lung Adenocarcinoma and Malignant Pleural Effusion.
ALDH1 expression correlates with an epithelial-like phenotype and favorable prognosis in lung adenocarcinoma: a study based on immunohistochemistry and mRNA expression data.
ALDH2 Repression Promotes Lung Tumor Progression via Accumulated Acetaldehyde and DNA Damage.
ALDH3A1 driving tumor metastasis is mediated by p53/BAG1 in lung adenocarcinoma.
ALDH3B1 Is an Independent Prognostic Biomarker of Lung Adenocarcinoma.
Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP.
Development of Selective Inhibitors for Human Aldehyde Dehydrogenase 3A1 (ALDH3A1) for the Enhancement of Cyclophosphamide Cytotoxicity.
Effect of aerobic exercise on acquired gefitinib resistance in lung adenocarcinoma.
Expression of the potential cancer stem cell markers, CD133, CD44, ALDH1, and ?-catenin, in primary lung adenocarcinoma--their prognostic significance.
Inhibitory effect of PPAR? on NR0B1 in tumorigenesis of lung adenocarcinoma.
KANK1 regulates paclitaxel resistance in lung adenocarcinoma A549 cells.
Methylation-Induced Silencing of ALDH2 Facilitates Lung Adenocarcinoma Bone Metastasis by Activating the MAPK Pathway.
Puerarin 6?-O-xyloside suppresses growth, self-renewal and invasion of lung cancer stem-like cells derived from A549 cells via regulating Akt/c-Myc signalling.
Role of leucine-rich pentatricopeptide repeat motif-containing protein (LRPPRC) for anti-apoptosis and tumourigenesis in cancers.
Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells.
Targeting USP22 Suppresses Tumorigenicity and Enhances Cisplatin Sensitivity Through ALDH1A3 Downregulation in Cancer-Initiating Cells from Lung Adenocarcinoma.
The Clinical Significance of Cancer Stem Cell Markers ALDH1A1 and CD133 in Lung Adenocarcinoma.
UPLC-MS-based metabolomics reveals metabolic dysregulation in ALDH1A1-overexpressed lung adenocarcinoma cells.
[Expression of Acetaldehyde Dehydrogenase in Gefitinib-resistant Human Lung Adenocarcinoma HCC-827/GR Cells].
[Increased expression of acetaldehyde dehydrogenase in cisplatin-resistant human lung adenocarcinoma A549/DDP cells].
Adenocarcinoma, Clear Cell
ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis.
Musashi-1 Expression is a Prognostic Factor in Ovarian Adenocarcinoma and Correlates with ALDH-1 Expression.
Adenocarcinoma, Mucinous
Musashi-1 Expression is a Prognostic Factor in Ovarian Adenocarcinoma and Correlates with ALDH-1 Expression.
Adenoma
Aldehyde dehydrogenase 1B1 is a potential marker of colorectal tumors.
ALDH Maintains the Stemness of Lung Adenoma Stem Cells by Suppressing the Notch/CDK2/CCNE Pathway.
Early gene expression differences in inbred mouse strains with susceptibility to pulmonary adenomas.
Genetic polymorphisms of methylenetetrahydrofolate reductase and aldehyde dehydrogenase 2, alcohol use and risk of colorectal adenomas: Self-Defense Forces Health Study.
Identification and Validation of Novel Serum Autoantibody Biomarkers for Early Detection of Colorectal Cancer and Advanced Adenoma.
Lack of Influence of the ADH1B Arg47His Genetic Polymorphism on Risk of Colorectal Adenoma in Middle-aged Japanese Men.
Oncogenic targets Mmp7, S100a9, Nppb and Aldh1a3 from transcriptome profiling of FAP and Pirc adenomas are downregulated in response to tumor suppression by Clotam.
Temporal and spatial changes of cells positive for stem-like markers in different compartments and stages of human colorectal adenoma-carcinoma sequence.
The different pathogeneses of sporadic adenoma and adenocarcinoma in non-ampullary lesions of the proximal and distal duodenum.
Adenoma, Liver Cell
ALDH3A1 is overexpressed in a subset of hepatocellular carcinoma characterised by activation of the Wnt/ß-catenin pathway.
Adenomatous Polyps
Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma.
Airway Obstruction
Association between the aldehyde dehydrogenase 2*2 allele and smoking-related chronic airway obstruction in a Japanese general population: a pilot study.
alcohol dehydrogenase deficiency
Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.
Alcohol Withdrawal Delirium
Association between personality traits and ALDH2 polymorphism in Japanese male alcoholics.
Alcohol-Related Disorders
Distribution of alcohol-metabolizing enzyme genotypes in trauma patients with excessive alcohol consumption in the emergency department.
Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms is strongly associated with depression and anxiety in Japanese employees.
Pharmacogenetics of alcohol metabolism and alcoholism.
Alcoholic Neuropathy
Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humans.
Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders.
aldehyde dehydrogenase (nad+) deficiency
Acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbates pressure overload-induced cardiac dysfunction by inhibiting Beclin-1 dependent autophagy pathway.
Acetaldehyde dehydrogenase 2 deficiency exacerbates cardiac fibrosis by promoting mobilization and homing of bone marrow fibroblast progenitor cells.
Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.
Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver.
Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids.
Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.
Aldehyde dehydrogenase 2 activation ameliorates CCl4 -induced chronic liver fibrosis in mice by up-regulating Nrf2/HO-1 antioxidant pathway.
Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology.
Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE.
Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice.
Aldehyde dehydrogenase 2 deficiency blunts compensatory cardiac hypertrophy through modulating Akt phosphorylation early after transverse aorta constriction in mice.
Aldehyde dehydrogenase 2 deficiency increases resting-state glutamate and expression of the GluN1 subunit of N-methyl-D-aspartate receptor in the frontal cortex of mice.
Aldehyde dehydrogenase 2 deficiency negates chronic low-to-moderate alcohol consumption-induced cardioprotecion possibly via ROS-dependent apoptosis and RIP1/RIP3/MLKL-mediated necroptosis.
Aldehyde dehydrogenase 2 deficiency promotes atherosclerotic plaque instability through accelerating mitochondrial ROS-mediated vascular smooth muscle cell senescence.
Aldehyde dehydrogenase 2 deficiency significantly exacerbates tert-butyl alcohol-induced toxicity in mice.
Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: Role of protein phosphatases.
Aldehyde dehydrogenase 2 protects against abdominal aortic aneurysm formation by reducing reactive oxygen species, vascular inflammation, and apoptosis of vascular smooth muscle cells.
Aldehyde dehydrogenase 2 protects against sympathetic excitation-induced cardiac fibrosis.
Aldehyde dehydrogenase-2 deficiency aggravates cardiac dysfunction elicited by endoplasmic reticulum stress induction.
Aldehyde dehydrogenase-2 deficiency and articular collagen.
Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development.
ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties.
ALDH1A1 Deficiency in Gorlin Syndrome Suggests a Central Role for Retinoic Acid and ATM Deficits in Radiation Carcinogenesis.
ALDH2 and Cardiovascular Disease.
ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis.
ALDH2 deficiency inhibits Ox-LDL induced foam cell formation via suppressing CD36 expression.
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles.
ALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice.
ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1/p53 pathway.
ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds.
ALDH2 protects against stroke by clearing 4-HNE.
Appropriate dose of ethanol exerts anti-senescence and anti-atherosclerosis protective effects by activating ALDH2.
Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population.
Deficiency of Retinaldehyde Dehydrogenase 1 Induces BMP2 and Increases Bone Mass In Vivo.
Deficient aldehyde dehydrogenase 2 is associated with increased risk for esophageal squamous cell carcinoma in the presence of gastric hypochlorhydria.
Detection of aldehyde dehydrogenase deficiency in Chachi Indians, Ecuador.
Dominance of the mutant ALDH2(2) allele in the expression of human stomach aldehyde dehydrogenase-2 activity.
Effect of Alcohol Sensitivity in Healthy Young Adults on Breath Pharmacokinetics of Acetaldehyde After Mouth Washing with Alcohol.
Effects of "Essential AD2" Supplement on Blood Acetaldehyde Levels in Individuals Who Have Aldehyde Dehydrogenase (ALDH2) Deficiency.
Effects of acetaldehyde inhalation in mitochondrial aldehyde dehydrogenase deficient mice (Aldh2-/-).
Effects of ALDH2 genotype, PPI treatment and L-cysteine on carcinogenic acetaldehyde in gastric juice and saliva after intragastric alcohol administration.
Ethanol and acetaldehyde differentially alter extracellular dopamine and serotonin in Aldh2-knockout mouse dorsal striatum: A reverse microdialysis study.
Ethanol induces skin hyperpigmentation in mice with aldehyde dehydrogenase 2 deficiency.
Ethanol metabolism, toxicity and genetic polymorphism.
Expression of aldehyde dehydrogenase 2 in the normal esophageal epithelium and alcohol consumption in patients with esophageal cancer.
Gene Therapy Correction of Aldehyde Dehydrogenase 2 Deficiency.
Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females.
Genetic Study of Fanconi Anemia in Infancy Revealed FANCI Mutations and Defective ALDH2 Variant: A Case Report.
Genetic testing for aldehyde dehydrogenase 2 deficiency in young adults.
Genotyping of the aldehyde dehydrogenase 2 (ALDH2) gene using the polymerase chain reaction: evidence for single point mutation in the ALDH2 gene of ALDH2-deficiency.
High ethanol and acetaldehyde impair spatial memory in mouse models: Opposite effects of aldehyde dehydrogenase 2 and apolipoprotein E on memory.
Human-induced pluripotent stem cell approaches to model inborn and acquired metabolic heart diseases.
Hypertrophic scar: a genetic hypothesis.
Increased formation of gastric N(2)-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol.
Mendelian randomization: A novel test of the gateway hypothesis and models of gene-environment interplay.
Mitochondrial aldehyde dehydrogenase 2 deficiency aggravates energy metabolism disturbance and diastolic dysfunction in diabetic mice.
Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic Ischemia: Potential Impact on the Development of Coronary Collateral Circulation.
Mitochondrial aldehyde dehydrogenase prevents ROS-induced vascular contraction in angiotensin-II hypertensive mice.
Mitochondrial aldehyde dehydrogenase-2 deficiency compromises therapeutic effect of ALDH bright cell on peripheral ischemia.
Mitochondrial ALDH2 deficiency as an oxidative stress.
Mitochondrial PKC-? deficiency promotes I/R-mediated myocardial injury via GSK3?-dependent mitochondrial permeability transition pore opening.
Moderate vitamin A supplementation in obese mice regulates tissue factor and cytokine production in a sex-specific manner.
Pharmacogenetics of alcohol sensitivity.
Polymorphism of aldehyde dehydrogenase and its application to alcoholism.
Population genetic and family studies on aldehyde dehydrogenase deficiency and alcohol sensitivity.
Population genetic studies on aldehyde dehydrogenase isozyme deficiency and alcohol sensitivity.
Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype.
Primum Non Nocere: Should Gene Therapy Be Used to Prevent Potentially Fatal Disease but Enable Potentially Destructive Behavior?
Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism.
Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region.
Role of the aldehyde dehydrogenase-1 isozyme in the metabolism of acetaldehyde.
Spinal astrocyte aldehyde dehydrogenase-2 mediates ethanol metabolism and analgesia in mice.
Steady-state metabolism of ethanol in perfused rat livers treated with cyanamide: quantitative analysis of acetaldehyde effects on the metabolic flux rates.
Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice.
Systemic Adeno-Associated Virus-Mediated Gene Therapy Prevents the Multiorgan Disorders Associated with Aldehyde Dehydrogenase 2 Deficiency and Chronic Ethanol Ingestion.
Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking.
The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells.
The role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes in alcohol metabolism, alcohol sensitivity, and alcoholism.
The Role of Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) in Neuropathology and Neurodegeneration.
Transformed ALDH2-/- hepatocytes by ethanol could serve as a useful tool for studying alcoholic hepatocarcinogenesis.
Validation of Alcohol Flushing Questionnaire to Identify ALDH2 Status in a Case-Control Study of Head and Neck Cancer.
Why can't Chinese Han drink alcohol? Hepatitis B virus infection and the evolution of acetaldehyde dehydrogenase deficiency.
[Roles of mitochondrial dysfunctions in Alzheimer's disease--contribution of deficiency of ALDH 2]
Alzheimer Disease
Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology.
Aldehyde dehydrogenase 2 protects against acute kidney injury by regulating autophagy via the Beclin-1 pathway.
Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population.
Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals.
Association between ALDH2 Gene Polymorphism and Late-onset Alzheimer Disease: An Up-to-date Meta-analysis.
Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's disease.
Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population.
Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification.
Effects of "Essential AD2" Supplement on Blood Acetaldehyde Levels in Individuals Who Have Aldehyde Dehydrogenase (ALDH2) Deficiency.
Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung.
Endogenous formaldehyde is a memory-related molecule in mice and humans.
Glu504Lys Single Nucleotide Polymorphism of Aldehyde Dehydrogenase 2 Gene and the Risk of Human Diseases.
Increased activity of mitochondrial aldehyde dehydrogenase (ALDH) in the putamen of individuals with Alzheimer's disease: a human postmortem study.
Meta-analysis of aldehyde dehydrogenase 2 gene polymorphism and Alzheimer's disease in East Asians.
Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis.
Mitochondrial aldehyde dehydrogenase polymorphism is not associated with incidence of Alzheimer's disease.
Multifaceted Regulation of ALDH1A1 by Cdk5 in Alzheimer's Disease Pathogenesis.
Neuronal Calcium Imaging, Excitability, and Plasticity Changes in the Aldh2-/- Mouse Model of Sporadic Alzheimer's Disease.
Oxadiazon affects the expression and activity of aldehyde dehydrogenase and acylphosphatase in human striatal precursor cells: A possible role in neurotoxicity.
Polymorphisms in the aldehyde dehydrogenase 2 and dopamine ? hydroxylase genes are not associated with Alzheimer's disease.
Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease.
The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer's disease in Chinese.
[Roles of mitochondrial dysfunctions in Alzheimer's disease--contribution of deficiency of ALDH 2]
Androgen-Insensitivity Syndrome
Biological role of human cytosolic aldehyde dehydrogenase 1: hormonal response, retinal oxidation and implication in testicular feminization.
The cytosolic aldehyde dehydrogenase gene (Aldh1) is developmentally expressed in Leydig cells.
Anemia
Recovery from anemia and leukocytopenia after abstinence in Japanese alcoholic men and their genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2.
Anemia, Aplastic
Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells.
Aldehyde dehydrogenase-2 polymorphism contributes to the progression of bone marrow failure in children with idiopathic aplastic anaemia.
Anemia, Diamond-Blackfan
ALDH2 polymorphism in patients with Diamond-Blackfan anemia in Japan.
Anemia, Macrocytic
Macrocytosis, Macrocytic Anemia, and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men.
Angina Pectoris
Efficient expression of codon-adapted human acetaldehyde dehydrogenase 2 cDNA with 6xHis tag in Pichia pastoris.
Angina, Stable
Combined effects of current-smoking and the aldehyde dehydrogenase 2*2 allele on the risk of myocardial infarction in Japanese patients.
Aniridia
Expression of retinoic acid signaling components ADH7 and ALDH1A1 is reduced in aniridia limbal epithelial cells and a siRNA primary cell based aniridia model.
Anophthalmos
A Novel Missense Mutation in the ALDH13 Gene Causes Anophthalmia in Two Unrelated Iranian Consanguineous Families.
ALDH1A3 loss of function causes bilateral anophthalmia/microphthalmia and hypoplasia of the optic nerve and optic chiasm.
ALDH1A3 mutations cause recessive anophthalmia and microphthalmia.
Novel compound heterozygous mutations of ALDH1A3 contribute to anophthalmia in a non-consanguineous Chinese family.
Novel mutations in ALDH1A3 associated with autosomal recessive anophthalmia/microphthalmia, and review of the literature.
Aortic Aneurysm, Abdominal
Aldehyde dehydrogenase 2 protects against abdominal aortic aneurysm formation by reducing reactive oxygen species, vascular inflammation, and apoptosis of vascular smooth muscle cells.
Arrhythmias, Cardiac
Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells.
Asthma
A rare case of Sjogren-Larsson syndrome with recurrent pneumonia and asthma.
Acute severe alcohol-induced bronchial asthma.
Correlation between alcohol-induced asthma and acetaldehyde dehydrogenase-2 genotype.
Genotypes of ALDH2 related to liver and pulmonary diseases and other genetic factors related to alcoholic liver disease.
Linking endotypes to omics profiles in difficult-to-control asthma using the diagnostic Chinese medicine syndrome differentiation algorithm.
Screening for acetaldehyde dehydrogenase 2 genotype in alcohol-induced asthma by using the ethanol patch test.
The Identification of Childhood Asthma Progression-Related lncRNAs and mRNAs Suitable as Biomarkers Using Weighted Gene Coexpression Network Analysis.
Astrocytoma
ALDH1 expression is correlated with pathologic grade and poor clinical outcome in patients with astrocytoma.
Expression and prognostic value of the aldehyde dehydrogenase 1 (ALDH1) and N-myc downstream regulated gene 2 (NDRG2) as potential markers in human astrocytomas.
Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes.
Prognostic Value of ALDH1, EZH2 and Ki-67 in Astrocytic Gliomas.
Retraction Note to: Expression and prognostic value of the aldehyde dehydrogenase 1 (ALDH1) and N-myc downstream regulated gene 2 (NDRG2) as potential markers in human astrocytomas.
Ataxia
A histochemical study of the distribution of aldehyde dehydrogenase activity in brain structures of rats with genetically different alcohol-related behaviour.
Ataxia Telangiectasia
ALDH1A1 Deficiency in Gorlin Syndrome Suggests a Central Role for Retinoic Acid and ATM Deficits in Radiation Carcinogenesis.
Novel composite drug delivery system as a novel radio sensitizer for the local treatment of cervical carcinoma.
Atherosclerosis
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells.
Appropriate dose of ethanol exerts anti-senescence and anti-atherosclerosis protective effects by activating ALDH2.
Association between Carotid Intima-media Thickness and Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism in Chinese Han with Essential Hypertension.
Effects of aldehyde dehydrogenase genotypes on carotid atherosclerosis.
Homozygous ALDH2*2 Is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men.
Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice.
Not just correlative: a new pathway defines how an ALDH2 SNP contributes to atherosclerosis.
Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype.
Targeting ALDH2 in Atherosclerosis: Molecular Mechanisms and Therapeutic Opportunities.
Atrial Fibrillation
Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE.
ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis.
Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese.
Basal Cell Nevus Syndrome
ALDH1A1 Deficiency in Gorlin Syndrome Suggests a Central Role for Retinoic Acid and ATM Deficits in Radiation Carcinogenesis.
Deficient expression of aldehyde dehydrogenase 1A1 is consistent with increased sensitivity of Gorlin syndrome patients to radiation carcinogenesis.
Bone Diseases, Metabolic
A critical assessment of the potential of pharmacological modulation of aldehyde dehydrogenases to treat the diseases of bone loss.
Astaxanthin improves osteopenia caused by aldehyde-stress resulting from Aldh2 mutation due to impaired osteoblastogenesis.
The Thiocarbamate Disulphide Drug, Disulfiram Induces Osteopenia in Rats by Inhibition of Osteoblast Function Due to Suppression of Acetaldehyde Dehydrogenase Activity.
Bone Marrow Failure Disorders
Aldehyde dehydrogenase-2 polymorphism contributes to the progression of bone marrow failure in children with idiopathic aplastic anaemia.
Maternal aldehyde elimination during pregnancy preserves the fetal genome.
The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype.
Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients.
Bowen's Disease
Aldehyde dehydrogenase 1 expression in basal cell carcinoma, actinic keratosis and Bowen's disease.
Brain Diseases, Metabolic
Discovery and development of selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors.
Brain Edema
ALDH2 Protects Against Ischemic Stroke in Rats by Facilitating 4-HNE Clearance and AQP4 Down-Regulation.
Brain Injuries
Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes.
Brain Ischemia
ALDH 2 conferred neuroprotection on cerebral ischemic injury by alleviating mitochondria-related apoptosis through JNK/caspase-3 signing pathway.
Brain Neoplasms
Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity.
Deubiquitinating ALDH1A3 key to maintaining the culprit of aggressive brain cancer.
FOXD1-ALDH1A3 signaling is a determinant for the self-renewal and tumorigenicity of mesenchymal glioma stem cells.
Synthesis and Preliminary Evaluation of n.c.a. Iodoquine: A Novel Radiotracer with High Uptake in Cells with High ALDH1 Expression.
Breast Diseases
Aldehyde dehydrogenase 1 expression correlates with the invasion of breast cancer.
Breast Neoplasms
A Novel Approach for Overcoming Drug Resistance in Breast Cancer Chemotherapy by Targeting new Synthetic Curcumin Analogues Against Aldehyde Dehydrogenase 1 (ALDH1A1) and Glycogen Synthase Kinase-3 ? (GSK-3?).
A positive cross-regulation of HER2 and ER-?36 controls ALDH1 positive breast cancer cells.
A review of the racial heterogeneity of breast cancer stem cells.
A triple negative breast cancer: what it is not!
ABCG2 is a potential marker of tumor-initiating cells in breast cancer.
Activation of ALDH1A1 in MDA-MB-468 breast cancer cells that over-express CYP2J2 protects against paclitaxel-dependent cell death mediated by reactive oxygen species.
Aldehyde dehydrogenase 1 (ALDH1) expression is an independent prognostic factor in triple negative breast cancer (TNBC).
Aldehyde dehydrogenase 1 as a predictor of the neoadjuvant chemotherapy response in breast cancer: A meta-analysis.
Aldehyde dehydrogenase 1 expression correlates with clinicopathologic features of patients with breast cancer: a meta-analysis.
Aldehyde dehydrogenase 1 expression correlates with the invasion of breast cancer.
Aldehyde dehydrogenase 1 expression is a predictor of poor prognosis in node-positive breast cancers: a long-term follow-up study.
Aldehyde dehydrogenase 1 expression is correlated with poor prognosis in breast cancer.
Aldehyde dehydrogenase 1 expression predicts poor prognosis in triple-negative breast cancer.
Aldehyde dehydrogenase 1-positive cells in axillary lymph node metastases after chemotherapy as a prognostic factor in patients with lymph node-positive breast cancer.
Aldehyde Dehydrogenase 1-related Genes in Triple-negative Breast Cancer Investigated Using Network Analysis.
Aldehyde dehydrogenase 1A1 expression in breast cancer is associated with stage, triple negativity, and outcome to neoadjuvant chemotherapy.
Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling.
Aldehyde dehydrogenase 2 genotype in tolerability of alcohol contained in paclitaxel in Japanese breast cancer patients.
Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells is Primarily Due to Isoform ALDH1A3 and Its Expression is Predictive of Metastasis.
Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis.
Aldehyde dehydrogenase1 immunohistochemical staining in primary breast cancer cells independently predicted overall survival but did not correlate with the presence of circulating or disseminated tumors cells.
ALDH(+)/CD44(+)/CD24(-) expression in cells from body cavity fluids.
ALDH1 and tumor infiltrating lymphocytes as predictors for neoadjuvant chemotherapy response in breast cancer.
ALDH1 as a Functional Marker of Cancer Stem and Progenitor Cells.
ALDH1 Cancer Stem Cell Marker as a Prognostic Factor in Triple-Negative Breast Cancer.
ALDH1 Expression and Vasculogenic Mimicry Are Positively Associated with Poor Prognosis in Patients with Breast Cancer.
ALDH1 expression correlates with favorable prognosis in ovarian cancers.
ALDH1 expression is enriched in breast cancers arising in young women but does not predict outcome.
ALDH1 is a better clinical indicator for relapse of invasive ductal breast cancer than the CD44+/CD24- phenotype.
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
ALDH1A1 expression correlates with clinicopathologic features and poor prognosis of breast cancer patients: a systematic review and meta-analysis.
ALDH1A1 mRNA expression in association with prognosis of triple-negative breast cancer.
Androgen Receptor and ALDH1 Expression Among Internationally Diverse Patient Populations.
Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma.
Association of aldehyde dehydrogenase 1 expression and biologically aggressive features in breast cancer.
Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers.
Associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white women diagnosed with breast cancer: the Breast Cancer Health Disparities Study.
Associations of mammographic breast density with breast stem cell marker-defined breast cancer subtypes.
BCMA (TNFRSF17) Induces APRIL and BAFF Mediated Breast Cancer Cell Stemness.
Breast cancer stem cell markers CD44 and ALDH1A1 in serum: distribution and prognostic value in patients with primary breast cancer.
Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype.
Breast cancer stem cells and intrinsic subtypes: controversies rage on.
Breast cancer stem cells.
Cancer stem cell markers ALDH1 and CD44+/CD24- phenotype and their prognosis impact in invasive ductal carcinoma.
Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types.
Carboxypeptidase A4 negatively correlates with p53 expression and regulates the stemness of breast cancer cells.
Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients.
Causal Bayesian gene networks associated with bone, brain and lung metastasis of breast cancer.
CD133 is a useful surrogate marker for predicting chemosensitivity to neoadjuvant chemotherapy in breast cancer.
CD44
CD44/CD24 and aldehyde dehydrogenase 1 in estrogen receptor-positive early breast cancer treated with tamoxifen: CD24 positivity is a poor prognosticator.
Cellular level classification of breast cancer through proteomic markers using nanochannel array sensors.
Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens.
Characteristic Genes in Luminal Subtype Breast Tumors with CD44+CD24-/Low Gene Expression Signature.
Characterizing Breast Cancer in a Population with Increased Prevalence of Triple-Negative Breast Cancer: Androgen Receptor and ALDH1 Expression in Ghanaian Women.
Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer.
Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3.
Clinical-pathologic significance of cancer stem cell marker expression in familial breast cancers.
Clinicopathologic characteristics of breast cancer stem cells identified on the basis of aldehyde dehydrogenase 1 expression.
Clinicopathological significance of ALDH1A1 in lung, colorectal, and breast cancers: a meta-analysis.
Clinicopathological significance of cancer stem cell markers CD44 and ALDH1 expression in breast cancer.
Clinicopathological Significance of CD133 and ALDH1 Cancer Stem Cell Marker Expression in Invasive Ductal Breast Carcinoma.
Co-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancer.
Combination of Cancer Stem Cell Markers CD44 and CD24 Is Superior to ALDH1 as a Prognostic Indicator in Breast Cancer Patients with Distant Metastases.
Combination Twist1 and CA15-3 in axillary lymph nodes for breast cancer prognosis.
Combined expression of aldehyde dehydrogenase 1A1 and ?-catenin is associated with lymph node metastasis and poor survival in breast cancer patients following cyclophosphamide treatment.
Correction to: Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1?/VEGF signalling in MCF-7 breast cancer cells.
Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer.
Correlations of aldehyde dehydrogenase-1 (ALDH1) expression with traditional prognostic parameters and different molecular subtypes of breast carcinoma.
Correlations of ALDH1 expression with molecular subtypes and ABCG2 in breast cancer.
Crosstalk between miR-203 and PKC? regulates breast cancer stem cell markers.
Cytokeratin 19 (KRT19) has a Role in the Reprogramming of Cancer Stem Cell-Like Cells to Less Aggressive and More Drug-Sensitive Cells.
Delivery of Anti-miRNA for Triple-Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting Stem Cell Marker CD133.
Differences in expression of the cancer stem cell marker aldehyde dehydrogenase 1 among estrogen receptor-positive/human epidermal growth factor receptor type 2-negative breast cancer cases with early, late, and no recurrence.
Differential Functional Roles of ALDH1A1 and ALDH1A3 in Mediating Metastatic Behavior and Therapy Resistance of Human Breast Cancer Cells.
Distinct patterns of promoter CpG island methylation of breast cancer subtypes are associated with stem cell phenotypes.
Distinct prognostic values of ALDH1 isoenzymes in breast cancer.
Distribution of aldehyde dehydrogenase 1-positive stem cells in benign mammary tissue from women with and without breast cancer.
Doxorubicin and ?-Mangostin oppositely affect luminal breast cancer cell stemness evaluated by a new retinaldehyde-dependent ALDH assay in MCF-7 tumor spheroids.
Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study.
DUSP9-mediated reduction of pERK1/2 supports cancer stem cell-like traits and promotes triple negative breast cancer.
Effect of ALDH1 on prognosis and chemoresistance by breast cancer subtype.
Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism.
Erratum: Clinicopathologic Characteristics of Breast Cancer Stem Cells Identified on the Basis of Aldehyde Dehydrogenase 1 Expression.
Evaluation of aldehyde dehydrogenase 1 and transcription factors in both primary breast cancer and axillary lymph node metastases as a prognostic factor.
Evaluation of ALDH1 expression in ipsilateral breast cancer recurrence.
Expression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer.
Expression of aldehyde dehydrogenase 1 as a marker of mammary stem cells in benign and malignant breast lesions of Ghanaian women.
Expression of ALDH1 and TGF?2 in benign and malignant breast tumors and their prognostic implications.
Expression of ALDH1 in axillary lymph node metastases is a prognostic factor of poor clinical outcome in breast cancer patients with 1-3 lymph node metastases.
Expression of ALDH1 in breast invasive ductal carcinoma: an independent predictor of early tumor relapse.
Expression of breast cancer stem cell markers as predictors of prognosis and response to trastuzumab in HER2-positive breast cancer.
Expression of embryonal stem cell transcription factors in breast cancer: Oct4 as an indicator for poor clinical outcome and tamoxifen resistance.
Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells.
Expression of the stem cell marker ALDH1 in BRCA1 related breast cancer.
EZH2 and ALDH1 expression in ductal carcinoma in situ: complex association with recurrence and progression to invasive breast cancer.
Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide.
Germline genetic variants in ABCB1, ABCC1 and ALDH1A1, and risk of hematological and gastrointestinal toxicities in a SWOG Phase III trial S0221 for breast cancer.
Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer.
High Expression of c-Met, PKC? and ALDH1A3 Predicts a Poor Prognosis in Late-stage Breast Cancer.
High Expression of Stem Cell Marker ALDH1 is Associated with Reduced BRCA1 in Invasive Breast Carcinomas.
High PKC? expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients.
Identification of ALDH1A3 as a viable therapeutic target in breast cancer metastasis-initiating cells.
Identification of new cancer stem cell markers and signaling pathways in HER?2?positive breast cancer by transcriptome sequencing.
IL-33 facilitates endocrine resistance of breast cancer by inducing cancer stem cell properties.
Immunocytochemical stem cell markers can predict clinical stage of breast cancer.
In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis.
Increased aldehyde dehydrogenase 1 (ALDH1) levels are associated with chemo-responsiveness in breast cancer patients treated with taxane-adriamycin-cyclophosphamide regimen.
Induced Expression of Cancer Stem Cell Markers ALDH1A3 and Sox-2 in Hierarchical Reconstitution of Apoptosis-resistant Human Breast Cancer Cells.
Inhibition of ALDH1A1 activity decreases expression of drug transporters and reduces chemotherapy resistance in ovarian cancer cell lines.
Inhibition of breast cancer growth via miR-7 suppressing ALDH1A3 activity concomitant with decreasing breast cancer stem cell subpopulation.
Inhibitor of DNA-binding 4 contributes to the maintenance and expansion of cancer stem cells in 4T1 mouse mammary cancer cell line.
Interaction of the effects of alcohol drinking and polymorphisms in alcohol-metabolizing enzymes on the risk of female breast cancer in Japan.
Is ALDH1 a good method for definition of breast cancer stem cells?
Knockdown of ALDH1A3 reduces breast cancer stem cell marker CD44 via the miR-7-TGFBR2-Smad3-CD44 regulatory axis.
Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion.
Limonin attenuates the stemness of breast cancer cells via suppressing MIR216A methylation.
Lnc RNA H19 is associated with poor prognosis in breast cancer patients and promotes cancer stemness.
Long-term PM2.5 exposure increases the risk of non-small cell lung cancer (NSCLC) progression by enhancing interleukin-17a (IL-17a)-regulated proliferation and metastasis.
Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness.
Measurement of Aldehyde Dehydrogenase 1 Expression Defines a Group with Better Prognosis in Patients with Non-Small Cell Lung Cancer.
miR-142-3p attenuates breast cancer stem cell characteristics and decreases radioresistance in vitro.
miR-199a-5p confers tumor-suppressive role in triple-negative breast cancer.
Molecular markers of therapeutic resistance in breast cancer.
Moving Forward in Human Mammary Stem Cell Biology and Breast Cancer Prognostication Using ALDH1.
Moving forward in human mammary stem cell biology and breast cancer prognostication using ALDH1.
MUC1-C Oncoprotein Activates ERK->C/EBP? Signaling and Induction of Aldehyde Dehydrogenase 1A1 in Breast Cancer Cells.
MYC dysfunction modulates stemness and tumorigenesis in breast cancer.
Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo.
Nodal signaling activates the Smad2/3 pathway to regulate stem cell-like properties in breast cancer cells.
NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells.
Novel prognostic markers for patients with triple-negative breast cancer.
Oncolytic vaccinia virus GLV-1h68 strain shows enhanced replication in human breast cancer stem-like cells in comparison to breast cancer cells.
P-Cadherin is Co-Expressed with Cd44 and Cd49f and Mediates Stem Cell Properties in Basal-Like Breast Cancer.
P2Y2R has a significant correlation with Notch-4 in patients with breast cancer.
Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance.
Preventive medical services not covered by public health insurance at Daiko Medical Center in Japan, 2004-2011.
Primary breast tumor levels of suspected molecular determinants of cellular sensitivity to cyclophosphamide, ifosfamide, and certain other anticancer agents as predictors of paired metastatic tumor levels of these determinants. Rational individualization of cancer chemotherapeutic regimens.
Profiling of the transcriptional response to all-trans retinoic acid in breast cancer cells reveals RARE-independent mechanisms of gene expression.
Prognostic Impact and Clinicopathological Correlation of CD133 and ALDH1 Expression in Invasive Breast Cancer.
Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment.
Prognostic Significance of TWIST1, CD24, CD44, and ALDH1 Transcript Quantification in EpCAM-Positive Circulating Tumor Cells from Early Stage Breast Cancer Patients.
Prognostic value of aldehyde dehydrogenase 1 (ALDH1) in invasive breast carcinomas.
Prognostic Value of Cancer Stem Cells Markers in Triple-Negative Breast Cancer.
Proliferation rate and breast cancer subtype, but not ALDH1 expression, predict pathological response to neoadjuvant chemotherapy in locally advanced breast cancer.
Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM).
Radioresistant breast cancer cells exhibit increased resistance to chemotherapy and enhanced invasive properties due to cancer stem cells.
Relationship between alcohol metabolism and chemotherapy-induced emetic events in breast cancer patients.
RhoC Impacts the Metastatic Potential and Abundance of Breast Cancer Stem Cells.
RNA binding protein PUM2 promotes the stemness of breast cancer cells via competitively binding to neuropilin-1 (NRP-1) mRNA with miR-376a.
Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development.
Role of aldehyde dehydrogenases, alcohol dehydrogenase 1B genotype, alcohol consumption, and their combination in breast cancer in East-Asian women.
Role of ALDH1A1 and HTRA2 expression in CCL2/CCR2-mediated breast cancer cell growth and invasion.
Role of the CXCR4-LASP1 Axis in the Stabilization of Snail1 in Triple-Negative Breast Cancer.
Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells.
SOX2 and ALDH1 as Predictors of Operable Breast Cancer.
Spectrum of Epithelial-Mesenchymal Transition Phenotypes in Circulating Tumour Cells from Early Breast Cancer Patients.
Stathmin1 expression is associated with aggressive phenotypes and cancer stem cell marker expression in breast cancer patients.
Stellate cells and mesenchymal stem cells in benign mammary stroma are associated with risk factors for breast cancer - an observational study.
Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients.
Stem cell biomarker ALDH1A1 in breast cancer shows an association with prognosis and clinicopathological variables that is highly cut-off dependent.
Stem cell marker aldehyde dehydrogenase 1 (ALDH1)-expressing cells are enriched in triple-negative breast cancer.
Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1?/VEGF signalling in MCF-7 breast cancer cells.
Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression.
Tamoxifen enhances stemness and promotes metastasis of ER?36
Tamoxifen induces a pluripotency signature in breast cancer cells and human tumors.
Tamoxifen, an anticancer drug, is an activator of human aldehyde dehydrogenase 1A1.
Targeting tumour-initiating cells to improve the cure rates for triple-negative breast cancer.
The absence of aldehyde dehydrogenase 1 A1-positive cells in benign mammary stroma is associated with risk factors for breast cancer.
The clinicopathological and prognostic significance of CD24, CD44, CD133, ALDH1 expressions in invasive ductal carcinoma of the breast: CD44/CD24 expression in breast cancer.
The discordance between primary breast cancer lesions and pulmonary metastatic lesions in expression of aldehyde dehydrogenase 1-positive cancer cells.
The expression of aldehyde dehydrogenase 1 in invasive primary breast tumors and axillary lymph node metastases is associated with poor clinical prognosis.
The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium.
The functional role of the EZH2 gene in controlling breast cancer stem cells.
The prognostic significance of ALDH1A1 expression in early invasive breast cancer.
The role of ALDH1A1 in contributing to breast tumour aggressiveness: A study conducted in an African population.
The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells.
Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression.
Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis.
ZFHX3 Promotes the Proliferation and Tumor Growth of ER-Positive Breast Cancer Cells Likely by Enhancing Stem-Like Features and MYC and TBX3 Transcription.
[Advancement of studies on ALDH1 as a universal marker of stem cells].
Carcinogenesis
Across-site differences in the mechanism of alcohol-induced digestive tract carcinogenesis: an evaluation by mediation analysis.
ADP-Ribosylation Factor Like GTPase 4C (ARL4C) augments stem-like traits of glioblastoma cells by upregulating ALDH1A3.
Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics.
Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics.
Alcohol and cancer.
Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.
Aldehyde dehydrogenase 1 (ALDH1) expression is associated with a poor prognosis of bladder cancer.
Aldehyde dehydrogenase 1 expression has prognostic significance in patients with glioma.
Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis.
Aldehyde dehydrogenase 1A1 up-regulates stem cell markers in benzo[a]pyrene-induced malignant transformation of BEAS-2B cells.
Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling.
Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer.
Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis.
Aldehyde dehydrogenase 3A1 is robustly upregulated in gastric cancer stem-like cells and associated with tumorigenesis.
ALDH1A1 Deficiency in Gorlin Syndrome Suggests a Central Role for Retinoic Acid and ATM Deficits in Radiation Carcinogenesis.
ALDH1A1 positive cells are a unique component of the tonsillar crypt niche and are lost along with NGFR positive stem cells during tumourigenesis.
Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.
ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/?-Catenin, Notch and PI3K/Akt Signaling Pathways.
ALDH2 and Cancer Therapy.
ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds.
ALDH2 Polymorphism and Ethanol Consumption: A Genetic-Environmental Interaction in Carcinogenesis.
ALDH2 polymorphism for the risk of cervical carcinogenesis.
All-trans retinoic acid downregulates ALDH1-mediated stemness and inhibits tumour formation in ovarian cancer cells.
Association Between ALDH2 Polymorphism and Gastric Cancer Risk in Terms of Alcohol Consumption: A Meta-Analysis.
Author Correction: Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis.
Deficient expression of aldehyde dehydrogenase 1A1 is consistent with increased sensitivity of Gorlin syndrome patients to radiation carcinogenesis.
Delivery of Anti-miRNA for Triple-Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting Stem Cell Marker CD133.
DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang, China.
Downregulation of ALDH1A1 expression in non-small cell lung carcinomas--its clinicopathologic and biological significance.
Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice.
Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer.
Expression of ALDH1A1 and CD44 in primary head and neck squamous cell carcinoma and their value for carcinogenesis, tumor progression and cancer stem cell identification.
Expression of cancer stem cell marker during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq technology.
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility.
Grape pomace inhibits colon carcinogenesis by suppressing cell proliferation and inducing epigenetic modifications.
High PKC? expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients.
Human papillomavirus 16 (HPV16) enhances tumor growth and cancer stemness of HPV-negative oral/oropharyngeal squamous cell carcinoma cells via miR-181 regulation.
Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma.
IL-33 facilitates endocrine resistance of breast cancer by inducing cancer stem cell properties.
Increased expression of aldehyde dehydrogenase 1 A1 in nasopharyngeal carcinoma is associated with enhanced invasiveness.
Increased Expression of ALDH1A1 in Prostate Cancer is Correlated With Tumor Aggressiveness: A Tissue Microarray Study of Iranian Patients.
Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans.
Integrated analysis reveals candidate mRNA and their potential roles in uterine leiomyomas.
Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene.
NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells.
p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma.
p53 protein accumulation, iodine-unstained lesions, and alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia.
Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer.
Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice.
Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM).
Recent Advances From Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma.
Relation of stem cell markers ALDH1 and CD44 with clinicopathological factors in urothelial carcinomas of urinary bladder.
Role of ALDH1 in the prognosis of esophageal cancer and its relationship with tumor microenvironment.
Silencing transcription factor FOXM1 represses proliferation, migration, and invasion while inducing apoptosis of liver cancer stem cells by regulating the expression of ALDH2.
Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence.
TAZ induces lung cancer stem cell properties and tumorigenesis by up-regulating ALDH1A1.
The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer.
The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment.
Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis.
[Alcohol and oropharyngolaryngeal and digestive tract cancer]
Carcinoma
A novel DNA-binding motif in prostate tumor overexpressed-1 (PTOV1) required for the expression of ALDH1A1 and CCNG2 in cancer cells.
A perspective on challenges and opportunities in characterizing oral cancer stem cells.
A prospective study of association of cancer stem cell marker aldehyde dehydrogenase 1 with clinicopathological profile in lung carcinoma patients.
A retrospective review of the prognostic value of ALDH-1, Bmi-1 and Nanog stem cell markers in esophageal squamous cell carcinoma.
ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma.
ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean population.
Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer.
Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians.
Aldehyde dehyderogenase (ALDH1A1) delineating the normal and cancer stem cells in spectral lung lesions: An immunohistochemical appraisal.
Aldehyde dehydrogenase 1 (ALDH1) positivity correlates with poor prognosis in cervical cancer.
Aldehyde dehydrogenase 1 (ALDH1A1) expression by immunohistochemistry is associated with chemo-refractoriness in patients with high-grade ovarian serous carcinoma.
Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer.
Aldehyde dehydrogenase 1 expression in basal cell carcinoma, actinic keratosis and Bowen's disease.
Aldehyde dehydrogenase 1 expression in primary and metastatic renal cell carcinoma: an immunohistochemistry study.
Aldehyde Dehydrogenase 1 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
Aldehyde dehydrogenase 1 identifies cells with cancer stem cell-like properties in a human renal cell carcinoma cell line.
Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer.
Aldehyde dehydrogenase 1/epidermal growth factor receptor coexpression is characteristic of a highly aggressive, poor-prognosis subgroup of high-grade serous ovarian carcinoma.
Aldehyde dehydrogenase 1A1 possesses stem-like properties and predicts lung cancer patient outcome.
Aldehyde Dehydrogenase-1 Expression Predicts Unfavorable Outcomes in Patients with Esophageal Squamous Cell Carcinoma.
Aldehyde dehydrogenase-1 predicts favorable prognosis in patients with vulvar squamous cell carcinoma.
ALDH1 expression correlates with favorable prognosis in ovarian cancers.
ALDH1 immunohistochemical expression and its significance in salivary adenoid cystic carcinoma.
ALDH1 in Combination with CD44 as Putative Cancer Stem Cell Markers are Correlated with Poor Prognosis in Urothelial Carcinoma of the Urinary Bladder.
ALDH1 might influence the metastatic capability of HeLa cells.
ALDH1A1 defines invasive cancer stem-like cells and predicts poor prognosis in patients with esophageal squamous cell carcinoma.
ALDH1A1 maintains the cancer stem-like cells properties of esophageal squamous cell carcinoma by activating the AKT signal pathway and interacting with ?-catenin.
ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer.
ALDH2 1510 G/A (Glu487Lys) polymorphism interaction with age in head and neck squamous cell carcinoma.
ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway.
Anticancer Activities of Thymus vulgaris L. in Experimental Breast Carcinoma in Vivo and in Vitro.
Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma.
Association of Genetic Polymorphisms of Aldehyde Dehydrogenase-2 and Cytochrome P450 2E1-RsaI and Alcohol Consumption with Oral Squamous Cell Carcinoma.
Associations of carboxypeptidase 4 with ALDH1A1 expression and their prognostic value in esophageal squamous cell carcinoma.
BMI1, ALDH1A1, and CD133 Transcripts Connect Epithelial-Mesenchymal Transition to Cancer Stem Cells in Lung Carcinoma.
Cancer stem cell marker ALDH1 expression is associated with lymph node metastasis and poor survival in esophageal squamous cell carcinoma: a study from high incidence area of northern China.
Cancer stem cell markers ALDH1 and Bmi1 expression in oral erythroplakia revisited: Implication for driving the process of field cancerization.
Cancer stem cell markers in eyelid sebaceous gland carcinoma: high expression of ALDH1, CD133, and ABCG2 correlates with poor prognosis.
Cancer stem-like cells of ovarian clear cell carcinoma are enriched in the ALDH-high population associated with an accelerated scavenging system in reactive oxygen species.
Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid.
Casticin suppresses self-renewal and invasion of lung cancer stem-like cells from A549 cells through down-regulation of pAkt.
CD44 and ALDH1 immunoexpression as prognostic indicators of invasion and metastasis in oral squamous cell carcinoma.
Clinical significance of ALDH1 combined with DAPI expression in patients with esophageal carcinoma.
Clinicopathological correlation of stem cell markers expression in oral squamous cell carcinoma; relation to patients` outcome.
Comparative expression analysis of putative cancer stem cell markers CD44 and ALDH1A1 in various skin cancer subtypes.
Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer.
Comprehensive in situ analysis of ALDH1 and SOX2 reveals increased expression of stem cell markers in high-grade serous carcinomas compared to low-grade serous carcinomas and atypical proliferative serous tumors.
Construction of a risk model for the development of metachronous squamous cell carcinoma after endoscopic resection of esopahageal squamous cell carcinoma.
Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse-type gastric carcinoma-initiating cells is inhibited by TGF-?
Correlation of ALDH1, CD44, OCT4 and SOX2 in tongue squamous cell carcinoma and their association with disease progression and prognosis.
Correlations of ALDH2 rs671 and C12orf30 rs4767364 polymorphisms with increased risk and prognosis of esophageal squamous cell carcinoma in the Kazak and Han populations in Xinjiang province.
Deficient aldehyde dehydrogenase 2 is associated with increased risk for esophageal squamous cell carcinoma in the presence of gastric hypochlorhydria.
Dietary selenium intake, aldehyde dehydrogenase-2 and X-ray repair cross-complementing 1 genetic polymorphisms, and the risk of esophageal squamous cell carcinoma.
Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer.
Downregulation of ALDH1A1 expression in non-small cell lung carcinomas--its clinicopathologic and biological significance.
Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer.
Esophageal squamous cell carcinoma and aldehyde dehydrogenase-2 genotypes in Japanese females.
Esophageal squamous cell carcinoma and ALDH2 and ADH1B polymorphisms in Chinese females.
Evaluation of ALDH1 expression in ipsilateral breast cancer recurrence.
Evaluation of the correlation of vasculogenic mimicry, ALDH1, KiSS-1, and MACC1 in the prediction of metastasis and prognosis in ovarian carcinoma.
Evaluation of the risk of metachronous multiple squamous cell carcinoma of the head and neck after transoral surgery based on the genetic polymorphisms of alcohol dehydrogenase 1B and aldehyde dehydrogenase 2.
Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma.
Expression and functional role of ALDH1 in cervical carcinoma cells.
Expression level of PD-L1 is involved in ALDH1A1-mediated poor prognosis in patients with head and neck squamous cell carcinoma.
Expression of ALDH1A1 and CD44 in primary head and neck squamous cell carcinoma and their value for carcinogenesis, tumor progression and cancer stem cell identification.
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer.
Expression of CD44, CD44v9, ABCG2, CD24, Bmi-1 and ALDH1 in stage I and II oral squamous cell carcinoma and their association with clinicopathological factors.
Expression of stem cell markers in oral cavity and oropharynx squamous cell carcinoma.
Expression profiling of adrenocortical neoplasms suggests a molecular signature of malignancy.
Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis.
Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males.
Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma.
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility.
Genomic characterization of early-stage esophageal squamous cell carcinoma in a Japanese population.
Global gene expression profiling identifies ALDH2, CCNE1 and SMAD3 as potential prognostic markers in upper tract urothelial carcinoma.
GnRH participates in the self-renewal of A549-derived lung cancer stem-like cells through upregulation of the JNK signaling pathway.
GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis.
Heavy alcohol drinking downregulates ALDH2 gene expression but heavy smoking up-regulates SOD2 gene expression in head and neck squamous cell carcinoma.
Helicobacter pylori, chronic atrophic gastritis, inactive aldehyde dehydrogenase-2, macrocytosis and multiple upper aerodigestive tract cancers and the risk for gastric cancer in alcoholic Japanese men.
High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis.
Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein.
Identification of Human Aldehyde Dehydrogenase 1 Family Member A1 as a Novel CD8+ T-Cell Defined Tumor Antigen in Squamous Cell Carcinoma of the Head and Neck.
Immunolocalization of Cancer Stem Cells Marker ALDH1 and its Association with Tumor Budding in Oral Squamous Cell Carcinoma.
Impact of alcohol dehydrogenase-aldehyde dehydrogenase polymorphism on clinical outcome in patients with hypopharyngeal cancer.
Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.
Impairment of aldehyde dehydrogenase 2 increases accumulation of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion.
In vitro and in vivo expression of aldehyde dehydrogenase 1 in oral squamous cell carcinoma.
Increased expression of ALDH1A1 protein is associated with poor prognosis in clear cell renal cell carcinoma.
Limitations of lymphoblastoid cell lines for functional analysis of SNPs.
Loss of ALDH1A1 expression is an early event in the pathogenesis of ovarian high-grade serous carcinoma.
Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men.
Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China.
Molecular Mechanisms of Acetaldehyde-Mediated Carcinogenesis in Squamous Epithelium.
Morphological and immunohistochemical study of ovarian and tubal dysplasia associated with tamoxifen.
Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers.
Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase-2 genotype of Japanese alcoholics.
Neuregulin-1-?1 and ?-secretase play a critical role in sphere-formation and cell survival of urothelial carcinoma cancer stem-like cells.
Normal and neoplastic urothelial stem cells: getting to the root of the problem.
Novel biomarker candidates for the diagnosis of ovarian clear cell carcinoma.
Overexpression of ALDH1 and EMT marker profile are linked with unfavorable outcome in head and neck cancer.
p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma.
Predictive Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio in Head and Neck Squamous Cell Carcinoma.
Prognostic Impact of ALDH1 Expression in Transitional Cell Carcinoma of the Renal Pelvis.
Prognostic impact of the expression of ALDH1 and SOX2 in urothelial cancer of the upper urinary tract.
Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer.
Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma.
Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma.
Prognostic Value of Drinking Status and Aldehyde Dehydrogenase 2 Polymorphism in Patients With Head and Neck Squamous Cell Carcinoma.
Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cell carcinoma.
Putative stem cell markers in cervical squamous cell carcinoma are correlated with poor clinical outcome.
Relation of stem cell markers ALDH1 and CD44 with clinicopathological factors in urothelial carcinomas of urinary bladder.
Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism.
Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma.
Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2: temperance reduces the risk.
Risk of metachronous squamous cell carcinoma in the upper aerodigestive tract of Japanese alcoholic men with esophageal squamous cell carcinoma: a long-term endoscopic follow-up study.
Risk of squamous cell carcinoma of the upper aerodigestive tract in cancer-free alcoholic Japanese men: an endoscopic follow-up study.
Role of ALDH1 in the prognosis of esophageal cancer and its relationship with tumor microenvironment.
Spatial distribution of cancer stem cells in head and neck squamous cell carcinomas.
Spectrum of ALDH1 mRNA in smokers and non-smokers with adenocarcinoma or squamous cell lung carcinoma.
ST6Gal-I Protein Expression Is Upregulated in Human Epithelial Tumors and Correlates with Stem Cell Markers in Normal Tissues and Colon Cancer Cell Lines.
Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.
Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.
The expression of aldehyde dehydrogenase 1 (ALDH1) in ovarian carcinomas and its clinicopathological associations: a retrospective study.
The expression of ALDH1 in cervical carcinoma.
The prognostic role of the cancer stem cell marker aldehyde dehydrogenase 1 in head and neck squamous cell carcinomas: a meta-analysis.
Upregulation of stem cell markers ALDH1A1 and OCT4 as potential biomarkers for the early detection of cervical carcinoma.
Vasculogenic mimicry and expression of ALDH1, Beclin1, and p16 correlate with metastasis and prognosis in oral squamous cell carcinoma.
VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2.
[Correlation between drinking behavior and polymorphisms of extracellular superoxide dismutase, aldehyde dehydrogenase 2 genes, and oral squamous cell carcinoma].
[Expression Level of Membrane-associated Proteins Numb in Epithelial Ovarian Carcinoma and Its Relationship with Ovarian Cancer Stem Cell Markers CD117, CD133, ALDH1.]
[Expression of ALDH1, CXCR4 and E-cadherin in castric carcinoma and their roles in lymphatic metastasis].
[Markers of stem cells and their prognostic values for urothelial carcinomas of the urinary tract].
Carcinoma in Situ
Loss of ALDH1A1 expression is an early event in the pathogenesis of ovarian high-grade serous carcinoma.
[Expansion of secretory cells in the fallopian tubal epithelium in the early stages of the pathogenesis of ovarian serous carcinomas].
Carcinoma, Adenoid Cystic
ALDH1 immunohistochemical expression and its significance in salivary adenoid cystic carcinoma.
Carcinoma, Basal Cell
Aldehyde dehydrogenase 1 expression in basal cell carcinoma, actinic keratosis and Bowen's disease.
Comparative expression analysis of putative cancer stem cell markers CD44 and ALDH1A1 in various skin cancer subtypes.
Carcinoma, Ductal
ABCG2 is a potential marker of tumor-initiating cells in breast cancer.
Aberrant expression of ALDH1, MMP9, Integrin ?v?3, and KiSS-1 in invasive ductal carcinoma and their clinical significance.
Aldehyde dehydrogenase 1 expression correlates with the invasion of breast cancer.
Cancer stem cell markers ALDH1 and CD44+/CD24- phenotype and their prognosis impact in invasive ductal carcinoma.
Clinicopathologic characteristics of breast cancer stem cells identified on the basis of aldehyde dehydrogenase 1 expression.
Clinicopathological analysis of breast ductal carcinoma in situ with ALDH1-positive cancer stem cells.
Expression of ALDH1 in breast invasive ductal carcinoma: an independent predictor of early tumor relapse.
EZH2 and ALDH1 expression in ductal carcinoma in situ: complex association with recurrence and progression to invasive breast cancer.
Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer.
The clinicopathological and prognostic significance of CD24, CD44, CD133, ALDH1 expressions in invasive ductal carcinoma of the breast: CD44/CD24 expression in breast cancer.
Carcinoma, Embryonal
Expression of RALDHs (ALDH1As) and CYP26s in human tissues and during the neural differentiation of P19 embryonal carcinoma stem cell.
Carcinoma, Endometrioid
ALDH1 expression correlates with favorable prognosis in ovarian cancers.
Expression of aldehyde dehydrogenase 1 (ALDH1) in endometrioid adenocarcinoma and its clinical implications.
Inhibitory effect of Nodal on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma of uterus.
Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line.
Serum deprivation-response protein regulates aldehyde dehydrogenase 1 through integrin-linked kinase signaling in endometrioid carcinoma cells.
Carcinoma, Hepatocellular
A multiple mediator analysis approach to quantify the effects of the ADH1B and ALDH2 genes on hepatocellular carcinoma risk.
AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells.
Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk of primary hepatocellular carcinoma in a chinese population.
Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma.
Aldehyde dehydrogenase (ALDH2) activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA.
Aldehyde dehydrogenase 1 (ALDH1) isoform expression and potential clinical implications in hepatocellular carcinoma.
Aldehyde dehydrogenase 1 is associated with recurrence-free survival but not stem cell-like properties in hepatocellular carcinoma.
Aldehyde dehydrogenase 2 polymorphism for development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis.
Aldehyde dehydrogenase 3 expression is decreased by clofibrate via PPAR gamma induction in JM2 rat hepatoma cell line.
Aldehyde dehydrogenase-2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP-activated protein kinase signaling in mice.
ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma.
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles.
ALDH3A1 is overexpressed in a subset of hepatocellular carcinoma characterised by activation of the Wnt/ß-catenin pathway.
Arachidonic acid suppresses growth of human lung tumor A549 cells through down-regulation of ALDH3A1 expression.
Decreased expression of ALDH1L1 is associated with a poor prognosis in hepatocellular carcinoma.
Effects of hepatocarcinogenic initiators on aldehyde dehydrogenase gene expression in cultured rat hepatic cells.
Eliciting the low-activity aldehyde dehydrogenase Asian phenotype by an antisense mechanism results in an aversion to ethanol.
Evaluation of the selective toxic effect of the charge switchable diethyldithiocarbamate-loaded nanoparticles between hepatic normal and cancerous cells.
Feedback inhibition of the retinaldehyde dehydrogenase gene ALDH1 by retinoic acid through retinoic acid receptor alpha and CCAAT/enhancer-binding protein beta.
Genetic polymorphisms of ALDH2 and ADH2 are not associated with risk of hepatocellular carcinoma among East Asians.
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma.
Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China.
Hepatocellular carcinoma associated with alcoholic liver disease: a clinicopathological study and genetic polymorphism of aldehyde dehydrogenase 2.
High FOXK1 expression correlates with poor outcomes in hepatocellular carcinoma and regulates stemness of hepatocellular carcinoma cells.
Increase in class 2 aldehyde dehydrogenase expression by arachidonic acid in rat hepatoma cells.
Influence of alcohol consumption and gene polymorphisms of ADH2 and ALDH2 on hepatocellular carcinoma in a Japanese population.
Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation.
Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): gene structure and regulation of constitutive and dioxin-inducible expression.
mTOR/HDAC1 Crosstalk Mediated Suppression of ADH1A and ALDH2 Links Alcohol Metabolism to Hepatocellular Carcinoma Onset and Progression in silico.
Preferential transcription of rabbit Aldh1a1 in the cornea: implication of hypoxia-related pathways.
Quantitative histochemistry of benzaldehyde dehydrogenase in hepatocellular carcinomas of vinyl chloride-treated rats.
Relationship between alcohol drinking, ADH2 and ALDH2 genotypes, and risk for hepatocellular carcinoma in Japanese.
Relationship of ALDH2 rs671 and CYP2E1 rs2031920 with hepatocellular carcinoma susceptibility in East Asians: a meta-analysis.
The Defective Allele of Aldehyde Dehydrogenase 2 Gene is Associated with Favorable Postoperative Prognosis in Hepatocellular Carcinoma.
The effect of a novel irreversible inhibitor of aldehyde dehydrogenases 1 and 3 on tumour cell growth and death.
The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme.
The transcriptional regulation of human aldehyde dehydrogenase I gene. The structural and functional analysis of the promoter.
Use of an "acetaldehyde clamp" in the determination of low-KM aldehyde dehydrogenase activity in H4-II-E-C3 rat hepatoma cells.
Carcinoma, Intraductal, Noninfiltrating
Aldehyde dehydrogenase 1 expression correlates with the invasion of breast cancer.
Characterization of a stem-like subpopulation in basal-like ductal carcinoma in situ (DCIS) lesions.
Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer.
EZH2 and ALDH1 expression in ductal carcinoma in situ: complex association with recurrence and progression to invasive breast cancer.
Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer.
Carcinoma, Neuroendocrine
High ALDH1A1 expression indicates a poor prognosis in gastric neuroendocrine carcinoma.
Carcinoma, Non-Small-Cell Lung
A prospective study of association of cancer stem cell marker aldehyde dehydrogenase 1 with clinicopathological profile in lung carcinoma patients.
Aldehyde Dehydrogenase 1 (ALDH1) Promotes the Toxicity of TRAIL in Non-Small Cell Lung Cancer Cells via Post-Transcriptional Regulation of MEK-1 Expression.
Aldehyde dehydrogenase 1 expression in cancer cells could have prognostic value for patients with non-small cell lung cancer who are treated with neoadjuvant therapy: identification of prognostic microenvironmental factors after chemoradiation.
Aldehyde dehydrogenase 1A1 possesses stem-like properties and predicts lung cancer patient outcome.
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling.
Aldehyde dehydrogenases in early stage lung cancer: nuclear expression.
ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors.
Casticin suppresses self-renewal and invasion of lung cancer stem-like cells from A549 cells through down-regulation of pAkt.
Downregulation of ALDH1A1 expression in non-small cell lung carcinomas--its clinicopathologic and biological significance.
Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway.
Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation.
Ginsenoside Rg3 attenuates the osimertinib resistance by reducing the stemness of non-small cell lung cancer cells.
GnRH participates in the self-renewal of A549-derived lung cancer stem-like cells through upregulation of the JNK signaling pathway.
Hedgehog signaling pathway molecules and ALDH1A1 expression in early-stage non-small cell lung cancer.
Measurement of Aldehyde Dehydrogenase 1 Expression Defines a Group with Better Prognosis in Patients with Non-Small Cell Lung Cancer.
Metastasis-associated in colon cancer-1 and aldehyde dehydrogenase 1 are metastatic and prognostic biomarker for non-small cell lung cancer.
Pivotal role of CD38 biomarker in combination with CD24, EpCAM, and ALDH for identification of H460 derived lung cancer stem cells.
Serum ALDH1A1 is a tumor marker for the diagnosis of non-small cell lung cancer.
Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells.
The prognostic significance of aldehyde dehydrogenase 1A1 (ALDH1A1) and CD133 expression in early stage non-small cell lung cancer.
The role of LGR5 and ALDH1A1 in non-small cell lung cancer: Cancer progression and prognosis.
Carcinoma, Ovarian Epithelial
ALDH1-Bright Epithelial Ovarian Cancer Cells Are Associated with CD44 Expression, Drug Resistance, and Poor Clinical Outcome.
ALDH1A1 contributes to PARP inhibitor resistance via enhancing DNA repair in BRCA2-/- ovarian cancer cells.
ALDH1A1 Is a Novel EZH2 Target Gene in Epithelial Ovarian Cancer Identified by Genome-Wide Approaches.
ALDH1A2 suppresses epithelial ovarian cancer cell proliferation and migration by downregulating STAT3.
High Expressions of Lgr5 and ALDH1 in Primary Epithelial Ovarian Cancer Correlate with Advanced Tumor Stage and Grade as well as Poor Prognosis of the Patients.
[Expression Level of Membrane-associated Proteins Numb in Epithelial Ovarian Carcinoma and Its Relationship with Ovarian Cancer Stem Cell Markers CD117, CD133, ALDH1.]
Carcinoma, Pancreatic Ductal
Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma.
Carcinoma, Renal Cell
Aldehyde dehydrogenase 1 expression in primary and metastatic renal cell carcinoma: an immunohistochemistry study.
Aldehyde dehydrogenase 1 identifies cells with cancer stem cell-like properties in a human renal cell carcinoma cell line.
Increased expression of ALDH1A1 protein is associated with poor prognosis in clear cell renal cell carcinoma.
VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2.
Carcinoma, Squamous Cell
ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma.
ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean population.
Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians.
Aldehyde dehyderogenase (ALDH1A1) delineating the normal and cancer stem cells in spectral lung lesions: An immunohistochemical appraisal.
Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer.
Aldehyde dehydrogenase-1 predicts favorable prognosis in patients with vulvar squamous cell carcinoma.
ALDH2 1510 G/A (Glu487Lys) polymorphism interaction with age in head and neck squamous cell carcinoma.
Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid.
Comparative expression analysis of putative cancer stem cell markers CD44 and ALDH1A1 in various skin cancer subtypes.
Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer.
Construction of a risk model for the development of metachronous squamous cell carcinoma after endoscopic resection of esopahageal squamous cell carcinoma.
Correlation of ALDH1, CD44, OCT4 and SOX2 in tongue squamous cell carcinoma and their association with disease progression and prognosis.
Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer.
Evaluation of the risk of metachronous multiple squamous cell carcinoma of the head and neck after transoral surgery based on the genetic polymorphisms of alcohol dehydrogenase 1B and aldehyde dehydrogenase 2.
Expression level of PD-L1 is involved in ALDH1A1-mediated poor prognosis in patients with head and neck squamous cell carcinoma.
Expression of ALDH1A1 and CD44 in primary head and neck squamous cell carcinoma and their value for carcinogenesis, tumor progression and cancer stem cell identification.
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer.
Expression of stem cell markers in oral cavity and oropharynx squamous cell carcinoma.
Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males.
Heavy alcohol drinking downregulates ALDH2 gene expression but heavy smoking up-regulates SOD2 gene expression in head and neck squamous cell carcinoma.
Identification of Human Aldehyde Dehydrogenase 1 Family Member A1 as a Novel CD8+ T-Cell Defined Tumor Antigen in Squamous Cell Carcinoma of the Head and Neck.
Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.
Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men.
Molecular Mechanisms of Acetaldehyde-Mediated Carcinogenesis in Squamous Epithelium.
Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers.
Overexpression of ALDH1 and EMT marker profile are linked with unfavorable outcome in head and neck cancer.
p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma.
Predictive Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio in Head and Neck Squamous Cell Carcinoma.
Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer.
Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma.
Prognostic Value of Drinking Status and Aldehyde Dehydrogenase 2 Polymorphism in Patients With Head and Neck Squamous Cell Carcinoma.
Putative stem cell markers in cervical squamous cell carcinoma are correlated with poor clinical outcome.
Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2: temperance reduces the risk.
Risk of metachronous squamous cell carcinoma in the upper aerodigestive tract of Japanese alcoholic men with esophageal squamous cell carcinoma: a long-term endoscopic follow-up study.
Risk of squamous cell carcinoma of the upper aerodigestive tract in cancer-free alcoholic Japanese men: an endoscopic follow-up study.
Spatial distribution of cancer stem cells in head and neck squamous cell carcinomas.
Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.
The expression of ALDH1 in cervical carcinoma.
The prognostic role of the cancer stem cell marker aldehyde dehydrogenase 1 in head and neck squamous cell carcinomas: a meta-analysis.
Carcinoma, Transitional Cell
Prognostic Impact of ALDH1 Expression in Transitional Cell Carcinoma of the Renal Pelvis.
Carcinoma, Verrucous
Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer.
Cardiomegaly
A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: Role of AMPK-regulated autophagy.
Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells.
Aldehyde dehydrogenase 2 deficiency blunts compensatory cardiac hypertrophy through modulating Akt phosphorylation early after transverse aorta constriction in mice.
Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress.
Complex Inhibition of Autophagy by Mitochondrial Aldehyde Dehydrogenase Shortens Lifespan and Exacerbates Cardiac Aging.
Impairment of aldehyde dehydrogenase-2 by 4-hydroxy-2-nonenal adduct formation and cardiomyocyte hypertrophy in mice fed a high-fat diet and injected with low-dose streptozotocin.
Increased clearance of reactive aldehydes and damaged proteins in hypertension-induced compensated cardiac hypertrophy: impact of exercise training.
Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function.
Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction.
Cardiomyopathies
Aldehyde dehydrogenase 2 ameliorates doxorubicin-induced myocardial dysfunction through detoxification of 4-HNE and suppression of autophagy.
Aldehyde dehydrogenase 2 protects cardiomyocytes against lipotoxicity via the AKT/glycogen synthase kinase 3 beta pathways.
Aldehyde Dehydrogenase-2 Attenuates Myocardial Remodeling and Contractile Dysfunction Induced by a High-Fat Diet.
Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1.
ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Correction to: ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1?.
Cardiomyopathy, Alcoholic
Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models.
Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: Role of protein phosphatases.
ALDH2 in alcoholic heart diseases: Molecular mechanism and clinical implications.
ALDH2 protects against alcoholic cardiomyopathy through a mechanism involving the p38 MAPK/CREB pathway and local renin-angiotensin system inhibition in cardiomyocytes.
Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling.
Deficiency of insulin-like growth factor 1 reduces vulnerability to chronic alcohol intake-induced cardiomyocyte mechanical dysfunction: Role of AMPK.
Cardiomyopathy, Dilated
Aldehyde dehydrogenase 2 ameliorates doxorubicin-induced myocardial dysfunction through detoxification of 4-HNE and suppression of autophagy.
Cardiotoxicity
Aldehyde dehydrogenase 2 activation ameliorates cyclophosphamide-induced acute cardiotoxicity via detoxification of toxic aldehydes and suppression of cardiac cell death.
Aldehyde dehydrogenase 2 ameliorates acute cardiac toxicity of ethanol: role of protein phosphatase and forkhead transcription factor.
ALDH2 attenuates Dox-induced cardiotoxicity by inhibiting cardiac apoptosis and oxidative stress.
ALDH2 Overexpression Alleviates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation.
Cardioprotection induced by a brief exposure to acetaldehyde:role of aldehyde dehydrogenase 2.
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism.
Cardiovascular Diseases
Acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbates pressure overload-induced cardiac dysfunction by inhibiting Beclin-1 dependent autophagy pathway.
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver.
Alda-1, an Aldehyde Dehydrogenase 2 Agonist, Improves Cutaneous Wound Healing by Activating Epidermal Keratinocytes via Akt/GSK-3?/?-Catenin Pathway.
Aldehyde dehydrogenase 2 protects against acute kidney injury by regulating autophagy via the Beclin-1 pathway.
Aldehyde Dehydrogenase-2 Roles in Ischemic Cardiovascular Disease.
ALDH2 activation inhibited cardiac fibroblast-to-myofibroblast transformation via TGF-?1/Smad signaling pathway.
ALDH2 and Cardiovascular Disease.
ALDH2 in alcoholic heart diseases: Molecular mechanism and clinical implications.
ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
ALDH2 rs671 polymorphism and the risk of heart failure with preserved ejection fraction (HFpEF) in patients with cardiovascular diseases.
ALDH2*2 Allele is a Negative Risk Factor for Cerebral Infarction in Chinese Women.
Association between Carotid Intima-media Thickness and Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism in Chinese Han with Essential Hypertension.
Association of an aldehyde dehydrogenase 2 (ALDH2) gene polymorphism with hyper-low-density lipoprotein cholesterolemia in a Japanese population.
Confirmation of ALDH2 as a Major Locus of Drinking Behavior and of Its Variants Regulating Multiple Metabolic Phenotypes in a Japanese Population.
Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population.
Glu504Lys Single Nucleotide Polymorphism of Aldehyde Dehydrogenase 2 Gene and the Risk of Human Diseases.
Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3? and mitochondrial function.
Mitochondrial aldehyde dehydrogenase and cardiac diseases.
Not just correlative: a new pathway defines how an ALDH2 SNP contributes to atherosclerosis.
Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update.
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.
The ALDH2 rs671 polymorphism affects post-stroke epilepsy susceptibility and plasma 4-HNE levels.
The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexes.
The potential of aldehyde dehydrogenase 2 as a therapeutic target in cardiovascular disease.
Carotid Artery Diseases
Effects of aldehyde dehydrogenase genotypes on carotid atherosclerosis.
The polymorphism in acetaldehyde dehydrogenase 2 gene, causing a substitution of Glu > Lys(504), is not associated with coronary atherosclerosis severity in Han Chinese.
Cataract
Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 Inhibitors.
Corneal haze phenotype in Aldh3a1-null mice: In vivo confocal microscopy and tissue imaging mass spectrometry.
Molecular characterization of the human lens epithelium-derived cell line SRA01/04.
Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice.
Cerebral Amyloid Angiopathy
Mitochondrial aldehyde dehydrogenase-2 activation prevents ? amyloids induced endothelial cell dysfunction and restores angiogenesis.
Cerebral Infarction
Aldehyde Dehydrogenase 2 (ALDH2) Glu504Lys Polymorphism Affects Collateral Circulation and Short-Term Prognosis of Acute Cerebral Infarction Patients.
ALDH2 and Stroke: A Systematic Review of the Evidence.
ALDH2*2 Allele is a Negative Risk Factor for Cerebral Infarction in Chinese Women.
Association Between the Polymorphism of Aldehyde Dehydrogenase 2 Gene and Cerebral Infarction in a Hakka Population in Southern China.
Cheilitis
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer.
Chemical and Drug Induced Liver Injury
Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.
Prospective study of ALDH1A1 gene polymorphisms associated with antituberculosis drug-induced liver injury in Western Chinese Han population.
Cholangiocarcinoma
ALDH1A3, the Major Aldehyde Dehydrogenase Isoform in Human Cholangiocarcinoma Cells, Affects Prognosis and Gemcitabine Resistance in Cholangiocarcinoma Patients.
Loss of ARID1A induces a stemness gene ALDH1A1 expression with histone acetylation in the malignant subtype of cholangiocarcinoma.
Ruxolitinib Combined with Gemcitabine against Cholangiocarcinoma Growth via the JAK2/STAT1/3/ALDH1A3 Pathway.
Cholecystitis
Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma.
Cholestasis
Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.
Chondrosarcoma
Proline?rich polypeptide?1 decreases cancer stem cell population by targeting BAFF chromatin?remodeling complexes in human chondrosarcoma JJ012 cells.
Colitis
Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression.
Taraxacum officinale extract ameliorates dextran sodium sulphate-induced colitis by regulating fatty acid degradation and microbial dysbiosis.
Coloboma
A homozygous mutation in a consanguineous family consolidates the role of ALDH1A3 in autosomal recessive microphthalmia.
Colonic Neoplasms
Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer.
Aldehyde Dehydrogenase 1B1 Is Associated with Altered Cell Morphology, Proliferation, Migration and Chemosensitivity in Human Colorectal Adenocarcinoma Cells.
ALDH1A3 affects colon cancer in vitro proliferation and invasion depending on CXCR4 status.
ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/?-Catenin, Notch and PI3K/Akt Signaling Pathways.
Association of aldehyde dehydrogenase 2 gene polymorphism with pancreatic cancer but not colon cancer.
Colon cancer stem cells: implications in carcinogenesis.
Colon cancer: cancer stem cells markers, drug resistance and treatment.
Combination of aging and dimethylhydrazine treatment causes an increase in cancer-stem cell population of rat colonic crypts.
Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers.
Eugenia jambolana (Java Plum) Fruit Extract Exhibits Anti-Cancer Activity against Early Stage Human HCT-116 Colon Cancer Cells and Colon Cancer Stem Cells.
Expression Analysis of Aldehyde Dehydrogenase 1A1 (ALDH1A1) in Colon and Rectal Cancer in Association with Prognosis and Response to Chemotherapy.
Expression of Aldehyde Dehydrogenase (ALDH1) and ATP Binding Cassette Transporter G2 (ABCG2) in Iraqi Patients with Colon Cancer and the Relation with Clinicopathological Features.
Expression of aldehyde dehydrogenase 1 in colon cancer.
Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer.
Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells.
Montelukast, a CysLT1 receptor antagonist, reduces colon cancer stemness and tumor burden in a mouse xenograft model of human colon cancer.
Objective analysis of cancer stem cell marker expression using immunohistochemistry.
The heparan sulfate proteoglycan syndecan-1 regulates colon cancer stem cell function via a focal adhesion kinase-Wnt signaling axis.
The impact of Aldehyde dehydrogenase 1 expression on prognosis for metastatic colon cancer.
[Prognostic values of the clinical, morphological and molecular biological characteristics of colon adenocarcinoma].
Colorectal Neoplasms
A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan.
A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population.
A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro.
ABCG5-positivity in tumor buds is an indicator of poor prognosis in node-negative colorectal cancer patients.
Across-site differences in the mechanism of alcohol-induced digestive tract carcinogenesis: an evaluation by mediation analysis.
Alcohol and cancer.
Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study.
Aldehyde Dehydragenase 1 and Nodal as Significant Prognostic Markers in Colorectal Cancer.
Aldehyde dehydrogenase 1: A specific cancer stem cell marker for human colorectal carcinoma.
Aldehyde dehydrogenase 1B1 is a potential marker of colorectal tumors.
Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer.
Aldehyde Dehydrogenase 2 Mediates Alcohol-Induced Colorectal Cancer Immune Escape through Stabilizing PD-L1 Expression.
ALDH1A1 expression is associated with poor differentiation, 'right-sidedness' and poor survival in human colorectal cancer.
ALDH1A3 upregulation and spontaneous metastasis formation is associated with acquired chemoresistance in colorectal cancer cells.
ALDH2 gene polymorphism in different types of cancers and its clinical significance.
Association between aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism and susceptibility to colorectal cancer: a meta-analysis.
Association between ALDH2 and ADH1B Polymorphisms and the Risk for Colorectal Cancer in Koreans.
Association of ADH1B Arg47His and ALDH2 Glu487Lys polymorphisms with risk of colorectal cancer and their interaction with environmental factors in a Chinese population.
CEACAM1 is associated with recurrence after hepatectomy for colorectal liver metastasis.
Clinical prognostic value of combined analysis of Aldh1, Survivin, and EpCAM expression in colorectal cancer.
Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas.
Clinicopathological significance of ALDH1A1 in lung, colorectal, and breast cancers: a meta-analysis.
Clinicopathological Significance of Tumor Stem Cell Markers ALDH1 and CD133 in Colorectal Carcinoma.
Colorectal cancer stem cell: a potential therapeutic target.
Complex Behavior of ALDH1A1 and IGFBP1 in Liver Metastasis from a Colorectal Cancer.
Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells.
Distinct patterns of ALDH1A1 expression predict metastasis and poor outcome of colorectal carcinoma.
Evaluation of the correlation of vasculogenic mimicry, ALDH1, KAI1 and microvessel density in the prediction of metastasis and prognosis in colorectal carcinoma.
Evaluation of the Role of ALDH1 as Cancer Stem Cell Marker in Colorectal Carcinoma: An Immunohistochemical Study.
Expression Analysis of Aldehyde Dehydrogenase 1A1 (ALDH1A1) in Colon and Rectal Cancer in Association with Prognosis and Response to Chemotherapy.
Expression and prognostic value of tumor stem cell markers ALDH1 and CD133 in colorectal carcinoma.
Expression of Aldehyde Dehydrogenase 1A1 (ALDH1A1) as a Prognostic Biomarker in Colorectal Cancer Using Immunohistochemistry.
Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer.
Folate, alcohol, ADH1B and ALDH2 and colorectal cancer risk.
Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer.
Genotype difference of aldehyde dehydrogenase 2 gene in alcohol drinkers influences the incidence of Japanese colorectal cancer patients.
Interplay between APC and ALDH1B1 in a newly developed mouse model of colorectal cancer.
L1CAM, CA9, KLK6, HPN, and ALDH1A1 as Potential Serum Markers in Primary and Metastatic Colorectal Cancer Screening.
Loss of expression of the cancer stem cell marker aldehyde dehydrogenase 1 correlates with advanced-stage colorectal cancer.
Meta-analysis of the ADH1B and ALDH2 polymorphisms and the risk of colorectal cancer in East Asians.
Meta-analysis of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and colorectal cancer risk.
MIR600HG suppresses metastasis and enhances oxaliplatin chemosensitivity by targeting ALDH1A3 in colorectal cancer.
Nuclear aldehyde dehydrogenase 1A1 (ALDH1A1) expression is a favorable prognostic indicator in colorectal carcinoma.
Polymorphisms in alcohol metabolism genes ADH1B and ALDH2, alcohol consumption and colorectal cancer.
Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males.
Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer.
Prognostic value of ALDH1 and Nestin in advanced cancer: a systematic meta-analysis with trial sequential analysis.
Prognostic Value of Cancer Stem Cell Marker ALDH1 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis.
Protein Markers Associated with an ALDH Sub-Population in Colorectal Cancer.
Reduction of NANOG Mediates the Inhibitory Effect of Aspirin on Tumor Growth and Stemness in Colorectal Cancer.
Relation of the CD36 gene A52C polymorphism to the risk of colorectal cancer among Japanese, with reference to with the aldehyde dehydrogenase 2 gene Glu487Lys polymorphism and drinking habit.
The expression pattern of aldehyde dehydrogenase 1 (ALDH1) is an independent prognostic marker for low survival in colorectal tumors.
The Identifications and Clinical Implications of Cancer Stem Cells in Colorectal Cancer.
The Prognostic Value of Cancer Stem Cell Markers (Notch1, ALDH1, and CD44) in Primary Colorectal Carcinoma.
TWIST1 and SNAI1 as markers of poor prognosis in human colorectal cancer are associated with the expression of ALDH1 and TGF-?1.
Verification of ALDH Activity as a Biomarker in Colon Cancer Stem Cells-Derived HT-29 Cell Line.
[CD133(+) Colo205 colorectal cancer cells express high levels of ALDH1 in serum-free culture].
[Role of alcohol-metabolizing enzymes gene polymorphisms and environmental exposure on colorectal cancer: a case-only study].
Congenital Abnormalities
Maternal aldehyde elimination during pregnancy preserves the fetal genome.
The Bidirectional Effect of Defective ALDH2 Polymorphism and Disease Prevention.
Contracture
Robotic-assisted latissimus dorsi harvest in delayed-immediate breast reconstruction.
Corneal Edema
Protective effect of aldehyde dehydrogenase 2 against rat corneal dysfunction caused by streptozotocin-induced type I diabetes.
Coronary Artery Disease
Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis.
Aldehyde dehydrogenase 2 polymorphism as a protective factor for intracranial vascular stenosis in ischemic stroke in Han Chinese.
ALDH2 deficiency inhibits Ox-LDL induced foam cell formation via suppressing CD36 expression.
ALDH2 gene G487A polymorphism and coronary artery disease: a meta-analysis including 5644 participants.
ALDH2 Glu504Lys polymorphism and susceptibility to coronary artery disease and myocardial infarction in East Asians: a meta-analysis.
Association between ALDH2 Glu504Lys Polymorphism and Susceptibility to Coronary Artery Disease and Myocardial Infarction: Need for Clarification of Data in a Recent Meta-analysis.
Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: a meta-analysis.
Associations of common variants at ALDH2 gene and the risk of stroke in patients with coronary artery diseases undergoing percutaneous coronary intervention.
Combined effects of current-smoking and the aldehyde dehydrogenase 2*2 allele on the risk of myocardial infarction in Japanese patients.
East Asians Variant Mitochondrial Aldehyde Dehydrogenase 2 Genotype Exacerbates Nitrate Tolerance in Patients With Coronary Spastic Angina.
Genetic risk score (GRS) constructed from polymorphisms in the PON1, IL-6, ITGB3, and ALDH2 genes is associated with the risk of coronary artery disease in Pakistani subjects.
Impact of Genetic Variation in Aldehyde Dehydrogenase 2 and Alcohol Consumption on Coronary Artery Lesions in Chinese Patients with Stable Coronary Artery Disease.
Impacts of common variants in ALDH2 on coronary artery disease patients.
Interactions between ALDH2 rs671 polymorphism and lifestyle behaviors on coronary artery disease risk in a Chinese Han population with dyslipidemia: A guide to targeted heart health management.
Mitochondrial aldehyde dehydrogenase in myocardial ischemia-reperfusion injury: from bench to bedside.
Relationship between ALDH2 genotype and in-stent restenosis in Chinese Han patients after percutaneous coronary intervention.
Reply to: ALDH2 Glu504Lys Polymorphism and Susceptibility to Coronary Artery Disease and Myocardial Infarction in East Asians: A Meta-analysis.
The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels.
The Glu504Lys polymorphism of aldehyde dehydrogenase 2 contributes to development of coronary artery disease.
The polymorphism in acetaldehyde dehydrogenase 2 gene, causing a substitution of Glu > Lys(504), is not associated with coronary atherosclerosis severity in Han Chinese.
Coronary Disease
Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells.
Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic plaque.
ALDH2 rs671 Polymorphism and coronary heart disease risk among Asian populations: a meta-analysis and meta-regression.
ALDH2 rs671 polymorphism and the risk of heart failure with preserved ejection fraction (HFpEF) in patients with cardiovascular diseases.
Associations of common variants at ALDH2 gene and the risk of stroke in patients with coronary artery diseases undergoing percutaneous coronary intervention.
Genotyping on ALDH2: comparison of four different technologies.
Mitochondrial aldehyde dehydrogenase in myocardial ischemia-reperfusion injury: from bench to bedside.
The impact of ALDH2 activation by Alda-1 on the expression of VEGF in the hippocampus of a rat model of post-MI depression.
[Correlation of aldehyde dehydrogenase-2 gene polymorphism with hypertension in patients with coronary heart disease complicated by diabetes mellitus].
[The relationship between aldehyde dehydrogenase-2 gene polymorphisms and efficacy of nitroglycerin]
Coronary Stenosis
Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells.
Cryptorchidism
[Expression changes of aldehyde dehydrogenase 1A1 in rat cryptorchidism and normal testis].
Cystadenoma
Musashi-1 Expression is a Prognostic Factor in Ovarian Adenocarcinoma and Correlates with ALDH-1 Expression.
Cystitis
Aldh2 gene reduces oxidative stress in the bladder by regulating the NF-?B pathway in a mouse model of ketamine-induced cystitis.
Cysts
A homozygous mutation in a consanguineous family consolidates the role of ALDH1A3 in autosomal recessive microphthalmia.
The stem-cell profile of ovarian surface epithelium is reproduced in the oviductal fimbriae, with increased stem-cell marker density in distal parts of the fimbriae.
Dehydration
Cloning of the black seabream (Acanthopagrus schlegeli) antiquitin gene and functional characterization of its promoter region.
Ethylene Glycol Metabolism in the Acetogen Acetobacterium woodii.
Sequence and functional analyses of the aldehyde dehydrogenase 7B4 gene promoter in Arabidopsis thaliana and selected Brassicaceae: regulation patterns in response to wounding and osmotic stress.
Dementia
Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population.
Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment.
Formaldehyde induces diabetes-associated cognitive impairments.
Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice.
Dermatitis
[Polymorphisms of aldehyde and alcohol dehydrogenase genes associated with susceptibility to trichloroethylene-induced medicamentosa-like dermatitis]
Dermatitis, Atopic
Functional study of acetaldehyde dehydrogenase 1 (ALDH1) in keratinocytes: Microarray integrating bioinformatics approaches.
Diabetes Complications
Association of Genetically Determined Aldehyde Dehydrogenase 2 Activity with Diabetic Complications in Relation to Alcohol Consumption in Japanese Patients with Type 2 Diabetes Mellitus: The Fukuoka Diabetes Registry.
Diabetic Aldehyde Dehydrogenase 2 Mutant (ALDH2*2) Mice Are More Susceptible to Cardiac Ischemic-Reperfusion Injury Due to 4-Hydroxy-2-Nonenal Induced Coronary Endothelial Cell Damage.
Inactive aldehyde dehydrogenase 2 worsens glycemic control in patients with type 2 diabetes mellitus who drink low to moderate amounts of alcohol.
Diabetes Mellitus
A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: Role of AMPK-regulated autophagy.
Activation of ALDH2 with Low Concentration of Ethanol Attenuates Myocardial Ischemia/Reperfusion Injury in Diabetes Rat Model.
Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus.
ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients.
ALDH2 rs671 polymorphism and the risk of heart failure with preserved ejection fraction (HFpEF) in patients with cardiovascular diseases.
Association between aldehyde dehydrogenase 2 polymorphisms and the incidence of diabetic retinopathy among Japanese subjects with type 2 diabetes mellitus.
Association of Genetically Determined Aldehyde Dehydrogenase 2 Activity with Diabetic Complications in Relation to Alcohol Consumption in Japanese Patients with Type 2 Diabetes Mellitus: The Fukuoka Diabetes Registry.
Changes in cardiac mitochondrial aldehyde dehydrogenase 2 activity in relation to oxidative stress and inflammatory injury in diabetic rats.
Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men.
Human-induced pluripotent stem cell approaches to model inborn and acquired metabolic heart diseases.
Inactive aldehyde dehydrogenase 2 worsens glycemic control in patients with type 2 diabetes mellitus who drink low to moderate amounts of alcohol.
Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update.
Targeting acetaldehyde dehydrogenase 2 (ALDH2) in heart failure-Recent insights and perspectives.
The Glu504Lys polymorphism of aldehyde dehydrogenase 2 contributes to development of coronary artery disease.
ULK1-regulated autophagy: A mechanism in cellular protection for ALDH2 against hyperglycemia.
[Aldehyde dehydrogenase 2(ALDH2) gene polymorphism in NIDDM patients with chronic renal failure]
Diabetes Mellitus, Type 1
Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus.
Diabetes Mellitus, Type 2
ALDH2 rs671 Is Associated With Elevated FPG, Reduced Glucose Clearance and Hepatic Insulin Resistance in Japanese Men.
ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes.
Association between aldehyde dehydrogenase 2 polymorphisms and the incidence of diabetic retinopathy among Japanese subjects with type 2 diabetes mellitus.
Association of aldehyde dehydrogenase with inheritance of NIDDM.
Association of Genetically Determined Aldehyde Dehydrogenase 2 Activity with Diabetic Complications in Relation to Alcohol Consumption in Japanese Patients with Type 2 Diabetes Mellitus: The Fukuoka Diabetes Registry.
Deficiency of mitochondrial aldehyde dehydrogenase increases type 2 diabetes risk in males via autophagy dysregulation.
Downregulation of the acetyl-CoA metabolic network in adipose tissue of obese diabetic individuals and recovery after weight loss.
Inactive aldehyde dehydrogenase 2 worsens glycemic control in patients with type 2 diabetes mellitus who drink low to moderate amounts of alcohol.
Mitochondrial aldehyde dehydrogenase in diabetes associated with mitochondrial tRNA(Leu(UUR)) mutation at position 3243.
[Aldehyde dehydrogenase 2(ALDH2) gene polymorphism in NIDDM patients with chronic renal failure]
[Correlation of aldehyde dehydrogenase-2 gene polymorphism with hypertension in patients with coronary heart disease complicated by diabetes mellitus].
Diabetic Cardiomyopathies
A Novel ALDH2 Activator AD-9308 Improves Diastolic and Systolic Myocardial Functions in Streptozotocin-Induced Diabetic Mice.
A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: Role of AMPK-regulated autophagy.
Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3? and mitochondrial function.
Diabetic Nephropathies
ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes.
Diabetic Retinopathy
ALDH2 attenuates early-stage STZ-induced aged diabetic rats retinas damage via Sirt1/Nrf2 pathway.
Association between aldehyde dehydrogenase 2 polymorphisms and the incidence of diabetic retinopathy among Japanese subjects with type 2 diabetes mellitus.
Association of aldehyde dehydrogenase with inheritance of NIDDM.
Meta-Analysis on the Association of ALDH2 Polymorphisms and Type 2 Diabetic Mellitus, Diabetic Retinopathy.
Drug-Related Side Effects and Adverse Reactions
Aldehyde dehydrogenases and cell proliferation.
Dupuytren Contracture
Common Variants of the ALDH2 and DHDH Genes and the Risk of Dupuytren's Disease.
[A coexistence of the Dupuytren's disease and malignant neoplasms: a review].
Dyskinesias
ALDH1A1 regulates postsynaptic ?-opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling.
Dyslipidemias
Acetaldehyde Dehydrogenase 2 rs671 Polymorphism Affects Hypertension Susceptibility and Lipid Profiles in a Chinese Population.
Interactions between ALDH2 rs671 polymorphism and lifestyle behaviors on coronary artery disease risk in a Chinese Han population with dyslipidemia: A guide to targeted heart health management.
The Glu504Lys polymorphism of aldehyde dehydrogenase 2 contributes to development of coronary artery disease.
Encephalitis
Systems Pharmacology-Based Approach to Comparatively Study the Independent and Synergistic Mechanisms of Danhong Injection and Naoxintong Capsule in Ischemic Stroke Treatment.
Endometrial Hyperplasia
ALDH1 expression predicts progression of premalignant lesions to cancer in Type I endometrial carcinomas.
Endometrial Neoplasms
ALDH1 expression predicts progression of premalignant lesions to cancer in Type I endometrial carcinomas.
Bioinformatic analysis of four miRNAs relevant to metastasis-regulated processes in endometrial carcinoma.
The combination of aldehyde dehydrogenase 1 (ALDH1) and CD44 is associated with poor outcomes in endometrial cancer.
Endometriosis
Aberrant reactive aldehyde detoxification by ALDH2 influences endometriosis development and pain-associated behaviors.
CD44, TGM2 and EpCAM as novel plasma markers in endometrial cancer diagnosis.
Expression Levels of the Oxidative Stress Response Gene ALDH3A2 in Granulosa-Lutein Cells Are Related to Female Age and Infertility Diagnosis.
Expression of ALDH1A Isozymes in Human Endometrium with and without Endometriosis and in Ovarian Endometrioma.
Epilepsy
Quantitative Proteomic Analysis To Identify Differentially Expressed Proteins in Myocardium of Epilepsy Using iTRAQ Coupled with Nano-LC-MS/MS.
The ALDH2 rs671 polymorphism affects post-stroke epilepsy susceptibility and plasma 4-HNE levels.
Erythema
[Associations between ALDH2 and ADH1B Genotypes and Ethanol-Induced Cutaneous Erythema in Young Japanese Women].
Esophageal Neoplasms
A health-risk appraisal model and endoscopic mass screening for esophageal cancer in Japanese men.
A variant allele of ADH1B and ALDH2, is associated with the risk of esophageal cancer.
Acetaldehyde inhibits the formation of retinoic acid from retinal in the rat esophagus.
Advances in cancer epidemiology in Japan.
Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population.
Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men.
Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach.
Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics.
Aldehyde dehydrogenase-2 genotypes and HLA haplotypes in Japanese patients with esophageal cancer.
ALDH2 gene polymorphism in different types of cancers and its clinical significance.
Analysis of risk factors for post-operative complications and prognostic predictors of disease recurrence following definitive treatment of patients with esophageal cancer from two medical centers in Northwest China.
Association between ALDH2 Glu487Lys polymorphism and the risk of esophageal cancer.
Association between ALDH2 polymorphism and esophageal cancer risk in South Koreans: a case-control study.
Association of aldehyde dehydrogenase 2 gene polymorphism with pancreatic cancer but not colon cancer.
Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia.
Association of low-activity ALDH2 and alcohol consumption with risk of esophageal cancer in Chinese adults: A population-based cohort study.
Cancer screening of upper aerodigestive tract in Japanese alcoholics with reference to drinking and smoking habits and aldehyde dehydrogenase-2 genotype.
CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis.
Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis.
Clinical significance of ALDH2 rs671 polymorphism in esophageal cancer: evidence from 31 case-control studies.
Combination of ADH1B*2/ALDH2*2 polymorphisms alters acetaldehyde-derived DNA damage in the blood of Japanese alcoholics.
Correlations of ALDH2 rs671 and C12orf30 rs4767364 polymorphisms with increased risk and prognosis of esophageal squamous cell carcinoma in the Kazak and Han populations in Xinjiang province.
Effect of ALDH2 polymorphism on cancer risk in Asians: A meta-analysis.
Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males.
Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions.
Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract.
Expression of aldehyde dehydrogenase 2 in the normal esophageal epithelium and alcohol consumption in patients with esophageal cancer.
Facial flushing after alcohol intake as a predictor for a high risk of synchronous or metachronous cancer of the upper gastrointestinal tract.
Functional Variants in ADH1B and ALDH2 Coupled With Alcohol and Smoking Synergistically Enhance Esophageal Cancer Risk.
Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer.
Gene-environment Interactions and Polymorphism Studies of Cancer Risk in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC-II).
Genetic polymorphism of aldehyde dehydrogenase 2 in patients with upper aerodigestive tract cancer.
Genetic Polymorphism of Aldehyde Dehydrogenase 2 in Patients With Upper Aerodigestive Tract Cancer.
Genetic polymorphisms and esophageal cancer risk.
Genetic polymorphisms of ADH2 and ALDH2 association with esophageal cancer risk in southwest China.
Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma.
Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers.
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility.
Hepatocellular carcinoma in heavy drinkers with negative markers for viral hepatitis.
Identifying genetic variation for alcohol dependence.
Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks.
Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population.
Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers.
Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China.
Meta-analysis of ALDH2 variants and esophageal cancer in Asians.
Multifocal accumulation of p53 protein in esophageal carcinoma: evidence for field cancerization.
p53 protein accumulation, iodine-unstained lesions, and alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia.
Polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 and esophageal cancer risk in Southeast Chinese males.
Proteome Profiling of Primary Pancreatic Ductal Adenocarcinomas Undergoing Additive Chemoradiation Link ALDH1A1 to Early Local Recurrence and Chemoradiation Resistance.
Relationship between alcohol drinking, ADH2 and ALDH2 genotypes, and risk for hepatocellular carcinoma in Japanese.
Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males.
Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis.
Role of ALDH1 in the prognosis of esophageal cancer and its relationship with tumor microenvironment.
Short-term follow-up after endoscopic mucosectomy of early esophageal cancer and aldehyde dehydrogenase-2 genotype in Japanese alcoholics.
Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: A population-based case-control study in china.
Specific Smad2/3 Linker Phosphorylation Indicates Esophageal Non-neoplastic and Neoplastic Stem-Like Cells and Neoplastic Development.
Systemic Adeno-Associated Virus-Mediated Gene Therapy Prevents the Multiorgan Disorders Associated with Aldehyde Dehydrogenase 2 Deficiency and Chronic Ethanol Ingestion.
The effect of ethanol on the formation of N?((2))-ethylidene-dG adducts in mice: implications for alcohol-related carcinogenicity of the oral cavity and esophagus.
[Alcohol and oropharyngolaryngeal and digestive tract cancer]
[Field cancerization and field therapy - the therapy of actinic keratosis by imiquimod].
[Genetic polymorphisms of ADH1B and ALDH-2 associated with risk of esophageal cancer: a meta-analysis].
[Genetic polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 associated with the susceptibility on esophageal cancer]
Esophageal Squamous Cell Carcinoma
A retrospective review of the prognostic value of ALDH-1, Bmi-1 and Nanog stem cell markers in esophageal squamous cell carcinoma.
ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma.
Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer.
Aldehyde Dehydrogenase 1 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
Aldehyde Dehydrogenase-1 Expression Predicts Unfavorable Outcomes in Patients with Esophageal Squamous Cell Carcinoma.
ALDH1A1 defines invasive cancer stem-like cells and predicts poor prognosis in patients with esophageal squamous cell carcinoma.
ALDH1A1 maintains the cancer stem-like cells properties of esophageal squamous cell carcinoma by activating the AKT signal pathway and interacting with ?-catenin.
Associations of carboxypeptidase 4 with ALDH1A1 expression and their prognostic value in esophageal squamous cell carcinoma.
Cancer stem cell marker ALDH1 expression is associated with lymph node metastasis and poor survival in esophageal squamous cell carcinoma: a study from high incidence area of northern China.
Correlations of ALDH2 rs671 and C12orf30 rs4767364 polymorphisms with increased risk and prognosis of esophageal squamous cell carcinoma in the Kazak and Han populations in Xinjiang province.
Deficient aldehyde dehydrogenase 2 is associated with increased risk for esophageal squamous cell carcinoma in the presence of gastric hypochlorhydria.
Dietary selenium intake, aldehyde dehydrogenase-2 and X-ray repair cross-complementing 1 genetic polymorphisms, and the risk of esophageal squamous cell carcinoma.
Esophageal squamous cell carcinoma and aldehyde dehydrogenase-2 genotypes in Japanese females.
Esophageal squamous cell carcinoma and ALDH2 and ADH1B polymorphisms in Chinese females.
Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis.
Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males.
Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma.
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility.
Genomic characterization of early-stage esophageal squamous cell carcinoma in a Japanese population.
Impairment of aldehyde dehydrogenase 2 increases accumulation of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion.
Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men.
Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China.
p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma.
Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism.
Role of ALDH1 in the prognosis of esophageal cancer and its relationship with tumor microenvironment.
Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.
Essential Hypertension
Acetaldehyde dehydrogenase 2 SNP rs671 and susceptibility to essential hypertension in Mongolians: a case control study.
ALDH2 Gene rs671 Polymorphism May Decrease the Risk of Essential Hypertension.
Association Between ALDH-2 rs671 and Essential Hypertension Risk or Blood Pressure Levels: A Systematic Review and Meta-Analysis.
Association between Carotid Intima-media Thickness and Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism in Chinese Han with Essential Hypertension.
Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population.
Association of the Glu504Lys polymorphism in the aldehyde dehydrogenase 2 gene with endothelium-dependent dilation disorder in Chinese Han patients with essential hypertension.
Common single nucleotide polymorphisms in Japanese patients with essential hypertension: aldehyde dehydrogenase 2 gene as a risk factor independent of alcohol consumption.
Meta-analysis of association between ALDH2 rs671 polymorphism and essential hypertension in Asian populations.
Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis.
The ALDH2 gene rs671 polymorphism is not associated with essential hypertension.
Exfoliation Syndrome
Quantitative analysis of SOD2, ALDH1A1 and MGST1 messenger ribonucleic acid in anterior lens epithelium of patients with pseudoexfoliation syndrome.
Eye Diseases
Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring.
Fanconi Anemia
Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells.
Associations of complementation group, ALDH2 genotype, and clonal abnormalities with hematological outcome in Japanese patients with Fanconi anemia.
Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.
Genetic Study of Fanconi Anemia in Infancy Revealed FANCI Mutations and Defective ALDH2 Variant: A Case Report.
Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function.
Maternal aldehyde elimination during pregnancy preserves the fetal genome.
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.
The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype.
Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia.
Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients.
Fatty Liver
Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury.
Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome.
ALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice.
Associations among liver disease, serum lipid profile, body mass index, ketonuria, meal skipping, and the alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese men with alcohol dependence.
Bioinformatic and biochemical findings disclosed anti-hepatic steatosis mechanism of calycosin.
Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice.
Role of PEG35, Mitochondrial ALDH2, and Glutathione in Cold Fatty Liver Graft Preservation: An IGL-2 Approach.
Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence.
SREBP1c mediates the effect of acetaldehyde on Cidea expression in Alcoholic fatty liver Mice.
The Association and Interaction of Aldehyde Dehydrogenase 2 Polymorphisms with Food Group Intake and Probability of Having Non-Alcoholic Fatty Liver Disease.
Vinyl chloride-induced interaction of nonalcoholic and toxicant-associated steatohepatitis: Protection by the ALDH2 activator Alda-1.
Fatty Liver, Alcoholic
Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice.
Fetal Alcohol Spectrum Disorders
Loss of the TGF-? Effector ?2SP Promotes Genomic Instability.
Loss of the transforming growth factor-? effector ?2-Spectrin promotes genomic instability.
The fetal alcohol syndrome: symptoms and pathogenesis.
Fibroadenoma
Expression of ALDH1 and TGF?2 in benign and malignant breast tumors and their prognostic implications.
Food Hypersensitivity
Ginger Increases ALDH1A1 Expression and Enhances Retinoic Acid Signaling in a Human Colonic Epithelial Cell Line.
Gallbladder Neoplasms
Positive ALDH1A3 and negative GPX3 expressions are biomarkers for poor prognosis of gallbladder cancer.
Gastritis
Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis.
Gastritis, Atrophic
Acetaldehyde and gastric cancer.
Acetaldehyde as a common denominator and cumulative carcinogen in digestive tract cancers.
Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population.
Helicobacter pylori, chronic atrophic gastritis, inactive aldehyde dehydrogenase-2, macrocytosis and multiple upper aerodigestive tract cancers and the risk for gastric cancer in alcoholic Japanese men.
Risk factors for esophageal iodine-unstained lesions and changing trends among Japanese alcohol-dependent men (2003-2018).
Genetic Diseases, Inborn
Ichthyosis in Sjögren-Larsson syndrome reflects defective barrier function due to abnormal lamellar body structure and secretion.
Glaucoma
Alcohol consumption is associated with glaucoma severity regardless of ALDH2 polymorphism.
Glioblastoma
A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro.
ADP-Ribosylation Factor Like GTPase 4C (ARL4C) augments stem-like traits of glioblastoma cells by upregulating ALDH1A3.
Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity.
Aldehyde dehydrogenase 1A3 (ALDH1A3) is regulated by autophagy in human glioblastoma cells.
ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients.
ALDH1A3 induces mesenchymal differentiation and serves as a predictor for survival in glioblastoma.
Development of Selective Inhibitors for Human Aldehyde Dehydrogenase 3A1 (ALDH3A1) for the Enhancement of Cyclophosphamide Cytotoxicity.
Genome-wide DNA methylation profiling identifies ALDH1A3 promoter methylation as a prognostic predictor in G-CIMP- primary glioblastoma.
Genome-wide methylation profiling reveals new biomarkers for prognosis prediction of glioblastoma.
Hypoxia upregulates aldehyde dehydrogenase isoform 1 (ALDH1) expression and induces functional stem cell characteristics in human glioblastoma cells.
Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro.
Prognostic Value of ALDH1A3 Promoter Methylation in Gliob;astoma: A Single Center Experience in Western China.
Retinoid resistance and multifaceted impairment of retinoic acid synthesis in glioblastoma.
Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells.
The predominant expression of cancer stem cell marker ALDH1A3 in tumor infiltrative area is associated with shorter overall survival of human glioblastoma.
USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells.
Glioma
Aldehyde dehydrogenase 1 expression has prognostic significance in patients with glioma.
Aldehyde dehydrogenase 1A1 circumscribes high invasive glioma cells and predicts poor prognosis.
ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients.
ALDH1A3 induces mesenchymal differentiation and serves as a predictor for survival in glioblastoma.
ALDH1A3: A Marker of Mesenchymal Phenotype in Gliomas Associated with Cell Invasion.
BRD4 promotes glioma cell stemness via enhancing miR-142-5p-mediated activation of Wnt/?-catenin signaling.
CD163, a novel therapeutic target, regulates the proliferation and stemness of glioma cells via casein kinase 2.
Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid.
FOXD1-ALDH1A3 signaling is a determinant for the self-renewal and tumorigenicity of mesenchymal glioma stem cells.
High expression of ALDH1A3 might independently influence poor progression-free and overall survival in patients with glioma via maintaining glucose uptake and lactate production.
KITENIN promotes glioma invasiveness and progression, associated with the induction of EMT and stemness markers.
Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3.
Regulation of gliomagenesis and stemness through acid sensor ASIC1a.
Serglycin activates pro-tumorigenic signaling and controls glioblastoma cell stemness, differentiation and invasive potential.
The stem cell/cancer stem cell marker ALDH1A3 regulates the expression of the survival factor tissue transglutaminase, in mesenchymal glioma stem cells.
TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways.
TRPM7 Induces Tumorigenesis and Stemness Through Notch Activation in Glioma.
Glucose Intolerance
Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome.
Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress.
Glycogen Storage Disease
Detection of single nucleotide substitution by competitive allele-specific short oligonucleotide hybridization (CASSOH) with immunochromatographic strip.
Gout
Analysis of the genotypes for aldehyde dehydrogenase 2 in Japanese patients with primary gout.
Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.
Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus.
Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk.
Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout.
Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population.
Risk of gout among Taiwanese adults with ALDH-2 rs671 polymorphism according to BMI and alcohol intake.
Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients.
Graft vs Host Disease
Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality.
Hallucinations
Evidence of Epistasis Between the Catechol-O-Methyltransferase and Aldehyde Dehydrogenase 3B1 Genes in Paranoid Schizophrenia.
Head and Neck Neoplasms
Aldehyde dehydrogenase 1 isoenzyme expression as a marker of cancer stem cells correlates to histopathological features in head and neck cancer: A meta-analysis.
Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendelian randomization approach.
Association Between the Aldehyde Dehydrogenase-2 rs671 G>A Polymorphism and Head and Neck Cancer Susceptibility: A Meta-Analysis in East Asians.
Association of aldehyde dehydrogenase 2 gene polymorphism with multiple oesophageal dysplasia in head and neck cancer patients.
Association of aldehyde dehydrogenase 2 gene polymorphism with pancreatic cancer but not colon cancer.
Cancer stem cell markers ALDH1 and Bmi1 expression in oral erythroplakia revisited: Implication for driving the process of field cancerization.
Cancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by aldehyde dehydrogenase 1 A1 inhibition.
Clinical features and treatment outcomes of Japanese head and neck cancer patients with a second primary cancer.
Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer.
Different Expression of Aldehyde Dehydrogenases 1A1 and 2 in Oral Leukoplakia With Epithelial Dysplasia and in Oral Squamous Cell Carcinoma.
Genetic polymorphism of aldehyde dehydrogenase 2 in patients with upper aerodigestive tract cancer.
Genetic Polymorphism of Aldehyde Dehydrogenase 2 in Patients With Upper Aerodigestive Tract Cancer.
Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population.
Overexpression of ALDH1 and EMT marker profile are linked with unfavorable outcome in head and neck cancer.
Prognostic value of ALDH1 and Nestin in advanced cancer: a systematic meta-analysis with trial sequential analysis.
Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer.
The interplay between alcohol consumption, oral hygiene, ALDH2, and ADH1B in the risk of head and neck cancer.
Validation of Alcohol Flushing Questionnaire to Identify ALDH2 Status in a Case-Control Study of Head and Neck Cancer.
Heart Arrest
Aldehyde Dehydrogenase 2 Protects Against Post-Cardiac Arrest Myocardial Dysfunction Through a Novel Mechanism of Suppressing Mitochondrial Reactive Oxygen Species Production.
Heart Defects, Congenital
ALDH1A2 (RALDH2) genetic variation in human congenital heart disease.
Effect of mitochondrial aldehyde dehydrogenase-2 genotype on cardioprotection in patients with congenital heart disease.
Influence of the aldehyde dehydrogenase 2 polymorphism on the vasodilatory effect of nitroglycerin in infants with congenital heart disease and pulmonary arterial hypertension.
Heart Diseases
(13) C magnetic resonance spectroscopic imaging of hyperpolarized [1-(13) C, U-(2) H5 ] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo.
Aldehyde Dehydrogenase (ALDH) 2 in Diabetic Heart Diseases.
Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE.
Aldehyde dehydrogenase-2 deficiency aggravates cardiac dysfunction elicited by endoplasmic reticulum stress induction.
ALDH2 in alcoholic heart diseases: Molecular mechanism and clinical implications.
Mitochondrial aldehyde dehydrogenase and cardiac diseases.
The Role of Cariporide in Protecting Saphenous Vein among Different Aldehyde Dehydrogenase Genotypes.
VISIONET: intuitive visualisation of overlapping transcription factor networks, with applications in cardiogenic gene discovery.
Heart Failure
Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells.
Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling.
Aldehyde Dehydrogenase 2 and Heart Failure.
Aldehyde dehydrogenase 2 as a potential protective factor for renal insufficiency in Japanese subjects with heart failure: a pilot study.
Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1.
ALDH2 rs671 polymorphism and the risk of heart failure with preserved ejection fraction (HFpEF) in patients with cardiovascular diseases.
Cardiac-specific overexpression of aldehyde dehydrogenase 2 exacerbates cardiac remodeling in response to pressure overload.
Correction: Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 2*2) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography.
Efficient expression of codon-adapted human acetaldehyde dehydrogenase 2 cDNA with 6xHis tag in Pichia pastoris.
Influence of ALDH2 Glu504Lys polymorphism on nitroglycerin response in chronic heart failure and involvement of Calcitonin Gene Related Peptide (CGRP).
Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice.
Molecular Mechanism of HSF1-Upregulated ALDH2 by PKC in Ameliorating Pressure Overload-Induced Heart Failure in Mice.
Potentiating mitochondrial aldehyde dehydrogenase 2 to treat post-infarction heart failure.
Salvaging the ischemic heart: Gi-coupled receptors in mast cells activate a PKC?/ALDH2 pathway providing anti-RAS cardioprotection.
Targeting acetaldehyde dehydrogenase 2 (ALDH2) in heart failure-Recent insights and perspectives.
Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 2*2) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography.
Hemangioendothelioma
Expression of cancer stem cell markers and their correlation with pathogenesis in vascular tumors.
Hemangioma
Expression of cancer stem cell markers and their correlation with pathogenesis in vascular tumors.
Hemangioma, Capillary
Expression of cancer stem cell markers and their correlation with pathogenesis in vascular tumors.
Hemangiosarcoma
Expression of cancer stem cell markers and their correlation with pathogenesis in vascular tumors.
Hematologic Neoplasms
Markers and Reporters to Reveal the Hierarchy in Heterogeneous Cancer Stem Cells.
Hepatitis
Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma.
Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids.
Blockade of Retinol Metabolism Protects T Cell-Induced Hepatitis by Increasing Migration of Regulatory T Cells.
Hepatitis B
Aldehyde dehydrogenase 1 (ALDH1) isoform expression and potential clinical implications in hepatocellular carcinoma.
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles.
Association between smoking, acetaldehyde dehydrogenase-2 1-1 status, and alcohol drinking among Taiwanese polyvinyl chloride workers.
Hepatitis B, Chronic
Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma.
Aldehyde dehydrogenase 2 polymorphism for development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis.
Risk and Predictors of Hepatocellular Carcinoma for Chronic Hepatitis b Patients With Newly Developed Cirrhosis.
Hepatitis C
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
HIV Infections
RALDH Activity Induced by Bacterial/Fungal Pathogens in CD16+ Monocyte-Derived Dendritic Cells Boosts HIV Infection and Outgrowth in CD4+ T Cells.
Hyperaldosteronism
Modulating ALDH2 reveals a differential dependence on ROS for hypertrophy and SR Ca2+ release in aldosterone-treated cardiac myocytes.
Hyperalgesia
TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice.
Hypercholesterolemia
The response of hepatic transcriptome to dietary cholesterol in Prague hereditary hypercholesterolemic (PHHC) rat.
Hyperglycemia
Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity.
Formaldehyde induces diabetes-associated cognitive impairments.
Inhibition of aldehyde dehydrogenase 2 by oxidative stress is associated with cardiac dysfunction in diabetic rats.
Inhibition of ALDH2 by O-GlcNAcylation contributes to the hyperglycemic exacerbation of myocardial ischemia/reperfusion injury.
The Glu504Lys polymorphism of aldehyde dehydrogenase 2 contributes to development of coronary artery disease.
ULK1-regulated autophagy: A mechanism in cellular protection for ALDH2 against hyperglycemia.
Hyperglycinemia, Nonketotic
Detection of single nucleotide substitution by competitive allele-specific short oligonucleotide hybridization (CASSOH) with immunochromatographic strip.
Hyperinsulinism
Inactive aldehyde dehydrogenase 2 worsens glycemic control in patients with type 2 diabetes mellitus who drink low to moderate amounts of alcohol.
Hyperlipidemias
Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome.
Sex differences in environmental and genetic factors for hypertension.
Hyperpigmentation
Ethanol induces skin hyperpigmentation in mice with aldehyde dehydrogenase 2 deficiency.
Targeting ALDH1A1 to treat pigmentary disorders.
Hypersensitivity
Aldehyde Dehydrogenase Inhibition Ameliorates Cardiac Dysfunction and Exacerbates Hypotension Caused by Alcohol in Female Rats.
Dihydromyricetin attenuates neuropathic pain via enhancing the transition from M1 to M2 phenotype polarization by potentially elevating ALDH2 activity in vitro and vivo.
Effect of Tongxieyaofang decoction on colonic mucosal protein expression profiles in rats with visceral hypersensitivity.
Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians.
Relationship between alcohol drinking, ADH2 and ALDH2 genotypes, and risk for hepatocellular carcinoma in Japanese.
Hypertension
A case-control study on male hepatocellular carcinoma based on hospital and community controls.
Acetaldehyde Dehydrogenase 2 rs671 Polymorphism Affects Hypertension Susceptibility and Lipid Profiles in a Chinese Population.
Alcohol intake and blood pressure: a systematic review implementing a mendelian randomization approach.
Aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism is associated with hypertension risk in Asians: a meta-analysis.
Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome.
Aldehyde dehydrogenase 2 partly mediates hypotensive effect of nitrite on l-NAME-induced hypertension in normoxic rat.
Aldehyde dehydrogenase 2 protects against oxidative stress associated with pulmonary arterial hypertension.
ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension.
ALDH2 improved irbesartan treatment efficacy among rats with hypertension.
ALDH2 rs671 polymorphism and the risk of heart failure with preserved ejection fraction (HFpEF) in patients with cardiovascular diseases.
ALDH2 rs671 polymorphisms and the risk of cerebral microbleeds in Chinese elderly: the Taizhou Imaging Study.
Association Between ALDH-2 rs671 and Essential Hypertension Risk or Blood Pressure Levels: A Systematic Review and Meta-Analysis.
Association between Carotid Intima-media Thickness and Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism in Chinese Han with Essential Hypertension.
Association of Aldehyde Dehydrogenase 2 Gene Polymorphism with Myocardial Infarction.
Associations between aldehyde dehydrogenase 2 (ALDH2) genetic polymorphisms, drinking status, and hypertension risk in Japanese adult male workers: a case-control study.
Associations between aldehyde dehydrogenase 2 (ALDH2) rs671 genetic polymorphisms, lifestyles and hypertension risk in Chinese Han people.
Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: Gene-environmental interaction with alcohol consumption.
Contribution of ALDH2 polymorphism to alcoholism-associated hypertension.
Effect Modification of Acetaldehyde Dehydrogenase 2 rs671 Polymorphism on the Association between Alcohol Intake and Blood Pressure: the Dong-gu Study.
Effect of alcohol and aldehyde dehydrogenase gene polymorphisms on alcohol-associated hypertension: the Guangzhou Biobank Cohort Study.
Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population.
Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females.
Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men.
Homozygous ALDH2*2 Is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men.
Influence of the aldehyde dehydrogenase 2 polymorphism on the vasodilatory effect of nitroglycerin in infants with congenital heart disease and pulmonary arterial hypertension.
Interaction between ALDH2 rs671 and life habits affects the risk of hypertension in Koreans: A STROBE observational study.
Low-Km aldehyde dehydrogenase deficiency does not influence the elevation of blood pressure by alcohol.
Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype.
Sex differences in environmental and genetic factors for hypertension.
Targeting acetaldehyde dehydrogenase 2 (ALDH2) in heart failure-Recent insights and perspectives.
The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: the Suita study.
The combination of mitochondrial low enzyme-activity aldehyde dehydrogenase 2 allele and superoxide dismutase 2 genotypes increases the risk of hypertension in relation to alcohol consumption.
The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexes.
The Glu504Lys polymorphism of aldehyde dehydrogenase 2 contributes to development of coronary artery disease.
[Correlation of aldehyde dehydrogenase-2 gene polymorphism with hypertension in patients with coronary heart disease complicated by diabetes mellitus].
Hypertension, Pulmonary
ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension.
ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension.
Hypoadrenocorticism, Familial
The combination of whole-exome sequencing and clinical analysis allows better diagnosis of rare syndromic retinal dystrophies.
Hypokinesia
Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson's Disease.
Hypopharyngeal Neoplasms
Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma.
Hypotension
Aldehyde Dehydrogenase Inhibition Ameliorates Cardiac Dysfunction and Exacerbates Hypotension Caused by Alcohol in Female Rats.
Tetrahydrobiopterin paradoxically mediates cardiac oxidative stress and mitigates ethanol-evoked cardiac dysfunction in conscious female rats.
Hypothyroidism
Adult-onset hypothyroidism increases ethanol consumption.
Ichthyosis
A Neurodegenerative Phenotype Associated With Sjögren-Larsson Syndrome.
Genetic assessment of ten Egyptian patients with Sjögren-Larsson syndrome: expanding the clinical spectrum and reporting a novel ALDH3A2 mutation.
Genotype and phenotype variability in Sjögren-Larsson syndrome.
Ichthyosis in Sjögren-Larsson syndrome reflects defective barrier function due to abnormal lamellar body structure and secretion.
Large contiguous gene deletions in Sjögren-Larsson syndrome.
Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3.
Novel Mutation in Sjogren-Larsson Syndrome Is Associated With Divergent Neurologic Phenotypes.
Phenotypic variability among adult siblings with Sjögren-Larsson syndrome.
Sjögren-Larsson syndrome: Novel mutations in the ALDH3A2 gene in a French cohort.
The combination of whole-exome sequencing and clinical analysis allows better diagnosis of rare syndromic retinal dystrophies.
Infarction, Middle Cerebral Artery
ALDH2 Protects Against Ischemic Stroke in Rats by Facilitating 4-HNE Clearance and AQP4 Down-Regulation.
Infections
AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells.
Acetaldehyde and gastric cancer.
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles.
Effects of alcohol consumption, ALDH2 rs671 polymorphism, and Helicobacter pylori infection on the gastric cancer risk in a Korean population.
Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung.
Gene-environment Interactions and Polymorphism Studies of Cancer Risk in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC-II).
HBV/HCV Infection, Alcohol, Tobacco and Genetic Polymorphisms for Hepatocellular Carcinoma in Nagoya, Japan.
Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China.
HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target.
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
Oxidative-stress-related proteome changes in Helicobacter pylori-infected human gastric mucosa.
Robotic-assisted latissimus dorsi harvest in delayed-immediate breast reconstruction.
The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer.
Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice.
Infertility
Autoantigens in ovarian autoimmunity associated with unexplained infertility and premature ovarian failure.
Expression Levels of the Oxidative Stress Response Gene ALDH3A2 in Granulosa-Lutein Cells Are Related to Female Age and Infertility Diagnosis.
Inflammatory Breast Neoplasms
Aldehyde Dehydrogenase 1 Expression in Inflammatory Breast Cancer as Measured by Immunohistochemical Staining.
Influenza, Human
Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung.
Insulin Resistance
Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress.
Aldehyde Dehydrogenase-2 Attenuates Myocardial Remodeling and Contractile Dysfunction Induced by a High-Fat Diet.
ALDH2 rs671 Is Associated With Elevated FPG, Reduced Glucose Clearance and Hepatic Insulin Resistance in Japanese Men.
Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: Gene-environmental interaction with alcohol consumption.
Contribution of Hepatic Retinaldehyde Dehydrogenase Induction to Impairment of Glucose Metabolism by High-Fat-Diet Feeding in C57BL/6J Mice.
Discovery of coumarin-based selective aldehyde dehydrogenase 1A1 inhibitors with glucose metabolism improving activity.
L-carnitine exerts a nutrigenomic effect via direct modulation of nuclear receptor signaling in adipocytes, hepatocytes and SKMC, demonstrating its nutritional impact.
Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1?.
Moderate vitamin A supplementation in obese mice regulates tissue factor and cytokine production in a sex-specific manner.
Resveratrol attenuates excessive ethanol exposure induced insulin resistance in rats via improving NAD(+) /NADH ratio.
Retinaldehyde represses adipogenesis and diet-induced obesity.
Insulinoma
Novel prognostic markers revealed by a proteomic approach separating benign from malignant insulinomas.
Intellectual Disability
A Neurodegenerative Phenotype Associated With Sjögren-Larsson Syndrome.
Genetic assessment of ten Egyptian patients with Sjögren-Larsson syndrome: expanding the clinical spectrum and reporting a novel ALDH3A2 mutation.
Genotype and phenotype variability in Sjögren-Larsson syndrome.
Ichthyosis in Sjögren-Larsson syndrome reflects defective barrier function due to abnormal lamellar body structure and secretion.
Large contiguous gene deletions in Sjögren-Larsson syndrome.
Novel Mutation in Sjogren-Larsson Syndrome Is Associated With Divergent Neurologic Phenotypes.
Phenotypic variability among adult siblings with Sjögren-Larsson syndrome.
Sjögren-Larsson syndrome: Novel mutations in the ALDH3A2 gene in a French cohort.
Intervertebral Disc Displacement
Genetic polymorphisms of ALDH2 are associated with lumbar disc herniation in a Chinese Han population.
Ischemic Stroke
Aldehyde dehydrogenase 2 polymorphism as a protective factor for intracranial vascular stenosis in ischemic stroke in Han Chinese.
Aldehyde dehydrogenase 2 rs671G>A polymorphism and ischemic stroke risk in Chinese population: a meta-analysis.
ALDH2 Protects Against Ischemic Stroke in Rats by Facilitating 4-HNE Clearance and AQP4 Down-Regulation.
Association between ALDH2 rs671 polymorphism and risk of ischemic stroke: A protocol for systematic review and meta analysis.
Association Between the Polymorphism of Aldehyde Dehydrogenase 2 Gene and Cerebral Infarction in a Hakka Population in Southern China.
Association of ADH1B polymorphism and alcohol consumption with increased risk of intracerebral hemorrhagic stroke.
Genetic variants in ALDH2 predict risk of ischemic stroke in a Chinese population.
Homozygous ALDH2*2 Is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men.
Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
Synergistic Effects of Aldehyde Dehydrogenase 2 Polymorphisms and Alcohol Consumption on Cognitive Impairment after Ischemic Stroke in Han Chinese.
Keloid
MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes.
Keratoconus
Association with Corneal Remodeling Related Genes, ALDH3A1, LOX, and SPARC Genes Variations in Korean Keratoconus Patients.
Keratosis, Actinic
Aldehyde dehydrogenase 1 expression in basal cell carcinoma, actinic keratosis and Bowen's disease.
Ketosis
Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes and Alcoholic Ketosis Are Associated with the Serum Uric Acid Level in Japanese Alcoholic Men.
Associations among liver disease, serum lipid profile, body mass index, ketonuria, meal skipping, and the alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese men with alcohol dependence.
Kidney Failure, Chronic
Influence of ALDH2 genetic polymorphisms on aciclovir pharmacokinetics following oral administration of valaciclovir in Japanese end-stage renal disease patients.
[Aldehyde dehydrogenase 2(ALDH2) gene polymorphism in NIDDM patients with chronic renal failure]
Kidney Neoplasms
Increased expression of ALDH1A1 protein is associated with poor prognosis in clear cell renal cell carcinoma.
Laryngeal Neoplasms
Heavy alcohol drinking downregulates ALDH2 gene expression but heavy smoking up-regulates SOD2 gene expression in head and neck squamous cell carcinoma.
[Aldehyde dehydrogenase 1 can be used as a new marker of cancer stem cells in laryngeal cancer cells in vitro].
Leiomyoma
Clonality of smooth muscle and fibroblast cell populations isolated from human fibroid and myometrial tissues.
Retinoic acid pathway genes show significantly altered expression in uterine fibroids when compared with normal myometrium.
Retinoids regulate genes involved in retinoic acid synthesis and transport in human myometrial and fibroid smooth muscle cells.
Screening of potential biomarkers in uterine leiomyomas disease via gene expression profiling analysis.
Lentivirus Infections
Aldehyde dehydrogenase 2 deficiency promotes atherosclerotic plaque instability through accelerating mitochondrial ROS-mediated vascular smooth muscle cell senescence.
Leukemia
4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.
A retrospective review of the prognostic value of ALDH-1, Bmi-1 and Nanog stem cell markers in esophageal squamous cell carcinoma.
ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome.
Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer.
Distinct prognostic values of ALDH1 isoenzymes in breast cancer.
Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma.
Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties.
Identification of cancer-type specific expression patterns for active aldehyde dehydrogenase (ALDH) isoforms in ALDEFLUOR assay.
Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer.
Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance.
Potentiation of the cytotoxic action of mafosfamide by N-isopropyl-p-formylbenzamide, a metabolite of procarbazine.
RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1.
Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent non-responsiveness associated with a D835 mutation.
Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1.
The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance.
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Identification of potential genes associated with ALDH1A1 overexpression and cyclophosphamide resistance in chronic myelogenous leukemia using network analysis.
Leukemia, Myeloid
Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Leukemia, Myeloid, Acute
Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1.
Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia.
Leukoencephalopathies
Phenotypic variability among adult siblings with Sjögren-Larsson syndrome.
Leukopenia
Recovery from anemia and leukocytopenia after abstinence in Japanese alcoholic men and their genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2.
Leukoplakia, Oral
ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia.
Different Expression of Aldehyde Dehydrogenases 1A1 and 2 in Oral Leukoplakia With Epithelial Dysplasia and in Oral Squamous Cell Carcinoma.
Expression patterns of cancer stem cell markers ALDH1 and CD133 correlate with a high risk of malignant transformation of oral leukoplakia.
Lichen Planus, Oral
Aldehyde dehydrogenase 1 expression correlated with malignant potential of oral lichen planus.
Increased salivary aldehyde dehydrogenase 1 in non-reticular oral lichen planus.
Lip Neoplasms
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer.
Lipid Metabolism Disorders
Transcriptome analysis in normal human liver cells exposed to 2, 3, 3', 4, 4', 5 - Hexachlorobiphenyl (PCB 156).
Liver Cirrhosis
Aldehyde dehydrogenase 2 activation ameliorates CCl4 -induced chronic liver fibrosis in mice by up-regulating Nrf2/HO-1 antioxidant pathway.
Association of restriction fragment-length polymorphisms in the alcohol dehydrogenase 2 gene with alcoholic brain atrophy.
Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis.
Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers.
Effects of "Essential AD2" Supplement on Blood Acetaldehyde Levels in Individuals Who Have Aldehyde Dehydrogenase (ALDH2) Deficiency.
Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men.
Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver.
Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men.
Liver Cirrhosis, Alcoholic
Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis.
Aldehyde dehydrogenase 2 activation ameliorates CCl4 -induced chronic liver fibrosis in mice by up-regulating Nrf2/HO-1 antioxidant pathway.
Aldehyde dehydrogenase 2 polymorphism affects the outcome of methanol poisoning in exposed humans.
Aldehyde dehydrogenase 2 polymorphism for development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis.
Association between aldehyde dehydrogenase 2 gene rs671 G>A polymorphism and alcoholic liver cirrhosis in southern Chinese Hakka population.
Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population.
CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis.
Genetic polymorphisms of ADH1B, ADH1C and ALDH2 in Turkish alcoholics: lack of association with alcoholism and alcoholic cirrhosis.
Genetic Polymorphisms of Genes Coding to Alcohol-Metabolizing Enzymes in Western Mexicans: Association of CYP2E1*c2/CYP2E1*5B Allele with Cirrhosis and Liver Function.
Genotypes of alcohol-metabolizing enzymes in Mexicans with alcoholic liver cirrhosis.
Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrhosis and chronic pancreatitis.
[Effects of genetic polymorphisms of ethanol-metabolizing enzymes on alcohol drinking behaviors]
[Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]
Liver Diseases
Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients.
Aldehyde dehydrogenase (E.C. 1.2.1.3) in chronic alcoholic liver diseases.
Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome.
Aldehyde Dehydrogenase Mutation Exacerbated High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease with Gut Microbiota Remodeling in Male Mice.
Aldehyde Dehydrogenase, Liver Disease and Cancer.
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles.
Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease.
Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population.
Associations among liver disease, serum lipid profile, body mass index, ketonuria, meal skipping, and the alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese men with alcohol dependence.
Change of components of the metabolic syndrome in a workers' health checkup after five years--relation with elevated liver enzymes, gene polymorphisms for ALDH 2, beta3-AR and lifestyle.
CYP2E1 genotypes and serum LAP in Japanese alcoholics.
Detection of usual and atypical aldehyde dehydrogenase alleles by mismatch amplification mutation assay.
Distribution of ADH2 and ALDH2 genotypes in different populations.
Effect of liver disorders on ethanol elimination and alcohol and aldehyde dehydrogenase activities in liver and erythrocytes.
Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population.
Ethanol-induced oxidative DNA damage and CYP2E1 expression in liver tissue of Aldh2 knockout mice.
Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease.
Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.
Influence of alcohol consumption and gene polymorphisms of ADH2 and ALDH2 on hepatocellular carcinoma in a Japanese population.
New strategy for detection of ALDH2 mutant.
Role of ALDH2 in Hepatic Disorders: Gene Polymorphism and Disease Pathogenesis.
The Association and Interaction of Aldehyde Dehydrogenase 2 Polymorphisms with Food Group Intake and Probability of Having Non-Alcoholic Fatty Liver Disease.
The murine hepatic sequelae of long-term ethanol consumption are sex-specific and exacerbated by Aldh1b1 loss.
Toxicogenomics directory of chemically exposed human hepatocytes.
Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease.
Liver Diseases, Alcoholic
Alcoholic liver disease in heterozygotes of mutant and normal aldehyde dehydrogenase-2 genes.
Aldehyde dehydrogenase (E.C. 1.2.1.3) in chronic alcoholic liver diseases.
Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease.
Effect of ALDH2 and CYP2E1 gene polymorphisms on drinking behavior and alcoholic liver disease in Japanese male workers.
Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease.
Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1(2)) with the disease.
Genotypes of ALDH2 related to liver and pulmonary diseases and other genetic factors related to alcoholic liver disease.
Genotyping of the aldehyde dehydrogenase 2 (ALDH2) gene using the polymerase chain reaction: evidence for single point mutation in the ALDH2 gene of ALDH2-deficiency.
Hepatocellular carcinoma associated with alcoholic liver disease: a clinicopathological study and genetic polymorphism of aldehyde dehydrogenase 2.
High incidence of ADH2*1/ALDH2*1 genes among Japanese alcohol dependents and patients with alcoholic liver disease.
Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease.
Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice.
Polymorphism of alcohol-metabolizing genes affects drinking behavior and alcoholic liver disease in Japanese men.
Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications.
The Role of ALDH2 in Alcoholic Liver Disease.
[Genetic and epidemiologic studies on alcoholic liver diseases]
[Genotypes of alcohol dehydrogenase and aldehyde dehydrogenase and their significance for alcohol sensitivity]
Liver Neoplasms
Aldehyde dehydrogenase 1A1 stabilizes transcription factor Gli2 and enhances the activity of Hedgehog signaling in hepatocellular cancer.
Aldehyde Dehydrogenase, Liver Disease and Cancer.
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles.
ALDH2 gene polymorphism in different types of cancers and its clinical significance.
Detection of ALDH1 activity in rabbit hepatic VX2 tumors and isolation of ALDH1 positive cancer stem cells.
Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism.
Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.
Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients.
Silencing transcription factor FOXM1 represses proliferation, migration, and invasion while inducing apoptosis of liver cancer stem cells by regulating the expression of ALDH2.
[Aldehyde dehydrogenase with hepatocellular carcinoma].
[Association between aldehyde dehydrogenase-2/cytochrome P450 2E1 genetic polymorphism and habit of alcohol drinking and the susceptibility of hepatocellular carcinoma]
Lung Diseases
Genotypes of ALDH2 related to liver and pulmonary diseases and other genetic factors related to alcoholic liver disease.
Lung Injury
Alda-1 Prevents Pulmonary Epithelial Barrier Dysfunction following Severe Hemorrhagic Shock through Clearance of Reactive Aldehydes.
Alda-1 Protects Against Acrolein-induced Acute Lung Injury and Endothelial Barrier Dysfunction.
Effect of low-dose ethanol on NLRP3 inflammasome in diabetes-induced lung injury.
Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung.
Ethanol at low concentration attenuates diabetes induced lung injury in rats model.
Metabolic disturbances of the vitamin A pathway in human diaphragmatic hernia.
Lung Neoplasms
?-Escin Inhibits NNK-Induced Lung Adenocarcinoma and ALDH1A1 and RhoA/Rock Expression in A/J Mice and Growth of H460 Human Lung Cancer Cells.
A prospective study of association of cancer stem cell marker aldehyde dehydrogenase 1 with clinicopathological profile in lung carcinoma patients.
Advances in cancer epidemiology in Japan.
Aldehyde dehyderogenase (ALDH1A1) delineating the normal and cancer stem cells in spectral lung lesions: An immunohistochemical appraisal.
Aldehyde Dehydrogenase 1 (ALDH1) Promotes the Toxicity of TRAIL in Non-Small Cell Lung Cancer Cells via Post-Transcriptional Regulation of MEK-1 Expression.
Aldehyde dehydrogenase 1 expression in cancer cells could have prognostic value for patients with non-small cell lung cancer who are treated with neoadjuvant therapy: identification of prognostic microenvironmental factors after chemoradiation.
Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer.
Aldehyde dehydrogenase 1A1 possesses stem-like properties and predicts lung cancer patient outcome.
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling.
Aldehyde dehydrogenases in early stage lung cancer: nuclear expression.
ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells.
ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors.
ALDH1 Expression and the Prognosis of Lung Cancer: A Systematic Review and Meta-Analysis.
ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors.
ALDH2 Repression Promotes Lung Tumor Progression via Accumulated Acetaldehyde and DNA Damage.
ATG7-mediated autophagy involves in miR-138-5p regulated self-renewal and invasion of lung cancer stem-like cells derived from A549 cells.
Auramine O, an incense smoke ingredient, promotes lung cancer malignancy.
Blockade of Notch3 inhibits the stem-like property and is associated with ALDH1A1 and CD44 via autophagy in non-small lung cancer.
Cancer stem cell marker Musashi-1 rs2522137 genotype is associated with an increased risk of lung cancer.
Cancer Stem-Like Cells in a Case of an Inflammatory Myofibroblastic Tumor of the Lung.
Casticin suppresses self-renewal and invasion of lung cancer stem-like cells from A549 cells through down-regulation of pAkt.
Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target.
CircRNA circ_POLA2 promotes lung cancer cell stemness via regulating the miR-326/GNB1 axis.
Clinicopathological significance of ALDH1A1 in lung, colorectal, and breast cancers: a meta-analysis.
Comparative proteomic analysis of anti-cancer mechanism by periplocin treatment in lung cancer cells.
Comprehensive proteomic profiling of aldehyde dehydrogenases in lung adenocarcinoma cell lines.
Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP.
Differential Expression of Cancer Stem Cell Markers ALDH1 and CD133 in Various Lung Cancer Subtypes.
Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer.
Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer.
Effect of alcohol and its metabolites in lung cancer: CAPUA study.
Effects of acetaldehyde inhalation in mitochondrial aldehyde dehydrogenase deficient mice (Aldh2-/-).
Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway.
Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis.
Finding Genes Discriminating Smokers from Non-smokers by Applying a Growing Self-organizing Clustering Method to Large Airway Epithelium Cell Microarray Data.
Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation.
Ginsenoside Rg3 attenuates the osimertinib resistance by reducing the stemness of non-small cell lung cancer cells.
GnRH participates in the self-renewal of A549-derived lung cancer stem-like cells through upregulation of the JNK signaling pathway.
Hedgehog signaling pathway molecules and ALDH1A1 expression in early-stage non-small cell lung cancer.
HSPA1L Enhances Cancer Stem Cell-Like Properties by Activating IGF1R? and Regulating ?-Catenin Transcription.
Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population.
Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans.
Itraconazole Alters the Stem Cell Characteristics of A549 and NCI-H460 Human Lung Cancer Cells by Suppressing Wnt Signaling.
Long-term PM2.5 exposure increases the risk of non-small cell lung cancer (NSCLC) progression by enhancing interleukin-17a (IL-17a)-regulated proliferation and metastasis.
Low-folate stress reprograms cancer stem cell-like potentials and bioenergetics metabolism through activation of mTOR signaling pathway to promote in vitro invasion and in vivo tumorigenicity of lung cancers.
Lung cancer stem cells-origin, characteristics and therapy.
Measurement of Aldehyde Dehydrogenase 1 Expression Defines a Group with Better Prognosis in Patients with Non-Small Cell Lung Cancer.
Metastasis-associated in colon cancer-1 and aldehyde dehydrogenase 1 are metastatic and prognostic biomarker for non-small cell lung cancer.
Multiple Copies in T-Cell Malignancy 1 (MCT-1) Promotes the Stemness of Non-Small Cell Lung Cancer Cells via Activating Interleukin-6 (IL-6) Signaling through Suppressing MiR-34a Expression.
Pivotal role of CD38 biomarker in combination with CD24, EpCAM, and ALDH for identification of H460 derived lung cancer stem cells.
PPARgamma-mediated ALDH1A3 suppression exerts anti-proliferative effects in lung cancer by inducing lipid peroxidation.
Prognostic value of ALDH1 expression in lung cancer: a meta-analysis.
Puerarin 6?-O-xyloside suppresses growth, self-renewal and invasion of lung cancer stem-like cells derived from A549 cells via regulating Akt/c-Myc signalling.
Serum ALDH1A1 is a tumor marker for the diagnosis of non-small cell lung cancer.
Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells.
Stem cell-like ALDH(bright) cellular states in EGFR-mutant non-small cell lung cancer: A novel mechanism of acquired resistance to erlotinib targetable with the natural polyphenol silibinin.
Susceptibility to lung cancer and genetic polymorphisms in the alcohol metabolite-related enzymes alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 in the Japanese population.
Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells.
TAZ induces lung cancer stem cell properties and tumorigenesis by up-regulating ALDH1A1.
The cancer stem-cell hypothesis: its emerging role in lung cancer biology and its relevance for future therapy.
The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance.
The prognostic significance of aldehyde dehydrogenase 1A1 (ALDH1A1) and CD133 expression in early stage non-small cell lung cancer.
The role of LGR5 and ALDH1A1 in non-small cell lung cancer: Cancer progression and prognosis.
[Expression of Acetaldehyde Dehydrogenase in Gefitinib-resistant Human Lung Adenocarcinoma HCC-827/GR Cells].
Lymphatic Metastasis
A review of the racial heterogeneity of breast cancer stem cells.
Aberrant expression of ALDH1, MMP9, Integrin ?v?3, and KiSS-1 in invasive ductal carcinoma and their clinical significance.
Aldehyde Dehydragenase 1 and Nodal as Significant Prognostic Markers in Colorectal Cancer.
Aldehyde dehydrogenase 1 expression is a predictor of poor prognosis in node-positive breast cancers: a long-term follow-up study.
ALDH1 as a prognostic marker for lymph node metastasis in OSCC.
ALDH1 Expression and the Prognosis of Lung Cancer: A Systematic Review and Meta-Analysis.
ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer.
ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway.
Cancer stem cell marker ALDH1 expression is associated with lymph node metastasis and poor survival in esophageal squamous cell carcinoma: a study from high incidence area of northern China.
Clinicopathological characteristics and prognostic value of the cancer stem cell marker ALDH1 in ovarian cancer: a meta-analysis.
Clinicopathological significance of ALDH1A1 in lung, colorectal, and breast cancers: a meta-analysis.
Clinicopathological Significance of CD133 and ALDH1 Cancer Stem Cell Marker Expression in Invasive Ductal Breast Carcinoma.
Combined expression of aldehyde dehydrogenase 1A1 and ?-catenin is associated with lymph node metastasis and poor survival in breast cancer patients following cyclophosphamide treatment.
Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer.
Differences in expression of the cancer stem cell marker aldehyde dehydrogenase 1 among estrogen receptor-positive/human epidermal growth factor receptor type 2-negative breast cancer cases with early, late, and no recurrence.
Evaluation of aldehyde dehydrogenase 1 and transcription factors in both primary breast cancer and axillary lymph node metastases as a prognostic factor.
Evaluation of the correlation of vasculogenic mimicry, ALDH1, KAI1 and microvessel density in the prediction of metastasis and prognosis in colorectal carcinoma.
Expression of Aldehyde Dehydrogenase 1A1 (ALDH1A1) as a Prognostic Biomarker in Colorectal Cancer Using Immunohistochemistry.
Expression of ALDH1 in axillary lymph node metastases is a prognostic factor of poor clinical outcome in breast cancer patients with 1-3 lymph node metastases.
Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer.
High ALDH1A1 expression indicates a poor prognosis in gastric neuroendocrine carcinoma.
High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis.
Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma.
Metastasis-associated in colon cancer-1 and aldehyde dehydrogenase 1 are metastatic and prognostic biomarker for non-small cell lung cancer.
Musashi-1 Expression is a Prognostic Factor in Ovarian Adenocarcinoma and Correlates with ALDH-1 Expression.
Prognostic Impact and Clinicopathological Correlation of CD133 and ALDH1 Expression in Invasive Breast Cancer.
Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma.
Prognostic value of ALDH1 expression in lung cancer: a meta-analysis.
Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression.
Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression.
The expression of aldehyde dehydrogenase 1 in invasive primary breast tumors and axillary lymph node metastases is associated with poor clinical prognosis.
The expressions of CD133, ALDH1, and vasculogenic mimicry in osteosarcoma and their clinical significance.
The long non-coding RNA MACC1-AS1 promotes nasopharyngeal carcinoma cell stemness via suppressing miR-145-mediated inhibition on SMAD2/MACC1-AS1 axis.
The prognostic significance of ALDH1A1 expression in early invasive breast cancer.
The Prognostic Value of Cancer Stem Cell Markers (Notch1, ALDH1, and CD44) in Primary Colorectal Carcinoma.
Value of CagA, HER2, ALDH1, and KiSS-1 in predicting metastasis and prognosis for gastric adenocarcinoma.
Vasculogenic mimicry and expression of ALDH1, Beclin1, and p16 correlate with metastasis and prognosis in oral squamous cell carcinoma.
[Expression and Clinical Significance of ALDH1 and Twist in Gastric Adenocarcinoma].
[Expression of ALDH1, CXCR4 and E-cadherin in castric carcinoma and their roles in lymphatic metastasis].
[Expressions and Significance of ALDH1, HIF-1? and VEGF in Laryngeal Squamous Cell Carcinoma].
[High aldehyde dehydrogenase 1A1 (ALDH1A1) expression correlated with risk of lymph node metastasis in papillary thyroid carcinoma].
Lymphoma
ALDH1A1 mediates resistance of diffuse large B cell lymphoma to the CHOP regimen.
Expression of CD44, CD44v9, ABCG2, CD24, Bmi-1 and ALDH1 in stage I and II oral squamous cell carcinoma and their association with clinicopathological factors.
Gene-environment Interactions and Polymorphism Studies of Cancer Risk in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC-II).
Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma.
Lymphoma, B-Cell
ALDH1A1 induces resistance to CHOP in diffuse large B-cell lymphoma through activation of the JAK2/STAT3 pathway.
ALDH1A1 mediates resistance of diffuse large B cell lymphoma to the CHOP regimen.
Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP.
Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma.
WITHDRAWN: ALDH1A1 induces resistance to CHOP in diffuse large B-cell lymphoma through activation of the JAK2/STAT3 pathway.
Lymphoma, Large B-Cell, Diffuse
ALDH1A1 induces resistance to CHOP in diffuse large B-cell lymphoma through activation of the JAK2/STAT3 pathway.
ALDH1A1 mediates resistance of diffuse large B cell lymphoma to the CHOP regimen.
Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma.
WITHDRAWN: ALDH1A1 induces resistance to CHOP in diffuse large B-cell lymphoma through activation of the JAK2/STAT3 pathway.
Lymphoma, Non-Hodgkin
The role of aldehyde dehydrogenase 1A1 in B-cell non-Hodgkin's lymphoma.
Macular Degeneration
Phenotypic variability among adult siblings with Sjögren-Larsson syndrome.
Malaria
Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage.
Mastitis
High expression of aldehyde dehydrogenase 1 and tissue necrosis factor alpha may relate to chronic infection of buffalo mammary gland.
medium-chain acyl-coa dehydrogenase deficiency
Detection of single nucleotide substitution by competitive allele-specific short oligonucleotide hybridization (CASSOH) with immunochromatographic strip.
Melanoma
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.
ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment.
ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output.
Clinical implications of ALDH1A1 and ALDH1A3 mRNA expression in melanoma subtypes.
Comparative expression analysis of putative cancer stem cell markers CD44 and ALDH1A1 in various skin cancer subtypes.
Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis.
High ALDH1 expression correlates with better prognosis in tumorigenic malignant melanoma.
Identification of a gene signature for discriminating metastatic from primary melanoma using a molecular interaction network approach.
Prognostic impact of the putative cancer stem cell markers ABCG2, CD133, ALDH1A1 and CD44V7/8 in metastatic melanoma.
Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype.
Targeting ALDH1 to decrease tumorigenicity, growth and metastasis of human melanoma.
Whole cell melanoma vaccine genetically modified to stem cells like phenotype generates specific immune responses to ALDH1A1 and long-term survival in advanced melanoma patients.
Melanosis
Esophageal melanosis, an endoscopic finding associated with squamous cell neoplasms of the upper aerodigestive tract, and inactive aldehyde dehydrogenase-2 in alcoholic Japanese men.
Melanosis and squamous cell neoplasms of the upper aerodigestive tract in Japanese alcoholic men.
Soft palatal melanosis, a simple predictor for neoplasia in the upper aerodigestive tract in Japanese alcoholic men.
MELAS Syndrome
No association of ALDH2 genotype in MELAS.
Memory Disorders
Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity.
Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification.
Meningioma
Differential Diagnosis of Meningeal SFT-HPC and Meningioma: Which Immunohistochemical Markers Should Be Used?
Intracranial anaplastic solitary fibrous tumor/hemangiopericytoma: immunohistochemical markers for definitive diagnosis.
Meningomyelocele
Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2.
Mesothelioma
Expression of ALCAM (CD166) and PD-L1 (CD274) independently predicts shorter survival in malignant pleural mesothelioma.
Metabolic Diseases
Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease.
Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders.
Metabolic Syndrome
Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome.
Aldehyde Dehydrogenase Mutation Exacerbated High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease with Gut Microbiota Remodeling in Male Mice.
Aldehyde Dehydrogenase-2 Attenuates Myocardial Remodeling and Contractile Dysfunction Induced by a High-Fat Diet.
Change of components of the metabolic syndrome in a workers' health checkup after five years--relation with elevated liver enzymes, gene polymorphisms for ALDH 2, beta3-AR and lifestyle.
Human-induced pluripotent stem cell approaches to model inborn and acquired metabolic heart diseases.
Microphthalmos
A homozygous mutation in a consanguineous family consolidates the role of ALDH1A3 in autosomal recessive microphthalmia.
ALDH1A3 mutations cause recessive anophthalmia and microphthalmia.
Conserved missense variant in ALDH1A3 ortholog impairs fecundity in C. elegans.
Mutations in ALDH1A3 cause microphthalmia.
Novel mutations in ALDH1A3 associated with autosomal recessive anophthalmia/microphthalmia, and review of the literature.
Mitochondrial Diseases
Mitochondrial aldehyde dehydrogenase in diabetes associated with mitochondrial tRNA(Leu(UUR)) mutation at position 3243.
Mouth Neoplasms
Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.
Aldehyde dehydrogenase 2 and glutathione S-transferase M 1 polymorphisms in relation to the risk for oral cancer in Japanese drinkers.
ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia.
Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer.
Expression of cancer stem cell markers ALDH1 and Bmi1 in oral erythroplakia and the risk of oral cancer.
Expression patterns of cancer stem cell markers ALDH1 and CD133 correlate with a high risk of malignant transformation of oral leukoplakia.
Investigation of ovatodiolide, a macrocyclic diterpenoid, as a potential inhibitor of oral cancer stem-like cells properties via the inhibition of the JAK2/STAT3/JARID1B signal circuit.
MiR-30a and miR-379 modulate retinoic acid pathway by targeting DNA methyltransferase 3B in oral cancer.
Nano formulated Resveratrol inhibits metastasis and angiogenesis by reducing inflammatory cytokines in oral cancer cells by targeting tumor associated macrophages.
Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer.
Multiple Myeloma
Aldehyde dehydrogenase 1A1: friend or foe to female metabolism?
Aldehyde dehydrogenase-1a1 induces oncogene suppressor genes in B cell populations.
ALDH1 activity identifies tumor-initiating cells and links to chromosomal instability signatures in multiple myeloma.
Disulfiram/copper targets stem cell-like ALDH+ population of multiple myeloma by inhibition of ALDH1A1 and Hedgehog pathway.
NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma.
[Gene expression of key enzymes for all-trans- retinoic acid biosynthesis - ALDHJAI and RDH10: relationship with co-expression of nuclear receptors RAR? and PPAR?/? genes and some clinical characteristics in multiple myeloma.
Muscle Spasticity
Alcohol flushing and positive ethanol patch test in patients with coronary spastic angina: possible role of aldehyde dehydrogenase 2 polymorphisms.
East Asian Variant of Aldehyde Dehydrogenase 2 (ALDH2*2) is Associated with Coronary Spastic Angina: Possible Roles of Reactive Aldehydes and Implications of Alcohol Flushing Syndrome.
East Asians Variant Mitochondrial Aldehyde Dehydrogenase 2 Genotype Exacerbates Nitrate Tolerance in Patients With Coronary Spastic Angina.
Letter by Ortega-Paz et al Regarding Article, "East Asian Variant of Aldehyde Dehydrogenase 2 Is Associated With Coronary Spastic Angina: Possible Roles of Reactive Aldehydes and Implications of Alcohol Flushing Syndrome".
Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3.
Novel Mutation in Sjogren-Larsson Syndrome Is Associated With Divergent Neurologic Phenotypes.
Response to Letter Regarding Article, "East Asian Variant of Aldehyde Dehydrogenase 2 Is Associated With Coronary Spastic Angina: Possible Roles of Reactive Aldehydes and Implications of Alcohol Flushing Syndrome".
Sjögren-Larsson syndrome: Novel mutations in the ALDH3A2 gene in a French cohort.
Muscular Atrophy
ALDH2 mutation promotes skeletal muscle atrophy in mice via accumulation of oxidative stress.
Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic Ischemia: Potential Impact on the Development of Coronary Collateral Circulation.
Preventive effects of Chlorella on skeletal muscle atrophy in muscle-specific mitochondrial aldehyde dehydrogenase 2 activity-deficient mice.
Myocardial Infarction
A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men.
Aberrant hypermethylation of aldehyde dehydrogenase 2 promoter upstream sequence in rats with experimental myocardial infarction.
Alda?1, an aldehyde dehydrogenase?2 agonist, improves long?term survival in rats with chronic heart failure following myocardial infarction.
Aldehyde dehydrogenase 2 activation and coevolution of its ?PKC-mediated phosphorylation sites.
Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men.
Aldehyde Dehydrogenase 2 Has Cardioprotective Effects on Myocardial Ischaemia/Reperfusion Injury via Suppressing Mitophagy.
Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?
Aldehyde dehydrogenase-2 protects against myocardial infarction-related cardiac fibrosis through modulation of the Wnt/?-catenin signaling pathway.
ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance.
ALDH2 Glu504Lys polymorphism and susceptibility to coronary artery disease and myocardial infarction in East Asians: a meta-analysis.
ALDH2 rs671 Polymorphism and coronary heart disease risk among Asian populations: a meta-analysis and meta-regression.
APSH YI-02 THE POLYMORPHISM IN ALDEHYDE DEHYDROGENASE-2 (ALDH2) GENE IS ASSOCIATED WITH MYOCARDIAL INFARCTION AND STROKE IN A CHINESE POPULATION.
Association between ALDH2 Glu504Lys Polymorphism and Susceptibility to Coronary Artery Disease and Myocardial Infarction: Need for Clarification of Data in a Recent Meta-analysis.
Association of Aldehyde Dehydrogenase 2 Gene Polymorphism with Myocardial Infarction.
Association of East Asian Variant Aldehyde Dehydrogenase 2 Genotype (ALDH2*2*) with Coronary Spasm and Acute Myocardial Infarction.
Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: a meta-analysis.
Association of Genetically Determined Aldehyde Dehydrogenase 2 Activity with Diabetic Complications in Relation to Alcohol Consumption in Japanese Patients with Type 2 Diabetes Mellitus: The Fukuoka Diabetes Registry.
Combined effects of current-smoking and the aldehyde dehydrogenase 2*2 allele on the risk of myocardial infarction in Japanese patients.
Diabetic Aldehyde Dehydrogenase 2 Mutant (ALDH2*2) Mice Are More Susceptible to Cardiac Ischemic-Reperfusion Injury Due to 4-Hydroxy-2-Nonenal Induced Coronary Endothelial Cell Damage.
East Asian variant aldehyde dehydrogenase type 2 genotype exacerbates ischemia/reperfusion injury with ST-elevation myocardial infarction in men: possible sex differences.
Efficient expression of codon-adapted human acetaldehyde dehydrogenase 2 cDNA with 6xHis tag in Pichia pastoris.
Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females.
Identification of Candidate Genes and MicroRNAs for Acute Myocardial Infarction by Weighted Gene Coexpression Network Analysis.
MicroRNA-34a Promotes Cardiomyocyte Apoptosis Post Myocardial Infarction Through Down-regulating Aldehyde Dehydrogenase 2.
miR-28 promotes cardiac ischemia by targeting mitochondrial aldehyde dehydrogenase 2 (ALDH2) in mus musculus cardiac myocytes.
Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice.
Mitochondrial aldehyde dehydrogenase in myocardial ischemia-reperfusion injury: from bench to bedside.
Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury.
Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications.
Regulation of Human Mitochondrial Aldehyde Dehydrogenase (ALDH-2) Activity by Electrophiles in Vitro.
Reply to: ALDH2 Glu504Lys Polymorphism and Susceptibility to Coronary Artery Disease and Myocardial Infarction in East Asians: A Meta-analysis.
The polymorphism in aldehyde dehydrogenase-2 gene is associated with elevated plasma levels of high-sensitivity C-reactive protein in the early phase of myocardial infarction.
Variant Aldehyde Dehydrogenase 2 (ALDH2*2) Is a Risk Factor for Coronary Spasm and ST-Segment Elevation Myocardial Infarction.
Myocardial Ischemia
Aberrant hypermethylation of aldehyde dehydrogenase 2 promoter upstream sequence in rats with experimental myocardial infarction.
Aldehyde dehydrogenase-2 protects against myocardial infarction-related cardiac fibrosis through modulation of the Wnt/?-catenin signaling pathway.
miR-28 promotes cardiac ischemia by targeting mitochondrial aldehyde dehydrogenase 2 (ALDH2) in mus musculus cardiac myocytes.
Salvaging the ischemic heart: Gi-coupled receptors in mast cells activate a PKC?/ALDH2 pathway providing anti-RAS cardioprotection.
Myoma
Acetaldehyde differentially affects the growth of uterine leiomyomata and myometrial cells in tissue cultures.
Nasopharyngeal Carcinoma
Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma.
Cancer stem cell characteristics, ALDH1 expression in the invasive front of nasopharyngeal carcinoma.
Increased expression of aldehyde dehydrogenase 1 A1 in nasopharyngeal carcinoma is associated with enhanced invasiveness.
Tumour budding and the expression of cancer stem cell marker aldehyde dehydrogenase 1 in nasopharyngeal carcinoma.
Nasopharyngitis
Inflammation-Related DNA Damage and Cancer Stem Cell Markers in Nasopharyngeal Carcinoma.
Neoplasm Metastasis
?-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
A review of the racial heterogeneity of breast cancer stem cells.
A triple negative breast cancer: what it is not!
Aberrant expression of ALDH1, MMP9, Integrin ?v?3, and KiSS-1 in invasive ductal carcinoma and their clinical significance.
Aldehyde Dehydragenase 1 and Nodal as Significant Prognostic Markers in Colorectal Cancer.
Aldehyde dehydrogenase 1 (ALDH1) expression is associated with a poor prognosis of bladder cancer.
Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer.
Aldehyde dehydrogenase 1 expression correlates with clinicopathologic features of patients with breast cancer: a meta-analysis.
Aldehyde dehydrogenase 1 expression is a predictor of poor prognosis in node-positive breast cancers: a long-term follow-up study.
Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer.
Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling.
Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells is Primarily Due to Isoform ALDH1A3 and Its Expression is Predictive of Metastasis.
Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis.
Aldehyde dehydrogenase-2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP-activated protein kinase signaling in mice.
ALDH1 as a prognostic marker for lymph node metastasis in OSCC.
ALDH1 Expression and the Prognosis of Lung Cancer: A Systematic Review and Meta-Analysis.
ALDH1-positive cancer stem-like cells are enriched in nodal metastases of oropharyngeal squamous cell carcinoma independent of HPV status.
ALDH1-positive intratumoral stromal cells indicate differentiated epithelial-like phenotype and good prognosis in prostate cancer.
ALDH1A1 expression is associated with poor differentiation, 'right-sidedness' and poor survival in human colorectal cancer.
ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer.
ALDH1A3 Accelerates Pancreatic Cancer Metastasis by Promoting Glucose Metabolism.
ALDH1A3 upregulation and spontaneous metastasis formation is associated with acquired chemoresistance in colorectal cancer cells.
ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway.
ALDH3A1 driving tumor metastasis is mediated by p53/BAG1 in lung adenocarcinoma.
Associations of carboxypeptidase 4 with ALDH1A1 expression and their prognostic value in esophageal squamous cell carcinoma.
Author Correction: Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis.
Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells.
Cancer stem cell marker ALDH1 expression is associated with lymph node metastasis and poor survival in esophageal squamous cell carcinoma: a study from high incidence area of northern China.
Cancer stem cell markers in eyelid sebaceous gland carcinoma: high expression of ALDH1, CD133, and ABCG2 correlates with poor prognosis.
Causal Bayesian gene networks associated with bone, brain and lung metastasis of breast cancer.
CD44 and ALDH1 immunoexpression as prognostic indicators of invasion and metastasis in oral squamous cell carcinoma.
Clinicopathological characteristics and prognostic value of the cancer stem cell marker ALDH1 in ovarian cancer: a meta-analysis.
Clinicopathological correlation of stem cell markers expression in oral squamous cell carcinoma; relation to patients` outcome.
Clinicopathological significance of ALDH1A1 in lung, colorectal, and breast cancers: a meta-analysis.
Clinicopathological Significance of CD133 and ALDH1 Cancer Stem Cell Marker Expression in Invasive Ductal Breast Carcinoma.
Combination of Cancer Stem Cell Markers CD44 and CD24 Is Superior to ALDH1 as a Prognostic Indicator in Breast Cancer Patients with Distant Metastases.
Combined expression of aldehyde dehydrogenase 1A1 and ?-catenin is associated with lymph node metastasis and poor survival in breast cancer patients following cyclophosphamide treatment.
Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer.
Complex Behavior of ALDH1A1 and IGFBP1 in Liver Metastasis from a Colorectal Cancer.
Correlations of aldehyde dehydrogenase-1 (ALDH1) expression with traditional prognostic parameters and different molecular subtypes of breast carcinoma.
Differences in expression of the cancer stem cell marker aldehyde dehydrogenase 1 among estrogen receptor-positive/human epidermal growth factor receptor type 2-negative breast cancer cases with early, late, and no recurrence.
Differential Functional Roles of ALDH1A1 and ALDH1A3 in Mediating Metastatic Behavior and Therapy Resistance of Human Breast Cancer Cells.
Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis.
Discovery of microarray-identified genes associated with ovarian cancer progression.
Distinct patterns of ALDH1A1 expression predict metastasis and poor outcome of colorectal carcinoma.
Effect of ALDH1 on prognosis and chemoresistance by breast cancer subtype.
EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect.
Evaluation of aldehyde dehydrogenase 1 and transcription factors in both primary breast cancer and axillary lymph node metastases as a prognostic factor.
Evaluation of expression of cancer stem cell markers and fusion gene in synovial sarcoma: Insights into histogenesis and pathogenesis.
Evaluation of the correlation of vasculogenic mimicry, ALDH1, KAI1 and microvessel density in the prediction of metastasis and prognosis in colorectal carcinoma.
Evaluation of the correlation of vasculogenic mimicry, ALDH1, KiSS-1, and MACC1 in the prediction of metastasis and prognosis in ovarian carcinoma.
Exploration of bladder cancer molecular mechanisms based on miRNA-mRNA regulatory network.
Expression Analysis of Aldehyde Dehydrogenase 1A1 (ALDH1A1) in Colon and Rectal Cancer in Association with Prognosis and Response to Chemotherapy.
Expression of Aldehyde Dehydrogenase (ALDH1) and ATP Binding Cassette Transporter G2 (ABCG2) in Iraqi Patients with Colon Cancer and the Relation with Clinicopathological Features.
Expression of Aldehyde Dehydrogenase 1A1 (ALDH1A1) as a Prognostic Biomarker in Colorectal Cancer Using Immunohistochemistry.
Expression of ALDH1 in axillary lymph node metastases is a prognostic factor of poor clinical outcome in breast cancer patients with 1-3 lymph node metastases.
Expression of ALDH1A1 and CD133 is associated with the prognosis and effect of different chemotherapeutic regimens in gastric cancer.
Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer.
Expression of CD44, CD44v9, ABCG2, CD24, Bmi-1 and ALDH1 in stage I and II oral squamous cell carcinoma and their association with clinicopathological factors.
Gastric Adenocarcinoma Biomarker Expression Profiles and their Prognostic Value.
High ALDH1A1 expression indicates a poor prognosis in gastric neuroendocrine carcinoma.
High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis.
Identification of ALDH1A3 as a viable therapeutic target in breast cancer metastasis-initiating cells.
Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma.
Loss of expression of the cancer stem cell marker aldehyde dehydrogenase 1 correlates with advanced-stage colorectal cancer.
Mesenchymal Stem/Stromal Cell Engulfment Reveals Metastatic Advantage in Breast Cancer.
Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma.
Metastasis-associated in colon cancer-1 and aldehyde dehydrogenase 1 are metastatic and prognostic biomarker for non-small cell lung cancer.
Methylation-Induced Silencing of ALDH2 Facilitates Lung Adenocarcinoma Bone Metastasis by Activating the MAPK Pathway.
MicroRNA?487b?3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3.
MicroRNAs overexpressed in ovarian ALDH1-positive cells are associated with chemoresistance.
MIR600HG suppresses metastasis and enhances oxaliplatin chemosensitivity by targeting ALDH1A3 in colorectal cancer.
Musashi-1 Expression is a Prognostic Factor in Ovarian Adenocarcinoma and Correlates with ALDH-1 Expression.
Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancer.
Nuclear aldehyde dehydrogenase 1A1 (ALDH1A1) expression is a favorable prognostic indicator in colorectal carcinoma.
Overexpression of ALDH1 and EMT marker profile are linked with unfavorable outcome in head and neck cancer.
Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer.
Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.
Prognostic Impact and Clinicopathological Correlation of CD133 and ALDH1 Expression in Invasive Breast Cancer.
Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy.
Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma.
Prognostic value of ALDH1 expression in lung cancer: a meta-analysis.
Prostate Tumor Overexpressed-1 (PTOV1) promotes docetaxel-resistance and survival of castration resistant prostate cancer cells.
RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance.
Reporters of Cancer Stem Cells as a Tool for Drug Discovery.
Silencing TAK1 alters gene expression signatures in bladder cancer cells.
Somatic aberrations of BRCA1 gene are associated with ALDH1, EGFR, and tumor progression in prostate cancer.
SOX9 Regulates Cancer Stem-Like Properties and Metastatic Potential of Single-Walled Carbon Nanotube-Exposed Cells.
Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression.
Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression.
Tamoxifen enhances stemness and promotes metastasis of ER?36
Targeting ALDH1 to decrease tumorigenicity, growth and metastasis of human melanoma.
The Effect of P-Glycoprotein (P-gp), Nuclear Factor-Kappa B (Nf-?b), and Aldehyde Dehydrogenase-1 (ALDH-1) Expression on Metastases, Recurrence and Survival in Advanced Breast Cancer Patients
The expression of aldehyde dehydrogenase 1 in invasive primary breast tumors and axillary lymph node metastases is associated with poor clinical prognosis.
The expression pattern of aldehyde dehydrogenase 1 (ALDH1) is an independent prognostic marker for low survival in colorectal tumors.
The expressions of CD133, ALDH1, and vasculogenic mimicry in osteosarcoma and their clinical significance.
The long non-coding RNA MACC1-AS1 promotes nasopharyngeal carcinoma cell stemness via suppressing miR-145-mediated inhibition on SMAD2/MACC1-AS1 axis.
The prognostic significance of ALDH1A1 expression in early invasive breast cancer.
The Prognostic Value of Cancer Stem Cell Markers (Notch1, ALDH1, and CD44) in Primary Colorectal Carcinoma.
The role of LGR5 and ALDH1A1 in non-small cell lung cancer: Cancer progression and prognosis.
Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis.
Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis.
Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain.
Value of CagA, HER2, ALDH1, and KiSS-1 in predicting metastasis and prognosis for gastric adenocarcinoma.
Vasculogenic mimicry and expression of ALDH1, Beclin1, and p16 correlate with metastasis and prognosis in oral squamous cell carcinoma.
[Expression and Clinical Significance of ALDH1 and Twist in Gastric Adenocarcinoma].
[Expression Level of Membrane-associated Proteins Numb in Epithelial Ovarian Carcinoma and Its Relationship with Ovarian Cancer Stem Cell Markers CD117, CD133, ALDH1.]
[Expression of ALDH1, CXCR4 and E-cadherin in castric carcinoma and their roles in lymphatic metastasis].
[Expressions and Significance of ALDH1, HIF-1? and VEGF in Laryngeal Squamous Cell Carcinoma].
[High aldehyde dehydrogenase 1A1 (ALDH1A1) expression correlated with risk of lymph node metastasis in papillary thyroid carcinoma].
[Proliferation of cancer stem cells in colorectal adenocarcinoma].
Neoplasm, Residual
IL-6 mediates platinum-induced enrichment of ovarian cancer stem cells.
Proliferation rate and breast cancer subtype, but not ALDH1 expression, predict pathological response to neoadjuvant chemotherapy in locally advanced breast cancer.
Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells.
[Expression Level of Membrane-associated Proteins Numb in Epithelial Ovarian Carcinoma and Its Relationship with Ovarian Cancer Stem Cell Markers CD117, CD133, ALDH1.]
Neoplasms
(-)-Epigallocatechin gallate inhibits stemness and tumourigenicity stimulated by AXL receptor tyrosine kinase in human lung cancer cells.
2D-PAGE of ovarian cancer: analysis of soluble and insoluble fractions using medium-range immobilized pH gradients.
75P Inhibition and exploitation of aldehyde dehydrogenase 1 (ALDH1) as a cancer stem cell marker in cisplatin resistant NSCLC.
?,?-Acetylenic Amino Thiolester Inhibitors of Aldehyde Dehydrogenases 1&3: Suppressors of Apoptogenic Aldehyde Oxidation and Activators of Apoptosis.
?-Arrestins regulate stem cell-like phenotype and response to chemotherapy in bladder cancer.
?-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
?-catenin/POU5F1/SOX2 transcription factor complex mediates IGF-1 receptor signaling and predicts poor prognosis in lung adenocarcinoma.
A basal-cell-like compartment in head and neck squamous cell carcinomas represents the invasive front of the tumor and is expressing MMP-9.
A combination of nuclear ?-catenin and atypical scores as useful diagnostic markers for borderline malignancy of gastric tumours.
A comparison of covalent binding of ethanol metabolites to DNA according to Aldh2 genotype.
A glycolysis-related gene expression signature in predicting recurrence of breast cancer.
A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.
A Novel ALDH1A1 Inhibitor Targets Cells with Stem Cell Characteristics in Ovarian Cancer.
A novel DNA-binding motif in prostate tumor overexpressed-1 (PTOV1) required for the expression of ALDH1A1 and CCNG2 in cancer cells.
A novel HSP90 inhibitor targeting the C-terminal domain attenuates trastuzumab resistance in HER2-positive breast cancer.
A novel orthotopic mouse model of head and neck cancer and lymph node metastasis.
A novel reporter construct for screening small molecule inhibitors that specifically target self-renewing cancer cells.
A prospective study of association of cancer stem cell marker aldehyde dehydrogenase 1 with clinicopathological profile in lung carcinoma patients.
A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro.
A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells.
A Therapeutic Strategy for Chemotherapy-Resistant Gastric Cancer via Destabilization of Both ?-Catenin and RAS.
A Transition Zone Showing Highly Discontinuous or Alternating Levels of Stem Cell and Proliferation Markers Characterizes the Development of PTEN-Haploinsufficient Colorectal Cancer.
A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer.
ABCG5-positivity in tumor buds is an indicator of poor prognosis in node-negative colorectal cancer patients.
Aberrant expression of ALDH1, MMP9, Integrin ?v?3, and KiSS-1 in invasive ductal carcinoma and their clinical significance.
Ablation of breast cancer stem cells with radiation.
Accumulation of ALDH1-positive cells after neoadjuvant chemotherapy predicts treatment resistance and prognosticates poor outcome in ovarian cancer.
Acetaldehyde and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers.
Acquisition cancer stemness, mesenchymal transdifferentiation, and chemoresistance properties by chronic exposure of oral epithelial cells to arecoline.
Across-site differences in the mechanism of alcohol-induced digestive tract carcinogenesis: an evaluation by mediation analysis.
Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis.
Activation of Inflammatory Responses Correlate With Hedgehog Activation and Precede Expansion of Cancer Stem-Like Cells in an Animal Model of Residual Triple Negative Breast Cancer after Neoadjuvant Chemotherapy.
Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays.
Acylglycerol kinase promotes the stemness of nasopharyngeal carcinoma cells by promoting ?-catenin translocation to the nucleus through activating PI3K/Akt pathway.
Advances in cancer epidemiology in Japan.
Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells.
Aggressive progression of breast cancer with microscopic pulmonary emboli possessing a stem cell-like phenotype independent of its origin.
Aggressive tumor microenvironment of solid predominant lung adenocarcinoma subtype harboring with epidermal growth factor receptor mutations.
Aggressiveness and Metastatic Potential of Breast Cancer Cells Co-Cultured with Preadipocytes and Exposed to an Environmental Pollutant Dioxin: An in Vitro and in Vivo Zebrafish Study.
Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics.
Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics.
Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians.
Alcohol and cancer.
Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer.
Alcohol drinking and bladder cancer risk from a pooled analysis of ten cohort studies in Japan.
Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention.
Alcohol drinking, mean corpuscular volume of erythrocytes, and alcohol metabolic genotypes in drunk drivers.
Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men.
Alcohol ingestion and colorectal neoplasia: a meta-analysis based on a Mendelian randomization approach.
Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.
Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics.
Aldehyde dehyderogenase (ALDH1A1) delineating the normal and cancer stem cells in spectral lung lesions: An immunohistochemical appraisal.
Aldehyde Dehydragenase 1 and Nodal as Significant Prognostic Markers in Colorectal Cancer.
Aldehyde dehydrogenase 1 (ALDH1) expression is an independent prognostic factor in triple negative breast cancer (TNBC).
Aldehyde dehydrogenase 1 (ALDH1) expression is associated with a poor prognosis of bladder cancer.
Aldehyde Dehydrogenase 1 (ALDH1) Is a Potential Marker for Cancer Stem Cells in Embryonal Rhabdomyosarcoma.
Aldehyde dehydrogenase 1 (ALDH1) isoform expression and potential clinical implications in hepatocellular carcinoma.
Aldehyde dehydrogenase 1 (ALDH1) positivity correlates with poor prognosis in cervical cancer.
Aldehyde dehydrogenase 1 (ALDH1A1) expression by immunohistochemistry is associated with chemo-refractoriness in patients with high-grade ovarian serous carcinoma.
Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer.
Aldehyde dehydrogenase 1 as a predictor of the neoadjuvant chemotherapy response in breast cancer: A meta-analysis.
Aldehyde dehydrogenase 1 expression correlated with malignant potential of oral lichen planus.
Aldehyde dehydrogenase 1 expression correlates with clinicopathologic features of patients with breast cancer: a meta-analysis.
Aldehyde dehydrogenase 1 expression correlates with the invasion of breast cancer.
Aldehyde dehydrogenase 1 expression has prognostic significance in patients with glioma.
Aldehyde dehydrogenase 1 expression in cancer cells could have prognostic value for patients with non-small cell lung cancer who are treated with neoadjuvant therapy: identification of prognostic microenvironmental factors after chemoradiation.
Aldehyde Dehydrogenase 1 Expression in Inflammatory Breast Cancer as Measured by Immunohistochemical Staining.
Aldehyde dehydrogenase 1 expression in primary and metastatic renal cell carcinoma: an immunohistochemistry study.
Aldehyde dehydrogenase 1 expression is a predictor of poor prognosis in node-positive breast cancers: a long-term follow-up study.
Aldehyde Dehydrogenase 1 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
Aldehyde dehydrogenase 1 expression is correlated with poor prognosis in breast cancer.
Aldehyde Dehydrogenase 1 Expression Predicts Chemoresistance and Poor Clinical Outcomes in Patients with Locally Advanced Cervical Cancer Treated with Neoadjuvant Chemotherapy Prior to Radical Hysterectomy.
Aldehyde dehydrogenase 1 identifies cells with cancer stem cell-like properties in a human renal cell carcinoma cell line.
Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis.
Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer.
Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer.
Aldehyde dehydrogenase 1 is associated with recurrence-free survival but not stem cell-like properties in hepatocellular carcinoma.
Aldehyde dehydrogenase 1 isoenzyme expression as a marker of cancer stem cells correlates to histopathological features in head and neck cancer: A meta-analysis.
Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity.
Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma.
Aldehyde dehydrogenase 1, a potential marker for cancer stem cells in human sarcoma.
Aldehyde dehydrogenase 1-positive cells in axillary lymph node metastases after chemotherapy as a prognostic factor in patients with lymph node-positive breast cancer.
Aldehyde Dehydrogenase 1-related Genes in Triple-negative Breast Cancer Investigated Using Network Analysis.
Aldehyde dehydrogenase 1/epidermal growth factor receptor coexpression is characteristic of a highly aggressive, poor-prognosis subgroup of high-grade serous ovarian carcinoma.
Aldehyde dehydrogenase 1: A specific cancer stem cell marker for human colorectal carcinoma.
Aldehyde dehydrogenase 1A1 and 1A3 isoforms - mechanism of activation and regulation in cancer.
Aldehyde dehydrogenase 1A1 circumscribes high invasive glioma cells and predicts poor prognosis.
Aldehyde dehydrogenase 1A1 confers intrinsic and acquired resistance to gemcitabine in human pancreatic adenocarcinoma MIA PaCa-2 cells.
Aldehyde dehydrogenase 1A1 expression in breast cancer is associated with stage, triple negativity, and outcome to neoadjuvant chemotherapy.
Aldehyde dehydrogenase 1A1 in stem cells and cancer.
Aldehyde dehydrogenase 1A1 increases NADH levels and promotes tumor growth via glutathione/dihydrolipoic acid-dependent NAD
Aldehyde dehydrogenase 1A1 up-regulates stem cell markers in benzo[a]pyrene-induced malignant transformation of BEAS-2B cells.
Aldehyde dehydrogenase 1A3 (ALDH1A3) is regulated by autophagy in human glioblastoma cells.
Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling.
Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer.
Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma.
Aldehyde dehydrogenase 1B1 is a potential marker of colorectal tumors.
Aldehyde Dehydrogenase 1B1 Is Associated with Altered Cell Morphology, Proliferation, Migration and Chemosensitivity in Human Colorectal Adenocarcinoma Cells.
Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer.
Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: Gene-environment interaction.
Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE.
Aldehyde dehydrogenase 2 and glutathione S-transferase M 1 polymorphisms in relation to the risk for oral cancer in Japanese drinkers.
Aldehyde dehydrogenase 2 genotype in tolerability of alcohol contained in paclitaxel in Japanese breast cancer patients.
Aldehyde Dehydrogenase 2 Mediates Alcohol-Induced Colorectal Cancer Immune Escape through Stabilizing PD-L1 Expression.
Aldehyde dehydrogenase 2 protects against acute kidney injury by regulating autophagy via the Beclin-1 pathway.
Aldehyde dehydrogenase 3A1 promotes multi-modality resistance and alters gene expression profile in human breast adenocarcinoma MCF-7 cells.
Aldehyde Dehydrogenase 3B1 (ALDH3B1): Immunohistochemical Tissue Distribution and Cellular-specific Localization in Normal and Cancerous Human Tissues.
Aldehyde dehydrogenase 3B1 (ALDH3B1): immunohistochemical tissue distribution and cellular-specific localization in normal and cancerous human tissues.
Aldehyde dehydrogenase activity as a functional marker for lung cancer.
Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells is Primarily Due to Isoform ALDH1A3 and Its Expression is Predictive of Metastasis.
Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis.
Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma.
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling.
Aldehyde dehydrogenase activity selects for the holoclone phenotype in prostate cancer cells.
Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors.
Aldehyde dehydrogenase is regulated by Beta-catenin/TCF and promotes radioresistance in prostate cancer progenitor cells.
Aldehyde dehydrogenase isoform 1 (ALDH1) expression as a predictor of radiosensitivity in laryngeal cancer.
Aldehyde Dehydrogenase, Liver Disease and Cancer.
Aldehyde Dehydrogenase-1 Expression Predicts Unfavorable Outcomes in Patients with Esophageal Squamous Cell Carcinoma.
Aldehyde dehydrogenase-1 positivity is associated with ER negativity in patients with invasive ductal carcinoma of the breast.
Aldehyde dehydrogenase-2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP-activated protein kinase signaling in mice.
Aldehyde dehydrogenase-2 genotypes and HLA haplotypes in Japanese patients with esophageal cancer.
Aldehyde dehydrogenase-mediated cellular relative insensitivity to the oxazaphosphorines.
Aldehyde dehydrogenase1 immunohistochemical staining in primary breast cancer cells independently predicted overall survival but did not correlate with the presence of circulating or disseminated tumors cells.
Aldehyde dehydrogenase: Its role as a cancer stem cell marker comes down to the specific isoform.
Aldehyde dehydrogenases and cell proliferation.
Aldehyde Dehydrogenases and Prostate Cancer: Shedding Light on Isoform Distribution to Reveal Druggable Target.
Aldehyde dehydrogenases in early stage lung cancer: nuclear expression.
Aldehyde Dehydrogenases: Not Just Markers, but Functional Regulators of Stem Cells.
Aldehyde-dehydrogenase gene-transduced hematopoietic cell line K562 overcomes the cytoxicity of cyclophosphamide in vitro.
ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors.
ALDH1 - A new immunohistochemical diagnostic marker for Schwann cell-derived tumors.
ALDH1 and tumor infiltrating lymphocytes as predictors for neoadjuvant chemotherapy response in breast cancer.
ALDH1 as a Functional Marker of Cancer Stem and Progenitor Cells.
ALDH1 as a prognostic marker for lymph node metastasis in OSCC.
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.
ALDH1 Cancer Stem Cell Marker as a Prognostic Factor in Triple-Negative Breast Cancer.
Aldh1 Expression and Activity Increase During Tumor Evolution in Sarcoma Cancer Stem Cell Populations.
ALDH1 Expression and the Prognosis of Lung Cancer: A Systematic Review and Meta-Analysis.
ALDH1 expression correlates with an epithelial-like phenotype and favorable prognosis in lung adenocarcinoma: a study based on immunohistochemistry and mRNA expression data.
ALDH1 expression correlates with favorable prognosis in ovarian cancers.
ALDH1 expression indicates chemotherapy resistance and poor outcome in node-negative rectal cancer.
ALDH1 expression is enriched in breast cancers arising in young women but does not predict outcome.
ALDH1 expression predicts progression of premalignant lesions to cancer in Type I endometrial carcinomas.
ALDH1 immunohistochemical expression and its significance in salivary adenoid cystic carcinoma.
ALDH1 in Combination with CD44 as Putative Cancer Stem Cell Markers are Correlated with Poor Prognosis in Urothelial Carcinoma of the Urinary Bladder.
ALDH1 is a better clinical indicator for relapse of invasive ductal breast cancer than the CD44+/CD24- phenotype.
ALDH1 is an immunohistochemical diagnostic marker for solitary fibrous tumours and haemangiopericytomas of the meninges emerging from gene profiling study.
ALDH1 might influence the metastatic capability of HeLa cells.
ALDH1-positive cancer stem-like cells are enriched in nodal metastases of oropharyngeal squamous cell carcinoma independent of HPV status.
ALDH1-positive intratumoral stromal cells indicate differentiated epithelial-like phenotype and good prognosis in prostate cancer.
ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors.
ALDH1A1 and HLTF modulate the activity of lysosomal autophagy inhibitors in cancer cells.
ALDH1A1 defines invasive cancer stem-like cells and predicts poor prognosis in patients with esophageal squamous cell carcinoma.
ALDH1A1 expression correlates with clinicopathologic features and poor prognosis of breast cancer patients: a systematic review and meta-analysis.
ALDH1A1 expression is associated with poor differentiation, 'right-sidedness' and poor survival in human colorectal cancer.
ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression.
ALDH1A1 induces resistance to CHOP in diffuse large B-cell lymphoma through activation of the JAK2/STAT3 pathway.
ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome.
ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients.
ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling.
ALDH1A1 maintains the cancer stem-like cells properties of esophageal squamous cell carcinoma by activating the AKT signal pathway and interacting with ?-catenin.
ALDH1A1 mRNA expression in association with prognosis of triple-negative breast cancer.
ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer.
ALDH1A1 positive cells are a unique component of the tonsillar crypt niche and are lost along with NGFR positive stem cells during tumourigenesis.
ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma.
ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors.
ALDH1A2 Is a Candidate Tumor Suppressor Gene in Ovarian Cancer.
ALDH1A2 suppresses epithelial ovarian cancer cell proliferation and migration by downregulating STAT3.
ALDH1A3 affects colon cancer in vitro proliferation and invasion depending on CXCR4 status.
ALDH1A3 correlates with luminal phenotype in prostate cancer.
ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment.
ALDH1A3, a metabolic target for cancer diagnosis and therapy.
ALDH1A3-mTOR axis as a therapeutic target for anticancer drug-tolerant persister cells in gastric cancer.
ALDH1A3: A Marker of Mesenchymal Phenotype in Gliomas Associated with Cell Invasion.
Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.
ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/?-Catenin, Notch and PI3K/Akt Signaling Pathways.
ALDH2 and Cancer Therapy.
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles.
ALDH2 gene polymorphism in different types of cancers and its clinical significance.
Aldh2 gene reduces oxidative stress in the bladder by regulating the NF-?B pathway in a mouse model of ketamine-induced cystitis.
ALDH2 Genotype Has No Effect on Salivary Acetaldehyde without the Presence of Ethanol in the Systemic Circulation.
ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds.
ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective.
ALDH2 Polymorphism and Ethanol Consumption: A Genetic-Environmental Interaction in Carcinogenesis.
ALDH2 polymorphism rs671 is a predictor of PD-1/PD-L1 inhibitor efficacy against thoracic malignancies.
ALDH2 Repression Promotes Lung Tumor Progression via Accumulated Acetaldehyde and DNA Damage.
ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.
ALDH2-deficiency as genetic epidemiologic and biochemical model for the carcinogenicity of acetaldehyde.
ALDH3A1 driving tumor metastasis is mediated by p53/BAG1 in lung adenocarcinoma.
ALDH3A1 is overexpressed in a subset of hepatocellular carcinoma characterised by activation of the Wnt/ß-catenin pathway.
ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output.
Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site.
All-trans retinoic acid downregulates ALDH1-mediated stemness and inhibits tumour formation in ovarian cancer cells.
All-trans retinoic acid targets gastric cancer stem cells and inhibits patient-derived gastric carcinoma tumor growth.
An Effective Primary Head and Neck Squamous Cell Carcinoma In Vitro Model.
An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis.
Androgen Deprivation Induces Transcriptional Reprogramming in Prostate Cancer Cells to Develop Stem Cell-Like Characteristics.
Androgen Receptor and ALDH1 Expression Among Internationally Diverse Patient Populations.
Anlotinib exerts anti-cancer efficiency on lung cancer stem cells in vitro and in vivo through reducing NF-?B activity.
Anti-colorectal cancer biotargets and biological mechanisms of puerarin: Study of molecular networks.
Antitumor activity of potent pyruvate dehydrogenase kinase 4 inhibitors from plants in pancreatic cancer.
Arachidonic acid suppresses growth of human lung tumor A549 cells through down-regulation of ALDH3A1 expression.
Artesunate induces apoptosis and inhibits the proliferation, stemness, and tumorigenesis of leukemia.
Assessment of cancer stem cell marker expression in primary head and neck squamous cell carcinoma shows prognostic value for aldehyde dehydrogenase (ALDH1A1).
Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma.
Association between Glu504Lys Polymorphism of ALDH2 Gene and Cancer Risk: A Meta-Analysis.
Association of aldehyde dehydrogenase 1 expression and biologically aggressive features in breast cancer.
Association of aldehyde dehydrogenase 2 gene polymorphism with pancreatic cancer but not colon cancer.
Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers.
Associations of carboxypeptidase 4 with ALDH1A1 expression and their prognostic value in esophageal squamous cell carcinoma.
Associations of mammographic breast density with breast stem cell marker-defined breast cancer subtypes.
ATG7-mediated autophagy involves in miR-138-5p regulated self-renewal and invasion of lung cancer stem-like cells derived from A549 cells.
Attenuation of p38? MAPK stress response signaling delays the in vivo aging of skeletal muscle myofibers and progenitor cells.
Auramine O, an incense smoke ingredient, promotes lung cancer malignancy.
Author Correction: Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis.
BCMA (TNFRSF17) Induces APRIL and BAFF Mediated Breast Cancer Cell Stemness.
BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer.
Bifunctional Duocarmycin Analogues as Inhibitors of Protein Tyrosine Kinases.
Biochemical and histochemical properties of hepatic tumors of rainbow trout, Oncorhynchus mykiss.
Bioinformatic analysis of differentially expressed genes as prognostic markers in pheochromocytoma and paraganglioma tumors.
Biological evaluation and 3D-QSAR studies of curcumin analogues as aldehyde dehydrogenase 1 inhibitors.
Bisphenol A and polychlorinated biphenyls enhance the cancer stem cell properties of human ovarian cancer cells by activating the WNT signaling pathway.
Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells.
BMI1, ALDH1A1, and CD133 Transcripts Connect Epithelial-Mesenchymal Transition to Cancer Stem Cells in Lung Carcinoma.
Bone Marrow Mesenchymal Stem Cells Promote the Stemness of Hypopharyngeal Cancer Cells.
Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype.
Breast cancer stem cells and intrinsic subtypes: controversies rage on.
Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1.
C/EBP?-1 promotes transformation and chemoresistance in Ewing sarcoma cells.
Can lower aldehyde dehydrogenase activity in saliva be a risk factor for oral cavity cancer?
Cancer Chemopreventive Activities of Silibinin on Colorectal Cancer through Regulation of E-Cadherin/?-Catenin Pathway.
Cancer screening of upper aerodigestive tract in Japanese alcoholics with reference to drinking and smoking habits and aldehyde dehydrogenase-2 genotype.
Cancer stem cell characteristics, ALDH1 expression in the invasive front of nasopharyngeal carcinoma.
Cancer stem cell marker ALDH1 expression is associated with lymph node metastasis and poor survival in esophageal squamous cell carcinoma: a study from high incidence area of northern China.
Cancer stem cell markers ALDH1 and Bmi1 expression in oral erythroplakia revisited: Implication for driving the process of field cancerization.
Cancer stem cell markers ALDH1 and CD44+/CD24- phenotype and their prognosis impact in invasive ductal carcinoma.
Cancer stem cell markers in adenocarcinoma of the salivary glands - reliable prognostic markers?
Cancer stem cell markers in eyelid sebaceous gland carcinoma: high expression of ALDH1, CD133, and ABCG2 correlates with poor prognosis.
Cancer stem cell markers in prostate cancer: an immunohistochemical study of ALDH1, SOX2 and EZH2.
Cancer Stem Cell Markers in Relation to Patient Survival Outcomes: Lessons for Integrative Diagnostics and Next-Generation Anticancer Drug Development.
Cancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by aldehyde dehydrogenase 1 A1 inhibition.
Cancer Stem Cell Properties as Factors Predictive of Chemoresistance in Neoadjuvantly-treated Patients with Ovarian Cancer.
Cancer stem cell related markers of radioresistance in head and neck squamous cell carcinoma.
Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis.
Cancer stem cells in oesophageal squamous cell carcinoma: Identification, prognostic and treatment perspectives.
Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types.
Cancer Stemness, Immune Cells, and Epithelial-Mesenchymal Transition Cooperatively Predict Prognosis in Colorectal Carcinoma.
CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway.
CCR9 Promotes Migration and Invasion of Lung Adenocarcinoma Cancer Stem Cells.
CD133 expression predicts post-operative recurrence in patients with colon cancer with peritoneal metastasis.
CD133 is a useful surrogate marker for predicting chemosensitivity to neoadjuvant chemotherapy in breast cancer.
CD163+ tumor-associated macrophages correlated with poor prognosis and cancer stem cells in oral squamous cell carcinoma.
CD44
CD44 and ALDH1 immunoexpression as prognostic indicators of invasion and metastasis in oral squamous cell carcinoma.
CD44(high) /ALDH1(high) head and neck squamous cell carcinoma cells exhibit mesenchymal characteristics and GSK3?-dependent cancer stem cell properties.
CD44+ cancer cell-induced metastasis: A feasible neck metastasis model.
Celastrol and Triptolide Suppress Stemness in Triple Negative Breast Cancer: Notch as a Therapeutic Target for Stem Cells.
Cell-based selection provides novel molecular probes for cancer stem cells.
Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: a retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens.
Characteristic Genes in Luminal Subtype Breast Tumors with CD44+CD24-/Low Gene Expression Signature.
Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice.
Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures.
Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 Inhibitors.
Chemoradiation therapy reduces aldehyde dehydrogenase 1 expression in cervical cancer but does not improve patient survival.
Chemosensitizing effect of honokiol in oral carcinoma stem cells via regulation of IL-6/Stat3 signaling.
Circulating tumor cells (CTCs) in metastatic breast cancer (MBC): prognosis, drug resistance and phenotypic characterization.
Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer.
Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3.
Clinical features and treatment outcomes of Japanese head and neck cancer patients with a second primary cancer.
Clinical implications of ALDH1A1 and ALDH1A3 mRNA expression in melanoma subtypes.
Clinical implications of cancer stem cells in digestive cancers: acquisition of stemness and prognostic impact.
Clinical influence of cancer stem cells on residual disease after preoperative chemoradiotherapy for rectal cancer.
Clinical prognostic value of combined analysis of Aldh1, Survivin, and EpCAM expression in colorectal cancer.
Clinical significance of a pvrl 4 encoded gene Nectin-4 in metastasis and angiogenesis for tumor relapse.
Clinical significance of ALDH1 combined with DAPI expression in patients with esophageal carcinoma.
Clinical significance of ALDH2 rs671 polymorphism in esophageal cancer: evidence from 31 case-control studies.
Clinical-pathologic significance of cancer stem cell marker expression in familial breast cancers.
Clinicopathological analysis of breast ductal carcinoma in situ with ALDH1-positive cancer stem cells.
Clinicopathological characteristics and prognostic value of the cancer stem cell marker ALDH1 in ovarian cancer: a meta-analysis.
Clinicopathological correlation of stem cell markers expression in oral squamous cell carcinoma; relation to patients` outcome.
Clinicopathological features to distinguish malignant solitary fibrous tumors of the prostate from prostatic stromal tumors.
Clinicopathological significance of ALDH1A1 in lung, colorectal, and breast cancers: a meta-analysis.
Clinicopathological significance of cancer stem cell markers CD44 and ALDH1 expression in breast cancer.
Clinicopathological Significance of CD133 and ALDH1 Cancer Stem Cell Marker Expression in Invasive Ductal Breast Carcinoma.
Clinicopathological Significance of Tumor Stem Cell Markers ALDH1 and CD133 in Colorectal Carcinoma.
Co-detection of ALDH1A1, ABCG2, ALCAM and CD133 in three A549 subpopulations at the single cell level by one-step digital RT-PCR.
Colorectal cancer-derived tumor spheroids retain the characteristics of original tumors.
Combination of Cancer Stem Cell Markers CD44 and CD24 Is Superior to ALDH1 as a Prognostic Indicator in Breast Cancer Patients with Distant Metastases.
Combination of dasatinib and gemcitabine reduces the ALDH1A1 expression and the proliferation of gemcitabine-resistant pancreatic cancer MIA PaCa-2 cells.
Comparative evaluation of cancer stem cell markers in normal pancreas and pancreatic ductal adenocarcinoma.
Comparative expression analysis of putative cancer stem cell markers CD44 and ALDH1A1 in various skin cancer subtypes.
Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population.
Comparison of hybrid clones derived from human breast epithelial cells and three different cancer cell lines regarding in vitro cancer stem/ initiating cell properties.
Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer.
Comparison of the PI3KCA pathway in circulating tumor cells and corresponding tumor tissue of patients with metastatic breast cancer.
Complex Behavior of ALDH1A1 and IGFBP1 in Liver Metastasis from a Colorectal Cancer.
Comprehensive DNA Methylation Analysis Reveals a Common Ten-Gene Methylation Signature in Colorectal Adenomas and Carcinomas.
Comprehensive in situ analysis of ALDH1 and SOX2 reveals increased expression of stem cell markers in high-grade serous carcinomas compared to low-grade serous carcinomas and atypical proliferative serous tumors.
Comprehensive prognostic analysis in breast cancer integrating clinical, tumoral, micro-environmental and immunohistochemical criteria.
Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men.
Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse-type gastric carcinoma-initiating cells is inhibited by TGF-?
Correction to: Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1?/VEGF signalling in MCF-7 breast cancer cells.
Correlations of aldehyde dehydrogenase-1 (ALDH1) expression with traditional prognostic parameters and different molecular subtypes of breast carcinoma.
Cryptotanshinone attenuates the stemness of non-small cell lung cancer cells via promoting TAZ translocation from nuclear to cytoplasm.
CSN6-TRIM21 axis instigates cancer stemness during tumorigenesis.
Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44(+)ALDH1(+) cells.
Cytokeratin 19 (KRT19) has a Role in the Reprogramming of Cancer Stem Cell-Like Cells to Less Aggressive and More Drug-Sensitive Cells.
DCLK1 Inhibition Sensitizes Colorectal Cancer Cells to Radiation Treatment.
DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1.
DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene.
Deep-Red/Near-Infrared Turn-On Fluorescence Probes for Aldehyde Dehydrogenase 1A1 in Cancer Stem Cells.
Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP.
Destruxin B Suppresses Drug-Resistant Colon Tumorigenesis and Stemness Is Associated with the Upregulation of miR-214 and Downregulation of mTOR/?-Catenin Pathway.
Detection of ALDH1 activity in rabbit hepatic VX2 tumors and isolation of ALDH1 positive cancer stem cells.
Detention and Identification of Cancer Stem Cells in Esophageal Squamous Cell Carcinoma.
Development of a prediction model and estimation of cumulative risk for upper aerodigestive tract cancer on the basis of the aldehyde dehydrogenase 2 genotype and alcohol consumption in a Japanese population.
Development of new disulfiram analogues as ALDH1a1-selective inhibitors.
Development of Selective Inhibitors for Human Aldehyde Dehydrogenase 3A1 (ALDH3A1) for the Enhancement of Cyclophosphamide Cytotoxicity.
Differences in expression of the cancer stem cell marker aldehyde dehydrogenase 1 among estrogen receptor-positive/human epidermal growth factor receptor type 2-negative breast cancer cases with early, late, and no recurrence.
Differential diagnosis of solitary fibrous tumors: A study of 454 soft tissue tumors indicating the diagnostic value of nuclear STAT6 relocation and ALDH1 expression combined with in situ proximity ligation assay.
Differential effects of drugs targeting cancer stem cell (CSC) and non-CSC populations on lung primary tumors and metastasis.
Differential expression of aldehyde dehydrogenase 1a1 (ALDH1) in normal ovary and serous ovarian tumors.
Differential Expression of Cancer Stem Cell Markers ALDH1 and CD133 in Various Lung Cancer Subtypes.
Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis.
Discovery and development of selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors.
Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity.
Discovery of novel regulators of aldehyde dehydrogenase isoenzymes.
Discrimination of Cancer Stem Cell Markers ALDH1A1, BCL11B, BMI-1, and CD44 in Different Tissues of HNSCC Patients.
Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells.
Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers.
Distinct patterns of promoter CpG island methylation of breast cancer subtypes are associated with stem cell phenotypes.
Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer.
Distinct prognostic values of ALDH1 isoenzymes in breast cancer.
Distribution of ADH1B, ALDH2, CYP2E1 *6, and CYP2E1 *7B genotypes in Turkish population.
Disulfiram targets cancer stem-like properties and the HER2/Akt signaling pathway in HER2-positive breast cancer.
Diversified expression of aryl hydrocarbon receptor dependent genes in human laryngeal squamous cell carcinoma cell lines treated with ?-naphthoflavone.
DKK1 maintained cancer stem-like properties of esophageal carcinoma cells via ALDH1A1/SOX2 axis.
Double-Negative Feedback Loop between Reprogramming Factor LIN28 and microRNA let-7 Regulates Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells.
Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15.
Downexpression of aldehyde dehydrogenase 1 in murine lung tumors.
Downregulation of ALDH1A1 expression in non-small cell lung carcinomas--its clinicopathologic and biological significance.
Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer.
DOXIL when combined with Withaferin A (WFA) targets ALDH1 positive cancer stem cells in ovarian cancer.
Doxorubicin and ?-Mangostin oppositely affect luminal breast cancer cell stemness evaluated by a new retinaldehyde-dependent ALDH assay in MCF-7 tumor spheroids.
Drastic morphological and molecular differences between lymph node micrometastatic tumors and macrometastatic tumors of lung adenocarcinoma.
Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer.
Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells.
DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties.
DUSP9-mediated reduction of pERK1/2 supports cancer stem cell-like traits and promotes triple negative breast cancer.
Effect of aerobic exercise on acquired gefitinib resistance in lung adenocarcinoma.
Effect of aldehyde dehydrogenase inhibitors on the ex vivo sensitivity of human multipotent and committed hematopoietic progenitor cells and malignant blood cells to oxazaphosphorines.
Effect of ALDH1 on prognosis and chemoresistance by breast cancer subtype.
Effect of ALDH2 polymorphism on cancer risk in Asians: A meta-analysis.
Effect of As2O3 on colorectal CSCs stained with ALDH1 in primary cell culture in vitro.
Effect of chemotherapy on cancer stem cells and tumor-associated macrophages in a prospective study of preoperative chemotherapy in soft tissue sarcoma.
Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice.
Effects of ADH1B and ALDH2 Genetic Polymorphisms on Alcohol Elimination Rates and Salivary Acetaldehyde Levels in Intoxicated Japanese Alcoholic Men.
Effects of Apatinib on the "Stemness" of Non-Small-Cell Lung Cancer Cells In Vivo and Its Related Mechanisms.
Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice.
Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung.
Efficient isolation, culture, purification, and stem cell expression profiles of primary tumor cells derived from uterine cervical squamous cell carcinoma.
EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect.
Ell3 stimulates proliferation, drug resistance, and cancer stem cell properties of breast cancer cells via a MEK/ERK-dependent signaling pathway.
Emerging targets for glioblastoma stem cell therapy.
EMP2 is a novel therapeutic target for endometrial cancer stem cells.
Enrichment and characterization of cancer stem?like cells from a cervical cancer cell line.
Epigenetic modifications of gene expression by lifestyle and environment.
Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer.
Epithelial membrane protein 3 regulates lung cancer stem cells via the TGF?? signaling pathway.
Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm.
Eprinomectin, a novel semi-synthetic macrocylic lactone is cytotoxic to PC3 metastatic prostate cancer cells via inducing apoptosis.
Epstein-Barr virus latent membrane protein 1 (LMP1) regulates the aldehyde dehydrogenase (ALDH) positive cell population in nasopharyngeal carcinoma cell lines.
Esculentoside A suppresses breast cancer stem cell growth through stemness attenuation and apoptosis induction by blocking IL-6/STAT3 signaling pathway.
Esophageal melanosis, an endoscopic finding associated with squamous cell neoplasms of the upper aerodigestive tract, and inactive aldehyde dehydrogenase-2 in alcoholic Japanese men.
Esophageal squamous cell carcinoma and aldehyde dehydrogenase-2 genotypes in Japanese females.
Ethanol-induced oxidative DNA damage and CYP2E1 expression in liver tissue of Aldh2 knockout mice.
Evaluation of a developmental hierarchy for breast cancer cells to assess risk-based patient selection for targeted treatment.
Evaluation of ALDH1 expression in ipsilateral breast cancer recurrence.
Evaluation of expression of cancer stem cell markers and fusion gene in synovial sarcoma: Insights into histogenesis and pathogenesis.
Evaluation of spice and herb as phyto-derived selective modulators of human retinaldehyde dehydrogenases using a simple in vitro method.
Evaluation of the correlation of vasculogenic mimicry, ALDH1, KAI1 and microvessel density in the prediction of metastasis and prognosis in colorectal carcinoma.
Evaluation of the correlation of vasculogenic mimicry, ALDH1, KiSS-1, and MACC1 in the prediction of metastasis and prognosis in ovarian carcinoma.
Evaluation of the Role of ALDH1 as Cancer Stem Cell Marker in Colorectal Carcinoma: An Immunohistochemical Study.
Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract.
Evolving views of breast cancer stem cells and their differentiation States.
Exploration of bladder cancer molecular mechanisms based on miRNA-mRNA regulatory network.
Expression Analysis of Aldehyde Dehydrogenase 1A1 (ALDH1A1) in Colon and Rectal Cancer in Association with Prognosis and Response to Chemotherapy.
Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma.
Expression and functional role of ALDH1 in cervical carcinoma cells.
Expression and prognostic value of the aldehyde dehydrogenase 1 (ALDH1) and N-myc downstream regulated gene 2 (NDRG2) as potential markers in human astrocytomas.
Expression and prognostic value of tumor stem cell markers ALDH1 and CD133 in colorectal carcinoma.
Expression of ALCAM (CD166) and PD-L1 (CD274) independently predicts shorter survival in malignant pleural mesothelioma.
Expression of Aldehyde Dehydrogenase (ALDH1) and ATP Binding Cassette Transporter G2 (ABCG2) in Iraqi Patients with Colon Cancer and the Relation with Clinicopathological Features.
Expression of aldehyde dehydrogenase 1 (ALDH1) in endometrioid adenocarcinoma and its clinical implications.
Expression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer.
Expression of aldehyde dehydrogenase 1 as a marker of mammary stem cells in benign and malignant breast lesions of Ghanaian women.
Expression of Aldehyde Dehydrogenase 1A1 (ALDH1A1) as a Prognostic Biomarker in Colorectal Cancer Using Immunohistochemistry.
Expression of ALDH1 and TGF?2 in benign and malignant breast tumors and their prognostic implications.
Expression of ALDH1 in breast invasive ductal carcinoma: an independent predictor of early tumor relapse.
Expression of ALDH1A Isozymes in Human Endometrium with and without Endometriosis and in Ovarian Endometrioma.
Expression of ALDH1A1 and CD133 is associated with the prognosis and effect of different chemotherapeutic regimens in gastric cancer.
Expression of ALDH1A1 and CD44 in primary head and neck squamous cell carcinoma and their value for carcinogenesis, tumor progression and cancer stem cell identification.
Expression of Androgen Receptor and Cancer Stem Cell Markers (CD44+/CD24- and ALDH1+): Prognostic Implications in Invasive Breast Cancer.
Expression of breast cancer stem cell markers as predictors of prognosis and response to trastuzumab in HER2-positive breast cancer.
Expression of cancer stem cell marker during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Expression of cancer stem cell markers ALDH1 and Bmi1 in oral erythroplakia and the risk of oral cancer.
Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer.
Expression of cancer stem cell markers and their correlation with pathogenesis in vascular tumors.
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer.
Expression of cancer stem cell markers in tall cell variant papillary thyroid cancer identifies a molecular profile predictive of recurrence in classic papillary thyroid cancer.
Expression of cancer stem cell markers is prognostic in metastatic gastroesophageal adenocarcinoma.
Expression of CD133 in endometrial cancer cells and its implications.
Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells.
Expression of stem cell markers as useful complementary factors in the early detection of urinary bladder carcinogens by immunohistochemistry for ?-H2AX.
Expression of the potential cancer stem cell markers, CD133, CD44, ALDH1, and ?-catenin, in primary lung adenocarcinoma--their prognostic significance.
Expression patterns of cancer stem cell markers ALDH1 and CD133 correlate with a high risk of malignant transformation of oral leukoplakia.
Expression Profile of Genes Related to Drug Metabolism in Human Brain Tumors.
EZH2 and ALDH1 expression in ductal carcinoma in situ: complex association with recurrence and progression to invasive breast cancer.
Faciogenital dysplasia 5 confers the cancer stem cell-like traits of gastric cancer cells through enhancing Sox2 protein stability.
Fibulin-3 negatively regulates ALDH1 via c-MET suppression and increases ?-radiation-induced sensitivity in some pancreatic cancer cell lines.
FL118, a novel survivin inhibitor, wins the battle against drug-resistant and metastatic lung cancers through inhibition of cancer stem cell-like properties.
Flubendazole elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition.
Folate, alcohol, ADH1B and ALDH2 and colorectal cancer risk.
Formation of acetaldehyde-derived DNA adducts due to alcohol exposure.
Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts.
FUBP1 promotes colorectal cancer stemness and metastasis via DVL1-mediated activation of Wnt/?-catenin signaling.
Ganoderma lucidum extract (GLE) impairs breast cancer stem cells by targeting the STAT3 pathway.
GAPDH and PUM1: Optimal Housekeeping Genes for Quantitative Polymerase Chain Reaction-Based Analysis of Cancer Stem Cells and Epithelial-Mesenchymal Transition Gene Expression in Rectal Tumors.
Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation.
Gastric Adenocarcinoma Biomarker Expression Profiles and their Prognostic Value.
Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation.
Gene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells.
Genetic polymorphism of aldehyde dehydrogenase 2 in patients with upper aerodigestive tract cancer.
Genetic Polymorphism of Aldehyde Dehydrogenase 2 in Patients With Upper Aerodigestive Tract Cancer.
Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers.
Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma.
Genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2, alcohol flushing, mean corpuscular volume, and aerodigestive tract neoplasia in Japanese drinkers.
Genetic polymorphisms of ALDH2 are associated with lumbar disc herniation in a Chinese Han population.
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer.
Genotype announcement in a genetic polymorphism study for health checkup examinees at Nagoya University Hospital.
Glioma-associated oncogene homolog 1 stimulates FOXP3 to promote non-small cell lung cancer stemness.
Glu504Lys Single Nucleotide Polymorphism of Aldehyde Dehydrogenase 2 Gene and the Risk of Human Diseases.
Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells.
GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis.
Hallmarks of the cancer cell of origin: Comparisons with "energetic" cancer stem cells (e-CSCs).
Heavy alcohol drinking downregulates ALDH2 gene expression but heavy smoking up-regulates SOD2 gene expression in head and neck squamous cell carcinoma.
Hedgehog signaling pathway molecules and ALDH1A1 expression in early-stage non-small cell lung cancer.
Helicobacter pylori, chronic atrophic gastritis, inactive aldehyde dehydrogenase-2, macrocytosis and multiple upper aerodigestive tract cancers and the risk for gastric cancer in alcoholic Japanese men.
Heme oxygenase 1 protects ethanol-administered liver tissue in Aldh2 knockout mice.
Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer.
Heterogeneity of vascular and progenitor cell compartments in tumours from MMTV-PyVmT transgenic mice during mammary cancer progression.
High ALDH1 expression correlates with better prognosis in tumorigenic malignant melanoma.
High ALDH1A1 expression correlates with poor survival in papillary thyroid carcinoma.
High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis.
High expression of ALDH1A3 might independently influence poor progression-free and overall survival in patients with glioma via maintaining glucose uptake and lactate production.
High Expression of c-Met, PKC? and ALDH1A3 Predicts a Poor Prognosis in Late-stage Breast Cancer.
High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in the novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma.
High Expression of Stem Cell Marker ALDH1 is Associated with Reduced BRCA1 in Invasive Breast Carcinomas.
High Expressions of Lgr5 and ALDH1 in Primary Epithelial Ovarian Cancer Correlate with Advanced Tumor Stage and Grade as well as Poor Prognosis of the Patients.
High FOXK1 expression correlates with poor outcomes in hepatocellular carcinoma and regulates stemness of hepatocellular carcinoma cells.
High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling.
High PKC? expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients.
High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism.
Histopathological findings and immunohistochemical expression of the stem cell markers CD44, ALDH1, Bmi-1, and Nanog in oral solitary fibrous tumors.
HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances.
Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties.
Hypoglycemia in a Patient With a Polyhormonal Pancreatic Neuroendocrine Tumor With Evidence of Endocrine Progenitors.
Hypoxia upregulates aldehyde dehydrogenase isoform 1 (ALDH1) expression and induces functional stem cell characteristics in human glioblastoma cells.
Identification of ALDH1A3 as a viable therapeutic target in breast cancer metastasis-initiating cells.
Identification of cancer-type specific expression patterns for active aldehyde dehydrogenase (ALDH) isoforms in ALDEFLUOR assay.
Identification of differentially-expressed genes by DNA methylation in cervical cancer.
Identification of Human Aldehyde Dehydrogenase 1 Family Member A1 as a Novel CD8+ T-Cell Defined Tumor Antigen in Squamous Cell Carcinoma of the Head and Neck.
Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma.
Identification of pancreatic cancer invasion-related proteins by proteomic analysis.
Identification of potential genes associated with ALDH1A1 overexpression and cyclophosphamide resistance in chronic myelogenous leukemia using network analysis.
Identifying and targeting cancer stem cells in leiomyosarcoma: prognostic impact and role to overcome secondary resistance to PI3K/mTOR inhibition.
Identifying genetic variation for alcohol dependence.
IL-33 facilitates endocrine resistance of breast cancer by inducing cancer stem cell properties.
Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells.
Immunohistochemical analysis of aldehyde dehydrogenase isoforms and their association with estrogen-receptor status and disease progression in breast cancer.
Immunohistochemical Expression of CD56 and ALDH1 in Common Salivary Gland Tumors.
Immunolocalization of Cancer Stem Cells Marker ALDH1 and its Association with Tumor Budding in Oral Squamous Cell Carcinoma.
Impact of diabetes type II and chronic inflammation on pancreatic cancer.
Impact of Multiple Alcohol Dehydrogenase Gene Polymorphisms on Risk of Upper Aerodigestive Tract Cancers in a Japanese Population.
Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.
Importance of inverse correlation between ALDH3A1 and PPAR? in tumor cells and tissue regeneration.
In phyllodes tumour of the breast expression of c-kit but not of ALDH1A1 is associated with adverse clinico-pathological features.
In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis.
In vitro and in vivo expression of aldehyde dehydrogenase 1 in oral squamous cell carcinoma.
In Vivo Study on the Effects of Xiaoaiping on the Stemness of Hepatocellular Carcinoma Cells.
Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population.
Inclusion of a gene-environment interaction between alcohol consumption and the aldehyde dehydrogenase 2 genotype in a risk prediction model for upper aerodigestive tract cancer in Japanese men.
Increased DNA damage in ALDH2-deficient alcoholics.
Increased expression of aldehyde dehydrogenase 1 A1 in nasopharyngeal carcinoma is associated with enhanced invasiveness.
Increased Expression of ALDH1A1 in Prostate Cancer is Correlated With Tumor Aggressiveness: A Tissue Microarray Study of Iranian Patients.
Increased expression of ALDH1A1 protein is associated with poor prognosis in clear cell renal cell carcinoma.
Increased levels of active c-Src distinguish invasive from in situ lobular lesions.
Increasing the number of thyroid lesions classes in microarray analysis improves the relevance of diagnostic markers.
Induced Expression of Cancer Stem Cell Markers ALDH1A3 and Sox-2 in Hierarchical Reconstitution of Apoptosis-resistant Human Breast Cancer Cells.
Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer.
Inflammation-Related DNA Damage and Cancer Stem Cell Markers in Nasopharyngeal Carcinoma.
Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders.
Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas.
Inhibition of aldehyde dehydrogenase 1 enhances the cytotoxic effect of retinaldehyde on A549 cancer cells.
Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues.
Inhibition of tumorigenicity and enhancement of radiochemosensitivity in head and neck squamous cell cancer-derived ALDH1-positive cells by knockdown of Bmi-1.
Inhibition of Wnt/?-catenin pathway by niclosamide: a therapeutic target for ovarian cancer.
Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells.
Inhibitory effect of Nodal on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma of uterus.
Insight into the Structural Requirements of Theophylline-Based Aldehyde Dehydrogenase lAl (ALDHlAl) Inhibitors Through Multi-QSAR Modeling and Molecular Docking Approaches.
Interleukin-1 and tumor necrosis factor alpha induce class 1 aldehyde dehydrogenase mRNA and protein in bone marrow cells.
Interplay between APC and ALDH1B1 in a newly developed mouse model of colorectal cancer.
Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients.
In Vivo Expansion of Cancer Stemness Affords Novel Cancer Stem Cell Targets: Malignant Rhabdoid Tumor as an Example.
Isolation of head and neck squamous carcinoma cancer stem-like cells in a syngeneic mouse model and analysis of hypoxia effect.
Key role of local acetaldehyde in upper GI tract carcinogenesis.
Lipid Peroxidation Plays an Important Role in Chemotherapeutic Effects of Temozolomide and the Development of Therapy Resistance in Human Glioblastoma.
lncRNA BORG:TRIM28 Complexes Drive Metastatic Progression by Inducing a6 Integrin/CD49f Expression in Breast Cancer Stem Cells.
Long non-coding RNA SNHG20 promotes the tumorigenesis of oral squamous cell carcinoma via targeting miR-197/LIN28 axis.
Long noncoding RNA MACC1-AS1 promotes the stemness of nonsmall cell lung cancer cells through promoting UPF1-mediated destabilization of LATS1/2.
Loss of ALDH1A1 expression is an early event in the pathogenesis of ovarian high-grade serous carcinoma.
Loss of ARID1A induces a stemness gene ALDH1A1 expression with histone acetylation in the malignant subtype of cholangiocarcinoma.
Loss of expression of the cancer stem cell marker aldehyde dehydrogenase 1 correlates with advanced-stage colorectal cancer.
Loss of N-Cadherin Expression in Tumor Transplants Produced From As+3- and Cd+2-Transformed Human Urothelial (UROtsa) Cell Lines.
Low expression of aldehyde dehydrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer.
Low P16INK4A Expression Associated with High Expression of Cancer Stem Cell Markers Predicts Poor Prognosis in Cervical Cancer after Radiotherapy.
Markers and Reporters to Reveal the Hierarchy in Heterogeneous Cancer Stem Cells.
Measurement of Aldehyde Dehydrogenase 1 Expression Defines a Group with Better Prognosis in Patients with Non-Small Cell Lung Cancer.
Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM.
Mesenchymal Stem/Stromal Cell Engulfment Reveals Metastatic Advantage in Breast Cancer.
Mesothelin blockage by Amatuximab suppresses cell invasiveness, enhances gemcitabine sensitivity and regulates cancer cell stemness in mesothelin-positive pancreatic cancer cells.
Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches.
Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma.
Metastasis of Cancer Stem Cells Developed in the Microenvironment of Hepatocellular Carcinoma.
Metastasis-associated in colon cancer-1 and aldehyde dehydrogenase 1 are metastatic and prognostic biomarker for non-small cell lung cancer.
Methylation-Induced Silencing of ALDH2 Facilitates Lung Adenocarcinoma Bone Metastasis by Activating the MAPK Pathway.
MicroRNA expression profiles of cancer stem cells in head and neck squamous cell carcinoma.
MicroRNA-761 suppresses tumor progression in osteosarcoma via negatively regulating ALDH1B1.
MicroRNAs overexpressed in ovarian ALDH1-positive cells are associated with chemoresistance.
Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer.
miR-155, identified as anti-metastatic by global miRNA profiling of a metastasis model, inhibits cancer cell extravasation and colonization in vivo and causes significant signaling alterations.
Modeling the effects of hyaluronic acid degradation on the regulation of human astrocyte phenotype using multicomponent interpenetrating polymer networks (mIPNs).
Modulation of tumor stem cell characteristics by 17?-estradiol in human mesenchymal stem cells derived from ovarian endometrioma.
Molecular epidemiology of preterm delivery: methodology and challenges.
Molecular organization of the Escherichia coli gab cluster: nucleotide sequence of the structural genes gabD and gabP and expression of the GABA permease gene.
Monitoring the response of urothelial precancerous lesions to Bacillus Calmette-Guerin at the proteome level in an in vivo rat model.
Montelukast, a CysLT1 receptor antagonist, reduces colon cancer stemness and tumor burden in a mouse xenograft model of human colon cancer.
Morusin inhibits human cervical cancer stem cell growth and migration through attenuation of NF-?B activity and apoptosis induction.
MUC1-C drives stemness in progression of colitis to colorectal cancer.
Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p.
Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers.
Multiple machine learning models combined with virtual screening and molecular docking to identify selective human ALDH1A1 inhibitors.
Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase-2 genotype of Japanese alcoholics.
Musashi-1 Expression is a Prognostic Factor in Ovarian Adenocarcinoma and Correlates with ALDH-1 Expression.
Nano Let?7b sensitization of eliminating esophageal cancer stem?like cells is dependent on blockade of Wnt activation of symmetric division.
NEDD9 promotes oncogenic signaling, a stem/mesenchymal gene signature, and aggressive ovarian cancer growth in mice.
NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma.
Neuregulin-1-?1 and ?-secretase play a critical role in sphere-formation and cell survival of urothelial carcinoma cancer stem-like cells.
Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancer.
New and Old Genes Associated with Primary and Established Responses to Paclitaxel Treatment in Ovarian Cancer Cell Lines.
NOR1 Suppresses Cancer Stem-Like Cells Properties of Tumor Cells via the Inhibition of the AKT-GSK-3?-Wnt/?-catenin-ALDH1A1 Signal Circuit.
Normal and neoplastic urothelial stem cells: getting to the root of the problem.
NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells.
Novel biomarker candidates for the diagnosis of ovarian clear cell carcinoma.
Novel composite drug delivery system as a novel radio sensitizer for the local treatment of cervical carcinoma.
Novel prognostic markers revealed by a proteomic approach separating benign from malignant insulinomas.
Nrf2 Depletion Sensitizes Pancreatic Cancer Cells to Gemcitabine via Aldehyde Dehydrogenase 3a1 Repression.
Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer.
Objective analysis of cancer stem cell marker expression using immunohistochemistry.
Oncogenic targets Mmp7, S100a9, Nppb and Aldh1a3 from transcriptome profiling of FAP and Pirc adenomas are downregulated in response to tumor suppression by Clotam.
Oncolytic vaccinia virus GLV-1h68 strain shows enhanced replication in human breast cancer stem-like cells in comparison to breast cancer cells.
Oncorequisite role of an aldehyde dehydrogenase in the pathogenesis of T-cell acute lymphoblastic leukemia.
Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy.
Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma.
Overexpression of ALDH1 and EMT marker profile are linked with unfavorable outcome in head and neck cancer.
Overexpression of CYP3A4 in a COLO 205 Colon Cancer Stem Cell Model in vitro.
Overexpression of RRM2 is related to poor prognosis in oral squamous cell carcinoma.
Overexpression of stem cell associated ALDH1A1, a target of the leukemogenic transcription factor TLX1/HOX11, inhibits lymphopoiesis and promotes myelopoiesis in murine hematopoietic progenitors.
P-Cadherin is Co-Expressed with Cd44 and Cd49f and Mediates Stem Cell Properties in Basal-Like Breast Cancer.
p21CIP1 Promotes Mammary Cancer-Initiating Cells via Activation of Wnt/TCF1/CyclinD1 Signaling.
P2Y2R has a significant correlation with Notch-4 in patients with breast cancer.
p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma.
p63 Cytoplasmic Aberrance is Associated with High Prostate Cancer Stem Cell Expression.
Patient-derived cell lines and orthotopic mouse model of peritoneal carcinomatosis recapitulate molecular and phenotypic features of human gastric adenocarcinoma.
Patterns of stemness-associated markers in the development of castration-resistant prostate cancer.
Phenethyl Isothiocyanate Exposure Promotes Oxidative Stress and Suppresses Sp1 Transcription Factor in Cancer Stem Cells.
Phenotypic and microRNA characterisation of the neglected CD24+ cell population in MCF-7 breast cancer 3D spheroid culture.
Phenotypic and microRNA characterization of the neglected CD24+ cell population in MCF-7 breast cancer 3-dimensional spheroid culture.
Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer.
Pivotal role of CD38 biomarker in combination with CD24, EpCAM, and ALDH for identification of H460 derived lung cancer stem cells.
PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation.
PO-52 - Effect of tissue factor expression by colorectal cancer on cancer stem cell activity.
PODXL2 maintains cellular stemness and promotes breast cancer development through the Rac1/Akt pathway.
Polymethoxylated Flavones Target Cancer Stemness and Improve the Antiproliferative Effect of 5-Fluorouracil in a 3D Cell Model of Colorectal Cancer.
Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men.
Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.
Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease.
Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance.
Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications.
Potential Involvement of Jagged1 in Metastatic Progression of Human Breast Carcinomas.
PPARgamma-mediated ALDH1A3 suppression exerts anti-proliferative effects in lung cancer by inducing lipid peroxidation.
Predictive Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio in Head and Neck Squamous Cell Carcinoma.
Preventive medical services not covered by public health insurance at Daiko Medical Center in Japan, 2004-2011.
Prognostic Impact and Clinicopathological Correlation of CD133 and ALDH1 Expression in Invasive Breast Cancer.
Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment.
Prognostic impact of the cancer stem cell related markers ALDH1 and EZH2 in triple negative and basal-like breast cancers.
Prognostic impact of the expression of ALDH1 and SOX2 in urothelial cancer of the upper urinary tract.
Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer.
Prognostic impact of the putative cancer stem cell markers ABCG2, CD133, ALDH1A1 and CD44V7/8 in metastatic melanoma.
Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer.
Prognostic significance of ABCB1 in stage I lung adenocarcinoma.
Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma.
Prognostic Significance of CD44v6, CD133, CD166, and ALDH1 Expression in Small Intestinal Adenocarcinoma.
Prognostic Significance of TWIST1, CD24, CD44, and ALDH1 Transcript Quantification in EpCAM-Positive Circulating Tumor Cells from Early Stage Breast Cancer Patients.
Prognostic value of aldehyde dehydrogenase 1 (ALDH1) in invasive breast carcinomas.
Prognostic value of ALDH1 and Nestin in advanced cancer: a systematic meta-analysis with trial sequential analysis.
Prognostic value of ALDH1 expression in lung cancer: a meta-analysis.
Prognostic Value of Cancer Stem Cell Marker ALDH1 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis.
Prognostic Value of Cancer Stem Cells Markers in Triple-Negative Breast Cancer.
Prognostic value of the expression of cancer stem cell-related markers CD133 and CD44 in hepatocellular carcinoma: From patients to patient-derived tumor xenograft models.
Prognostic values of aldehyde dehydrogenase 1 isoenzymes in ovarian cancer.
Prohibitin identified by proteomic analysis of prostate biopsies distinguishes hyperplasia and cancer.
Proliferation rate and breast cancer subtype, but not ALDH1 expression, predict pathological response to neoadjuvant chemotherapy in locally advanced breast cancer.
Proline?rich polypeptide?1 decreases cancer stem cell population by targeting BAFF chromatin?remodeling complexes in human chondrosarcoma JJ012 cells.
Prostate Tumor Overexpressed-1 (PTOV1) promotes docetaxel-resistance and survival of castration resistant prostate cancer cells.
Proteomic-based biosignatures in breast cancer classification and prediction of therapeutic response.
PTPRK Expression Is Downregulated in Drug Resistant Ovarian Cancer Cell Lines, and Especially in ALDH1A1 Positive CSCs-Like Populations.
Pulmonary carcinosarcoma characterized by small round cells with neuroendocrine, myogenic, and chondrogenic differentiation: An extremely rare case.
Putative stem cell markers in cervical squamous cell carcinoma are correlated with poor clinical outcome.
Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM).
RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance.
Radioimmunotherapy for CD133(+) colonic cancer stem cells inhibits tumor development in nude mice.
RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis.
Rational Design of a Red Fluorescent Sensor for ALDH1A1 Displaying Enhanced Cellular Uptake and Reactivity.
Rationales for the Use of Cancer Stem Cells Markers in the Staging of Papillary Thyroid Carcinoma.
Re-purposing of curcumin as an anti-metastatic agent for the treatment of epithelial ovarian cancer: in vitro model using cancer stem cell enriched ovarian cancer spheroids.
Relevance of mortalin to cancer cell stemness and cancer therapy.
Reliability of a flushing questionnaire and the ethanol patch test in screening for inactive aldehyde dehydrogenase-2 and alcohol-related cancer risk.
Renal cell carcinoma with synchronous ipsilateral urothelial carcinoma of the renal pelvis.
Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate.
Reporter gene systems for the identification and characterization of cancer stem cells.
Reporters of Cancer Stem Cells as a Tool for Drug Discovery.
Retinoid resistance and multifaceted impairment of retinoic acid synthesis in glioblastoma.
Retinoid signaling regulates breast cancer stem cell differentiation.
Reversal of cisplatin sensitization and abrogation of cisplatin-enriched cancer stem cells in 5-8F nasopharyngeal carcinoma cell line through a suppression of Wnt/?-catenin-signaling pathway.
Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis.
Role of ALDH1 in the prognosis of esophageal cancer and its relationship with tumor microenvironment.
Role of cancer stem cell markers ALDH1, BCL11B, BMI-1, and CD44 in the prognosis of advanced HNSCC.
Role of leucine-rich pentatricopeptide repeat motif-containing protein (LRPPRC) for anti-apoptosis and tumourigenesis in cancers.
Roles of defective ALDH2 polymorphism on liver protection and cancer development.
ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.
Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway.
Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype.
Salivary gland cancer patient-derived xenografts enable characterization of cancer stem cells and new gene fusions associated with tumor progression.
Screening of potentially crucial genes and regulatory factors involved in epithelial ovarian cancer using microarray analysis.
Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness.
Selection of radioresistant tumor cells and presence of ALDH1 activity in vitro.
Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells.
Serum ALDH1A1 is a tumor marker for the diagnosis of non-small cell lung cancer.
SGCE Promotes Breast Cancer Stem Cells by Stabilizing EGFR.
Short-term follow-up after endoscopic mucosectomy of early esophageal cancer and aldehyde dehydrogenase-2 genotype in Japanese alcoholics.
Significant association between decreased ALDH2 activity and increased sensitivity to genotoxic effects in workers occupationally exposed to styrene.
Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes.
Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2.
Silencing TAK1 alters gene expression signatures in bladder cancer cells.
Silencing transcription factor FOXM1 represses proliferation, migration, and invasion while inducing apoptosis of liver cancer stem cells by regulating the expression of ALDH2.
Single-cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT-related genes in metastatic prostate cancer.
Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells.
SIX1 maintains tumor basal cells via transforming growth factor-? pathway and associates with poor prognosis in esophageal cancer.
Somatic aberrations of BRCA1 gene are associated with ALDH1, EGFR, and tumor progression in prostate cancer.
Sonic hedgehog and Wnt/?-catenin pathways mediate curcumin inhibition of breast cancer stem cells.
SOX9 Regulates Cancer Stem-Like Properties and Metastatic Potential of Single-Walled Carbon Nanotube-Exposed Cells.
Spatial distribution of cancer stem cells in head and neck squamous cell carcinomas.
Spectral overlap-free quantum dot-based determination of benzo[a]pyrene-induced cancer stem cells by concurrent monitoring of CD44, CD24 and aldehyde dehydrogenase 1.
Spectrum of Epithelial-Mesenchymal Transition Phenotypes in Circulating Tumour Cells from Early Breast Cancer Patients.
Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients.
Stem cell biomarker ALDH1A1 in breast cancer shows an association with prognosis and clinicopathological variables that is highly cut-off dependent.
Stem cell marker aldehyde dehydrogenase 1 (ALDH1)-expressing cells are enriched in triple-negative breast cancer.
Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression.
Stem Cells Inhibition by Bevacizumab in Combination with Neoadjuvant Chemotherapy for Breast Cancer.
Stem-like Human Breast Cancer Cells Initiate Vasculogenic Mimicry on Matrigel.
Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1?/VEGF signalling in MCF-7 breast cancer cells.
Stromal CD10 expression in breast cancer correlates with tumor invasion and cancer stem cell phenotype.
Stromal cells in phyllodes tumors of the breast are enriched for EZH2 and stem cell marker expression.
Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression.
Studies on expression of aldehyde dehydrogenase in normal and cancerous tissues of thyroids.
Sulforaphane Suppresses the Growth of Triple-negative Breast Cancer Stem-like Cells In vitro and In vivo.
Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction.
SUMO-Activating Enzyme Subunit 1 (SAE1) Is a Promising Diagnostic Cancer Metabolism Biomarker of Hepatocellular Carcinoma.
Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1.
Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma.
Synergistic anti-cancer mechanisms of curcumin and paclitaxel for growth inhibition of human brain tumor stem cells and LN18 and U138MG cells.
Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.
Tamoxifen induces a pluripotency signature in breast cancer cells and human tumors.
TAp63 and ?Np63 (p40) in prostate adenocarcinomas: ?Np63 associates with a basal-like cancer stem cell population but not with metastasis.
Targeted therapy aimed at cancer stem cells: Wilms' tumor as an example.
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.
Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian Cancer.
Targeting aldehyde dehydrogenase: a potential approach for cell labeling.
Targeting ALDH1 to decrease tumorigenicity, growth and metastasis of human melanoma.
Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells.
Targeting ALDH2 with disulfiram/copper reverses the resistance of cancer cells to microtubule inhibitors.
Targeting ALDHbright human carcinoma initiating cells with ALDH1A1- specific CD8+ T cells.
Targeting c-kit inhibits gefitinib resistant NSCLC cell growth and invasion through attenuations of stemness, EMT and acquired resistance.
Targeting the cancer stem cell marker, aldehyde dehydrogenase 1, to circumvent cisplatin resistance in NSCLC.
Targets and pathways involved in the antitumor activity of citral and its stereo-isomers.
TAZ induces lung cancer stem cell properties and tumorigenesis by up-regulating ALDH1A1.
TDO2 overexpression correlates with poor prognosis, cancer stemness, and resistance to cetuximab in bladder cancer.
Telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde.
Telomere Shortening in the Oral Epithelium in Relation to Alcohol Intake, Alcohol Dehydrogenase (ADH-1B) and Acetaldehyde Dehydrogenase (ALDH-2) Genotypes and Clinicopathologic Features.
Tescalcin/c-Src/IGF1R?-mediated STAT3 activation enhances cancer stemness and radioresistant properties through ALDH1.
Tetrandrine inhibits glioma stem-like cells by repressing ?-catenin expression.
The Clinical Significance of Cancer Stem Cell Markers ALDH1A1 and CD133 in Lung Adenocarcinoma.
The combination of aldehyde dehydrogenase 1 (ALDH1) and CD44 is associated with poor outcomes in endometrial cancer.
The different pathogeneses of sporadic adenoma and adenocarcinoma in non-ampullary lesions of the proximal and distal duodenum.
The effect of genetic polymorphisms in the vinyl chloride metabolic pathway on mutagenic risk.
The expression of aldehyde dehydrogenase 1 (ALDH1) in ovarian carcinomas and its clinicopathological associations: a retrospective study.
The expression of aldehyde dehydrogenase 1 in invasive primary breast tumors and axillary lymph node metastases is associated with poor clinical prognosis.
The expression of ALDH1 in cervical carcinoma.
The expression pattern of aldehyde dehydrogenase 1 (ALDH1) is an independent prognostic marker for low survival in colorectal tumors.
The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma.
The functional role of the EZH2 gene in controlling breast cancer stem cells.
The genetic basis of addictive disorders.
The Heparan Sulfate Sulfotransferases HS2ST1 and HS3ST2 Are Novel Regulators of Breast Cancer Stem-Cell Properties.
The Identifications and Clinical Implications of Cancer Stem Cells in Colorectal Cancer.
The impact of Aldehyde dehydrogenase 1 expression on prognosis for metastatic colon cancer.
The inhibitor of differentiation isoform Id1b, generated by alternative splicing, maintains cell quiescence and confers self-renewal and cancer stem cell-like properties.
The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells.
The long non-coding RNA MACC1-AS1 promotes nasopharyngeal carcinoma cell stemness via suppressing miR-145-mediated inhibition on SMAD2/MACC1-AS1 axis.
The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype.
The murine hepatic sequelae of long-term ethanol consumption are sex-specific and exacerbated by Aldh1b1 loss.
The predominant expression of cancer stem cell marker ALDH1A3 in tumor infiltrative area is associated with shorter overall survival of human glioblastoma.
The prognostic impact of cancer stem-like cell biomarker aldehyde dehydrogenase-1 (ALDH1) in ovarian cancer: A meta-analysis.
The prognostic role of cancer stem cells in breast cancer: a meta-analysis of published literatures.
The prognostic role of the cancer stem cell marker aldehyde dehydrogenase 1 in head and neck squamous cell carcinomas: a meta-analysis.
The prognostic roles of ALDH1 isoenzymes in gastric cancer.
The prognostic roles of circulating ALDH1+ tumor cell in the patients with non-small cell lung cancer.
The Prognostic Value of Cancer Stem Cell Markers (Notch1, ALDH1, and CD44) in Primary Colorectal Carcinoma.
The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma.
The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer.
The role of ALDH1A1 in contributing to breast tumour aggressiveness: A study conducted in an African population.
The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment.
The role of LGR5 and ALDH1A1 in non-small cell lung cancer: Cancer progression and prognosis.
The role of myeloid-derived suppressor cells in increasing cancer stem-like cells and promoting PD-L1 expression in epithelial ovarian cancer.
The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells.
The stem cell/cancer stem cell marker ALDH1A3 regulates the expression of the survival factor tissue transglutaminase, in mesenchymal glioma stem cells.
The utility of STAT6 and ALDH1 expression in the differential diagnosis of solitary fibrous tumor versus prostate-specific stromal neoplasms.
Through the glass darkly: intraepithelial neoplasia, top-down differentiation and the road to ovarian cancer.
Transcriptome analysis and prognosis of ALDH isoforms in human cancer.
Transcriptomic Analysis of Breast Cancer Stem Cells and Development of a pALDH1A1:mNeptune Reporter System for Live Tracking.
Treatment resistance in stem cells and breast cancer.
Tumorigenesis of smoking carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is related to its ability to stimulate thromboxane synthase and enhance stemness of non-small cell lung cancer stem cells.
Tumour budding and the expression of cancer stem cell marker aldehyde dehydrogenase 1 in nasopharyngeal carcinoma.
Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality.
Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis.
UPLC-MS-based metabolomics reveals metabolic dysregulation in ALDH1A1-overexpressed lung adenocarcinoma cells.
Upregulation of ALDH1B1 promotes tumor progression in osteosarcoma.
Urokinase Plasminogen Activator System Targeted Delivery of Nanobins as a Novel Ovarian Cancer Therapeutics.
Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain.
Value of CagA, HER2, ALDH1, and KiSS-1 in predicting metastasis and prognosis for gastric adenocarcinoma.
Vasculogenic mimicry and expression of ALDH1, Beclin1, and p16 correlate with metastasis and prognosis in oral squamous cell carcinoma.
VEGFA activates an epigenetic pathway upregulating ovarian cancer-initiating cells.
Verification of ALDH Activity as a Biomarker in Colon Cancer Stem Cells-Derived HT-29 Cell Line.
Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells.
Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells.
WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer.
Women with familial risk for breast cancer have an increased frequency of aldehyde dehydrogenase expressing cells in breast ductules.
Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors.
Zinc-finger E-box-binding homeobox 1 (ZEB1) plays a crucial role in the maintenance of lung cancer stem cells resistant to gefitinib.
[A coexistence of the Dupuytren's disease and malignant neoplasms: a review].
[Abnormal expression of genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer].
[Advance in research on the association of ALDH2 gene polymorphisms with cancer susceptibility in drinkers].
[Advancement of studies on ALDH1 as a universal marker of stem cells].
[Alcohol and oropharyngolaryngeal and digestive tract cancer]
[Anti-tumor mechanism of Artemisia annua based on bioinformatics].
[Effect of aspirin on breast cancer stem cells and stemness of breast cancer].
[Expansion of secretory cells in the fallopian tubal epithelium in the early stages of the pathogenesis of ovarian serous carcinomas].
[Expression and Clinical Significance of ALDH1 and Twist in Gastric Adenocarcinoma].
[Expression Level of Membrane-associated Proteins Numb in Epithelial Ovarian Carcinoma and Its Relationship with Ovarian Cancer Stem Cell Markers CD117, CD133, ALDH1.]
[Expression of Acetaldehyde Dehydrogenase in Gefitinib-resistant Human Lung Adenocarcinoma HCC-827/GR Cells].
[Expression of ALDH1, CXCR4 and E-cadherin in castric carcinoma and their roles in lymphatic metastasis].
[Expressions and Significance of ALDH1, HIF-1? and VEGF in Laryngeal Squamous Cell Carcinoma].
[Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]
[High aldehyde dehydrogenase 1A1 (ALDH1A1) expression correlated with risk of lymph node metastasis in papillary thyroid carcinoma].
[Lung non-terminal respiratory unit type adenocarcinoma: a clinicopathologic study].
Neoplasms, Second Primary
Clinical features and treatment outcomes of Japanese head and neck cancer patients with a second primary cancer.
Neoplasms, Squamous Cell
ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors.
Esophageal melanosis, an endoscopic finding associated with squamous cell neoplasms of the upper aerodigestive tract, and inactive aldehyde dehydrogenase-2 in alcoholic Japanese men.
In vitro and in vivo expression of aldehyde dehydrogenase 1 in oral squamous cell carcinoma.
Neoplastic Cells, Circulating
Aldehyde dehydrogenase1 immunohistochemical staining in primary breast cancer cells independently predicted overall survival but did not correlate with the presence of circulating or disseminated tumors cells.
Identification of ALDH1A3 as a viable therapeutic target in breast cancer metastasis-initiating cells.
Prognostic Significance of TWIST1, CD24, CD44, and ALDH1 Transcript Quantification in EpCAM-Positive Circulating Tumor Cells from Early Stage Breast Cancer Patients.
Nervous System Diseases
A Neurodegenerative Phenotype Associated With Sjögren-Larsson Syndrome.
Conserved missense variant in ALDH1A3 ortholog impairs fecundity in C. elegans.
Neural Tube Defects
Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2.
Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects.
Neuralgia
Dihydromyricetin attenuates neuropathic pain via enhancing the transition from M1 to M2 phenotype polarization by potentially elevating ALDH2 activity in vitro and vivo.
Neurilemmoma
ALDH1 - A new immunohistochemical diagnostic marker for Schwann cell-derived tumors.
Neuroblastoma
Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma.
Overexpression of aldehyde dehydrogenase 1A1 reduces oxidation-induced toxicity in SH-SY5Y neuroblastoma cells.
Neurocutaneous Syndromes
Compound heterozygous mutations in the ALDH3A2 gene cause Sjögren-Larsson syndrome: a case report.
Impaired skin barrier function due to reduced ?-O-acylceramide levels in a mouse model of Sjögren-Larsson syndrome.
Restoration of fatty aldehyde dehydrogenase deficiency in Sjögren-Larsson syndrome.
Sjögren-Larsson syndrome: molecular genetics and biochemical pathogenesis of fatty aldehyde dehydrogenase deficiency.
Sjögren-Larsson syndrome: phenotypic variability in two brothers with a neurocutaneous disorder.
Neurodegenerative Diseases
Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity.
Aldehyde dehydrogenase 2 in the spotlight: The link between mitochondria and neurodegeneration.
Association between ALDH2 Gene Polymorphism and Late-onset Alzheimer Disease: An Up-to-date Meta-analysis.
Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system.
Overexpression of Aldehyde Dehydrogenase-2 Attenuates Neurotoxicity Induced by 4-Hydroxynonenal in Cultured Primary Hippocampal Neurons.
Oxadiazon affects the expression and activity of aldehyde dehydrogenase and acylphosphatase in human striatal precursor cells: A possible role in neurotoxicity.
Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update.
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.
The Role of Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) in Neuropathology and Neurodegeneration.
Neuroendocrine Tumors
ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome.
Neurofibroma
ALDH1 - A new immunohistochemical diagnostic marker for Schwann cell-derived tumors.
Neurofibrosarcoma
ALDH1 - A new immunohistochemical diagnostic marker for Schwann cell-derived tumors.
Neuroinflammatory Diseases
Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology.
Neuroprotective effects of Alda-1 mitigate spinal cord injury in mice: involvement of Alda-1-induced ALDH2 activation-mediated suppression of reactive aldehyde mechanisms.
Non-alcoholic Fatty Liver Disease
Differences in the genetic backgrounds of patients with alcoholic liver disease and non-alcoholic fatty liver disease.
Outcomes of Japanese patients with non-alcoholic fatty liver disease according to genetic background and lifestyle-related diseases.
The Association and Interaction of Aldehyde Dehydrogenase 2 Polymorphisms with Food Group Intake and Probability of Having Non-Alcoholic Fatty Liver Disease.
Vinyl chloride-induced interaction of nonalcoholic and toxicant-associated steatohepatitis: Protection by the ALDH2 activator Alda-1.
Obesity
Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome.
Aldehyde Dehydrogenases Genetic Polymorphism and Obesity: From Genomics to Behavior and Health.
ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 Inhibitors.
Correction to: ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1? deacetylation.
Development of new disulfiram analogues as ALDH1a1-selective inhibitors.
Discovery and development of selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors.
Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity.
Discovery of coumarin-based selective aldehyde dehydrogenase 1A1 inhibitors with glucose metabolism improving activity.
Episodic ?-cell death and dedifferentiation during diet-induced obesity and dysglycemia in male mice.
Investigation of an ALDH1A1-specific inhibitor for suppression of weight gain in a diet-induced mouse model of obesity.
Moderate vitamin A supplementation in obese mice regulates tissue factor and cytokine production in a sex-specific manner.
Obesity, Current Treatment and Future Horizons.
Pharmacological inhibition of ALDH1A enzymes suppresses weight gain in a mouse model of diet-induced obesity.
The prolonged survival of fibroblasts with forced lipid catabolism in visceral fat following encapsulation in alginate-poly-L-lysine.
Obesity, Abdominal
The contribution of vitamin A to autocrine regulation of fat depots.
Odontogenic Cysts
Can lower aldehyde dehydrogenase activity in saliva be a risk factor for oral cavity cancer?
Odontogenic Tumors
Can lower aldehyde dehydrogenase activity in saliva be a risk factor for oral cavity cancer?
Optic Nerve Injuries
Optic nerve injury upregulates retinoic acid signaling in the adult frog visual system.
Oropharyngeal Neoplasms
Alcohol-metabolizing Enzymes' Gene Polymorphisms and Susceptibility to Multiple Head and Neck Cancers.
Heavy alcohol drinking downregulates ALDH2 gene expression but heavy smoking up-regulates SOD2 gene expression in head and neck squamous cell carcinoma.
Local Acetaldehyde: Its Key Role in Alcohol-Related Oropharyngeal Cancer.
Prognostic value of ALDH2 polymorphism for patients with oropharyngeal cancer in a Japanese population.
Osteoarthritis
Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant.
Genetic contribution to osteoarthritis development: current state of evidence.
Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.
The rs4238326 polymorphism in ALDH1A2 gene potentially associated with non-post traumatic knee osteoarthritis susceptibility: a two-stage population-based study.
Osteoarthritis, Knee
The rs4238326 polymorphism in ALDH1A2 gene potentially associated with non-post traumatic knee osteoarthritis susceptibility: a two-stage population-based study.
Osteonecrosis
A case-control study of association between life-style, alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotype and idiopathic osteonecrosis of the femoral head.
Osteoporosis
A critical assessment of the potential of pharmacological modulation of aldehyde dehydrogenases to treat the diseases of bone loss.
Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis.
Astaxanthin improves osteopenia caused by aldehyde-stress resulting from Aldh2 mutation due to impaired osteoblastogenesis.
Disruption of aldehyde dehydrogenase 2 gene results in altered cortical bone structure and increased cortical bone mineral density in the femoral diaphysis of mice.
Disruption of the Aldehyde Dehydrogenase 2 Gene Results in No Increase in Trabecular Bone Mass Due to Skeletal Loading in Association with Impaired Cell Cycle Regulation Through p21 Expression in the Bone Marrow Cells of Mice.
Effects of "Essential AD2" Supplement on Blood Acetaldehyde Levels in Individuals Who Have Aldehyde Dehydrogenase (ALDH2) Deficiency.
Systemic Adeno-Associated Virus-Mediated Gene Therapy Prevents the Multiorgan Disorders Associated with Aldehyde Dehydrogenase 2 Deficiency and Chronic Ethanol Ingestion.
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.
The Role of Alcohol, LPS Toxicity, and ALDH2 in Dental Bony Defects.
Osteosarcoma
MicroRNA-761 suppresses tumor progression in osteosarcoma via negatively regulating ALDH1B1.
MicroRNA?487b?3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3.
Overexpression of FER1L4 promotes the apoptosis and suppresses epithelial-mesenchymal transition and stemness markers via activating PI3K/AKT signaling pathway in osteosarcoma cells.
The expressions of CD133, ALDH1, and vasculogenic mimicry in osteosarcoma and their clinical significance.
Upregulation of ALDH1B1 promotes tumor progression in osteosarcoma.
Ovarian Neoplasms
?-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
A Novel ALDH1A1 Inhibitor Targets Cells with Stem Cell Characteristics in Ovarian Cancer.
ALDH1 expression correlates with favorable prognosis in ovarian cancers.
ALDH1-Bright Epithelial Ovarian Cancer Cells Are Associated with CD44 Expression, Drug Resistance, and Poor Clinical Outcome.
ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis.
ALDH1A1 contributes to PARP inhibitor resistance via enhancing DNA repair in BRCA2-/- ovarian cancer cells.
ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling.
ALDH1A2 Is a Candidate Tumor Suppressor Gene in Ovarian Cancer.
All-trans retinoic acid downregulates ALDH1-mediated stemness and inhibits tumour formation in ovarian cancer cells.
Association of ALDH1A1-NEK-2 axis in cisplatin resistance in ovarian cancer cells.
BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer.
CD166 Promotes the Cancer Stem-like Properties of Primary Epithelial Ovarian Cancer Cells.
Characterization of aldehyde dehydrogenase 1 high ovarian cancer cells: Towards targeted stem cell therapy.
Clinicopathological characteristics and prognostic value of the cancer stem cell marker ALDH1 in ovarian cancer: a meta-analysis.
DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1.
Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy.
Discovery of microarray-identified genes associated with ovarian cancer progression.
Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers.
DOXIL when combined with Withaferin A (WFA) targets ALDH1 positive cancer stem cells in ovarian cancer.
Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells.
Early detection biomarkers for ovarian cancer.
Effect of targeted ovarian cancer immunotherapy using ovarian cancer stem cell vaccine.
Gene expression profiling of single circulating tumor cells in ovarian cancer - Establishment of a multi-marker gene panel.
Inhibition of ALDH1A1 activity decreases expression of drug transporters and reduces chemotherapy resistance in ovarian cancer cell lines.
MicroRNAs overexpressed in ovarian ALDH1-positive cells are associated with chemoresistance.
Mutual Expression of ALDH1A1, LOX, and Collagens in Ovarian Cancer Cell Lines as Combined CSCs- and ECM-Related Models of Drug Resistance Development.
Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium.
Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy.
Prognostic values of aldehyde dehydrogenase 1 isoenzymes in ovarian cancer.
PTPRK Expression Is Downregulated in Drug Resistant Ovarian Cancer Cell Lines, and Especially in ALDH1A1 Positive CSCs-Like Populations.
Sensitization of ovarian cancer cells to cisplatin by gold nanoparticles.
Solanum Incanum Extract Downregulates Aldehyde Dehydrogenase 1-Mediated Stemness and Inhibits Tumor Formation in Ovarian Cancer Cells.
Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian Cancer.
The prognostic impact of cancer stem-like cell biomarker aldehyde dehydrogenase-1 (ALDH1) in ovarian cancer: A meta-analysis.
[Expression Level of Membrane-associated Proteins Numb in Epithelial Ovarian Carcinoma and Its Relationship with Ovarian Cancer Stem Cell Markers CD117, CD133, ALDH1.]
Pancreatic Neoplasms
Acetaldehyde and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers.
Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells.
Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma.
ALDH1A3 Accelerates Pancreatic Cancer Metastasis by Promoting Glucose Metabolism.
Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.
Association of aldehyde dehydrogenase 2 gene polymorphism with pancreatic cancer but not colon cancer.
Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine.
Combination of dasatinib and gemcitabine reduces the ALDH1A1 expression and the proliferation of gemcitabine-resistant pancreatic cancer MIA PaCa-2 cells.
Correlations between polymorphisms of extracellular superoxide dismutase, aldehyde dehydrogenase-2 genes, as well as drinking behavior and pancreatic cancer.
Fibulin-3 negatively regulates ALDH1 via c-MET suppression and increases ?-radiation-induced sensitivity in some pancreatic cancer cell lines.
Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts.
Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells.
Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population.
Low expression of aldehyde dehydrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer.
Nrf2 Depletion Sensitizes Pancreatic Cancer Cells to Gemcitabine via Aldehyde Dehydrogenase 3a1 Repression.
Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer.
Silencing of NRF2 Reduces the Expression of ALDH1A1 and ALDH3A1 and Sensitizes to 5-FU in Pancreatic Cancer Cells.
Smad4 Decreases the Population of Pancreatic Cancer-Initiating Cells through Transcriptional Repression of ALDH1A1.
Pancreatic Pseudocyst
SPINK1 gene mutations and pancreatitis in Japan.
Pancreatitis
A small-molecule activator of mitochondrial aldehyde dehydrogenase 2 reduces the severity of cerulein-induced acute pancreatitis.
Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individuals.
Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients.
Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis.
Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men.
Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in Japan.
Genotypes of Alcohol-Metabolizing Enzymes in Relation to Alcoholic Chronic Pancreatitis in Japan.
Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver.
Pancreatitis, Alcoholic
Alcohol and aldehyde dehydrogenase polymorphisms in Japanese patients with alcohol-induced chronic pancreatitis.
Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients.
CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis.
Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in Japan.
Genotypes of Alcohol-Metabolizing Enzymes in Relation to Alcoholic Chronic Pancreatitis in Japan.
[Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]
Pancreatitis, Chronic
Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals.
Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individuals.
Genetic polymorphisms in alcohol dehydrogenase, aldehyde dehydrogenase and alcoholic chronic pancreatitis susceptibility: A meta-analysis.
Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage.
Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.
Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrhosis and chronic pancreatitis.
SPINK1, ADH2, and ALDH2 gene variants and alcoholic chronic pancreatitis in Japan.
Papilloma
ALDH1 as a prognostic marker for lymph node metastasis in OSCC.
Heavy alcohol drinking downregulates ALDH2 gene expression but heavy smoking up-regulates SOD2 gene expression in head and neck squamous cell carcinoma.
Paraparesis, Spastic
Phenotypic variability among adult siblings with Sjögren-Larsson syndrome.
Parkinson Disease
Aldehyde dehydrogenase (ALDH) in Alzheimer's and Parkinson's disease.
Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease.
Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum.
Aldehyde dehydrogenase 2 genetic variations may increase susceptibility to Parkinson's disease in Han Chinese population.
Aldehyde dehydrogenase 2 in sporadic Parkinson's disease.
Aldehyde dehydrogenase 2 is associated with cognitive functions in patients with Parkinson's disease.
ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia.
ALDH1A1 Genetic Variations May Modulate Risk of Parkinson's Disease in Han Chinese Population.
ALDH1A1 regulates postsynaptic ?-opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling.
Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals.
Benomyl, aldehyde dehydrogenase, DOPAL, and the catecholaldehyde hypothesis for the pathogenesis of Parkinson's disease.
Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 Inhibitors.
Effect of ALDH2 on Sleep Disturbances in Patients with Parkinson's Disease.
Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system.
Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population.
Identification of aldehyde dehydrogenase 1A1 modulators using virtual screening.
Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson's Disease.
Neurorescue by a ROS Decomposition Catalyst.
Oxadiazon affects the expression and activity of aldehyde dehydrogenase and acylphosphatase in human striatal precursor cells: A possible role in neurotoxicity.
Psychotropics regulate Skp1a, Aldh1a1, and Hspa8 transcription--potential to delay Parkinson's disease.
Role of ADH2 and ALDH2 gene polymorphisms in the development of Parkinson's disease in a Chinese population.
Study on Parkinson's disease and alcohol drinking.
Parkinsonian Disorders
Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism.
Pentalogy of Cantrell
Duplication of the ALDH1A2 gene in association with pentalogy of Cantrell: a case report.
Periodontal Diseases
Association of ALDH2 genotypes with periodontitis progression.
Periodontitis
ALDH2 genotype is associated in the relation between alcohol intake and periodontitis.
Association of ALDH2 genotypes with periodontitis progression.
Peripheral Nervous System Diseases
Influence of alcohol intake and aldehyde dehydrogenase 2 phenotype on peripheral neuropathy of diabetes.
Perivascular Epithelioid Cell Neoplasms
Expression of CD44 and CD29 by PEComa cells suggests their possible origin of mesenchymal stem cells.
Persistent Infection
High expression of aldehyde dehydrogenase 1 and tissue necrosis factor alpha may relate to chronic infection of buffalo mammary gland.
Pharyngeal Neoplasms
Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese.
[Field cancerization and field therapy - the therapy of actinic keratosis by imiquimod].
Phyllodes Tumor
In phyllodes tumour of the breast expression of c-kit but not of ALDH1A1 is associated with adverse clinico-pathological features.
Pituitary Neoplasms
Reduction of retinaldehyde dehydrogenase 1 expression and production in estrogen-induced prolactinoma of rat.
Pleural Effusion, Malignant
ALDH1 and SALL4 Expression in Cell Block Samples from Patients with Lung Adenocarcinoma and Malignant Pleural Effusion.
Polycystic Ovary Syndrome
Expression Levels of the Oxidative Stress Response Gene ALDH3A2 in Granulosa-Lutein Cells Are Related to Female Age and Infertility Diagnosis.
Polyneuropathies
ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Oncorequisite role of an aldehyde dehydrogenase in the pathogenesis of T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Aberrant expression of aldehyde dehydrogenase 1A (ALDH1A) subfamily genes in acute lymphoblastic leukaemia is a common feature of T-lineage tumours.
Oncorequisite role of an aldehyde dehydrogenase in the pathogenesis of T-cell acute lymphoblastic leukemia.
Prolactinoma
Reduction of retinaldehyde dehydrogenase 1 expression and production in estrogen-induced prolactinoma of rat.
Prostatic Intraepithelial Neoplasia
Increased Expression of ALDH1A1 in Prostate Cancer is Correlated With Tumor Aggressiveness: A Tissue Microarray Study of Iranian Patients.
Prostatic Neoplasms
Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis.
ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome.
ALDH1A3 correlates with luminal phenotype in prostate cancer.
ALDH1A3 serves as a predictor for castration resistance in prostate cancer patients.
Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP.
Association study between genetic variants in retinol metabolism pathway genes and prostate cancer risk.
Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer.
Cancer stem cell markers in prostate cancer: an immunohistochemical study of ALDH1, SOX2 and EZH2.
Increased Expression of ALDH1A1 in Prostate Cancer is Correlated With Tumor Aggressiveness: A Tissue Microarray Study of Iranian Patients.
MiR-187 Targets the Androgen-Regulated Gene ALDH1A3 in Prostate Cancer.
p63 Cytoplasmic Aberrance is Associated with High Prostate Cancer Stem Cell Expression.
Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate model.
Shikonin enhances the antitumor effect of cabazitaxel in prostate cancer stem cells and reverses cabazitaxel resistance by inhibiting ABCG2 and ALDH3A1.
Silybin Prevents Prostate Cancer by Inhibited the ALDH1A1 Expression in the Retinol Metabolism Pathway.
Somatic aberrations of BRCA1 gene are associated with ALDH1, EGFR, and tumor progression in prostate cancer.
Sulforaphane Inhibits c-Myc-Mediated Prostate Cancer Stem-Like Traits.
The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer.
Tissue Biomarkers for Prognosis of prostate cancer: A Systematic Review and Meta-analysis.
Protein Deficiency
Deficient expression of aldehyde dehydrogenase 1A1 is consistent with increased sensitivity of Gorlin syndrome patients to radiation carcinogenesis.
Proteinuria
ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes.
Pterygium
Proteomic analysis in pterygium; upregulated protein expression of ALDH3A1, PDIA3, and PRDX2.
Pulmonary Arterial Hypertension
Aldehyde dehydrogenase 2 protects against oxidative stress associated with pulmonary arterial hypertension.
ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension.
Influence of the aldehyde dehydrogenase 2 polymorphism on the vasodilatory effect of nitroglycerin in infants with congenital heart disease and pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
Aldehyde dehydrogenase 2-a potential genetic risk factor for lung function among southern Chinese: evidence from the Guangzhou Biobank Cohort Study.
Large-scale, ion-current-based proteomics investigation of bronchoalveolar lavage fluid in chronic obstructive pulmonary disease patients.
Susceptibility to COPD: differential proteomic profiling after acute smoking.
Pulmonary Fibrosis
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
Quadriplegia
Sjögren-Larsson syndrome: Novel mutations in the ALDH3A2 gene in a French cohort.
Rectal Neoplasms
A critical Analysis of the Relationship Between Aldehyde dehydrogenases-2 Glu487Lys Polymorphism and Colorectal Cancer Susceptibility.
Aldehyde dehydrogenase 2 (ALDH2) genotype affects rectal cancer susceptibility due to alcohol consumption.
ALDH1 expression indicates chemotherapy resistance and poor outcome in node-negative rectal cancer.
ALDH1 is a prognostic factor for patients treated with neoadjuvant chemoradiotherapy and radical resection for stage III rectal cancer.
ALDH1 is an independent prognostic factor for patients with stages II-III rectal cancer after receiving radiochemotherapy.
Expression Analysis of Aldehyde Dehydrogenase 1A1 (ALDH1A1) in Colon and Rectal Cancer in Association with Prognosis and Response to Chemotherapy.
GAPDH and PUM1: Optimal Housekeeping Genes for Quantitative Polymerase Chain Reaction-Based Analysis of Cancer Stem Cells and Epithelial-Mesenchymal Transition Gene Expression in Rectal Tumors.
Genotype difference of aldehyde dehydrogenase 2 gene in alcohol drinkers influences the incidence of Japanese colorectal cancer patients.
Renal Insufficiency
Aldehyde dehydrogenase 2 as a potential protective factor for renal insufficiency in Japanese subjects with heart failure: a pilot study.
Maternal inheritance of diabetes is associated with inactive ALDH2 genotype in diabetics with renal failure in Japanese.
Reperfusion Injury
A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: Role of AMPK-regulated autophagy.
Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice.
Alda-1 Attenuates Lung Ischemia-Reperfusion Injury by Reducing 4-Hydroxy-2-Nonenal in Alveolar Epithelial Cells.
Alda-1, an aldehyde dehydrogenase-2 agonist, causes deterioration in renal functions following ischemia-reperfusion injury due to crystalline nephropathy.
Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury.
Aldehyde dehydrogenase 2 regulates autophagy via the Akt-mTOR pathway to mitigate renal ischemia-reperfusion injury in hypothermic machine perfusion.
Aldehyde Dehydrogenase-2 Activation during Cardioplegic Arrest Enhances the Cardioprotection against Myocardial Ischemia-Reperfusion Injury.
Aldehyde dehydrogenase-2 acts as a potential genetic target for renal fibrosis.
Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation.
Isoflurane Preconditioning Confers Cardioprotection by Activation of ALDH2.
Mitochondrial aldehyde dehydrogenase in myocardial ischemia-reperfusion injury: from bench to bedside.
Mitochondrial Aldehyde Dehydrogenase in Myocardial Ischemic and Ischemia-Reperfusion Injury.
Poly(ADP-ribose) polymerase inhibition prevents reactive oxygen species induced inhibition of aldehyde dehydrogenase2 activity.
Precision Medicine Considerations for the Management of Heart Disease and Stroke in East Asians.
Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update.
Respiratory Insufficiency
Biallelic hypomorphic variants in ALDH1A2 cause a novel lethal human multiple congenital anomaly syndrome encompassing diaphragmatic, pulmonary, and cardiovascular defects.
Retinitis Pigmentosa
Protection of retinal function and morphology in MNU-induced retinitis pigmentosa rats by ALDH2: an in-vivo study.
Retinoblastoma
Cancer stem cell characteristics in retinoblastoma.
Rhabdomyosarcoma
Aldehyde Dehydrogenase 1 (ALDH1) Is a Potential Marker for Cancer Stem Cells in Embryonal Rhabdomyosarcoma.
Rhabdomyosarcoma, Embryonal
Aldehyde Dehydrogenase 1 (ALDH1) Is a Potential Marker for Cancer Stem Cells in Embryonal Rhabdomyosarcoma.
Rosacea
Hypothesis of demodicidosis rosacea flushing etiopathogenesis.
Sarcoma
Aldehyde Dehydrogenase 1 (ALDH1) Is a Potential Marker for Cancer Stem Cells in Embryonal Rhabdomyosarcoma.
Aldehyde dehydrogenase 1, a potential marker for cancer stem cells in human sarcoma.
Aldh1 Expression and Activity Increase During Tumor Evolution in Sarcoma Cancer Stem Cell Populations.
ALDH1 is an immunohistochemical diagnostic marker for solitary fibrous tumours and haemangiopericytomas of the meninges emerging from gene profiling study.
Effect of chemotherapy on cancer stem cells and tumor-associated macrophages in a prospective study of preoperative chemotherapy in soft tissue sarcoma.
Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance.
Preclinical activity of palifosfamide lysine (ZIO-201) in pediatric sarcomas including oxazaphosphorine-resistant osteosarcoma.
The utility of STAT6 and ALDH1 expression in the differential diagnosis of solitary fibrous tumor versus prostate-specific stromal neoplasms.
Sarcoma, Ewing
C/EBP?-1 promotes transformation and chemoresistance in Ewing sarcoma cells.
Sarcoma, Kaposi
Expression of cancer stem cell markers and their correlation with pathogenesis in vascular tumors.
Sarcoma, Synovial
Evaluation of expression of cancer stem cell markers and fusion gene in synovial sarcoma: Insights into histogenesis and pathogenesis.
Scleroderma, Systemic
Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma.
Sepsis
Inhibition of ALDH2 expression aggravates renal injury in a rat sepsis syndrome model.
Proteomic alteration of mitochondrial aldehyde dehydrogenase 2 in sepsis regulated by heat shock response.
The Role of ALDH2 in Sepsis and the To-Be-Discovered Mechanisms.
Sjogren-Larsson Syndrome
Bezafibrate induces FALDH in human fibroblasts; implications for Sjögren-Larsson syndrome.
Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.
Comprehensive in silico screening and molecular dynamics studies of missense mutations in Sjogren-Larsson syndrome associated with the ALDH3A2 gene.
Enzymatic diagnosis of Sjögren-Larsson syndrome using electrospray ionization mass spectrometry.
Ichthyosis in Sjögren-Larsson syndrome reflects defective barrier function due to abnormal lamellar body structure and secretion.
Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3.
Neurodegeneration in an adolescent with Sjogren-Larsson syndrome: a decade-long follow-up case report.
Novel ALDH3A2 heterozygous mutations are associated with defective lamellar granule formation in a Japanese family of Sjögren-Larsson syndrome.
Novel ALDH3A2 heterozygous mutations in a Japanese family with Sjögren-Larsson syndrome.
Novel and recurrent ALDH3A2 mutations in Italian patients with Sjögren-Larsson syndrome.
Phenotypic variability among adult siblings with Sjögren-Larsson syndrome.
Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease.
Restoration of fatty aldehyde dehydrogenase deficiency in Sjögren-Larsson syndrome.
Sjögren-Larsson syndrome in Brazil is caused by a common c.1108-1G-->C splice-site mutation in the ALDH3A2 gene.
Sjögren-Larsson syndrome: molecular genetics and biochemical pathogenesis of fatty aldehyde dehydrogenase deficiency.
Sjögren-Larsson syndrome: seven novel mutations in the fatty aldehyde dehydrogenase gene ALDH3A2.
Sjogren-Larsson Syndrome: Mechanisms and Management.
Sjögren-Larsson syndrome: Novel mutations in the ALDH3A2 gene in a French cohort.
Skin Neoplasms
Comparative expression analysis of putative cancer stem cell markers CD44 and ALDH1A1 in various skin cancer subtypes.
Small Cell Lung Carcinoma
ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells.
ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors.
Solitary Fibrous Tumors
ALDH1 is an immunohistochemical diagnostic marker for solitary fibrous tumours and haemangiopericytomas of the meninges emerging from gene profiling study.
Differential diagnosis of solitary fibrous tumors: A study of 454 soft tissue tumors indicating the diagnostic value of nuclear STAT6 relocation and ALDH1 expression combined with in situ proximity ligation assay.
Histopathological findings and immunohistochemical expression of the stem cell markers CD44, ALDH1, Bmi-1, and Nanog in oral solitary fibrous tumors.
The utility of STAT6 and ALDH1 expression in the differential diagnosis of solitary fibrous tumor versus prostate-specific stromal neoplasms.
Spasm
Association of East Asian Variant Aldehyde Dehydrogenase 2 Genotype (ALDH2*2*) with Coronary Spasm and Acute Myocardial Infarction.
Risk and Protective Factors of Lifetime Cocaine-Associated Chest Pain.
Variant Aldehyde Dehydrogenase 2 (ALDH2*2) Is a Risk Factor for Coronary Spasm and ST-Segment Elevation Myocardial Infarction.
Spinal Cord Injuries
GSNOR and ALDH2 alleviate traumatic spinal cord injury.
Neuroprotective effects of Alda-1 mitigate spinal cord injury in mice: involvement of Alda-1-induced ALDH2 activation-mediated suppression of reactive aldehyde mechanisms.
Spinal Dysraphism
Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2.
Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development.
Spinocerebellar Ataxias
Clinical significance of a pvrl 4 encoded gene Nectin-4 in metastasis and angiogenesis for tumor relapse.
Squamous Cell Carcinoma of Head and Neck
A basal-cell-like compartment in head and neck squamous cell carcinomas represents the invasive front of the tumor and is expressing MMP-9.
A novel orthotopic mouse model of head and neck cancer and lymph node metastasis.
A perspective on challenges and opportunities in characterizing oral cancer stem cells.
Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer.
ALDH1 as a prognostic marker for lymph node metastasis in OSCC.
ALDH2 1510 G/A (Glu487Lys) polymorphism interaction with age in head and neck squamous cell carcinoma.
ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway.
Assessment of cancer stem cell marker expression in primary head and neck squamous cell carcinoma shows prognostic value for aldehyde dehydrogenase (ALDH1A1).
Association of Genetic Polymorphisms of Aldehyde Dehydrogenase-2 and Cytochrome P450 2E1-RsaI and Alcohol Consumption with Oral Squamous Cell Carcinoma.
Cancer stem cell phenotype relates to radio-chemotherapy outcome in locally advanced squamous cell head-neck cancer.
Cancer stem cell related markers of radioresistance in head and neck squamous cell carcinoma.
CD44 and ALDH1 immunoexpression as prognostic indicators of invasion and metastasis in oral squamous cell carcinoma.
CD44(high) /ALDH1(high) head and neck squamous cell carcinoma cells exhibit mesenchymal characteristics and GSK3?-dependent cancer stem cell properties.
Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer.
Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44(+)ALDH1(+) cells.
Discrimination of Cancer Stem Cell Markers ALDH1A1, BCL11B, BMI-1, and CD44 in Different Tissues of HNSCC Patients.
Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer.
Evaluation of the risk of metachronous multiple squamous cell carcinoma of the head and neck after transoral surgery based on the genetic polymorphisms of alcohol dehydrogenase 1B and aldehyde dehydrogenase 2.
Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma.
Expression level of PD-L1 is involved in ALDH1A1-mediated poor prognosis in patients with head and neck squamous cell carcinoma.
Expression of ALDH1A1 and CD44 in primary head and neck squamous cell carcinoma and their value for carcinogenesis, tumor progression and cancer stem cell identification.
Expression of CD44, CD44v9, ABCG2, CD24, Bmi-1 and ALDH1 in stage I and II oral squamous cell carcinoma and their association with clinicopathological factors.
Heavy alcohol drinking downregulates ALDH2 gene expression but heavy smoking up-regulates SOD2 gene expression in head and neck squamous cell carcinoma.
High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis.
Immunolocalization of Cancer Stem Cells Marker ALDH1 and its Association with Tumor Budding in Oral Squamous Cell Carcinoma.
Impact of alcohol dehydrogenase-aldehyde dehydrogenase polymorphism on clinical outcome in patients with hypopharyngeal cancer.
Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.
In vitro and in vivo expression of aldehyde dehydrogenase 1 in oral squamous cell carcinoma.
Overexpression of ALDH1 and EMT marker profile are linked with unfavorable outcome in head and neck cancer.
Pharmacological inhibition of Bmi1 by PTC-209 impaired tumor growth in head neck squamous cell carcinoma.
Predictive Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio in Head and Neck Squamous Cell Carcinoma.
Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer.
Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma.
Prognostic significance of ALDH1A1-positive cancer stem cells in patients with locally advanced, metastasized head and neck squamous cell carcinoma.
Prognostic Value of Drinking Status and Aldehyde Dehydrogenase 2 Polymorphism in Patients With Head and Neck Squamous Cell Carcinoma.
Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cell carcinoma.
Role of cancer stem cell markers ALDH1, BCL11B, BMI-1, and CD44 in the prognosis of advanced HNSCC.
SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates.
Spatial distribution of cancer stem cells in head and neck squamous cell carcinomas.
Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.
Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor.
The prognostic role of the cancer stem cell marker aldehyde dehydrogenase 1 in head and neck squamous cell carcinomas: a meta-analysis.
Vasculogenic mimicry and expression of ALDH1, Beclin1, and p16 correlate with metastasis and prognosis in oral squamous cell carcinoma.
[Correlation between drinking behavior and polymorphisms of extracellular superoxide dismutase, aldehyde dehydrogenase 2 genes, and oral squamous cell carcinoma].
ST Elevation Myocardial Infarction
Role of Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism in Acute Coronary Syndrome.
Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome.
Starvation
Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1.
Stress responses of testicular development, inflammatory and apoptotic activities in male zebrafish (Danio rerio) under starvation.
Stomach Neoplasms
Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for stomach cancer in Chinese males.
Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics.
Aldehyde dehydrogenase 3A1 is robustly upregulated in gastric cancer stem-like cells and associated with tumorigenesis.
ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer.
ALDH1A3-mTOR axis as a therapeutic target for anticancer drug-tolerant persister cells in gastric cancer.
ALDH2 and ADH1 Genetic Polymorphisms May Contribute to the Risk of Gastric Cancer: A Meta-Analysis.
Analysis of ADH1B Arg47His, ALDH2 Glu487Lys, and CYP4502E1 polymorphisms in gastric cancer risk and interaction with environmental factors.
Association between alcohol intake and risk for gastric cancer with regard to ALDH2 genotype in the Korean population.
Association between ALDH2 and ADH1B polymorphisms, alcohol drinking and gastric cancer: a replication and mediation analysis.
Association between ALDH2 Polymorphism and Gastric Cancer Risk in a Korean Population.
Association Between ALDH2 Polymorphism and Gastric Cancer Risk in Terms of Alcohol Consumption: A Meta-Analysis.
Association between ALDH2 rs671 G>A polymorphism and gastric cancer susceptibility in Eastern Asia.
Bioinformatics analysis with graph-based clustering to detect gastric cancer-related pathways.
BRD4 promotes the stemness of gastric cancer cells via attenuating miR-216a-3p-mediated inhibition of Wnt/?-catenin signaling.
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
Chronic atrophic gastritis and metachronous gastric cancer in Japanese alcoholic men with esophageal squamous cell carcinoma.
Effects of "Essential AD2" Supplement on Blood Acetaldehyde Levels in Individuals Who Have Aldehyde Dehydrogenase (ALDH2) Deficiency.
Effects of alcohol consumption, ALDH2 rs671 polymorphism, and Helicobacter pylori infection on the gastric cancer risk in a Korean population.
Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer.
Expression of ALDH1A1 and CD133 is associated with the prognosis and effect of different chemotherapeutic regimens in gastric cancer.
Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer.
Expression of NUAK2 in gastric cancer tissue and its effects on the proliferation of gastric cancer cells.
Faciogenital dysplasia 5 confers the cancer stem cell-like traits of gastric cancer cells through enhancing Sox2 protein stability.
Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation.
Genetic polymorphisms in alcohol metabolism, alcohol intake and the risk of stomach cancer in Warsaw, Poland.
Genetic polymorphisms of ADH1B, ADH1C and ALDH2, alcohol consumption, and the risk of gastric cancer: the Japan Public Health Center-based prospective study.
Helicobacter pylori, chronic atrophic gastritis, inactive aldehyde dehydrogenase-2, macrocytosis and multiple upper aerodigestive tract cancers and the risk for gastric cancer in alcoholic Japanese men.
Increased formation of gastric N(2)-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol.
Kimchi and soybean pastes are risk factors of gastric cancer.
Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer.
miR-625 reverses multidrug resistance in gastric cancer cells by directly targeting ALDH1A1.
Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of gastric cancer in West Bengal, India.
Predictive Value of Stemness Factor Sox2 in Gastric Cancer Is Associated with Tumor Location and Stage.
The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer.
The prognostic roles of ALDH1 isoenzymes in gastric cancer.
Stomach Ulcer
Lipoic acid protects gastric mucosa from ethanol-induced injury in rat through a mechanism involving aldehyde dehydrogenase 2 activation.
Stroke
Aldehyde dehydrogenase 2 activation and coevolution of its ?PKC-mediated phosphorylation sites.
Aldehyde dehydrogenase 2 polymorphism as a protective factor for intracranial vascular stenosis in ischemic stroke in Han Chinese.
Aldehyde Dehydrogenase Mutation Exacerbated High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease with Gut Microbiota Remodeling in Male Mice.
ALDH 2 conferred neuroprotection on cerebral ischemic injury by alleviating mitochondria-related apoptosis through JNK/caspase-3 signing pathway.
ALDH2 and Stroke: A Systematic Review of the Evidence.
ALDH2 attenuates early-stage STZ-induced aged diabetic rats retinas damage via Sirt1/Nrf2 pathway.
ALDH2 protects against stroke by clearing 4-HNE.
ALDH2 rs671 polymorphisms and the risk of cerebral microbleeds in Chinese elderly: the Taizhou Imaging Study.
ALDH2, a novel protector against stroke?
APSH YI-02 THE POLYMORPHISM IN ALDEHYDE DEHYDROGENASE-2 (ALDH2) GENE IS ASSOCIATED WITH MYOCARDIAL INFARCTION AND STROKE IN A CHINESE POPULATION.
Association of ADH1B polymorphism and alcohol consumption with increased risk of intracerebral hemorrhagic stroke.
Associations of common variants at ALDH2 gene and the risk of stroke in patients with coronary artery diseases undergoing percutaneous coronary intervention.
Homozygous ALDH2*2 Is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men.
Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
Sex-specific differences in the association of a common aldehyde dehydrogenase 2 gene polymorphism and alcohol consumption with stroke risk in a Korean population: a prospective cohort study.
Synergistic Effects of Aldehyde Dehydrogenase 2 Polymorphisms and Alcohol Consumption on Cognitive Impairment after Ischemic Stroke in Han Chinese.
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.
The role of ALDH2 and ADH1B polymorphism in alcohol consumption and stroke in Han Chinese.
Stroke, Lacunar
A polymorphism of the aldehyde dehydrogenase 2 gene is a risk factor for multiple lacunar infarcts in Japanese men: the Takahata Study.
Tachycardia
Developing precision medicine for people of East Asian descent.
Gene Therapy Correction of Aldehyde Dehydrogenase 2 Deficiency.
Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease.
Tendinopathy
Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models.
Teratocarcinoma
Enzymatic conversion of retinaldehyde to retinoic acid by cloned murine cytosolic and mitochondrial aldehyde dehydrogenases.
Thrombosis
Aldehyde dehydrogenase-2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP-activated protein kinase signaling in mice.
Thyroid Cancer, Papillary
Aldehyde dehydrogenase activity plays no functional role in stem cell-like properties in anaplastic thyroid cancer cell lines.
High ALDH1A1 expression correlates with poor survival in papillary thyroid carcinoma.
[High aldehyde dehydrogenase 1A1 (ALDH1A1) expression correlated with risk of lymph node metastasis in papillary thyroid carcinoma].
Thyroid Carcinoma, Anaplastic
Aldehyde dehydrogenase activity plays no functional role in stem cell-like properties in anaplastic thyroid cancer cell lines.
Thyroid Neoplasms
BRAFV600E-Associated Gene Expression Profile: Early Changes in the Transcriptome, Based on a Transgenic Mouse Model of Papillary Thyroid Carcinoma.
Tics
ABCG2 is a potential marker of tumor-initiating cells in breast cancer.
Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma.
Targeting tumour-initiating cells to improve the cure rates for triple-negative breast cancer.
Tremor
Effect of tremorogenic and antitumor agents on enzymes regulating a minor metabolic pathway of biogenic amines: an hypothesis for the underlying mechanism.
Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson's Disease.
Triple Negative Breast Neoplasms
A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer.
A triple negative breast cancer: what it is not!
Aldehyde dehydrogenase 1 (ALDH1) expression is an independent prognostic factor in triple negative breast cancer (TNBC).
Aldehyde dehydrogenase 1 expression predicts poor prognosis in triple-negative breast cancer.
Aldehyde dehydrogenase 1/epidermal growth factor receptor coexpression is characteristic of a highly aggressive, poor-prognosis subgroup of high-grade serous ovarian carcinoma.
Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling.
ALDH1 Cancer Stem Cell Marker as a Prognostic Factor in Triple-Negative Breast Cancer.
ALDH1 Expression and Vasculogenic Mimicry Are Positively Associated with Poor Prognosis in Patients with Breast Cancer.
ALDH1A1 mRNA expression in association with prognosis of triple-negative breast cancer.
Characterizing Breast Cancer in a Population with Increased Prevalence of Triple-Negative Breast Cancer: Androgen Receptor and ALDH1 Expression in Ghanaian Women.
Cytokeratin 19 (KRT19) has a Role in the Reprogramming of Cancer Stem Cell-Like Cells to Less Aggressive and More Drug-Sensitive Cells.
Effect of ALDH1 on prognosis and chemoresistance by breast cancer subtype.
Prognostic Impact and Clinicopathological Correlation of CD133 and ALDH1 Expression in Invasive Breast Cancer.
Stem cell marker aldehyde dehydrogenase 1 (ALDH1)-expressing cells are enriched in triple-negative breast cancer.
Tuberculosis
Functional polymorphism in aldehyde dehydrogenase-2 gene associated with risk of tuberculosis.
Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against Mycobacterium tuberculosis.
Urinary Bladder Neoplasms
Alcohol drinking and bladder cancer risk from a pooled analysis of ten cohort studies in Japan.
Aldehyde dehydrogenase 1 (ALDH1) expression is associated with a poor prognosis of bladder cancer.
Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer.
Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: Gene-environment interaction.
ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression.
HOXA9, ISL1 and ALDH1A3 methylation patterns as prognostic markers for nonmuscle invasive bladder cancer: Array-based DNA methylation and expression profiling.
Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2.
Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer.
YAP regulates ALDH1A1 expression and stem cell property of bladder cancer cells.
[Effects of 5-Aza-2'-deoxycitydine and trichostatin A on expression and apoptosis of ALDH1a2 gene in human bladder cancer cell lines]
Uterine Cervical Neoplasms
Aldehyde dehydrogenase 1 (ALDH1) positivity correlates with poor prognosis in cervical cancer.
Aldehyde Dehydrogenase 1 Expression Predicts Chemoresistance and Poor Clinical Outcomes in Patients with Locally Advanced Cervical Cancer Treated with Neoadjuvant Chemotherapy Prior to Radical Hysterectomy.
Aldehyde dehydrogenase 1, a target of miR-222, is expressed at elevated levels in cervical cancer.
Chemoradiation therapy reduces aldehyde dehydrogenase 1 expression in cervical cancer but does not improve patient survival.
Evidence for epithelial-mesenchymal transition in cancer stem-like cells derived from carcinoma cell lines of the cervix uteri.
Expression and functional role of ALDH1 in cervical carcinoma cells.
Low P16INK4A Expression Associated with High Expression of Cancer Stem Cell Markers Predicts Poor Prognosis in Cervical Cancer after Radiotherapy.
MiR-23b controls ALDH1A1 expression in cervical cancer stem cells.
The expression of ALDH1 in cervical carcinoma.
Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways.
Virus Diseases
Aldehyde dehydrogenase 2 polymorphism for development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis.
Association between smoking, acetaldehyde dehydrogenase-2 1-1 status, and alcohol drinking among Taiwanese polyvinyl chloride workers.
Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China.
Vitamin A Deficiency
A human ALDH1A2 gene variant is associated with increased newborn kidney size and serum retinoic acid.
Cellular expression of retinal dehydrogenase types 1 and 2: effects of vitamin A status on testis mRNA.
Differentiation-dependent regulation of retinal dehydrogenase gene expression in the trachea.
Localization of retinaldehyde dehydrogenases and retinoid binding proteins to sustentacular cells, glia, Bowman's gland cells, and stroma: Potential sites of retinoic acid synthesis in the postnatal rat olfactory organ.
Retinal dehydrogenase gene expression in stomach and small intestine of rats during postnatal development and in vitamin A deficiency.
Vitamin A deficiency induces congenital spinal deformities in rats.
Wilms Tumor
Inhibition of GSK3 Represses the Expression of Retinoic Acid Synthetic Enzyme ALDH1A2 via Wnt/?-Catenin Signaling in WiT49 Cells.
Xeroderma Pigmentosum
DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang, China.
Xerostomia
Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.