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Information on EC 1.2.1.28 - benzaldehyde dehydrogenase (NAD+)
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1.2.1.28 benzaldehyde dehydrogenase (NAD+)Specify your search results
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
baldh, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
benzaldehyde dehydrogenase
benzaldehyde dehydrogenase (NAD)
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-
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BZDH
additional information
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
benzaldehyde + NAD+ + H2O = benzoate + NADH + H+
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
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reduction
oxidation
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reduction
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
benzaldehyde:NAD+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
37250-93-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-bromobenzaldehyde + NAD+ + H2O
2-bromobenzoate + NADH
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-
-
?
2-fluorobenzaldehyde + NAD+ + H2O
2-fluorobenzoate + NADH + H+
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41% of activity with benzaldehyde
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?
2-methoxybenzaldehyde + NAD+ + H2O
2-methoxybenzoate + NADH + H+
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-
-
?
2-methylbenzaldehyde + NAD+ + H2O
2-methylbenzoate + NADH + 2 H+
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-
-
-
?
2-naphthaldehyde + NAD+ + H2O
naphthalene-2-carboxylic acid + NADH + 2 H+
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-
-
-
?
3,4-dihydroxybenzaldehyde + NAD+ + H2O
3,4-dihydroxybenzoate + NADH + H+
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-
-
?
3-chlorobenzaldehyde + NAD+ + H2O
3-chlorobenzoate + NADH + 2 H+
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-
-
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?
3-methoxy-4-hydroxybenzaldehyde + NAD+ + H2O
3-methoxy-4-hydroxybenzoate + NADH + H+
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-
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?
3-methoxybenzaldehyde + NAD+ + H2O
3-methoxybenzoate + NADH + 2 H+
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-
-
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?
3-methoxybenzaldehyde + NAD+ + H2O
3-methoxybenzoate + NADH + H+
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-
-
-
?
3-methylbenzaldehyde + NAD+ + H2O
3-methylbenzoate + NADH + 2 H+
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-
-
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?
4-chlorobenzaldehyde + H2O + NADP+
4-chlorobenzoate + NADPH + 2 H+
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-
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?
4-chlorobenzaldehyde + NAD+ + H2O
4-chlorobenzoate + NADH + 2 H+
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-
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?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + 2 H+
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14.7% realtive activity as compared to benzaldehyde
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?
4-methoxy-3-hydroxybenzaldehyde + NAD+ + H2O
4-methoxy-3-hydroxybenzoate + NADH + H+
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-
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?
4-methoxybenzaldehyde + H2O + NADP+
4-methoxybenzoate + NADPH + 2 H+
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-
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?
4-methoxybenzaldehyde + NAD+ + H2O
4-methoxybenzoate + NADH + 2 H+
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-
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?
4-methylbenzaldehyde + NAD+ + H2O
4-methylbenzoate + NADH + 2 H+
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-
-
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?
4-nitrobenzaldehyde + H2O + NADP+
4-nitrobenzoate + NADPH + 2 H+
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-
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?
acetaldehyde + NAD+ + H2O
acetate + NADH + 2 H+
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25.8% realtive activity as compared to benzaldehyde
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?
benzaldehyde + FAD + H2O
benzoate + FADH2
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the preferred cofactor is NAD+ followed by NADP+ (82%), FAD (40%) and FMN (34%)
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?
benzaldehyde + FMN + H2O
benzoate + FMNH2
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the preferred cofactor is NAD+ followed by NADP+ (82%), FAD (40%) and FMN (34%)
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?
benzaldehyde + NADP+ + H2O
benzoate + NADPH + 2 H+
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the preferred cofactor is NAD+ followed by NADP+ (82%), FAD (40%) and FMN (34%)
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?
cinnamaldehyde + NAD+ + H2O
cinnamate + NADH + H+
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benzaldehyde dehydrogenase II
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?
furan-2-carboxyaldehyde + NAD+ + H2O
furan-2-formiate + NADH
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benzaldehyde dehydrogenase II
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?
propionaldehyde + NAD+ + H2O
propionate + NADH + 2 H+
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10% realtive activity as compared to benzaldehyde
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?
pyridin-3-carboxyaldehyde + NAD+ + H2O
pyridin-3-formiate + NADH
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benzaldehyde dehydrogenase II
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?
thiophen-2-carboxaldehyde + NAD+ + H2O
thiophen-2-formiate + NADH
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-
-
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r
thiophen-2-carboxyaldehyde + NAD+ + H2O
thiophen-2-formiate + NADH
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benzaldehyde dehydrogenase II
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?
2-chlorobenzaldehyde + NAD+ + H2O
2-chlorobenzoate + NADH + H+
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low activity
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?
2-chlorobenzaldehyde + NAD+ + H2O
2-chlorobenzoate + NADH + H+
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low activity
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?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + 2 H+
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?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + 2 H+
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2% realtive activity as compared to benzaldehyde
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?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + H+
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benzaldehyde dehydrogenase II
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?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + H+
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39% of activity with benzaldehyde
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?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + H+
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16% of activity with benzaldehyde
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?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + H+
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16% of the activity with benzaldehyde
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?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + H+
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?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + H+
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?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + H+
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?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + H+
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?
2-methylbenzaldehyde + NAD+ + H2O
2-methylbenzoate + NADH
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?
2-methylbenzaldehyde + NAD+ + H2O
2-methylbenzoate + NADH
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13% of activity with benzaldehyde
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?
2-methylbenzaldehyde + NAD+ + H2O
2-methylbenzoate + NADH
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low activity
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?
3-chlorobenzaldehyde + NAD+ + H2O
3-chlorobenzoate + NADH
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?
3-chlorobenzaldehyde + NAD+ + H2O
3-chlorobenzoate + NADH
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low activity
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?
3-chlorobenzaldehyde + NAD+ + H2O
3-chlorobenzoate + NADH
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low activity
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?
3-fluorobenzaldehyde + NAD+ + H2O
3-fluorobenzoate + NADH + H+
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benzaldehyde dehydrogenase II
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?
3-fluorobenzaldehyde + NAD+ + H2O
3-fluorobenzoate + NADH + H+
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98% of activity with benzaldehyde
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?
3-fluorobenzaldehyde + NAD+ + H2O
3-fluorobenzoate + NADH + H+
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?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + 2 H+
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?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + 2 H+
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1.5% realtive activity as compared to benzaldehyde
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?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + H+
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benzaldehyde dehydrogenase II
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?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + H+
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222% of activity with benzaldehyde
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?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + H+
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38% of activity with benzaldehyde
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?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + H+
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38% of the activity with benzaldehyde
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?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + H+
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?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + H+
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?
3-methoxybenzaldehyde + NAD+ + H2O
3-methoxybenzoate + NADH
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benzaldehyde dehydrogenase II
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?
3-methoxybenzaldehyde + NAD+ + H2O
3-methoxybenzoate + NADH
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235% of activity with benzaldehyde
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?
3-methoxybenzaldehyde + NAD+ + H2O
3-methoxybenzoate + NADH
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?
3-methylbenzaldehyde + NAD+ + H2O
3-methylbenzoate + NADH
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-
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?
3-methylbenzaldehyde + NAD+ + H2O
3-methylbenzoate + NADH
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119% of activity with benzaldehyde
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?
3-methylbenzaldehyde + NAD+ + H2O
3-methylbenzoate + NADH
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-
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?
3-nitrobenzaldehyde + NAD+ + H2O
3-nitrobenzoate + NADH
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-
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?
4-carboxybenzaldehyde + NAD+ + H2O
4-carboxybenzoate + NADH
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1650% of activity with benzaldehyde
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?
4-carboxybenzaldehyde + NAD+ + H2O
4-carboxybenzoate + NADH
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1650% of activity with benzaldehyde
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?
4-fluorobenzaldehyde + NAD+ + H2O
4-fluorobenzoate + NADH + H+
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benzaldehyde dehydrogenase II
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?
4-fluorobenzaldehyde + NAD+ + H2O
4-fluorobenzoate + NADH + H+
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210% of activity with benzaldehyde
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?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
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-
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?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
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benzaldehyde dehydrogenase II
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?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
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24% of activity with benzaldehyde
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?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
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24% of the activity with benzaldehyde
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?
4-methoxybenzaldehyde + NAD+ + H2O
4-methoxybenzoate + NADH + H+
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benzaldehyde dehydrogenase II
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?
4-methoxybenzaldehyde + NAD+ + H2O
4-methoxybenzoate + NADH + H+
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-
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?
4-methoxybenzaldehyde + NAD+ + H2O
4-methoxybenzoate + NADH + H+
-
90% of activity with benzaldehyde
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?
4-methylbenzaldehyde + NAD+ + H2O
4-methylbenzoate + NADH
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-
-
-
?
4-methylbenzaldehyde + NAD+ + H2O
4-methylbenzoate + NADH
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240% of activity with benzaldehyde
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?
benzaldehyde + NAD+ + H2O
benzoate + NADH + 2 H+
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the enzyme is involved in biphenyl phytoalexin biosynthesis. Pyrus pyrifolia cell cultures respond to yeast extract treatment by accumulating benzoate-derived biphenyl phytoalexins, namely, noraucuparin and aucuparin
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?
benzaldehyde + NAD+ + H2O
benzoate + NADH + 2 H+
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the preferred cofactor is NAD+ followed by NADP+ (82%), FAD (40%) and FMN (34%)
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?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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benzaldehyde dehydrogenase II exhibits esterase activity with 4-nitrophenyl acetate
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?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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benzaldehyde dehydrogenase II exhibits esterase activity with 4-nitrophenyl acetate
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?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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benzaldehyde dehydrogenase I exhibits esterase activity, approx. 2% of dehydrogenase activity
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ir
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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also active with NADP+, see also EC 1.2.1.7
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ir
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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also active with NADP+, see also EC 1.2.1.7
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ir
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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-
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?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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last step in the biosynthesis of benzoic acid from cinnamic acid, a precursor of xanthones
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?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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also active with NADP+, see also EC 1.2.1.7
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ir
hexan-1-al + NAD+ + H2O
hexanoate + NADH
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benzaldehyde dehydrogenase II
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?
octan-1-al + NAD+ + H2O
octanoate + NADH
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benzaldehyde dehydrogenase II
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?
perillaldehyde + NAD+ + H2O
perillic acid + NADH
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benzaldehyde dehydrogenase II
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?
pyridine 4-carboxyaldehyde + NAD+ + H2O
pyridine 4-formiate + NADH
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benzaldehyde dehydrogenase II
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?
pyridine 4-carboxyaldehyde + NAD+ + H2O
pyridine 4-formiate + NADH
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1380% of activity with benzaldehyde
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?
additional information
?
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enzyme has a broad substrate specificity accepting mono- and di-aromatic aldehydes but not 2-methoxy derivatives or aliphatic primary aldehydes with 1-6 carbon atoms, no activity with NADP+ or NADPH, BZDH prefers benzaldehydes having substitution either at meta- or para-positions
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?
additional information
?
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the enzyme fails to show activity with NADP+ or NADPH and is inactive with 2-methoxybenzaldehyde, 4-hydroxybenzaldehyde, 2-chlorobenzaldehyde, and 1-naphthaldehyde
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?
additional information
?
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specificity data for PpBADH shows that long chain aliphatics containing 5-8 carbons have about twice the relative rate of reactivity than benzaldehyde. As the chain length decreases, the activity declines quickly, with less than 0.1% activity being observed with acetaldehyde. Structure-function analysis
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additional information
?
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enzyme has a broad substrate specificity accepting mono- and di-aromatic aldehydes but not 2-methoxy derivatives or aliphatic primary aldehydes with 1-6 carbon atoms, no activity with NADP+ or NADPH, BZDH prefers benzaldehydes having substitution either at meta- or para-positions
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?
additional information
?
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the enzyme fails to show activity with NADP+ or NADPH and is inactive with 2-methoxybenzaldehyde, 4-hydroxybenzaldehyde, 2-chlorobenzaldehyde, and 1-naphthaldehyde
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?
additional information
?
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metabolite identification by gas chromatography mass spectrometry (GC-MS)
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additional information
?
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metabolite identification by gas chromatography mass spectrometry (GC-MS)
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
benzaldehyde + NAD+ + H2O
benzoate + NADH + 2 H+
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the enzyme is involved in biphenyl phytoalexin biosynthesis. Pyrus pyrifolia cell cultures respond to yeast extract treatment by accumulating benzoate-derived biphenyl phytoalexins, namely, noraucuparin and aucuparin
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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-
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?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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last step in the biosynthesis of benzoic acid from cinnamic acid, a precursor of xanthones
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?