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Information on EC 1.2.1.27 - methylmalonate-semialdehyde dehydrogenase (CoA-acylating)

for references in articles please use BRENDA:EC1.2.1.27

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IUBMB Comments

Also converts 3-oxopropanoate into acetyl-CoA . The reaction occurs in two steps with the decarboxylation process preceding CoA-binding . Bicarbonate rather than CO2 is released as a final product .

The enzyme appears in viruses and cellular organisms

Synonyms
msdh, mmsdh, methylmalonate semialdehyde dehydrogenase, odommsdh, momsdh, methylmalonic acid semialdehyde dehydrogenase, mmsadh, sso1218, methylmalonate semialdehyde dehydrogenase protein, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
2,4-dinitrotoluene degradation, L-valine degradation I
Highest Expressing Human Cell Lines
Cell Line Links Gene Links